Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7743 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7743 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2407 | 0.2407 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0016 | 0.0151 | 0.0151 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2407 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 | |
Activity (binding) | 0 | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 |
IC50 (binding) | = 12 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
IC50 (binding) | = 12 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
IC50 (binding) | > 1000 nM | Inhibition of vaccinia virus system-induced human NOS expressed in BSC1 cells | ChEMBL. | 17315988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.