Detailed information for compound 414933

Basic information

Technical information
  • TDR Targets ID: 414933
  • Name: (2-carboxyphenyl)sulfanyl-ethylmercury
  • MW: 382.83 | Formula: C9H10HgO2S
  • H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[Hg]Sc1ccccc1C(=O)O
  • InChi: 1S/C7H6O2S.C2H5.Hg/c8-7(9)5-3-1-2-4-6(5)10;1-2;/h1-4,10H,(H,8,9);1H2,2H3;/q;;+1/p-1
  • InChiKey: HXQVQGWHFRNKMS-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • (2-carboxyphenyl)sulfanyl-ethyl-mercury
  • 2-(ETHYLMERCURI-THIO)-BENZOIC ACID
  • 2-carboxybenzenethiolate; ethylmercury(1+)
  • 5396-12-3
  • 5401-59-2
  • BSPBio_001984
  • CHEBI:33214
  • DivK1c_000617
  • EMT
  • ethylmercury(1+); 2-sulfanylbenzoate
  • ethylmercury(1+); 2-mercaptobenzoate
  • ethylmercurithiosalicylic acid
  • ethylmercury; 2-sulfanylbenzoate
  • ethylmercury; 2-mercaptobenzoate
  • IDI1_000617
  • KBio1_000617
  • KBio2_001542
  • KBio2_004110
  • KBio2_006678
  • KBio3_001484
  • KBioGR_000789
  • KBioSS_001542
  • Mercurate(1-), ethyl[2-mercaptobenzoato(2-)-O,S]-, sodium
  • Mercurate(1-), ethyl[o-mercaptobenzoato(2-)]-, sodium
  • Mercury, ethyl(hydrogen o-mercaptobenzoato)-, sodium salt
  • Mercury, [(o-carboxyphenyl)thio]ethyl-, sodium salt
  • Merseptyl
  • Merzonin, sodium salt
  • NINDS_000617
  • NSC3908
  • NSC3909
  • NSC4794
  • QTL1_000081
  • Sodium salt of 2-(carboxyphenyl)thioethylmercury
  • SPBio_000623
  • Spectrum2_000552
  • Spectrum3_000572
  • Spectrum4_000355
  • Spectrum5_001805
  • Spectrum_001062
  • Thimerosal
  • Thimerosal solution
  • Thimerosol solution
  • Thiomerosal
  • WLN: QVR BS-HG-2 &-NA-
  • [(2-carboxyphenyl)thio]-ethylmercury
  • [(2-carboxyphenyl)thio]-ethyl-mercury
  • [(2-carboxyphenyl)sulfanyl](ethyl)mercury
  • [(o-carboxyphenyl)thio]ethylmercury
  • [(o-Carboxyphenyl)thio]ethylmercury sodium salt

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References
Plasmodium falciparum esterase, putative Curated by TDR Targets References
Plasmodium falciparum lysophospholipase, putative Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania donovani monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium vivax PST-A protein Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium vivax lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania mexicana monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania braziliensis monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium ulcerans lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
Neospora caninum hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma cruzi monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania infantum monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Toxoplasma gondii hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium vivax unspecified product Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_144587 All targets in OG5_144587
Plasmodium falciparum esterase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma brucei gambiense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Mycobacterium tuberculosis Possible lysophospholipase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma congolense monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Theileria parva hypothetical protein Get druggable targets OG5_144587 All targets in OG5_144587
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum lysophospholipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trypanosoma brucei monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Plasmodium falciparum esterase, putative Get druggable targets OG5_144587 All targets in OG5_144587
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127037 All targets in OG5_127037
Leishmania major monoglyceride lipase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein Get druggable targets OG5_127037 All targets in OG5_127037
Trichomonas vaginalis valacyclovir hydrolase, putative Get druggable targets OG5_127037 All targets in OG5_127037
Candida albicans similar to YJU3 Get druggable targets OG5_127037 All targets in OG5_127037
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 353 aa 379 aa 44.3 %
Plasmodium falciparum lysophospholipase, putative esterase, putative 373 aa 405 aa 51.6 %
Plasmodium falciparum lysophospholipase, putative lysophospholipase, putative 371 aa 380 aa 41.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Echinococcus multilocularis cathepsin b 0.049 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0196 0.1169 0.1169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0293 0.4085 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0201 0.13 0.13
Echinococcus granulosus cathepsin L cysteine proteinase 0.0293 0.4085 0.4085
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0178 0.0613 0.1499
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.0613 0.1499
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.0484 0.1186
Toxoplasma gondii cathepsin B 0.0196 0.1169 0.1602
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Plasmodium falciparum esterase, putative 0.0178 0.0613 0.1499
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0293 0.4085 0.3303
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Echinococcus multilocularis cysteine protease 0.0293 0.4085 0.4085
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.049 1 1
Plasmodium falciparum lysophospholipase, putative 0.0178 0.0613 0.1499
Brugia malayi cathepsin L-like precursor 0.0201 0.13 0.13
Plasmodium falciparum cysteine proteinase falcipain 3 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0201 0.13 0.3182
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Echinococcus granulosus cathepsin l cysteine peptidase 0.0293 0.4085 0.4085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Schistosoma mansoni cathepsin F (C01 family) 0.0293 0.4085 0.4085
Echinococcus granulosus cathepsin b 0.049 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0293 0.4085 0.4085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.0484 0.1186
Loa Loa (eye worm) ctsf protein 0.0293 0.4085 0.3303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.0484 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trypanosoma cruzi cysteine peptidase, putative 0.0293 0.4085 0.4085
Plasmodium vivax vivapain-2 0.0293 0.4085 1
Echinococcus granulosus cathepsin l1 0.0201 0.13 0.13
Entamoeba histolytica cysteine proteinase, putative 0.0293 0.4085 1
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0484 0.1186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0196 0.1169 0.2861
Loa Loa (eye worm) hypothetical protein 0.0201 0.13 0.0148
Plasmodium vivax lysophospholipase, putative 0.0178 0.0613 0.1499
Entamoeba histolytica cysteine protease, putative 0.0293 0.4085 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0293 0.4085 0.4085
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0173 0.0484 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0201 0.13 0.3182
Onchocerca volvulus 0.0293 0.4085 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0201 0.13 0.13
Giardia lamblia Cathepsin B precursor 0.0196 0.1169 0.5
Plasmodium falciparum esterase, putative 0.0178 0.0613 0.1499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Onchocerca volvulus Cathepsin F homolog 0.0293 0.4085 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0196 0.1169 0.1901
Loa Loa (eye worm) hypothetical protein 0.0201 0.13 0.0148
Echinococcus multilocularis cathepsin b 0.049 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Onchocerca volvulus 0.0293 0.4085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Brugia malayi Cathepsin L-like precursor 0.0201 0.13 0.13
Schistosoma mansoni cathepsin F (C01 family) 0.0201 0.13 0.13
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.0484 0.1186
Entamoeba histolytica cysteine proteinase, putative 0.0201 0.13 0.3182
Loa Loa (eye worm) fibroinase 0.0293 0.4085 0.3303
Loa Loa (eye worm) cysteine protease 0.0293 0.4085 0.3303
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Plasmodium falciparum lysophospholipase, putative 0.0173 0.0484 0.1186
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.0484 0.1186
Mycobacterium tuberculosis Possible lysophospholipase 0.0173 0.0484 0.5
Echinococcus granulosus cathepsin l1 0.0293 0.4085 0.4085
Schistosoma mansoni cathepsin F (C01 family) 0.0293 0.4085 0.4085
Onchocerca volvulus 0.0293 0.4085 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0196 0.1169 0.2861
Mycobacterium ulcerans lysophospholipase 0.0173 0.0484 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Plasmodium falciparum lysophospholipase, putative 0.0173 0.0484 0.1186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Giardia lamblia Cathepsin B precursor 0.0196 0.1169 0.5
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Brugia malayi Cathepsin L-like precursor 0.0201 0.13 0.13
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.049 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0293 0.4085 0.4085
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0293 0.4085 0.3303
Brugia malayi Cathepsin L-like precursor 0.0293 0.4085 0.4085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Echinococcus granulosus cathepsin b 0.049 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Onchocerca volvulus Cathepsin L homolog 0.0293 0.4085 1
Plasmodium falciparum esterase, putative 0.0173 0.0484 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Loa Loa (eye worm) hypothetical protein 0.049 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Plasmodium falciparum lysophospholipase, putative 0.0173 0.0484 0.1186
Onchocerca volvulus Cathepsin L homolog 0.0293 0.4085 1
Leishmania major cysteine peptidase A (CPA) 0.0293 0.4085 1
Trypanosoma cruzi monoglyceride lipase, putative 0.0173 0.0484 0.0484
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.0484 0.1186
Toxoplasma gondii cathepsin CPL 0.0293 0.4085 1
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0293 0.4085 1
Plasmodium vivax PST-A protein 0.0173 0.0484 0.1186
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0484 0.1186
Trypanosoma cruzi cruzipain precursor, putative 0.0293 0.4085 0.4085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Giardia lamblia Cathepsin B precursor 0.0196 0.1169 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Loa Loa (eye worm) hypothetical protein 0.0293 0.4085 0.3303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.13 0.0148
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0173 0.0484 0.1186
Plasmodium vivax unspecified product 0.0178 0.0613 0.1499
Echinococcus multilocularis cysteine protease 0.0293 0.4085 0.4085
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0293 0.4085 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0173 0.0484 0.1186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Plasmodium vivax vivapain-2 0.0293 0.4085 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0293 0.4085 0.4085
Onchocerca volvulus 0.0293 0.4085 1
Brugia malayi Papain family cysteine protease containing protein 0.0293 0.4085 0.4085
Leishmania major cathepsin L-like protease 0.0293 0.4085 1
Trypanosoma cruzi cysteine peptidase, putative 0.0293 0.4085 0.4085
Onchocerca volvulus 0.0293 0.4085 1
Trypanosoma cruzi cysteine peptidase, putative 0.0293 0.4085 0.4085
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.049 1 1
Onchocerca volvulus 0.0293 0.4085 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.049 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0293 0.4085 1
Onchocerca volvulus 0.0293 0.4085 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0293 0.4085 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.049 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0196 0.1169 0.1169
Mycobacterium ulcerans hypothetical protein 0.0173 0.0484 0.5
Trypanosoma brucei monoglyceride lipase, putative 0.0173 0.0484 0.1186
Entamoeba histolytica cysteine proteinase, putative 0.0293 0.4085 1
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0173 0.0484 0.1186

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.603 uM Inhibition of pyoverdin production in Pseudomonas aeruginosa ChEMBL. 16945524
IC50 (functional) = 0.708 uM Inhibition of pyocyanin production in Pseudomonas aeruginosa ChEMBL. 16945524
IC50 (functional) = 3.162 uM Inhibition of pyocyanin production in Pseudomonas aeruginosa ATCC9027 ChEMBL. 16945524
IC50 (functional) = 3.166 uM Inhibition of pyoverdin production in Pseudomonas aeruginosa ATCC9027 ChEMBL. 16945524

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 2350  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 3067  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 3068  
Annotator: saralph@unimelb.edu.au Comment: 012/Mar/09 References: 8022653

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.