Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7709 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2291 | 0.2291 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7709 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2291 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 | |
Activity (binding) | 0 | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 |
IC50 (binding) | 0 | Inhibition of vaccinia virus system-induced human NOS expressed in BSC1 cells | ChEMBL. | 17315988 |
IC50 (binding) | = 1805 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
IC50 (binding) | = 1805 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
Ratio IC50 (binding) | 0 | Selectivity ratio, IC50 for ecNOS/IC50 for iNOS using vaccinia virus-induced system in BSC1 cells | ChEMBL. | 17315988 |
Ratio IC50 (binding) | 0 | Selectivity ratio, IC50 for bcNOS/IC50 for iNOS using vaccinia virus-induced system in BSC1 cells | ChEMBL. | 17315988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.