TDR Targets

Basic information

Technical information

TDR Targets ID: 415380
Name: (2R,3R,4S,5R)-2-[2-[2-(2-hydroxycyclohexyl)et hynyl]-6-(methoxyamino)purin-9-yl]-5-(hydroxy methyl)oxolane-3,4-diol
MW: 419.432 | Formula: C19H25N5O6
H donors: 5 H acceptors: 7 LogP: 0.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CONc1nc(C#CC2CCCCC2O)nc2c1ncn2[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO
InChi: 1S/C19H25N5O6/c1-29-23-17-14-18(22-13(21-17)7-6-10-4-2-3-5-11(10)26)24(9-20-14)19-16(28)15(27)12(8-25)30-19/h9-12,15-16,19,25-28H,2-5,8H2,1H3,(H,21,22,23)/t10?,11?,12-,15-,16-,19-/m1/s1
InChiKey: FEYPBAUWNQTFHW-GEPILXKISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3R,4S,5R)-2-[2-[2-(2-hydroxycyclohexyl)ethynyl]-6-(methoxyamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-[2-[2-(2-hydroxycyclohexyl)ethynyl]-6-(methoxyamino)-9-purinyl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-[2-[2-(2-hydroxycyclohexyl)ethynyl]-6-(methoxyamino)purin-9-yl]-5-methylol-tetrahydrofuran-3,4-diol

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adenosine A3 receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A1 receptor	Starlite/ChEMBL	References
Homo sapiens	adenosine A2a receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	follicle stimulating hormone receptor	adenosine A2a receptor	412 aa	336 aa	22.3 %
Brugia malayi	hypothetical protein	adenosine A1 receptor	326 aa	305 aa	21.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Brugia malayi	Peripheral plasma membrane protein CASK	0.0027	0.0597	0.0122
Schistosoma mansoni	tensin	0.0028	0.0633	0.0578
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Schistosoma mansoni	adapter molecule crk	0.0055	0.2045	0.2046
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0038	0.1147	0.1182
Schistosoma mansoni	tyrosine kinase	0.0019	0.0192	0.0121
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0064	0.2558	0.2638
Echinococcus multilocularis	breast cancer anti estrogen resistance protein	0.0027	0.0597	0.0615
Schistosoma mansoni	dynamin-associated protein	0.0027	0.0597	0.0541
Brugia malayi	Protein kinase domain containing protein	0.0038	0.1147	0.0699
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0201	0.9699	1
Echinococcus granulosus	tyrosine kinase	0.0038	0.1147	0.1182
Brugia malayi	Src substrate cortactin	0.0027	0.0597	0.0122
Onchocerca volvulus		0.0028	0.0633	0.552
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0633	0.0653
Schistosoma mansoni	tyrosine kinase	0.0064	0.2558	0.258
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Schistosoma mansoni	sorting nexin	0.0027	0.0597	0.0541
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0028	0.0633	0.0653
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0064	0.2558	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0269	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0038	0.1147	0.1182
Brugia malayi	Sex muscle abnormal protein 5	0.0055	0.2045	0.1643
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0064	0.2558	0.2638
Brugia malayi	Myosin tail family protein	0.0027	0.0597	0.0122
Echinococcus multilocularis	neuroglian	0.0017	0.0076	0.0079
Schistosoma mansoni	hypothetical protein	0.0027	0.0597	0.0541
Leishmania major	hypothetical protein, conserved	0.0027	0.0597	0.5
Schistosoma mansoni	tensin	0.0028	0.0633	0.0578
Trichomonas vaginalis	p67phox protein, putative	0.0027	0.0597	0.5
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0027	0.0597	0.0615
Echinococcus granulosus	tensin	0.0028	0.0633	0.0653
Schistosoma mansoni	hypothetical protein	0.0028	0.0633	0.0578
Brugia malayi	Variant SH3 domain containing protein	0.0028	0.0633	0.016
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0064	0.2558	0.2638
Brugia malayi	SH2 domain containing protein	0.0038	0.1147	0.0699
Schistosoma mansoni	hypothetical protein	0.0028	0.0633	0.0578
Loa Loa (eye worm)	guanylate kinase	0.0027	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Schistosoma mansoni	formin binding protein and related proteins	0.0027	0.0597	0.0541
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0028	0.0633	0.0653
Onchocerca volvulus	LIM and SH3 domain protein homolog	0.0027	0.0597	0.5206
Echinococcus granulosus	src region	0.0027	0.0597	0.0615
Trypanosoma cruzi	paraflagellar rod protein 5, putative	0.0027	0.0597	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.2045	0.1643
Echinococcus granulosus	tyrosine protein kinase shark	0.0038	0.1147	0.1182
Echinococcus granulosus	tyrosine protein kinase Srms	0.0038	0.1147	0.1182
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.1111	0.1075
Brugia malayi	Variant SH3 domain containing protein	0.0055	0.2045	0.1643
Echinococcus granulosus	c src tyrosine kinase	0.0064	0.2558	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Trichomonas vaginalis	neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative	0.0027	0.0597	0.5
Schistosoma mansoni	signal transducing adapter molecule (stam)	0.0027	0.0597	0.0541
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0633	0.0653
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0028	0.0633	0.0578
Onchocerca volvulus		0.0038	0.1147	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0028	0.0633	0.0653
Brugia malayi	Fes/CIP4 homology domain containing protein	0.0027	0.0597	0.0122
Loa Loa (eye worm)	SH2 domain-containing protein	0.0028	0.0633	0.0633
Echinococcus multilocularis	SH2 motif	0.0028	0.0633	0.0653
Echinococcus multilocularis	transfer RNA-Ala	0.0027	0.0597	0.0615
Echinococcus multilocularis	SH2 motif	0.0028	0.0633	0.0653
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0038	0.1147	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Echinococcus granulosus	hematopoietic lineage cell specific protein	0.0027	0.0597	0.0615
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0028	0.0633	0.0654
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Echinococcus granulosus	slit robo rho gtpase activating protein 1	0.0027	0.0597	0.0615
Echinococcus granulosus	SHC transforming protein 3	0.0028	0.0633	0.0653
Echinococcus granulosus	rho guanine nucleotide exchange factor 7	0.0027	0.0597	0.0615
Brugia malayi	Tyrosine-protein kinase abl-1	0.0064	0.2558	0.2182
Schistosoma mansoni	suppressor of cytokine signaling	0.0028	0.0633	0.0578
Echinococcus granulosus	expressed conserved protein	0.0028	0.0633	0.0653
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0028	0.0633	0.0633
Echinococcus multilocularis	epidermal growth factor receptor kinase	0.0027	0.0597	0.0615
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0028	0.0633	0.0653
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0064	0.2558	0.2638
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0027	0.0597	0.0615
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0038	0.1147	0.1182
Echinococcus granulosus	Spectrin alpha actinin	0.0027	0.0597	0.0615
Echinococcus granulosus	twitchin	0.0017	0.0076	0.0079
Echinococcus multilocularis	SH2 motif	0.0028	0.0633	0.0653
Schistosoma mansoni	tensin-related	0.0028	0.0633	0.0578
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0027	0.0597	0.0541
Echinococcus multilocularis	c src tyrosine kinase	0.0064	0.2558	0.2638
Schistosoma mansoni	dreadlocks/dock	0.0027	0.0597	0.0541
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0055	0.2045	0.2045
Brugia malayi	Protein kinase domain containing protein	0.0038	0.1147	0.0699
Schistosoma mansoni	slit-robo rho gtpase activating protein	0.0027	0.0597	0.0541
Onchocerca volvulus		0.0027	0.0597	0.5206
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0028	0.0633	0.0653
Onchocerca volvulus		0.0038	0.1147	1
Entamoeba histolytica	protein kinase, putative	0.0028	0.0633	0.0654
Onchocerca volvulus	Putative cortactin	0.0027	0.0597	0.5206
Echinococcus granulosus	roundabout 2	0.0021	0.0269	0.0277
Schistosoma mansoni	sorbin	0.0027	0.0597	0.0541
Echinococcus granulosus	signal transduction protein lnk realted	0.0028	0.0633	0.0653
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0028	0.0633	0.016
Schistosoma mansoni	nck2/grb4	0.0055	0.2045	0.2046
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0064	0.2558	0.2638
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Schistosoma mansoni	tyrosine kinase	0.0201	0.9699	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0028	0.0633	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Loa Loa (eye worm)	TK/ABL protein kinase	0.0038	0.1147	0.1147
Echinococcus granulosus	endophilin A3	0.0027	0.0597	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0028	0.0633	0.0633
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0028	0.0633	0.0653
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0038	0.1147	0.1182
Echinococcus multilocularis	intersectin 2	0.0027	0.0597	0.0615
Onchocerca volvulus		0.0028	0.0633	0.552
Brugia malayi	SH3 domain containing protein	0.0027	0.0597	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Schistosoma mansoni	Dab2-interacting protein-like	0.0027	0.0597	0.0541
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122
Onchocerca volvulus		0.0028	0.0633	0.552
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0038	0.1147	0.1182
Onchocerca volvulus		0.0038	0.1147	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0025	0.0481	0.0481
Onchocerca volvulus		0.0028	0.0633	0.552
Onchocerca volvulus		0.0028	0.0633	0.552
Onchocerca volvulus		0.0027	0.0597	0.5206
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0055	0.2045	0.2046
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0055	0.2045	0.2045
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122
Echinococcus granulosus	neuroglian	0.0017	0.0076	0.0079
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0028	0.0633	0.0653
Schistosoma mansoni	growth factor receptor-bound protein	0.0055	0.2045	0.2046
Schistosoma mansoni	shc transforming protein	0.0028	0.0633	0.0578
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0028	0.0633	0.016
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0597	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0028	0.0633	0.0653
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0028	0.0633	0.0653
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0028	0.0633	0.0653
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Echinococcus multilocularis	nostrin	0.0027	0.0597	0.0615
Loa Loa (eye worm)	SH2 domain-containing protein	0.0028	0.0633	0.0633
Echinococcus multilocularis	Spectrin alpha actinin	0.0027	0.0597	0.0615
Echinococcus multilocularis	tyrosine kinase	0.0038	0.1147	0.1182
Echinococcus granulosus	SH2 motif	0.0028	0.0633	0.0653
Echinococcus multilocularis	hematopoietic lineage cell specific protein	0.0027	0.0597	0.0615
Schistosoma mansoni	tyrosine kinase	0.0064	0.2558	0.258
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0064	0.2558	0.2638
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0038	0.1147	0.1182
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Schistosoma mansoni	eps8-related protein	0.0027	0.0597	0.0541
Echinococcus granulosus	N chimaerin	0.0028	0.0633	0.0653
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0028	0.0633	0.0633
Echinococcus granulosus	NCK adaptor protein	0.0055	0.2045	0.2108
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122
Brugia malayi	Variant SH3 domain containing protein	0.0028	0.0633	0.016
Echinococcus granulosus	epidermal growth factor receptor kinase	0.0027	0.0597	0.0615
Brugia malayi	hypothetical protein	0.0038	0.1147	0.0699
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Echinococcus granulosus	SH2 domain containing protein 7	0.0028	0.0633	0.0653
Echinococcus multilocularis	endophilin A3	0.0027	0.0597	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Echinococcus multilocularis	slit robo rho gtpase activating protein 1	0.0027	0.0597	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2045	0.2045
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Loa Loa (eye worm)	TK protein kinase	0.0038	0.1147	0.1147
Brugia malayi	Guanylate kinase family protein	0.0027	0.0597	0.0122
Echinococcus multilocularis	NCK adaptor protein	0.0055	0.2045	0.2108
Trypanosoma brucei	conserved protein	0.0027	0.0597	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0064	0.2558	0.2638
Echinococcus multilocularis	signal transduction protein lnk realted	0.0028	0.0633	0.0653
Echinococcus granulosus	fch and double sh3 domains protein 2	0.0027	0.0597	0.0615
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0038	0.1147	0.1182
Echinococcus granulosus	growth factor receptor bound protein 2	0.0055	0.2045	0.2108
Echinococcus granulosus	expressed protein	0.0027	0.0597	0.0615
Echinococcus multilocularis	tyrosine protein kinase shark	0.0038	0.1147	0.1182
Brugia malayi	Protein kinase domain containing protein	0.0038	0.1147	0.0699
Echinococcus granulosus	intersectin 2	0.0027	0.0597	0.0615
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Brugia malayi	protein-tyrosine kinase	0.0027	0.0597	0.0122
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0201	0.9699	1
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122
Onchocerca volvulus		0.0027	0.0597	0.5206
Schistosoma mansoni	tyrosine kinase	0.0064	0.2558	0.258
Brugia malayi	SH2 domain containing protein	0.0038	0.1147	0.0699
Schistosoma mansoni	hypothetical protein	0.0027	0.0597	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Schistosoma mansoni	growth factor receptor-bound protein	0.0055	0.2045	0.2046
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0028	0.0633	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0038	0.1147	0.1182
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0028	0.0633	0.0633
Echinococcus multilocularis		0.0028	0.0633	0.0653
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Loa Loa (eye worm)	SH2 domain-containing protein	0.0028	0.0633	0.0633
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0028	0.0633	0.016
Echinococcus multilocularis	tensin	0.0028	0.0633	0.0653
Echinococcus granulosus	tyrosine kinase	0.0038	0.1147	0.1182
Loa Loa (eye worm)	p53BP2	0.0027	0.0597	0.0597
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Echinococcus multilocularis	fch and double sh3 domains protein 2	0.0027	0.0597	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Onchocerca volvulus		0.0038	0.1147	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1147	0.1147
Echinococcus granulosus	nostrin	0.0027	0.0597	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Echinococcus granulosus	SH2 motif	0.0028	0.0633	0.0653
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0064	0.2558	0.2638
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0064	0.2558	0.258
Onchocerca volvulus		0.0038	0.1147	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0028	0.0633	0.0578
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Onchocerca volvulus		0.0027	0.0597	0.5206
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0064	0.2558	0.2638
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0028	0.0633	0.0653
Schistosoma mansoni	SH2A	0.0028	0.0633	0.0578
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0055	0.2045	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Brugia malayi	RhoGAP domain containing protein	0.0028	0.0633	0.016
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0201	0.9699	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0597	0.5
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Brugia malayi	SRC-1	0.0064	0.2558	0.2182
Schistosoma mansoni	GTPase activating protein	0.0028	0.0633	0.0578
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0028	0.0633	0.016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Schistosoma mansoni	tensin	0.0028	0.0633	0.0578
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0028	0.0633	0.0578
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0201	0.9699	1
Echinococcus multilocularis	N chimaerin	0.0028	0.0633	0.0653
Schistosoma mansoni	signal transduction protein lnk-related	0.0028	0.0633	0.0578
Brugia malayi	protein-tyrosine kinase	0.0038	0.1147	0.0699
Brugia malayi	SH2 domain containing protein	0.0028	0.0633	0.016
Echinococcus granulosus	tyrosine protein kinase Blk	0.0038	0.1147	0.1182
Loa Loa (eye worm)	thyroid receptor interactor	0.0027	0.0597	0.0597
Brugia malayi	Protein kinase domain containing protein	0.0038	0.1147	0.0699
Echinococcus multilocularis	rho guanine nucleotide exchange factor 7	0.0027	0.0597	0.0615
Onchocerca volvulus		0.0027	0.0597	0.5206
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0028	0.0633	0.0653
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0064	0.2558	0.2638
Echinococcus multilocularis	SHC transforming protein 3	0.0028	0.0633	0.0653
Echinococcus multilocularis	SH2 domain containing protein 7	0.0028	0.0633	0.0653
Schistosoma mansoni	tyrosine kinase	0.0064	0.2558	0.258
Echinococcus multilocularis	roundabout 2	0.0021	0.0269	0.0277
Onchocerca volvulus		0.0038	0.1147	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Schistosoma mansoni	tyrosine kinase	0.0038	0.1147	0.1112
Schistosoma mansoni	tyrosine kinase	0.0038	0.1147	0.1112
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0028	0.0633	0.0653
Schistosoma mansoni	sh3-containing grb2-like protein 1 (endophilin II)	0.0027	0.0597	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0269	0.0269
Schistosoma mansoni	tensin-related	0.0028	0.0633	0.0578
Echinococcus granulosus	breast cancer anti estrogen resistance protein	0.0027	0.0597	0.0615
Loa Loa (eye worm)	STAT protein	0.0028	0.0633	0.0633
Loa Loa (eye worm)	TK/FER protein kinase	0.0038	0.1147	0.1147
Brugia malayi	Protein kinase domain containing protein	0.0038	0.1147	0.0699
Schistosoma mansoni	cell polarity protein	0.0027	0.0597	0.0541
Onchocerca volvulus		0.0028	0.0633	0.552
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0028	0.0633	0.0578
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0027	0.0597	0.0597
Loa Loa (eye worm)	SRC-1	0.0064	0.2558	0.2558
Schistosoma mansoni	vav2	0.0028	0.0633	0.0578
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0597	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0597	0.5
Brugia malayi	hypothetical protein	0.0028	0.0633	0.016
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0064	0.2558	0.2638
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0028	0.0633	0.552
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Echinococcus multilocularis	tensin	0.0028	0.0633	0.0653
Loa Loa (eye worm)	protein-tyrosine kinase	0.0027	0.0597	0.0597
Brugia malayi	Tensin	0.0028	0.0633	0.016
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Schistosoma mansoni	run and tbc1 domain containing	0.0027	0.0597	0.0541
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0064	0.2558	0.2638
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0633	0.0633
Echinococcus granulosus	hypothetical protein	0.0028	0.0633	0.0653
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0027	0.0597	0.0597
Loa Loa (eye worm)	TK protein kinase	0.0207	1	1
Brugia malayi	Spectrin alpha chain	0.0027	0.0597	0.0122
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0064	0.2558	0.2638
Schistosoma mansoni	suppressor of cytokine signaling	0.0028	0.0633	0.0578
Schistosoma mansoni	C-fyn	0.0027	0.0597	0.0541
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0064	0.2558	0.2638
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0028	0.0633	0.552
Entamoeba histolytica	SH2 domain containing protein	0.0028	0.0633	0.0654
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0028	0.0633	0.0653
Echinococcus multilocularis	expressed protein	0.0027	0.0597	0.0615
Schistosoma mansoni	apoptosis stimulating of P53	0.0027	0.0597	0.0541
Brugia malayi	Variant SH3 domain containing protein	0.0027	0.0597	0.0122

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.7 nM	Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells	ChEMBL.	17309246
Ki (binding)	= 1.7 nM	Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells	ChEMBL.	17309246
Ki (binding)	= 34 nM	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	ChEMBL.	17309246
Ki (binding)	= 34 nM	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	ChEMBL.	17309246
Ki (binding)	= 91 nM	Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells	ChEMBL.	17309246
Ki (binding)	= 91 nM	Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells	ChEMBL.	17309246
Ratio Ki (binding)	= 20	Selectivity for human adenosine A3 receptor over human adenosine A1 receptor	ChEMBL.	17309246
Ratio Ki (binding)	= 53	Selectivity for human adenosine A3 receptor over human adenosine A2A receptor	ChEMBL.	17309246

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL223326
PubChem: 10047690

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 415380