Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate [NMDA] receptor subunit epsilon 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma japonicum | ko:K05314 glutamate receptor, ionotropic, N-methyl-D-aspartate 2, invertebrate, putative | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Schistosoma mansoni | glutamate receptor NMDA | Get druggable targets OG5_129290 | All targets in OG5_129290 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tissue type plasminogen activator | 0.0558 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0285 | 0.2553 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0558 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0558 | 1 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0285 | 0.2553 | 0.2553 |
Brugia malayi | Kringle domain containing protein | 0.0558 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0285 | 0.2553 | 0.2553 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0558 | 1 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0285 | 0.2553 | 0.2553 |
Toxoplasma gondii | kringle domain-containing protein | 0.0558 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.2553 | 0.2553 |
Echinococcus granulosus | acetylcholinesterase | 0.0285 | 0.2553 | 0.2553 |
Schistosoma mansoni | hypothetical protein | 0.0558 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0285 | 0.2553 | 0.2553 |
Mycobacterium ulcerans | hypothetical protein | 0.0191 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0285 | 0.2553 | 0.2553 |
Leishmania major | hypothetical protein, conserved | 0.0558 | 1 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0558 | 1 | 1 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0558 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0285 | 0.2553 | 0.2553 |
Onchocerca volvulus | 0.0558 | 1 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0285 | 0.2553 | 0.2553 |
Echinococcus multilocularis | acetylcholinesterase | 0.0285 | 0.2553 | 0.2553 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.2553 | 0.2553 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0285 | 0.2553 | 0.2553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 9 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (binding) | = 9 nM | Displacement of [3H]Ro 25,6981 from NR2B NMDA receptor in rat forebrain | ChEMBL. | 17290978 |
IC50 (functional) | = 30 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
IC50 (functional) | = 30 nM | Antagonist activity at NR2B NMDA receptor in Wistar rat neocortical cells assessed as inhibition of NMDA-evoked elevation of intracellular calcium concentration | ChEMBL. | 17290978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.