Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0214 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | fibroinase | 0.0214 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0149 | 0.0582 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0214 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0214 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.0582 | 0.2606 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine protease, putative | 0.0214 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0214 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0214 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.1828 | 0.1323 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0639 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0214 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0639 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0214 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0149 | 0.0582 | 0.2606 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0149 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0214 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0639 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0235 | 0.2232 | 0.2232 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0214 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin l1 | 0.0214 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0214 | 0.1828 | 0.1828 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0214 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin F homolog | 0.0214 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0214 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0235 | 0.2232 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0149 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0235 | 0.2232 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0214 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.0582 | 0.0582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0214 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0235 | 0.2232 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0639 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0639 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0149 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0149 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | cathepsin B | 0.0235 | 0.2232 | 0.1752 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0214 | 0.1828 | 0.1323 |
Brugia malayi | cathepsin L-like precursor | 0.0149 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0235 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.0639 | 1 | 1 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0214 | 0.1828 | 0.1828 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0214 | 0.1828 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0214 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0235 | 0.2232 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0235 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0639 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0214 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0149 | 0.0582 | 0.0582 |
Plasmodium vivax | vivapain-2 | 0.0214 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0214 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0214 | 0.1828 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0214 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0214 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0214 | 0.1828 | 1 |
Toxoplasma gondii | cathepsin B | 0.0235 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0214 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0214 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0214 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0214 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0639 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0235 | 0.2232 | 0.2232 |
Loa Loa (eye worm) | ctsf protein | 0.0214 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0214 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0214 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0639 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0639 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0214 | 0.1828 | 0.8189 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta Tm (binding) | = 14.8 | Delta TM value showing the stabilisation of the dodecanucleotide d(CGCGAATTCGCG)2 produced by the compound binding. | ChEMBL. | No reference |
IC50 (functional) | = 3.3 uM | The compound was tested for cytotoxic potency against A2780R human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 4.2 uM | The compound was tested for cytotoxic potency against CH1 human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 11 uM | Cytotoxicity of the compound against A2780 ovarian carcinoma cells was evaluated using standard sulforhodamine 96h assay test | ChEMBL. | 11128631 |
IC50 (functional) | = 11 uM | The compound was tested for cytotoxic potency against A2780 human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 25 uM | The compound was tested for cytotoxic potency against SKOV-3 human tumor cell lines. | ChEMBL. | No reference |
PCP activity (functional) | = 0.05 cysts g-1 | Number of mean cysts/g of lung tissue observed at 9-10 microM/kg/day dose of compound tested invivo against Pneumocystis carinii pneumonia infected rats | ChEMBL. | 11128631 |
PCP activity (functional) | = 0.67 cysts g-1 | Number of mean cysts/g of lung tissue observed at 0.9 microM/kg/day dose of compound tested invivo against Pneumocystis carinii pneumonia infected rats | ChEMBL. | 11128631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.