TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 565.704 | Formula: C31H43N5O5
H donors: 6 H acceptors: 5 LogP: 4.07 Rotable bonds: 16
Rule of 5 violations (Lipinski): 3
SMILES: CC(C[C@@H](C(=O)N[C@@H](C(=O)NCCC(=O)O)Cc1c[nH]c2c1cccc2)NC(=O)NC12CC3CC(C2)CC(C1)C3)C
InChi: 1S/C31H43N5O5/c1-18(2)9-25(35-30(41)36-31-14-19-10-20(15-31)12-21(11-19)16-31)29(40)34-26(28(39)32-8-7-27(37)38)13-22-17-33-24-6-4-3-5-23(22)24/h3-6,17-21,25-26,33H,7-16H2,1-2H3,(H,32,39)(H,34,40)(H,37,38)(H2,35,36,41)/t19?,20?,21?,25-,26+,31?/m0/s1
InChiKey: ZLWNKQVWHKWFSP-LHEMBZLFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Endothelin receptor ET-A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0104	0	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0104	0	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Schistosoma mansoni	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0104	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0104	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0104	0	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Entamoeba histolytica	hypothetical protein	0.0294	0.1774	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0104	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0104	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Brugia malayi	neuropeptide F receptor	0.0104	0	0.5
Brugia malayi	Serotonin receptor	0.0104	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0104	0	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Brugia malayi	Dopamine receptor protein 2	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0294	0.1774	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0104	0	0.5
Brugia malayi	AKH receptor	0.0104	0	0.5
Schistosoma mansoni	amine GPCR	0.0104	0	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0104	0	0.5
Brugia malayi	Dopamine receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	Serotonin receptor	0.0104	0	0.5
Brugia malayi	neuropeptide F receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Schistosoma mansoni	adenoreceptor	0.0104	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0	0.5
Brugia malayi	sulfakinin receptor protein	0.0104	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0104	0	0.5
Brugia malayi	G-protein coupled receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0104	0	0.5
Schistosoma mansoni	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	fmrfamide receptor	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0104	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0104	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	hypothetical protein	0.0104	0	0.5
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0294	0.1774	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0104	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0104	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1178	1	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Echinococcus granulosus	orexin receptor type 2	0.0104	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0104	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0104	0	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0104	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0104	0	0.5
Echinococcus granulosus	allatostatin A receptor	0.0104	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0104	0	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0884	0.726	0.6669
Schistosoma mansoni	amine GPCR	0.0104	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0104	0	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0104	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0104	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Giardia lamblia	NADPH oxidoreductase, putative	0.1178	1	0.5
Brugia malayi	larval opioid receptor	0.0104	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0104	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0104	0	0.5
Brugia malayi	RE15519p	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	serotonin receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	somatostatin receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1178	1	1
Schistosoma mansoni	neuropeptide receptor	0.0104	0	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.1178	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0104	0	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0104	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0104	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0104	0	0.5
Brugia malayi	Dopamine receptor protein 1	0.0104	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0104	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0104	0	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0104	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0104	0	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0104	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0	0.5
Schistosoma mansoni	histamine h1 receptor	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0104	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0104	0	0.5
Schistosoma mansoni	amine GPCR	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0104	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0104	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	sex peptide receptor	0.0104	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Giardia lamblia	NADPH oxidoreductase, putative	0.1178	1	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0104	0	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0104	0	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0104	0	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0104	0	0.5
Echinococcus multilocularis	somatostatin receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0	0.5
Schistosoma mansoni	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0104	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0104	0	0.5
Brugia malayi	G-protein coupled receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0104	0	0.5
Brugia malayi	hypothetical protein	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0104	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0104	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0104	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0104	0	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0104	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Schistosoma mansoni	amine GPCR	0.0104	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Brugia malayi	G protein-coupled receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0104	0	0.5
Brugia malayi	ORL1-like opioid receptor	0.0104	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.1178	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0104	0	0.5
Schistosoma mansoni	amine GPCR	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0104	0	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0104	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0104	0	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0104	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0104	0	0.5
Onchocerca volvulus		0.0104	0	0.5
Brugia malayi	GnHR receptor homolog	0.0104	0	0.5
Schistosoma mansoni	myosin xvIII	0.0104	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0104	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.33 uM	Binding affinity determined against ETA receptor in porcine aortic smooth muscle membrane	ChEMBL.	No reference
IC50 max (binding)	= 0.33 uM	Binding affinity determined against ETA receptor in porcine aortic smooth muscle membrane	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 41575