Detailed information for compound 415935

Basic information

Technical information
  • TDR Targets ID: 415935
  • Name: 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(4-me thylphenyl)urea
  • MW: 357.408 | Formula: C21H19N5O
  • H donors: 4 H acceptors: 2 LogP: 3.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C)Nc1ccc(cc1)c1cccc2c1c(N)n[nH]2
  • InChi: 1S/C21H19N5O/c1-13-5-9-15(10-6-13)23-21(27)24-16-11-7-14(8-12-16)17-3-2-4-18-19(17)20(22)26-25-18/h2-12H,1H3,(H3,22,25,26)(H2,23,24,27)
  • InChiKey: ZVVIKPIHXSNXJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(p-tolyl)urea
  • 1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(4-methylphenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0275 0.1527 0.1517
Echinococcus granulosus tyrosine kinase 0.0073 0.0181 0.0166
Schistosoma mansoni growth factor receptor-bound protein 0.0064 0.0124 0.0113
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0154 0.0719 0.0706
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0079 0.0225 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0223 0.1177 0.1167
Trypanosoma cruzi casein kinase, putative 0.0067 0.014 0.014
Loa Loa (eye worm) AGC/PKA protein kinase 0.0069 0.0158 0.0207
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0083 0.0251 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0584 0.0573
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0143 0.0648 0.0635
Loa Loa (eye worm) hypothetical protein 0.0091 0.0301 0.041
Entamoeba histolytica protein kinase, putative 0.0085 0.0262 0.0244
Toxoplasma gondii aurora kinase 0.0156 0.0736 0.4252
Echinococcus granulosus Glutaredoxin protein 5 0.0149 0.0685 0.0671
Trypanosoma cruzi p21-activated kinase 3, putative 0.0047 0.0011 0.0011
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0164 0.0787 0.1096
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0158 0.0147
Loa Loa (eye worm) hypothetical protein 0.0073 0.0181 0.0239
Entamoeba histolytica protein kinase, putative 0.0059 0.0089 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Echinococcus multilocularis mitogen activated protein kinase 14 0.0173 0.0845 0.0832
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Echinococcus multilocularis tyrosine protein kinase HCK 0.0108 0.0413 0.0399
Schistosoma mansoni protein kinase 0.0048 0.0019 0.0008
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1551 1 1
Schistosoma mansoni hypothetical protein 0.0073 0.0186 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0719 0.0709
Echinococcus granulosus c src tyrosine kinase 0.0101 0.0371 0.0357
Echinococcus multilocularis serine:threonine protein kinase 0.0119 0.0486 0.0472
Brugia malayi intracellular kinase 0.0136 0.0602 0.0834
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1003 0.0992
Entamoeba histolytica protein kinase, putative 0.0156 0.0736 0.0719
Echinococcus multilocularis tyrosine protein kinase shark 0.0073 0.0181 0.0166
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0079 0.0225 0.0211
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0169 0.0821 0.1144
Onchocerca volvulus 0.0372 0.2169 0.5487
Entamoeba histolytica protein kinase, putative 0.0154 0.0719 0.0702
Brugia malayi Protein kinase domain containing protein 0.0119 0.0486 0.067
Toxoplasma gondii CMGC kinase, CK2 family 0.0102 0.0374 0.2107
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0119 0.0489 0.0675
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0243 0.0232
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0225 0.0214
Schistosoma mansoni protein kinase 0.0058 0.0085 0.0074
Echinococcus multilocularis serine:threonine protein kinase 38 0.0154 0.0719 0.0706
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Echinococcus granulosus epidermal growth factor receptor 0.0466 0.2792 0.2782
Loa Loa (eye worm) hypothetical protein 0.0107 0.041 0.0564
Echinococcus multilocularis mitogen activated protein kinase 11 0.0173 0.0845 0.0832
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0164 0.0787 0.0774
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Echinococcus multilocularis protein kinase c iota type 0.0294 0.1654 0.1642
Brugia malayi Cam kinase protein 1 0.0048 0.0019 0.0011
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0173 0.0845 0.0845
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Leishmania major casein kinase, putative 0.0067 0.014 0.0122
Loa Loa (eye worm) hypothetical protein 0.0091 0.0303 0.0412
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Plasmodium falciparum NIMA related kinase 1 0.0145 0.0661 0.7974
Echinococcus multilocularis rac serine:threonine kinase 0.0176 0.0869 0.0856
Echinococcus granulosus tyrosine protein kinase Srms 0.0073 0.0181 0.0166
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.007 0.0165 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0225 0.0214
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Loa Loa (eye worm) hypothetical protein 0.0113 0.0447 0.0616
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0082 0.0243 0.0225
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0069 0.0158 0.0825
Echinococcus multilocularis cyclin dependent kinase 1 0.0124 0.0523 0.051
Entamoeba histolytica protein kinase domain containing protein 0.0128 0.0551 0.0533
Brugia malayi serine/threonine kinase 12 0.0156 0.0736 0.1024
Schistosoma mansoni tyrosine kinase 0.0101 0.0371 0.036
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0133 0.0584 0.0571
Giardia lamblia Kinase, CMGC GSK 0.0136 0.0602 0.0585
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0067 0.014 0.0126
Schistosoma mansoni protein kinase 0.0048 0.0019 0.0008
Brugia malayi putative serine/threonine kinase SADA gamma 0.0048 0.0018 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0466 0.2792 0.2782
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0085 0.0262 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0015 0.0005
Echinococcus granulosus activin receptor type 0.0058 0.0085 0.0071
Trichomonas vaginalis STE family protein kinase 0.0085 0.0262 0.0251
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0048 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0018 0.001
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0225 0.0214
Schistosoma mansoni protein kinase 0.0102 0.0374 0.0363
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0154 0.0719 0.1
Entamoeba histolytica hypothetical protein 0.0128 0.0551 0.0533
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0057 0.0078 0.0064
Echinococcus multilocularis mitogen activated protein kinase 14 0.0173 0.0845 0.0832
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0326 0.0315
Entamoeba histolytica protein kinase 2, putative 0.017 0.0825 0.0808
Brugia malayi casein kinase I 0.0067 0.014 0.0182
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0113 0.0447 0.0434
Plasmodium falciparum serine/threonine protein kinase, putative 0.0156 0.0736 0.8898
Entamoeba histolytica casein kinase, putative 0.0102 0.0374 0.0356
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0079 0.0225 0.0302
Schistosoma mansoni growth factor receptor-bound protein 0.0064 0.0124 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0372 0.2169 0.216
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0057 0.0074 0.0056
Entamoeba histolytica protein kinase, putative 0.0079 0.0225 0.0207
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0172 0.0839 0.0826
Loa Loa (eye worm) TK protein kinase 0.0295 0.166 0.2329
Plasmodium falciparum calcium-dependent protein kinase 4 0.0048 0.0019 0.0005
Schistosoma mansoni tyrosine kinase 0.0172 0.0839 0.0828
Brugia malayi Casein kinase II, alpha chain 0.0102 0.0374 0.0512
Loa Loa (eye worm) hypothetical protein 0.032 0.1827 0.2564
Loa Loa (eye worm) AUR protein kinase 0.0156 0.0736 0.1024
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0196 0.1003 0.14
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0306 0.1732 0.172
Trichomonas vaginalis STE family protein kinase 0.0083 0.0251 0.024
Echinococcus multilocularis insulin receptor 0.0521 0.3156 0.3146
Echinococcus multilocularis rho associated protein kinase 0.0372 0.2169 0.2158
Echinococcus granulosus cyclin dependent kinase 5 0.0124 0.0523 0.051
Trichomonas vaginalis AGC family protein kinase 0.0145 0.0661 0.0651
Schistosoma mansoni kinase 0.0328 0.1879 0.187
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0133 0.0584 0.0571
Leishmania major protein kinase, putative 0.0083 0.0251 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0719 0.0709
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0262 0.0248
Entamoeba histolytica protein kinase, putative 0.0057 0.0074 0.0056
Schistosoma mansoni tyrosine kinase 0.0233 0.1245 0.1235
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Giardia lamblia Kinase, CMGC GSK 0.0136 0.0602 0.0585
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0018 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.0736 0.0719
Schistosoma mansoni tyrosine kinase 0.0521 0.3156 0.3148
Brugia malayi Protein kinase domain containing protein 0.1113 0.709 1
Brugia malayi protein-tyrosine kinase 0.0143 0.0648 0.09
Brugia malayi Variant SH3 domain containing protein 0.0064 0.0124 0.0159
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0455 0.272 0.271
Schistosoma mansoni serine/threonine protein kinase 0.0306 0.1732 0.1722
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0736 0.0726
Leishmania major protein kinase A catalytic subunit isoform 2 0.0069 0.0158 0.014
Onchocerca volvulus 0.0146 0.0666 0.1685
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Loa Loa (eye worm) TK protein kinase 0.0108 0.0413 0.0567
Echinococcus granulosus roundabout 2 0.0136 0.06 0.0587
Toxoplasma gondii AGC kinase 0.0069 0.0158 0.0825
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Loa Loa (eye worm) hypothetical protein 0.0064 0.0121 0.0155
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0213 0.1113 0.2816
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0156 0.0736 0.8898
Giardia lamblia Kinase, CMGC CDK 0.0124 0.0523 0.0506
Brugia malayi Tyrosine-protein kinase abl-1 0.0197 0.1004 0.1402
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Giardia lamblia Kinase, CMGC CDK 0.0124 0.0523 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0523 0.0512
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0322 0.1835 0.1824
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0261 0.1435 0.1423
Schistosoma mansoni serine/threonine protein kinase 0.0255 0.139 0.1381
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.1319 0.1309
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0128 0.0551 0.0551
Brugia malayi SH2 domain containing protein 0.0073 0.0181 0.0239
Echinococcus granulosus twitchin 0.0132 0.0575 0.0562
Plasmodium falciparum calcium-dependent protein kinase 3 0.0048 0.0019 0.0005
Brugia malayi Protein kinase domain containing protein 0.0073 0.0181 0.0239
Onchocerca volvulus 0.0583 0.3573 0.9038
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0154 0.0719 0.0706
Loa Loa (eye worm) TK/EPH protein kinase 0.0135 0.0596 0.0826
Entamoeba histolytica cell division protein kinase 2, putative 0.0124 0.0523 0.0506
Giardia lamblia Kinase, STE STE20 0.0085 0.0262 0.0244
Echinococcus granulosus mitogen activated protein kinase 11 0.0173 0.0845 0.0832
Echinococcus multilocularis growth factor receptor bound protein 2 0.0064 0.0124 0.011
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0048 0.0019 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0192 0.0973 0.096
Loa Loa (eye worm) hypothetical protein 0.0143 0.0647 0.0898
Echinococcus granulosus Protein kinase C brain isozyme 0.0244 0.1319 0.1306
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0067 0.014 0.0182
Echinococcus multilocularis raf serine:threonine protein kinase 0.0078 0.0218 0.0204
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0128 0.0551 0.0551
Brugia malayi Variant SH3 domain containing protein 0.0064 0.0124 0.0159
Echinococcus granulosus serine threonine protein kinase nrc 0.017 0.0825 0.0812
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Echinococcus multilocularis hypothetical protein 0.0073 0.0186 0.0172
Schistosoma mansoni protein kinase 0.0156 0.0736 0.0726
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0085 0.0085
Echinococcus multilocularis casein kinase I delta 0.0067 0.014 0.0126
Echinococcus granulosus mitogen activated protein kinase 14 0.0173 0.0845 0.0832
Giardia lamblia Kinase, AGC AKT 0.0122 0.0509 0.0492
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Echinococcus multilocularis 0.0209 0.1084 0.1071
Brugia malayi cell division control protein 2 homolog 0.0124 0.0523 0.0723
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0136 0.0602 0.0585
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0066 0.0137 0.0177
Echinococcus granulosus tyrosine protein kinase Src64B 0.0172 0.0839 0.0826
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0083 0.0251 0.0251
Onchocerca volvulus 0.0073 0.0181 0.0457
Onchocerca volvulus 0.0167 0.0805 0.2037
Brugia malayi P38 map kinase family protein 2 0.0173 0.0845 0.1177
Onchocerca volvulus 0.0073 0.0181 0.0457
Echinococcus multilocularis cyclin dependent kinase 0.0124 0.0523 0.051
Echinococcus multilocularis dual specificity 0.0128 0.0551 0.0537
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0067 0.014 0.0182
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0048 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0133 0.0581 0.0805
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0069 0.0158 0.0158
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0367 0.2135 0.3001
Echinococcus multilocularis Immunoglobulin 0.0091 0.0301 0.0287
Entamoeba histolytica protein kinase, putative 0.0309 0.175 0.1735
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0136 0.0602 0.0588
Schistosoma mansoni nck2/grb4 0.0064 0.0124 0.0113
Plasmodium falciparum protein kinase, putative 0.0058 0.0085 0.0829
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0154 0.0719 0.0706
Trichomonas vaginalis STE family protein kinase 0.0085 0.0262 0.0251
Onchocerca volvulus Tyrosine kinase homolog 0.0641 0.3954 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0306 0.1732 0.243
Echinococcus multilocularis protein kinase c epsilon type 0.0196 0.1003 0.099
Echinococcus multilocularis mitogen activated protein kinase 3 0.0082 0.0243 0.0229
Plasmodium falciparum calcium-dependent protein kinase 1 0.0048 0.0019 0.0005
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0073 0.0181 0.0166
Loa Loa (eye worm) hypothetical protein 0.0094 0.0321 0.0437
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0047 0.0011 0.0011
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1551 1 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0048 0.0019 0.0005
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0069 0.0158 0.0207
Schistosoma mansoni serine/threonine-protein kinase 0.0176 0.0869 0.0858
Onchocerca volvulus 0.0067 0.014 0.0355
Loa Loa (eye worm) hypothetical protein 0.0048 0.0014 0.0004
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.029 0.1624 0.2279
Brugia malayi hypothetical protein 0.0094 0.0321 0.0437
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Echinococcus granulosus casein kinase I alpha 0.0067 0.014 0.0126
Trypanosoma cruzi cdc2-related kinase 1 0.0124 0.0523 0.0523
Brugia malayi ephrin receptor 1 precursor 0.0073 0.0186 0.0246
Echinococcus multilocularis epidermal growth factor receptor 0.0716 0.4453 0.4445
Echinococcus granulosus protein kinase c epsilon type 0.0196 0.1003 0.099
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0172 0.0839 0.0826
Loa Loa (eye worm) hypothetical protein 0.0172 0.0843 0.1176
Plasmodium falciparum calcium-dependent protein kinase 2 0.0048 0.0019 0.0005
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.026 0.1427 0.2
Brugia malayi Protein kinase domain containing protein 0.0079 0.0225 0.0302
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0172 0.0839 0.0826
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0155 0.0731 0.0717
Loa Loa (eye worm) hypothetical protein 0.0048 0.0019 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.1551 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Brugia malayi serine/threonine protein kinase 6 0.0156 0.0736 0.1024
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Entamoeba histolytica cell division protein kinase 2, putative 0.0124 0.0523 0.0506
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0124 0.0523 0.0723
Loa Loa (eye worm) hypothetical protein 0.0089 0.0287 0.039
Loa Loa (eye worm) hypothetical protein 0.0073 0.0186 0.0246
Loa Loa (eye worm) TK/INSR protein kinase 0.0521 0.3156 0.4442
Schistosoma mansoni tyrosine kinase 0.0429 0.2545 0.2537
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0136 0.0602 0.3457
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0121 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0018 0.0007
Brugia malayi Protein kinase domain containing protein 0.0095 0.0326 0.0445
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0083 0.0251 0.0251
Schistosoma mansoni protein kinase 0.0059 0.0089 0.0077
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0069 0.0158 0.0158
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0202 0.0183
Schistosoma mansoni vav2 0.0083 0.0251 0.0239
Trypanosoma cruzi polo-like protein kinase, putative 0.0306 0.1732 0.1732
Echinococcus granulosus tyrosine protein kinase shark 0.0073 0.0181 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0523 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0584 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.0133 0.0584 0.0573
Echinococcus granulosus casein kinase I alpha 0.0067 0.014 0.0126
Onchocerca volvulus 0.0073 0.0181 0.0457
Trypanosoma cruzi Protein kinase B 0.0176 0.0869 0.0869
Echinococcus granulosus NDR protein kinase 0.0154 0.0719 0.0706
Brugia malayi phosphoinositide-dependent protein kinase I 0.0079 0.0225 0.0302
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0073 0.0181 0.0162
Echinococcus granulosus tyrosine kinase 0.0143 0.0648 0.0635
Entamoeba histolytica casein kinase 1, putative 0.0067 0.014 0.0122
Schistosoma mansoni protein kinase 0.0085 0.0262 0.0251
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0192 0.0973 0.096
Brugia malayi STE20-like kinase MST 0.029 0.1624 0.2279
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1204 0.7695 0.7692
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0119 0.0486 0.067
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.1319 0.1309
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus multilocularis calcium activated potassium channel 0.0095 0.0326 0.0312
Onchocerca volvulus 0.0139 0.0622 0.1574
Loa Loa (eye worm) hypothetical protein 0.0107 0.041 0.0564
Brugia malayi Protein kinase domain containing protein 0.0213 0.1113 0.1557
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0082 0.0243 0.0243
Leishmania major protein kinase, putative 0.0058 0.0085 0.0067
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0128 0.0551 0.0533
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0082 0.0243 0.0225
Trichomonas vaginalis CK1 family protein kinase 0.0067 0.014 0.0129
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.1551 1 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0156 0.0736 0.0719
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0102 0.0374 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0326 0.0315
Onchocerca volvulus 0.0136 0.0602 0.1522
Loa Loa (eye worm) hypothetical protein 0.0091 0.0301 0.041
Loa Loa (eye worm) hypothetical protein 0.0133 0.0581 0.0805
Trichomonas vaginalis CK1 family protein kinase 0.0067 0.014 0.0129
Echinococcus multilocularis c src tyrosine kinase 0.0101 0.0371 0.0357
Onchocerca volvulus 0.0098 0.0349 0.0883
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0101 0.0371 0.036
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Schistosoma mansoni tyrosine kinase 0.0466 0.2792 0.2784
Plasmodium vivax glycogen synthase kinase 3, putative 0.0136 0.0602 0.7235
Trichomonas vaginalis STE family protein kinase 0.0085 0.0262 0.0251
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0243 0.0232
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0064 0.0124 0.0159
Echinococcus multilocularis serine threonine protein kinase 0.0203 0.1046 0.1033
Entamoeba histolytica protein kinase, putative 0.0136 0.0602 0.0585
Echinococcus granulosus insulin receptor 0.0521 0.3156 0.3146
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.1551 1 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0349 0.0477
Schistosoma mansoni serine/threonine protein kinase 0.0154 0.0719 0.0709
Entamoeba histolytica protein kinase, putative 0.0065 0.0132 0.0114
Toxoplasma gondii AGC kinase 0.0069 0.0158 0.0825
Schistosoma mansoni tyrosine kinase 0.0079 0.0224 0.0213
Brugia malayi Furin-like cysteine rich region family protein 0.0716 0.4453 0.6274
Echinococcus multilocularis N chimaerin 0.0077 0.0207 0.0193
Giardia lamblia Rrm3p helicase 0.1551 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0306 0.1732 0.1732
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.017 0.0825 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0069 0.0158 0.1727
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0128 0.0551 0.0533
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0124 0.0523 0.0506
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.1551 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0172 0.0839 0.0826
Giardia lamblia Kinase, CMGC MAPK 0.0082 0.0243 0.0225
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0073 0.0181 0.0166
Onchocerca volvulus 0.0052 0.0045 0.0113
Brugia malayi p70 ribosomal S6 kinase beta 0.0302 0.1706 0.2394
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0149 0.0685 0.0671
Plasmodium vivax unspecified product 0.0102 0.0374 0.4409
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0058 0.0085 0.0396
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0275 0.1527 0.1515
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0243 0.0243
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0095 0.0326 0.0445
Echinococcus multilocularis tyrosine protein kinase Srms 0.0143 0.0648 0.0635
Schistosoma mansoni atypical protein kinase C 0.0302 0.1702 0.1693
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0262 0.0248
Brugia malayi SH2 domain containing protein 0.0073 0.0181 0.0239
Brugia malayi hypothetical protein 0.0073 0.0181 0.0239
Brugia malayi Protein kinase c protein 2 0.0111 0.0438 0.0602
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0136 0.0602 0.0588
Entamoeba histolytica protein kinase, putative 0.0128 0.0551 0.0533
Giardia lamblia Kinase, CK1 Casein kinase 0.0067 0.014 0.0122
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0048 0.0019 0.0011
Leishmania major protein kinase, putative 0.0156 0.0736 0.0719
Echinococcus multilocularis casein kinase I delta 0.0067 0.014 0.0126
Echinococcus multilocularis roundabout 2 0.0136 0.06 0.0587
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0048 0.0019 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0736 0.0726
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0213 0.1113 0.11
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Echinococcus multilocularis casein kinase I alpha 0.0067 0.014 0.0126
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.017 0.0825 1
Echinococcus granulosus calcium activated potassium channel 0.0095 0.0326 0.0312
Entamoeba histolytica protein kinase domain containing protein 0.0058 0.0085 0.0067
Entamoeba histolytica protein kinase, putative 0.0067 0.0141 0.0122
Echinococcus multilocularis death associated protein kinase 1 0.1 0.6344 0.6338
Trypanosoma cruzi rac serine-threonine kinase, putative 0.017 0.0825 0.0825
Echinococcus multilocularis neuroglian 0.0111 0.0435 0.0421
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0172 0.0839 0.0826
Loa Loa (eye worm) hypothetical protein 0.0094 0.0321 0.0437
Trypanosoma brucei protein kinase, putative 0.0058 0.0085 0.0067
Schistosoma mansoni tyrosine kinase 0.0101 0.0371 0.036
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0091 0.0301 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0067 0.0141 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) TK/EGFR protein kinase 0.0716 0.4453 0.6274
Trichomonas vaginalis AGC family protein kinase 0.0154 0.0719 0.0709
Schistosoma mansoni tyrosine kinase 0.0521 0.3156 0.3148
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0136 0.0602 0.0834
Onchocerca volvulus 0.0073 0.0181 0.0457
Echinococcus granulosus defective proboscis extension response 0.0091 0.0301 0.0287
Plasmodium falciparum glycogen synthase kinase 3 0.0136 0.0602 0.7235
Brugia malayi C1-like domain containing protein 0.016 0.0762 0.1061
Loa Loa (eye worm) hypothetical protein 0.0098 0.0349 0.0477
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0602 0.0591
Trypanosoma brucei rac serine-threonine kinase, putative 0.0309 0.175 0.1735
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0173 0.0845 0.0828
Echinococcus granulosus myotubularin protein 13 0.0048 0.0015 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0523 0.0512
Entamoeba histolytica protein kinase , putative 0.0156 0.0736 0.0719
Echinococcus granulosus protein kinase shaggy 0.0136 0.0602 0.0588
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0091 0.0301 0.0287
Brugia malayi protein kinase C3,putative 0.0162 0.0773 0.1076
Plasmodium vivax casein kinase 1, putative 0.0067 0.014 0.1511
Schistosoma mansoni serine/threonine kinase 0.0154 0.0719 0.0709
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0085 0.0067
Echinococcus multilocularis casein kinase I alpha 0.0067 0.014 0.0126
Trypanosoma brucei casein kinase I, isoform 2 0.0067 0.014 0.0122
Loa Loa (eye worm) SRC-1 0.0172 0.0839 0.1169
Loa Loa (eye worm) hypothetical protein 0.0094 0.0321 0.0437
Leishmania major protein kinase A catalytic subunit isoform 1 0.0069 0.0158 0.014
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0124 0.0523 0.2991
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0455 0.272 0.271
Onchocerca volvulus 0.0073 0.0181 0.0457
Schistosoma mansoni tyrosine kinase 0.0716 0.4453 0.4447
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0069 0.0158 0.0158
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0154 0.0719 0.0706
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0069 0.0158 0.014
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0173 0.0845 0.0845
Schistosoma mansoni serine/threonine protein kinase 0.0078 0.0218 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0158 0.0147
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0064 0.0124 0.0113
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0255 0.139 0.1378
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0048 0.0019 0.0005
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0077 0.0207 0.0193
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0048 0.0019 0.0011
Loa Loa (eye worm) TK/ABL protein kinase 0.0322 0.1835 0.2577
Entamoeba histolytica casein kinase, putative 0.0067 0.014 0.0122
Schistosoma mansoni tyrosine kinase 0.0073 0.0181 0.0169
Echinococcus granulosus serine:threonine kinase SAD 1 0.0048 0.0018 0.0004
Echinococcus granulosus casein kinase I delta 0.0067 0.014 0.0126
Giardia lamblia Kinase, PLK 0.0306 0.1732 0.1716
Entamoeba histolytica hypothetical protein, conserved 0.1551 1 1
Trichomonas vaginalis AGC family protein kinase 0.0154 0.0719 0.0709
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0048 0.0017 0.0003
Schistosoma mansoni hypothetical protein 0.1551 1 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0172 0.0839 0.0826
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0082 0.0243 0.0328
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus multilocularis tyrosine protein kinase Abl 0.0197 0.1004 0.0991
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0048 0.0019 0.0002
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0245 0.1326 0.1313
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0255 0.139 0.1378
Echinococcus granulosus tyrosine protein kinase Lyn 0.0193 0.0979 0.0966
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0973 0.0963
Trypanosoma brucei cdc2-related kinase 1 0.0124 0.0523 0.0506
Echinococcus granulosus neuroglian 0.0111 0.0435 0.0421
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0736 0.0726
Echinococcus granulosus tyrosine protein kinase Blk 0.0143 0.0648 0.0635
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0102 0.0374 0.4409
Echinococcus multilocularis Glutaredoxin protein 5 0.0149 0.0685 0.0671
Giardia lamblia Kinase, AGC PKA 0.0069 0.0158 0.014
Schistosoma mansoni tyrosine kinase 0.0466 0.2792 0.2784
Echinococcus granulosus casein kinase I alpha 0.0067 0.014 0.0126
Echinococcus multilocularis aurora kinase A 0.0156 0.0736 0.0723
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) TK protein kinase 0.0143 0.0648 0.09
Trypanosoma brucei polo-like protein kinase 0.0306 0.1732 0.1716
Brugia malayi Stress-activated protein kinase jnk-1 0.0299 0.1684 0.2362
Echinococcus granulosus growth factor receptor bound protein 2 0.0064 0.0124 0.011
Trypanosoma cruzi cdc2-related kinase 1 0.0124 0.0523 0.0523
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Echinococcus granulosus mitogen activated protein kinase 0.0082 0.0243 0.0229
Echinococcus granulosus casein kinase ii subunit alpha 0.0102 0.0374 0.036
Entamoeba histolytica protein kinase, putative 0.0067 0.0141 0.0122
Echinococcus multilocularis cyclin dependent kinase 1 0.0124 0.0523 0.051
Giardia lamblia Kinase, NEK 0.0145 0.0661 0.0644
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0082 0.0243 0.0243
Trypanosoma brucei Casein kinase II 0.0102 0.0374 0.0356
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0455 0.272 0.3827
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0202 0.0183
Brugia malayi Protein kinase domain containing protein 0.0223 0.1177 0.1647
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0085 0.0262 0.0248
Onchocerca volvulus 0.0073 0.0181 0.0457
Toxoplasma gondii casein kinase I 0.0067 0.014 0.0722
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0015 0.0001
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0069 0.0158 0.0143
Entamoeba histolytica protein kinase, putative 0.0309 0.175 0.1735
Loa Loa (eye worm) hypothetical protein 0.0077 0.0209 0.0279
Trypanosoma brucei cdc2-related kinase 3 0.0124 0.0523 0.0506
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0523 0.0512
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0077 0.0207 0.0276
Entamoeba histolytica protein kinase, putative 0.0128 0.0551 0.0533
Echinococcus multilocularis cyclin dependent kinase 5 0.0124 0.0523 0.051
Echinococcus granulosus protein kinase C gamma type 0.0203 0.1046 0.1033
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0374 0.0356
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0164 0.0787 0.0774
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.014 0.0129
Loa Loa (eye worm) hypothetical protein 0.0208 0.1078 0.1507
Echinococcus multilocularis serine:threonine protein kinase 3 0.029 0.1624 0.1612
Onchocerca volvulus 0.0351 0.2029 0.5132
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.016 0.0762 0.1061
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0192 0.0973 0.096
Entamoeba histolytica DNA repair and recombination protein, putative 0.1551 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1551 1 1
Schistosoma mansoni adapter molecule crk 0.0064 0.0124 0.0113
Trypanosoma cruzi cdc2-related kinase 3 0.0124 0.0523 0.0523
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0067 0.0141 0.0126
Brugia malayi RhoGAP domain containing protein 0.0077 0.0207 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus multilocularis casein kinase ii subunit alpha 0.0102 0.0374 0.036
Entamoeba histolytica PH domain containing protein kinase, putative 0.0176 0.0869 0.0852
Echinococcus granulosus casein kinase I delta 0.0067 0.014 0.0126
Echinococcus granulosus Immunoglobulin 0.0091 0.0301 0.0287
Trypanosoma cruzi aurora B kinase, putative 0.0156 0.0736 0.0736
Schistosoma mansoni serine/threonine kinase 0.0095 0.0326 0.0315
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0155 0.0731 0.0717
Brugia malayi Immunoglobulin I-set domain containing protein 0.0295 0.166 0.2329
Schistosoma mansoni serine/threonine protein kinase 0.0455 0.272 0.2712
Brugia malayi serine/threonine-protein kinase 6 0.0156 0.0736 0.1024
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0057 0.0078 0.0064
Schistosoma mansoni protein kinase 0.0048 0.0019 0.0008
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0176 0.0869 0.0869
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0213 0.1113 0.1557
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Giardia lamblia Kinase, NEK 0.0145 0.0661 0.0644
Schistosoma mansoni tyrosine kinase 0.0075 0.0195 0.0184
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0172 0.0839 0.0826
Leishmania major protein kinase A catalytic subunit 0.0069 0.0158 0.014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0048 0.0019 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0383 0.0525
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0326 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0213 0.1113 0.1103
Plasmodium vivax calcium-dependent protein kinase, putative 0.0048 0.0019 0.0005
Plasmodium vivax protein kinase Crk2 0.0124 0.0523 0.6259
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0213 0.1113 0.1557
Loa Loa (eye worm) hypothetical protein 0.0069 0.0158 0.0207
Echinococcus granulosus c-Jun N-terminal kinases 0.0299 0.1684 0.1672
Entamoeba histolytica protein kinase, putative 0.0156 0.0736 0.0719
Giardia lamblia Aurora kinase 0.0156 0.0736 0.0719
Giardia lamblia Kinase, NEK 0.0145 0.0661 0.0644
Echinococcus multilocularis serine:threonine protein kinase N2 0.0154 0.0719 0.0706
Loa Loa (eye worm) hypothetical protein 0.0146 0.0666 0.0925
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Brugia malayi casein kinase 1, delta 0.0067 0.014 0.0182
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0083 0.0251 0.0233
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0119 0.0486 0.067
Schistosoma mansoni protein kinase 0.0245 0.1326 0.1316
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0213 0.1113 0.11
Echinococcus granulosus nervana 2 0.0149 0.0685 0.0671
Echinococcus multilocularis NCK adaptor protein 0.0064 0.0124 0.011
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Entamoeba histolytica protein kinase domain containing protein 0.0136 0.0602 0.0585
Brugia malayi Protein kinase domain containing protein 0.0073 0.0181 0.0239
Trypanosoma brucei protein kinase, putative 0.0136 0.0602 0.0585
Entamoeba histolytica protein kinase, putative 0.005 0.0029 0.001
Trichomonas vaginalis STE family protein kinase 0.0085 0.0262 0.0251
Echinococcus multilocularis Immunoglobulin 0.0091 0.0301 0.0287
Loa Loa (eye worm) AGC/NDR protein kinase 0.0154 0.0719 0.1
Brugia malayi Temporarily assigned gene name protein 59 0.0155 0.0727 0.1011
Entamoeba histolytica protein kinase, putative 0.0065 0.0132 0.0114
Echinococcus granulosus ephrin type A receptor 4 A 0.0114 0.0456 0.0442
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.0787 0.0777
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0243 0.0232
Echinococcus granulosus tyrosine protein kinase Src42A 0.0172 0.0839 0.0826
Entamoeba histolytica PH domain containing protein kinase, putative 0.0176 0.0869 0.0852
Brugia malayi Sex muscle abnormal protein 5 0.0064 0.0124 0.0159
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0306 0.1732 0.172
Brugia malayi Protein kinase domain containing protein 0.0073 0.0181 0.0239
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0302 0.1706 0.2394
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0244 0.1319 0.1306
Toxoplasma gondii AGC kinase 0.0302 0.1706 1
Trichomonas vaginalis CMGC family protein kinase 0.0124 0.0523 0.0512
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0299 0.1684 0.1672
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Loa Loa (eye worm) hypothetical protein 0.0167 0.0805 0.1122
Schistosoma mansoni nephrin 0.0114 0.0454 0.0443
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0069 0.0158 0.014
Brugia malayi Protein kinase domain 0.0085 0.0262 0.0354
Trichomonas vaginalis STE family protein kinase 0.0059 0.0089 0.0077
Brugia malayi Immunoglobulin I-set domain containing protein 0.0733 0.457 0.6439
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Schistosoma mansoni cell adhesion molecule 0.0116 0.0467 0.0456
Schistosoma mansoni tyrosine kinase 0.0172 0.0839 0.0828
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0019 0.0008
Echinococcus multilocularis casein kinase I alpha 0.0067 0.014 0.0126
Schistosoma mansoni ste20-related kinase 0.0228 0.1212 0.1202
Echinococcus granulosus N chimaerin 0.0077 0.0207 0.0193
Echinococcus multilocularis nervana 2 0.0149 0.0685 0.0671
Echinococcus granulosus serine:threonine protein kinase 0.0119 0.0486 0.0472
Schistosoma mansoni tyrosine kinase 0.0429 0.2545 0.2537
Trichomonas vaginalis CMGC family protein kinase 0.0082 0.0243 0.0232
Giardia lamblia Kinase, STE STE20 0.0083 0.0251 0.0233
Onchocerca volvulus 0.0077 0.0209 0.0528
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0077 0.0207 0.0193
Echinococcus multilocularis myosin iiia 0.0083 0.0251 0.0237
Schistosoma mansoni ephrin receptor 0.0114 0.0456 0.0445
Brugia malayi Protein kinase domain containing protein 0.0128 0.0551 0.0762
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Brugia malayi Protein kinase domain containing protein 0.0154 0.0719 0.1
Brugia malayi map kinase activated protein kinase protein 2 0.0455 0.272 0.3827
Trichomonas vaginalis AGC family protein kinase 0.0154 0.0719 0.0709
Brugia malayi Fibronectin type III domain containing protein 0.0094 0.0321 0.0437
Brugia malayi MAP kinase sur-1 0.0082 0.0243 0.0328
Brugia malayi protein kinase C II. 0.0196 0.1003 0.14
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0048 0.0019 0.0002
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0223 0.1177 0.1164
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0069 0.0158 0.0158
Echinococcus multilocularis casein kinase i 0.0067 0.014 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0736 0.0726
Loa Loa (eye worm) AGC/PKN protein kinase 0.0154 0.0719 0.1
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0018 0.0007
Echinococcus granulosus protein kinase c iota type 0.0294 0.1654 0.1642
Trypanosoma cruzi casein kinase, putative 0.0067 0.014 0.014
Echinococcus granulosus casein kinase i 0.0067 0.014 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0124 0.0523 0.0506
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0083 0.0251 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0079 0.0225 0.0214
Brugia malayi Variant SH3 domain containing protein 0.0077 0.0207 0.0276
Schistosoma mansoni serine/threonine protein kinase 0.0299 0.1684 0.1674
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0082 0.0243 0.1333
Trypanosoma cruzi casein kinase, putative 0.0067 0.014 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0141 0.0129
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.072 0.1001
Trichomonas vaginalis AGC family protein kinase 0.016 0.0763 0.0753
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0173 0.0845 0.1177
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0019 0.0008
Trichomonas vaginalis CK1 family protein kinase 0.0067 0.014 0.0129
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0523 0.3175 0.3165
Plasmodium falciparum casein kinase 2, alpha subunit 0.0102 0.0374 0.4409
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0143 0.0648 0.0635
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0156 0.0736 0.0723
Giardia lamblia Kinase, CMGC CK2 0.0102 0.0374 0.0356
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0172 0.0839 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0064 0.0124 0.0159
Schistosoma mansoni tyrosine kinase 0.0429 0.2545 0.2537
Entamoeba histolytica protein kinase domain containing protein 0.0136 0.0602 0.0585
Loa Loa (eye worm) AGC/AKT protein kinase 0.0309 0.175 0.2456
Brugia malayi serine/threonine-protein kinase plk-2 0.0306 0.1732 0.243
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0551 0.054
Echinococcus granulosus rho-associated protein kinase 1 0.0372 0.2169 0.2158
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0223 0.1177 0.1647
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0085 0.0262 0.0248
Echinococcus granulosus aurora kinase A 0.0156 0.0736 0.0723
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0048 0.0018 0.001
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0158 0.0147
Schistosoma mansoni vesicular amine transporter 0.0091 0.0301 0.029
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0149 0.0685 0.0671
Echinococcus multilocularis mitogen activated protein kinase 0.0082 0.0243 0.0229
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Brugia malayi serine/threonine-protein kinase PAK 7 0.026 0.1427 0.2
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0048 0.0018 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0326 0.0315
Echinococcus granulosus tyrosine protein kinase HCK 0.0108 0.0413 0.0399
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0523 0.3175 0.3165
Trichomonas vaginalis CMGC family protein kinase 0.0102 0.0374 0.0363
Brugia malayi Protein kinase domain containing protein 0.0154 0.0719 0.1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0156 0.0736 0.0719
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0067 0.014 0.0126
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0067 0.014 0.0182
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0136 0.0602 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Entamoeba histolytica protein kinase, putative 0.0302 0.1706 0.1691
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0048 0.0018 0.0018
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0306 0.1732 0.1716
Brugia malayi Kinase associated domain 1 family protein 0.0073 0.0186 0.0246
Entamoeba histolytica protein kinase, putative 0.0108 0.0413 0.0395
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.1551 1 1
Brugia malayi Protein kinase domain containing protein 0.0205 0.106 0.1482
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0275 0.1527 0.1515
Echinococcus multilocularis activin receptor type 0.0058 0.0085 0.0071
Brugia malayi Hr1 repeat family protein 0.0154 0.0719 0.1
Brugia malayi Protein kinase domain containing protein 0.0124 0.0523 0.0723
Trypanosoma brucei aurora B kinase 0.0156 0.0736 0.0719
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0058 0.0085 0.0085
Echinococcus granulosus raf serine:threonine protein kinase 0.0078 0.0218 0.0204
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0136 0.0602 0.0834
Echinococcus granulosus fibroblast growth factor receptor 4 0.0275 0.1527 0.1515
Trichomonas vaginalis CAMK family protein kinase 0.0306 0.1732 0.1722
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0079 0.0225 0.0302
Schistosoma mansoni protein kinase 0.0067 0.014 0.0129
Echinococcus multilocularis ephrin type A receptor 4 A 0.0114 0.0456 0.0442
Trichomonas vaginalis AGC family protein kinase 0.0309 0.175 0.1741
Trichomonas vaginalis AGC family protein kinase 0.0156 0.0736 0.0726
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0091 0.0301 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0243 0.0232
Echinococcus granulosus serine:threonine protein kinase 0.0119 0.0486 0.0472
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0133 0.0579 0.0569
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0145 0.0661 0.7974
Echinococcus granulosus nervana 2 0.0149 0.0685 0.0671
Leishmania major casein kinase II, putative 0.0102 0.0374 0.0356
Echinococcus multilocularis protein kinase shaggy 0.0136 0.0602 0.0588
Schistosoma mansoni hypothetical protein 0.0073 0.0186 0.0175
Loa Loa (eye worm) AGC/PKA protein kinase 0.0069 0.0158 0.0207
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.017 0.0825 0.0812
Echinococcus granulosus mitogen activated protein kinase 3 0.0082 0.0243 0.0229
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0128 0.0551 0.0762
Loa Loa (eye worm) hypothetical protein 0.0167 0.0805 0.1122
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0156 0.0736 0.0723
Brugia malayi Immunoglobulin I-set domain containing protein 0.0094 0.0321 0.0437
Loa Loa (eye worm) AUR protein kinase 0.0156 0.0736 0.1024
Entamoeba histolytica serine/threonine protein kinase, putative 0.0306 0.1732 0.1716
Loa Loa (eye worm) hypothetical protein 0.0139 0.0622 0.0863
Brugia malayi Protein kinase domain containing protein 0.0521 0.3156 0.4442
Echinococcus granulosus tyrosine protein kinase ABL1 0.0322 0.1835 0.1824
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0386 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0973 0.0963
Schistosoma mansoni serine/threonine-protein kinase 0.0176 0.0869 0.0858
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0069 0.0158 0.1727
Echinococcus granulosus tyrosine protein kinase Fyn 0.0172 0.0839 0.0826
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0124 0.0523 0.051
Brugia malayi Protein kinase domain containing protein 0.0073 0.0181 0.0239
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0261 0.1435 0.1423
Schistosoma mansoni protein kinase 0.0085 0.0262 0.0251
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0255 0.139 0.1948
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0048 0.0019 0.0005
Trypanosoma cruzi casein kinase II, putative 0.0102 0.0374 0.0374
Echinococcus granulosus serine:threonine protein kinase 3 0.029 0.1624 0.1612
Brugia malayi Protein kinase domain containing protein 0.021 0.109 0.1524
Echinococcus multilocularis serine:threonine protein kinase 0.0119 0.0486 0.0472
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0275 0.1527 0.1515
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0073 0.0181 0.0239
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0164 0.0787 0.1096
Trypanosoma cruzi casein kinase, putative 0.0067 0.014 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus multilocularis nervana 2 0.0149 0.0685 0.0671
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0173 0.0845 0.0828
Giardia lamblia Kinase, AGC PKA 0.017 0.0825 0.0808
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0124 0.0523 0.0723
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0064 0.0124 0.0159
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0077 0.0207 0.0196
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0223 0.1177 0.1164
Echinococcus multilocularis tyrosine protein kinase Blk 0.0143 0.0648 0.0635
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0733 0.457 0.6439
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.017 0.0825 0.0812
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0158 0.0147
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0082 0.0243 0.0225
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0106 0.0401 0.0388
Echinococcus granulosus tyrosine protein kinase Src42A 0.0106 0.0401 0.0388
Trypanosoma cruzi cdc2-related kinase 3 0.0124 0.0523 0.0523
Trichomonas vaginalis CMGC family protein kinase 0.0136 0.0602 0.0591
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0069 0.0158 0.014
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0015 0.0005
Plasmodium falciparum protein kinase 5 0.0124 0.0523 0.6259
Plasmodium falciparum casein kinase 1 0.0067 0.014 0.1511
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0048 0.0019 0.0005
Trichomonas vaginalis STE family protein kinase 0.0145 0.0661 0.0651
Schistosoma mansoni tyrosine kinase 0.0286 0.16 0.159
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0122 0.0509 0.0704
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0299 0.1684 0.2362
Echinococcus granulosus cyclin dependent kinase 0.0124 0.0523 0.051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0048 0.0019 0.0004
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0145 0.0661 0.3811
Echinococcus granulosus serine/threonine protein kinase 0.0176 0.0869 0.0856
Echinococcus granulosus NCK adaptor protein 0.0064 0.0124 0.011
Echinococcus multilocularis mitogen activated protein kinase 11 0.0173 0.0845 0.0832
Loa Loa (eye worm) hypothetical protein 0.0132 0.0578 0.08
Schistosoma mansoni protein kinase C mu 0.016 0.0762 0.0752
Brugia malayi Protein kinase domain containing protein 0.0309 0.175 0.2456
Loa Loa (eye worm) CAMK/PKD protein kinase 0.016 0.0762 0.1061
Echinococcus granulosus dual specificity 0.0128 0.0551 0.0537
Brugia malayi Protein kinase domain containing protein 0.0073 0.0181 0.0239
Echinococcus multilocularis epidermal growth factor receptor 0.0466 0.2792 0.2782
Brugia malayi SRC-1 0.0172 0.0839 0.1169
Echinococcus multilocularis tyrosine kinase 0.0073 0.0181 0.0166
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0192 0.0973 0.096
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.0486 0.0475
Loa Loa (eye worm) AUR protein kinase 0.0156 0.0736 0.1024
Schistosoma mansoni serine/threonine protein kinase 0.0133 0.0584 0.0574
Echinococcus multilocularis PAK box P21 Rho binding 0.0059 0.0089 0.0074
Echinococcus granulosus epidermal growth factor receptor 0.0716 0.4453 0.4445
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0082 0.0243 0.0243
Loa Loa (eye worm) TK/ROR protein kinase 0.0057 0.0078 0.0095
Trypanosoma cruzi casein kinase, putative 0.0067 0.014 0.014
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0129 0.0553 0.0536
Echinococcus granulosus cyclin dependent kinase 1 0.0124 0.0523 0.051
Schistosoma mansoni protein kinase 0.0245 0.1326 0.1316
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0136 0.0602 0.0591
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0018 0.0007
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0245 0.1326 0.1313
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0085 0.0262 0.0248
Entamoeba histolytica p21-activated kinase 0.0091 0.0305 0.0288
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1113 0.709 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0154 0.0719 0.0706
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0124 0.0523 0.0723
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.1551 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0805 0.1122
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0156 0.0736 0.0719
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0077 0.0207 0.0196
Onchocerca volvulus Serine\/threonine kinase homolog 0.0306 0.1732 0.438
Echinococcus multilocularis serine:threonine protein kinase N2 0.0154 0.0719 0.0706
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0213 0.1113 0.1557
Trypanosoma brucei protein kinase, putative 0.0082 0.0243 0.0225
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0067 0.014 0.014

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2 nM Inhibition of FLT3 by HTRF assay ChEMBL. 17343372
IC50 (binding) = 2 nM Inhibition of FLT3 by HTRF assay ChEMBL. 17343372
IC50 (binding) = 12 nM Inhibition of KDR by HTRF assay ChEMBL. 17343372
IC50 (functional) = 12 nM Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA ChEMBL. 17343372
IC50 (binding) = 12 nM Inhibition of KDR by HTRF assay ChEMBL. 17343372
IC50 (functional) = 12 nM Inhibition of VEGF-induced human KDR phosphorylation in mouse 3T3 cells by ELISA ChEMBL. 17343372
IC50 (binding) = 17 nM Inhibition of c-Kit by HTRF assay ChEMBL. 17343372
IC50 (binding) = 17 nM Inhibition of c-Kit by HTRF assay ChEMBL. 17343372
IC50 (binding) = 17 nM Inhibition of c-Kit by HTRF method ChEMBL. 19892442
Inhibition (functional) = 0 % Inhibition of estradiol-stimulated fluid content in Balb/c mouse uterus at 10 mg/kg ChEMBL. 17343372
Inhibition (functional) = 0 % Inhibition of estradiol-stimulated fluid content in Balb/c mouse uterus at 10 mg/kg ChEMBL. 17343372

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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