TDR Targets

Basic information

Technical information

TDR Targets ID: 415209
Name: 1-[4-[3-amino-7-[2-(2-oxopyrrolidin-1-yl)etho xy]-1H-indazol-4-yl]phenyl]-3-(3-methylphenyl )urea
MW: 484.55 | Formula: C27H28N6O3
H donors: 4 H acceptors: 3 LogP: 3.29 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccc(c1)C)Nc1ccc(cc1)c1ccc(c2c1c(N)n[nH]2)OCCN1CCCC1=O
InChi: 1S/C27H28N6O3/c1-17-4-2-5-20(16-17)30-27(35)29-19-9-7-18(8-10-19)21-11-12-22(25-24(21)26(28)32-31-25)36-15-14-33-13-3-6-23(33)34/h2,4-5,7-12,16H,3,6,13-15H2,1H3,(H3,28,31,32)(H2,29,30,35)
InChiKey: LXNNTWRSZCNLBX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[4-[3-amino-7-[2-(2-oxopyrrolidin-1-yl)ethoxy]-1H-indazol-4-yl]phenyl]-3-(m-tolyl)urea
1-[4-[3-amino-7-[2-(2-oxo-1-pyrrolidinyl)ethoxy]-1H-indazol-4-yl]phenyl]-3-(m-tolyl)urea
1-[4-[3-azanyl-7-[2-(2-oxopyrrolidin-1-yl)ethoxy]-1H-indazol-4-yl]phenyl]-3-(3-methylphenyl)urea
1-[4-[3-amino-7-[2-(2-ketopyrrolidino)ethoxy]-1H-indazol-4-yl]phenyl]-3-(m-tolyl)urea
1-[4-[3-amino-7-[2-(2-oxo-1-pyrrolidinyl)ethoxy]-1H-indazol-4-yl]phenyl]-3-(3-methylphenyl)urea
1-[4-[3-amino-7-[2-(2-ketopyrrolidin-1-yl)ethoxy]-1H-indazol-4-yl]phenyl]-3-(3-methylphenyl)urea

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	Get druggable targets OG5_132967	All targets in OG5_132967

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0128	0.0828	0.0828
Giardia lamblia	Cathepsin B precursor	0.0389	0.3665	1
Echinococcus multilocularis	cathepsin b	0.097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0397	0.3758	0.3758
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0581	0.5756	0.5743
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0128	0.0828	0.0828
Onchocerca volvulus		0.0581	0.5756	1
Brugia malayi	cathepsin L-like precursor	0.0397	0.3758	0.3195
Onchocerca volvulus		0.0397	0.3758	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0312	0.2826	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0312	0.2826	0.2826
Brugia malayi	Cathepsin L-like precursor	0.0397	0.3758	0.3195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0397	0.3758	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0389	0.3665	0.5756
Echinococcus multilocularis	cysteine protease	0.0581	0.5756	0.5743
Onchocerca volvulus	Tyrosine kinase homolog	0.0174	0.1325	0.1007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0128	0.0828	0.0828
Trypanosoma cruzi	cysteine proteinase, putative	0.0312	0.2826	0.2178
Trypanosoma cruzi	cysteine peptidase, putative	0.0312	0.2826	0.2178
Trypanosoma cruzi	cysteine proteinase, putative	0.0312	0.2826	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0581	0.5756	0.5756
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0581	0.5756	0.5756
Entamoeba histolytica	cysteine proteinase, putative	0.0397	0.3758	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Echinococcus granulosus	cathepsin L cysteine protease	0.0312	0.2826	0.2826
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0397	0.3758	0.3195
Trypanosoma cruzi	cysteine peptidase, putative	0.0183	0.1427	0.0653
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0397	0.3758	0.5946
Schistosoma mansoni	cathepsin s	0.0183	0.1427	0.1427
Entamoeba histolytica	cysteine proteinase, putative	0.0581	0.5756	1
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Leishmania major	cysteine peptidase A (CPA)	0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1427	0.1427
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Onchocerca volvulus		0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0183	0.1427	0.1427
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0183	0.1427	0.0653
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0183	0.1427	0.0653
Echinococcus multilocularis	cathepsin L	0.0312	0.2826	0.2804
Loa Loa (eye worm)	hypothetical protein	0.097	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0581	0.5756	0.5373
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0128	0.0828	0.0828
Echinococcus multilocularis	cathepsin L cysteine protease	0.0581	0.5756	0.5743
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1427	0.1427
Entamoeba histolytica	cysteine proteinase 1, putative	0.0312	0.2826	0.4054
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0223	0.1864	0.1864
Loa Loa (eye worm)	hypothetical protein	0.0183	0.1427	0.1427
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0389	0.3665	0.2863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0581	0.5756	0.5373
Loa Loa (eye worm)	cysteine protease	0.0581	0.5756	0.5756
Trypanosoma cruzi	cysteine peptidase, putative	0.0581	0.5756	0.5373
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0581	0.5756	0.5756
Trypanosoma cruzi	cysteine protease, putative	0.0312	0.2826	0.2178
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0389	0.3665	0.3093
Brugia malayi	Papain family cysteine protease containing protein	0.0312	0.2826	0.2178
Entamoeba histolytica	cysteine proteinase, putative	0.0312	0.2826	0.4054
Toxoplasma gondii	cathepsin B	0.0389	0.3665	0.5756
Echinococcus granulosus	cathepsin L	0.0128	0.0828	0.0828
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0581	0.5756	1
Onchocerca volvulus		0.0581	0.5756	1
Echinococcus multilocularis	cathepsin b	0.097	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0397	0.3758	0.3195
Trypanosoma cruzi	cysteine peptidase, putative	0.0581	0.5756	0.5373
Schistosoma mansoni	cathepsin C	0.0128	0.0828	0.0828
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Echinococcus granulosus	cysteine protease	0.0312	0.2826	0.2826
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0128	0.0828	0.0828
Entamoeba histolytica	cysteine protease, putative	0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0397	0.3758	0.3758
Plasmodium vivax	vivapain-2	0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0223	0.1864	0.1129
Plasmodium vivax	unspecified product	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0128	0.0828	0.0828
Entamoeba histolytica	cysteine proteinase, putative	0.0312	0.2826	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0128	0.0828	0.0828
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Loa Loa (eye worm)	fibroinase	0.0581	0.5756	0.5756
Echinococcus granulosus	cathepsin b	0.097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Loa Loa (eye worm)	ctsf protein	0.0581	0.5756	0.5756
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Schistosoma mansoni	cathepsin F (C01 family)	0.0581	0.5756	0.5756
Schistosoma mansoni	cathepsin S (C01 family)	0.0128	0.0828	0.0828
Toxoplasma gondii	cathepsin CPL	0.0581	0.5756	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0397	0.3758	0.3758
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0671	0.674	0.674
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0581	0.5756	0.5756
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0312	0.2826	0.2826
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0581	0.5756	1
Echinococcus multilocularis	cathepsin L	0.0128	0.0828	0.08
Plasmodium vivax	unspecified product	0.0183	0.1427	0.1215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Loa Loa (eye worm)	cathepsin B	0.0389	0.3665	0.3665
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0581	0.5756	0.5743
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Echinococcus granulosus	cathepsin l1	0.0397	0.3758	0.3758
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0581	0.5756	0.5756
Trypanosoma cruzi	cruzipain precursor, putative	0.0183	0.1427	0.0653
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Giardia lamblia	Cathepsin B precursor	0.0389	0.3665	1
Brugia malayi	Cathepsin L-like precursor	0.0183	0.1427	0.0653
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Plasmodium vivax	vivapain-1	0.0312	0.2826	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0312	0.2826	0.4054
Plasmodium vivax	vivapain-2	0.0581	0.5756	1
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0128	0.0828	0.0828
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0128	0.0828	0.0828
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.097	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Entamoeba histolytica	cysteine proteinase, putative	0.0581	0.5756	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0389	0.3665	0.3665
Plasmodium vivax	vivapain-3	0.0312	0.2826	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0128	0.0828	0.0828
Echinococcus multilocularis	cathepsin L cysteine protease	0.0581	0.5756	0.5743
Onchocerca volvulus	Cathepsin L homolog	0.0581	0.5756	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.097	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.097	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0581	0.5756	0.5373
Onchocerca volvulus		0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Onchocerca volvulus		0.0581	0.5756	1
Onchocerca volvulus		0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Echinococcus multilocularis	cysteine protease	0.0581	0.5756	0.5743
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0128	0.0828	0.0828
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.097	1	1
Leishmania major	cathepsin L-like protease	0.0581	0.5756	1
Giardia lamblia	Cathepsin B precursor	0.0389	0.3665	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0581	0.5756	0.5373
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Brugia malayi	Cathepsin L-like precursor	0.0397	0.3758	0.3195
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0312	0.2826	0.2178
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0828	0.0828
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0312	0.2826	0.2826
Loa Loa (eye worm)	hypothetical protein	0.0397	0.3758	0.3758
Onchocerca volvulus		0.0581	0.5756	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0031	0.0031
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Echinococcus granulosus	cathepsin l1	0.0581	0.5756	0.5756
Schistosoma mansoni	cathepsin F (C01 family)	0.0581	0.5756	0.5756
Entamoeba histolytica	cysteine protease, putative	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Brugia malayi	Papain family cysteine protease containing protein	0.0312	0.2826	0.2178
Brugia malayi	Cathepsin L-like precursor	0.0581	0.5756	0.5373
Onchocerca volvulus	Cathepsin L homolog	0.0581	0.5756	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0128	0.0828	0.0828
Entamoeba histolytica	cysteine proteinase, putative	0.0312	0.2826	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0128	0.0828	0.0828
Onchocerca volvulus		0.0167	0.1245	0.0846
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0581	0.5756	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0581	0.5756	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0031	0.0031
Echinococcus granulosus	cathepsin L	0.0312	0.2826	0.2826
Echinococcus granulosus	roundabout 2	0.0055	0.0031	0.0031
Onchocerca volvulus	Cathepsin F homolog	0.0581	0.5756	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0581	0.5756	1
Entamoeba histolytica	cysteine proteinase, putative	0.0312	0.2826	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1
Echinococcus granulosus	cathepsin b	0.097	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0581	0.5756	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 15 nM	Inhibition of FLT3 by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 15 nM	Inhibition of FLT3 by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 25 nM	Inhibition of KDR by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 25 nM	Inhibition of KDR by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 53 nM	Inhibition of c-Kit by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 53 nM	Inhibition of c-Kit by HTRF assay	ChEMBL.	17343372
IC50 (binding)	= 53 nM	Inhibition of c-Kit by HTRF method	ChEMBL.	19892442

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL376245
PubChem: 11340683

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 415209