Detailed information for compound 415872

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 236.267 | Formula: C12H16N2O3
  • H donors: 2 H acceptors: 3 LogP: 0.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)CC(=O)CN(Cc1ccccc1)C
  • InChi: 1S/C12H16N2O3/c1-14(8-10-5-3-2-4-6-10)9-11(15)7-12(16)13-17/h2-6,17H,7-9H2,1H3,(H,13,16)
  • InChiKey: WQPQRXRNXGTHER-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase family protein 0.0028 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0192 0.0192
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0323 0.0323
Echinococcus granulosus prostaglandin H2 D isomerase 0.0208 0.1537 0.4527
Echinococcus granulosus Protein kinase C brain isozyme 0.0024 0.0076 0.0223
Schistosoma mansoni lipoxygenase 0.003 0.0129 0.0381
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0323 0.0952
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0094 0.0094
Echinococcus multilocularis beta LACTamase domain containing family member 0.0028 0.0108 0.0318
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0323 0.0323
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0653 0.1429
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0323 0.0952
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0045 0.0243 0.1111
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0041 0.0216 0.2912
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0031 0.0137 0.1268
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0323 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0287 0.2161 0.6364
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0094 0.0275
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0049 0.0279 0.0579
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0577 0.1255
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0279 0.1276
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0224 0.0995
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0323 0.1696
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0108 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0108 0.0844
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0049 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0079 0.0232
Echinococcus granulosus glutathione S transferase 0.013 0.0923 0.2717
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.219 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0117 0.0117
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0255 0.1906 0.5613
Loa Loa (eye worm) beta-lactamase 0.0028 0.0108 0.0108
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0045 0.0243 0.3284
Trypanosoma cruzi plasma-membrane proton-efflux P-type ATPase, putative 0.0024 0.0082 0.0468
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0243 0.1111
Brugia malayi protein kinase C3,putative 0.0141 0.1005 0.1005
Onchocerca volvulus 0.0191 0.14 0.7346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0323 0.0323
Echinococcus granulosus nuclear factor of activated T cells 5 0.0233 0.1736 0.5112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0323 0.0323
Brugia malayi steroid hormone receptor 0.0055 0.0323 0.0323
Echinococcus granulosus tar DNA binding protein 0.0049 0.0275 0.0809
Brugia malayi Membrane calcium atpase protein 3 0.0049 0.0279 0.0279
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0233 0.1736 0.5112
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.103 0.3033
Echinococcus multilocularis geminin 0.0442 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0216 0.0985
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0577 0.1255
Loa Loa (eye worm) hypothetical protein 0.008 0.0526 0.0526
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0224 0.3024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0243 0.1111
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0028 0.0108 0.019
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0323 0.0952
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0118 0.0118
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0653 0.1429
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.0085 0.025
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0154 0.0453
Brugia malayi Hemopexin family protein 0.002 0.0047 0.0047
Leishmania major elongation factor 1-gamma, putative 0.0108 0.0741 1
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0045 0.0243 0.2467
Schistosoma mansoni jun-related protein 0.0133 0.0944 0.2781
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0049 0.0279 0.0823
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0118
Onchocerca volvulus 0.0024 0.0079 0.0413
Trypanosoma brucei trypanothione reductase 0.0038 0.019 0.2566
Schistosoma mansoni lamin 0.0029 0.0121 0.0357
Onchocerca volvulus 0.0026 0.0094 0.049
Mycobacterium tuberculosis Probable lipase LipE 0.0028 0.0108 0.019
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0094 0.0094
Echinococcus granulosus nervana 2 0.0211 0.1557 0.4586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0121 0.0121
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 0.2161 0.6364
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0323 0.0952
Echinococcus multilocularis lamin dm0 0.0029 0.0121 0.0357
Brugia malayi Na,K-ATPase alpha subunit 0.013 0.0918 0.0918
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0216 0.0985
Schistosoma mansoni zinc finger protein 0.0026 0.0094 0.0275
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0577 0.1255
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0196 0.0548
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0094 0.0275
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Brugia malayi calcium ATPase 0.0025 0.0086 0.0086
Onchocerca volvulus 0.0211 0.1557 0.817
Trypanosoma brucei protein kinase, putative 0.0041 0.0216 0.2912
Brugia malayi beta-lactamase 0.0028 0.0108 0.0108
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Plasmodium falciparum calcium-transporting ATPase 0.0049 0.0279 0.0664
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0022 0.0061 0.018
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0323 0.0952
Schistosoma mansoni coup transcription factor 0.0055 0.0323 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0024 0.008 0.0367
Echinococcus multilocularis nervana 2 0.0255 0.1906 0.5613
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0572 0.4425 1
Echinococcus multilocularis glutathione S transferase 0.0078 0.0503 0.1481
Trichomonas vaginalis GTP-binding protein rit, putative 0.0023 0.007 0.0318
Schistosoma mansoni transmemberane protein 0.0255 0.1906 0.5613
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0323 0.0952
Schistosoma mansoni hypothetical protein 0.0026 0.0096 0.0283
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0094 0.0275
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0031 0.0137 0.0137
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0323 0.0952
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0049 0.0279 0.1276
Echinococcus multilocularis prostaglandin H2 D isomerase 0.0208 0.1537 0.4527
Echinococcus granulosus beta LACTamase domain containing family member 0.0028 0.0108 0.0318
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0082 0.0468
Schistosoma mansoni elongation factor 1-gamma 0.0108 0.0741 0.2182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0079 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0076 0.0223
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0094 0.0275
Toxoplasma gondii P-type ATPase4, putative 0.0049 0.0279 0.3773
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0094 0.0094
Loa Loa (eye worm) E1-E2 ATPase 0.0024 0.0082 0.0082
Leishmania major calcium motive p-type ATPase, putative 0.0049 0.0279 0.3016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.019 0.056
Echinococcus multilocularis nervana 2 0.0211 0.1557 0.4586
Brugia malayi RNA binding protein 0.0049 0.0275 0.0275
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0013 0.0013
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0045 0.0243 0.0772
Schistosoma mansoni hypothetical protein 0.0133 0.0944 0.2781
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0323 0.0323
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0049 0.0279 0.3773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Echinococcus multilocularis mitogen activated protein kinase 3 0.0041 0.0216 0.0635
Trichomonas vaginalis cation-transporting ATPase, putative 0.0045 0.0243 0.1111
Toxoplasma gondii cathepsin B 0.0024 0.008 0.1084
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0196 0.0044
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0031 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0323 0.0323
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Onchocerca volvulus 0.0029 0.0121 0.0636
Plasmodium falciparum elongation factor 1-gamma, putative 0.0108 0.0741 0.4088
Echinococcus multilocularis ras gtpase 0.0023 0.007 0.0205
Schistosoma mansoni ATPase 0.0045 0.0243 0.0717
Echinococcus granulosus glutathione S transferase 0.0078 0.0503 0.1481
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0024 0.0076 0.0076
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0082 0.1107
Leishmania major P-type H -ATPase, putative 0.0024 0.0082 0.0025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0049 0.0275 0.0275
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0232 0.1726 0.5083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0323 0.0952
Loa Loa (eye worm) cathepsin B 0.0024 0.008 0.008
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0029 0.0118 0.054
Schistosoma mansoni na+/k+ atpase alpha subunit 0.013 0.0918 0.2702
Echinococcus granulosus eukaryotic translation elongation factor 1 0.0108 0.0741 0.2182
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0323 0.0323
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0211 0.1557 0.4586
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0025 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0028 0.0108 0.019
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0094 0.0275
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Onchocerca volvulus 0.003 0.0126 0.0662
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0094 0.0275
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0041 0.0216 0.2403
Mycobacterium tuberculosis Probable reductase 0.0087 0.0577 0.1255
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0323 0.0952
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.019 0.019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0323 0.0952
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0024 0.0082 0.0082
Brugia malayi Ras-related protein R-Ras2 0.0023 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0076 0.0223
Onchocerca volvulus 0.003 0.0126 0.0662
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0096
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0094 0.0094
Brugia malayi hypothetical protein 0.0026 0.0094 0.0094
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0094 0.0094
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Plasmodium vivax calcium-transporting ATPase, putative 0.0049 0.0279 0.1376
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0041 0.0216 0.205
Echinococcus granulosus nervana 2 0.0211 0.1557 0.4586
Brugia malayi Pre-SET motif family protein 0.0024 0.0079 0.0079
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0196 0.0895
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0216 0.2403
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0079 0.1064
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0323 0.1696
Onchocerca volvulus 0.003 0.0126 0.0662
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0027 0.0101 0.0174
Echinococcus multilocularis glutathione S transferase 0.0208 0.1537 0.4527
Brugia malayi E1-E2 ATPase family protein 0.0029 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0442 0.3395 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0094 0.049
Toxoplasma gondii P-type ATPase PMA1 0.0024 0.0082 0.1107
Brugia malayi Ras protein let-60 0.0023 0.007 0.007
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0572 0.4425 1
Brugia malayi ecdysone receptor 0.0026 0.0094 0.0094
Loa Loa (eye worm) matrixin family protein 0.0034 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0126 0.0577
Echinococcus multilocularis nervana 2 0.0255 0.1906 0.5613
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0049 0.0279 0.0823
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0108 0.0844
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0211 0.1557 0.4586
Echinococcus granulosus ras gtpase 0.0023 0.007 0.0205
Brugia malayi nuclear hormone receptor 0.0026 0.0094 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.047 0.1385
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0653 0.1429
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0094 0.0275
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0001 0.0002
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0108 0.0493
Onchocerca volvulus Matrix metalloproteinase homolog 0.0031 0.0136 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0275 0.0809
Mycobacterium tuberculosis Conserved protein 0.0028 0.0108 0.019
Mycobacterium ulcerans lipase LipD 0.0028 0.0108 0.019
Echinococcus granulosus cathepsin b 0.0073 0.047 0.1385
Loa Loa (eye worm) hypothetical protein 0.0101 0.0688 0.0688
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0255 0.1906 0.5613
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0051 0.0295 0.0868
Toxoplasma gondii thioredoxin reductase 0.0038 0.019 0.2566
Echinococcus granulosus nervana 2 0.0255 0.1906 0.5613
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0118 0.0118
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0224 0.1023
Loa Loa (eye worm) DR-78 0.0026 0.0094 0.0094
Echinococcus granulosus Na:K ATPase alpha subunit 0.013 0.0918 0.2702
Brugia malayi nuclear receptor RXR 0.0029 0.0118 0.0118
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0049 0.0279 0.0823
Mycobacterium tuberculosis Probable lipase LipD 0.0028 0.0108 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0323 0.0323
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0118 0.0348
Giardia lamblia Elongation factor 1-gamma 0.003 0.0126 0.0218
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0323 0.0952
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0255 0.1906 0.5613
Trichomonas vaginalis ras-dva small GTPase, putative 0.0023 0.007 0.0318
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0024 0.008 0.0444
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0045 0.0243 0.2802
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0024 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.003 0.0126 0.0126
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0045 0.0243 0.3284
Brugia malayi ecdysteroid receptor 0.0055 0.0323 0.0323
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0107 0.0739 0.1624
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Loa Loa (eye worm) acetyltransferase 0.0144 0.103 0.103
Loa Loa (eye worm) hypothetical protein 0.013 0.0923 0.0923
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0045 0.0243 0.2467
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0079
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0028 0.0108 0.019
Leishmania major P-type ATPase, putative 0.0049 0.0279 0.3016
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0118 0.0348
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0577 0.1255
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0049 0.0279 0.0823
Loa Loa (eye worm) hypothetical protein 0.0255 0.1906 0.1906
Toxoplasma gondii elongation factor 1-gamma, putative 0.0108 0.0741 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0255 0.1906 0.5613
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.013 0.0918 0.3968
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0323 0.0952
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0041 0.0216 0.2912
Brugia malayi Pre-SET motif family protein 0.0168 0.1217 0.1217
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0275 0.0809
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0216 0.0985
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0049 0.0279 0.0823
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0216 0.0635
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0255 0.1906 0.5613
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0112 0.0775 0.0775
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0076 0.0223
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0323 0.0952
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.047 0.1385
Leishmania major hypothetical protein, conserved 0.0028 0.0108 0.0419
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0118
Echinococcus multilocularis glutathione S transferase 0.0208 0.1537 0.4527
Echinococcus granulosus cathepsin b 0.0073 0.047 0.1385
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.019 0.2033
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0243 0.0243
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0094 0.0275
Toxoplasma gondii ABC1 family protein 0.0028 0.0108 0.1458
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0323 0.0952
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0049 0.0279 0.1276
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0028 0.0108 0.0108
Onchocerca volvulus 0.0028 0.0108 0.0566
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0073 0.047 0.1385
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0094 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0096 0.0096
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0049 0.0279 0.0823
Plasmodium vivax glutathione S-transferase, putative 0.0208 0.1537 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0027 0.0101 0.0174
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.0085 0.025
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0028 0.0108 0.019
Brugia malayi hypothetical protein 0.0029 0.0118 0.0118
Wolbachia endosymbiont of Brugia malayi glutathione S-transferase 0.003 0.0126 0.5
Mycobacterium ulcerans hypothetical protein 0.0028 0.0108 0.019
Brugia malayi protein kinase C II. 0.0024 0.0076 0.0076
Trichomonas vaginalis dexras1, putative 0.0023 0.007 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0323 0.0952
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0323 0.0952
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0049 0.0279 0.3326
Brugia malayi Glutathione S-transferase 4 0.013 0.0923 0.0923
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0108 0.0318
Mycobacterium ulcerans esterase/lipase LipP 0.0028 0.0108 0.019
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0025 0.0086 0.0392
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0049 0.0279 0.0823
Plasmodium vivax glutathione reductase, putative 0.0038 0.019 0.0763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Entamoeba histolytica ras-1, putative 0.0023 0.007 0.0318
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.019 0.0376
Mycobacterium tuberculosis Conserved protein 0.0028 0.0108 0.019
Brugia malayi conserved hypotetical protein 0.0026 0.0094 0.0094
Brugia malayi hypothetical protein 0.0026 0.0094 0.0094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0079 0.0232
Echinococcus granulosus stringent starvation protein A 0.003 0.0126 0.0372
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0118
Brugia malayi hypothetical protein 0.0029 0.0118 0.0118
Mycobacterium ulcerans isocitrate lyase Icl 0.0572 0.4425 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0323 0.0323
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.015 0.1081 0.1081
Onchocerca volvulus 0.0028 0.0108 0.0566
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0232 0.1726 0.5083
Leishmania major trypanothione reductase 0.0038 0.019 0.1662
Echinococcus granulosus glutathione S transferase 0.0208 0.1537 0.4527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0079 0.0232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0192 0.0192
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0216 0.2403
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0168 0.1217 0.1217
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0041 0.0216 0.2403
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.003 0.0129 0.0381
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0025 0.0085 0.1147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Brugia malayi Glutathione S-transferase, N-terminal domain containing protein 0.003 0.0126 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0323 0.0323
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0094 0.0094
Onchocerca volvulus 0.003 0.0126 0.0662
Brugia malayi calcium ATPase 0.0024 0.0082 0.0082
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0045 0.0243 0.0717
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0125 0.0881 0.1947
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0094 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0323 0.0323
Echinococcus multilocularis glutathione S transferase 0.0208 0.1537 0.4527
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0118
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0275 0.0809
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.0085 0.025
Echinococcus granulosus glutathione s transferase mu 0.0208 0.1537 0.4527
Brugia malayi glutathione reductase 0.0038 0.019 0.019
Trypanosoma brucei calcium-transporting ATPase, putative 0.0031 0.0137 0.1853
Echinococcus granulosus lamin 0.0029 0.0121 0.0357
Schistosoma mansoni hypothetical protein 0.0442 0.3395 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0094 0.0275
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0118 0.0348
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0049 0.0279 0.0823
Leishmania major calcium-transporting ATPase, putative 0.0049 0.0279 0.3016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0323 0.0952
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0112 0.0775 0.0775
Echinococcus multilocularis protein kinase c epsilon type 0.0024 0.0076 0.0223
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0323 0.0323
Trichomonas vaginalis glutaminyl-tRNA synthetase, putative 0.013 0.0923 0.4213
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0025 0.0085 0.0022
Leishmania major P-type H -ATPase, putative 0.0024 0.0082 0.0025
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0323 0.1696
Loa Loa (eye worm) hypothetical protein 0.013 0.0918 0.0918
Echinococcus granulosus calcium transporting atpase 0.0049 0.0279 0.0823
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0118 0.0348
Loa Loa (eye worm) hypothetical protein 0.0159 0.1152 0.1152
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0094 0.0275
Plasmodium vivax elongation factor 1-gamma, putative 0.0108 0.0741 0.4539
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0049 0.0279 0.3773
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0177 0.1292 0.2879
Brugia malayi nuclear receptor NHR-88 0.0026 0.0094 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0118 0.0118
Echinococcus multilocularis nervana 2 0.0211 0.1557 0.4586
Brugia malayi cathepsin B-like cysteine proteinase 0.0073 0.047 0.047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0323 0.0952
Leishmania major calcium-translocating P-type ATPase 0.0045 0.0243 0.2467
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0216 0.0985
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0045 0.0243 0.2802
Echinococcus granulosus glutathione S transferase 0.003 0.0126 0.0372
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0001 0.0002
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0051 0.0295 0.0868
Echinococcus multilocularis jun protein 0.0164 0.1188 0.3498
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0022 0.0061 0.0061
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0049 0.0279 0.0823
Loa Loa (eye worm) TAR-binding protein 0.0049 0.0275 0.0275
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.0085 0.025
Loa Loa (eye worm) calcium ATPase 0.0025 0.0086 0.0086
Schistosoma mansoni hypothetical protein 0.0039 0.0196 0.0578
Brugia malayi nuclear receptor RXR 0.0026 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.219 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0323 0.0323
Echinococcus granulosus mitogen activated protein kinase 3 0.0041 0.0216 0.0635
Brugia malayi intermediate filament protein 0.0029 0.0121 0.0121
Onchocerca volvulus 0.0028 0.0108 0.0566
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0653 0.1429
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0079 0.0232
Onchocerca volvulus 0.003 0.0126 0.0662
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0255 0.1906 0.5613
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0031
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.219 0.5
Echinococcus multilocularis cathepsin b 0.0073 0.047 0.1385
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0094 0.0275
Echinococcus multilocularis glutathione S transferase 0.013 0.0923 0.2717
Trichomonas vaginalis cation-transporting ATPase, putative 0.0024 0.0082 0.0374
Echinococcus granulosus intermediate filament protein 0.0029 0.0121 0.0357
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Loa Loa (eye worm) Ras protein let-60 0.0023 0.007 0.007
Onchocerca volvulus 0.0055 0.0323 0.1696
Schistosoma mansoni glutathione-S-transferase 0.0208 0.1537 0.4527
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0041 0.0216 0.0216
Echinococcus multilocularis glutathione s transferase mu 0.0208 0.1537 0.4527
Brugia malayi tailless protein 0.0026 0.0094 0.0094
Echinococcus granulosus protein kinase c iota type 0.0154 0.111 0.3269
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0094 0.0275
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0108 0.1458
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0041 0.0216 0.205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0323 0.0952
Onchocerca volvulus 0.013 0.0923 0.4841
Loa Loa (eye worm) hypothetical protein 0.0087 0.0578 0.0578
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0323 0.0323
Brugia malayi Matrixin family protein 0.0034 0.0159 0.0159
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0108 0.0318
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0323 0.0323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0024 0.008 0.0237
Schistosoma mansoni Glutathione S-transferase 28 kDa (GST 28) (GST class-mu) 0.0208 0.1537 0.4527
Onchocerca volvulus 0.0026 0.0094 0.049
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0323 0.0323
Trypanosoma cruzi calcium-translocating P-type ATPase, putative 0.0024 0.0082 0.0468
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0255 0.1906 0.5613
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0323 0.0952
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0045 0.0243 0.0717
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0108 0.0493
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0024 0.0079 0.0232
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0025 0.0085 0.025
Onchocerca volvulus 0.0129 0.0909 0.4768
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0224 0.1023
Loa Loa (eye worm) matrixin family protein 0.0031 0.0136 0.0136
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0094 0.0275
Echinococcus multilocularis mitogen activated protein kinase 0.0041 0.0216 0.0635
Brugia malayi Thioredoxin reductase 0.0038 0.019 0.019
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0255 0.1906 0.5613
Echinococcus multilocularis tar DNA binding protein 0.0049 0.0275 0.0809
Entamoeba histolytica Ras family GTPase 0.0023 0.007 0.0318
Entamoeba histolytica Ras family GTPase 0.0023 0.007 0.0318
Echinococcus multilocularis musashi 0.0029 0.0121 0.0357
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0572 0.4425 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0211 0.1557 0.4586
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0577 0.1255
Echinococcus granulosus glutathione S transferase 0.0078 0.0503 0.1481
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0049 0.0279 0.3773
Loa Loa (eye worm) glutathione reductase 0.0038 0.019 0.019
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0108 0.019
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Mycobacterium tuberculosis Probable hydrolase 0.0028 0.0108 0.019
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0998 0.2939
Schistosoma mansoni hypothetical protein 0.002 0.0047 0.0138
Trichomonas vaginalis rap1 and, putative 0.0023 0.007 0.0318
Trypanosoma brucei elongation factor 1 gamma, putative 0.0108 0.0741 1
Brugia malayi nuclear hormone receptor 0.0055 0.0323 0.0323
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.103 0.103
Onchocerca volvulus 0.0029 0.0121 0.0636
Brugia malayi TAR-binding protein 0.0049 0.0275 0.0275
Echinococcus multilocularis lamin 0.0029 0.0121 0.0357
Giardia lamblia Kinase, CMGC MAPK 0.0041 0.0216 0.0642
Schistosoma mansoni thyroid hormone receptor 0.0287 0.2161 0.6364
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Echinococcus granulosus protein kinase c epsilon type 0.0024 0.0076 0.0223
Loa Loa (eye worm) RNA binding protein 0.0049 0.0275 0.0275
Brugia malayi hypothetical protein 0.0129 0.0909 0.0909
Schistosoma mansoni hypothetical protein 0.0232 0.1726 0.5083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0323 0.0323
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0108 0.0493
Trichomonas vaginalis rheb, putative 0.0023 0.007 0.0318
Schistosoma mansoni atypical protein kinase C 0.0164 0.1186 0.3492
Brugia malayi MAP kinase sur-1 0.0041 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0085 0.0085
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0078 0.0503 0.6556
Brugia malayi hypothetical protein 0.003 0.0126 0.0126
Toxoplasma gondii E1-E2 ATPase subfamily protein 0.0024 0.0082 0.1107
Brugia malayi nuclear receptor NHR-88 0.0055 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0323 0.0952
Brugia malayi follicle stimulating hormone receptor 0.0193 0.1416 0.1416
Brugia malayi nuclear receptor NHR-67 0.0026 0.0094 0.0094
Echinococcus multilocularis calcium transporting atpase 0.0049 0.0279 0.0823
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0164 0.1188 0.3498
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1013 0.2245
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0049 0.0279 0.0823
Echinococcus granulosus nervana 2 0.0255 0.1906 0.5613
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.019 0.0763
Echinococcus granulosus glutathione S transferase Mu 1 0.0208 0.1537 0.4527
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.007 0.007
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0045 0.0243 0.0772
Echinococcus multilocularis protein kinase c iota type 0.0154 0.111 0.3269
Schistosoma mansoni ATPase 0.0045 0.0243 0.0717
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0192 0.0192
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0082 0.0468
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0023 0.0072 0.0212
Echinococcus multilocularis eukaryotic translation elongation factor 1 0.0108 0.0741 0.2182
Echinococcus granulosus arachidonate 5 lipoxygenase 0.003 0.0129 0.0381
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0045 0.0243 0.3284
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0094 0.0094
Schistosoma mansoni intermediate filament proteins 0.0029 0.0121 0.0357
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0049 0.0279 0.0823
Trypanosoma brucei cysteine peptidase C (CPC) 0.0024 0.008 0.1084
Onchocerca volvulus Matrilysin homolog 0.0031 0.0136 0.0715
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Schistosoma mansoni memapsin-2 (A01 family) 0.0177 0.129 0.38
Plasmodium vivax P-type ATPase4, putative 0.0049 0.0279 0.1376
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0045 0.0243 0.3284
Schistosoma mansoni GST class-mu 0.0208 0.1537 0.4527
Schistosoma mansoni nuclear receptor 0.0026 0.0094 0.0275
Trichomonas vaginalis ral, putative 0.0023 0.007 0.0318
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1013 0.2245
Trypanosoma brucei calcium-translocating P-type ATPase 0.0049 0.0279 0.3773
Loa Loa (eye worm) hypothetical protein 0.0026 0.0094 0.0094
Schistosoma mansoni nuclear receptor 0.0026 0.0094 0.0275
Loa Loa (eye worm) hypothetical protein 0.0029 0.0118 0.0118
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0323 0.0952
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0577 0.1255
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0164 0.1188 0.3498
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0323 0.0952
Leishmania major hypothetical protein, conserved 0.0078 0.0503 0.6396
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0094 0.0275
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.219 1
Brugia malayi beta-lactamase family protein 0.0028 0.0108 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.0503 0.6786
Trichomonas vaginalis set domain proteins, putative 0.0191 0.14 0.6393
Echinococcus granulosus geminin 0.0442 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.219 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0323 0.0952
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0572 0.4425 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0193 0.1416 0.1416
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0323 0.0952
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0211 0.1557 0.4586
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1013 0.2245
Onchocerca volvulus 0.002 0.0047 0.0245
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0121 0.0121
Echinococcus multilocularis glutathione S transferase 0.0078 0.0503 0.1481
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0108 0.02
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0017 0.0025 0.0025
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0094 0.049
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Echinococcus granulosus lamin dm0 0.0029 0.0121 0.0357
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0082 0.1107
Trypanosoma brucei elongation factor 1 gamma, putative 0.0108 0.0741 1
Plasmodium falciparum glutathione S-transferase 0.0208 0.1537 1
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0275 0.0809
Brugia malayi bZIP transcription factor family protein 0.0164 0.1188 0.1188
Echinococcus granulosus jun protein 0.0164 0.1188 0.3498
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0073 0.047 0.6084
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0049 0.0279 0.3326
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0094 0.0094
Echinococcus multilocularis glutathione S transferase 0.003 0.0126 0.0372
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0024 0.0076 0.0223
Onchocerca volvulus 0.003 0.0126 0.0662
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.103 0.3033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0028 0.0108 0.0108
Mycobacterium leprae Probable lipase LipE 0.0028 0.0108 0.019
Loa Loa (eye worm) hypothetical protein 0.0073 0.047 0.047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0224 0.3024
Mycobacterium ulcerans beta-lactamase 0.0028 0.0108 0.019
Mycobacterium ulcerans isocitrate lyase AceAb 0.0572 0.4425 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0073 0.047 0.1385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0323 0.0323
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0049 0.0279 0.0664
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0323 0.0952
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0108 0.0493
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0031 0.0137 0.0137
Mycobacterium leprae Isocitrate lyase 0.0268 0.2015 0.4523
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0049 0.0279 0.0823
Echinococcus multilocularis glutathione S transferase 0.013 0.0923 0.2717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0094 0.0275
Mycobacterium tuberculosis Conserved protein 0.0028 0.0108 0.019
Onchocerca volvulus 0.0255 0.1906 1
Echinococcus multilocularis cathepsin b 0.0073 0.047 0.1385
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.013 0.0918 0.0918
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0082 0.0468
Mycobacterium tuberculosis Probable esterase LipL 0.0028 0.0108 0.019
Trypanosoma cruzi elongation factor 1-gamma (EF-1-gamma), putative 0.0108 0.0741 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.019 0.056
Onchocerca volvulus 0.003 0.0126 0.0662
Echinococcus multilocularis glutathione S-transferase 0.0208 0.1537 0.4527
Onchocerca volvulus 0.0125 0.0881 0.4624
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0022 0.0061 0.018
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.013 0.0918 0.2702
Loa Loa (eye worm) hypothetical protein 0.0255 0.1906 0.1906
Trichomonas vaginalis esterase, putative 0.0028 0.0108 0.0493
Schistosoma mansoni lamin 0.0029 0.0121 0.0357
Schistosoma mansoni tar DNA-binding protein 0.0049 0.0275 0.0809
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.002 0.005 0.0227
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0022 0.0061 0.0061
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0323 0.0323
Echinococcus granulosus mitogen activated protein kinase 0.0041 0.0216 0.0635
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0045 0.0243 0.1111
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0323 0.0952
Brugia malayi RNA recognition motif domain containing protein 0.0049 0.0275 0.0275
Leishmania major elongation factor-1 gamma 0.0108 0.0741 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0049 0.0279 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0323 0.0323
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0224 0.066
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0094 0.0275
Loa Loa (eye worm) hypothetical protein 0.0055 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.1276 1 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.013 0.0918 0.2702
Brugia malayi Elongation factor 1 gamma, conserved domain containing protein 0.003 0.0126 0.0126
Echinococcus granulosus histone lysine methyltransferase setb 0.0024 0.0079 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0323 0.0323
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0045 0.0243 0.2802

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = -4 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = -4 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 9 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615
Inhibition (binding) = 9 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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