Detailed information for compound 416280

Basic information

Technical information
  • TDR Targets ID: 416280
  • Name: 3-[8-[[(2S,5R)-5-(5-methyl-2,4-dioxopyrimidin -1-yl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7 ,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1( 6),2,4-trien-3-yl]propanoyloxymethyl 2-methyl propanoate
  • MW: 564.478 | Formula: C25H29N2O11P
  • H donors: 1 H acceptors: 5 LogP: 1.62 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(CCc1ccc2c(c1)COP(=O)(O2)OC[C@@H]1C=C[C@@H](O1)n1cc(C)c(=O)[nH]c1=O)OCOC(=O)C(C)C
  • InChi: 1S/C25H29N2O11P/c1-15(2)24(30)34-14-33-22(28)9-5-17-4-7-20-18(10-17)12-35-39(32,38-20)36-13-19-6-8-21(37-19)27-11-16(3)23(29)26-25(27)31/h4,6-8,10-11,15,19,21H,5,9,12-14H2,1-3H3,(H,26,29,31)/t19-,21+,39?/m0/s1
  • InChiKey: IWHVNLGECWKICB-YAVZSSHRSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[8-[[(2S,5R)-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-trien-3-yl]propanoyloxymethyl 2-methylpropanoate
  • 2-methylpropanoic acid [3-[8-[[(2S,5R)-5-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2,5-dihydrofuran-2-yl]methoxy]-8-oxo-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-trien-3-yl]-1-oxopropoxy]methyl ester
  • 2-methylpropionic acid 3-[8-[[(2S,5R)-5-(2,4-diketo-5-methyl-pyrimidin-1-yl)-2,5-dihydrofuran-2-yl]methoxy]-8-keto-7,9-dioxa-8$l^{5}-phosphabicyclo[4.4.0]deca-1(6),2,4-trien-3-yl]propanoyloxymethyl ester
  • 4H-1,3,2-Benzodioxaphosphorin-6-propanoic acid, 2-[[(2S,5R)-5-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)-2,5-dihydro-2-furanyl]methoxy]-, (2-methyl-1-oxopropoxy)methyl ester, 2-oxide
  • AIDS-356380
  • AIDS356380

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0074 0.1072 0.2205
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0355 0.0355
Echinococcus granulosus mitogen activated protein kinase 0.006 0.08 0.08
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1072 0.1072
Brugia malayi steroid hormone receptor 0.0173 0.2934 0.6036
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0173 0.2934 1
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0473 0.0974
Onchocerca volvulus 0.0042 0.0473 0.1613
Loa Loa (eye worm) MH2 domain-containing protein 0.0141 0.2326 0.4785
Schistosoma mansoni retinoic acid receptor RXR 0.0173 0.2934 0.2934
Echinococcus granulosus survival motor neuron protein 1 0.0276 0.486 0.486
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0173 0.2934 0.6036
Onchocerca volvulus 0.0056 0.0741 0.2525
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0355 0.0945
Onchocerca volvulus 0.0058 0.0768 0.2617
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0071 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.1218 0.1218
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.000000018241 0.000000018241
Brugia malayi nuclear receptor NHR-67 0.0082 0.1218 0.2506
Schistosoma mansoni nuclear hormone receptor 0.0082 0.1218 0.1218
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.2857 0.5879
Echinococcus multilocularis tumor protein p63 0.0395 0.7079 0.7079
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.005 0.0626 0.5
Loa Loa (eye worm) hypothetical protein 0.0092 0.1401 0.2884
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Loa Loa (eye worm) endoplasmin 0.0054 0.0688 0.1416
Brugia malayi Endoplasmin precursor 0.0054 0.0688 0.1416
Brugia malayi nuclear hormone receptor family member nhr-6 0.0082 0.1218 0.2506
Toxoplasma gondii heat shock protein HSP90 0.0054 0.0688 0.1908
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0237 0.1892
Schistosoma mansoni lamin 0.0031 0.0276 0.0276
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1072 0.1072
Schistosoma mansoni loxhd1 0.0104 0.1639 0.1639
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0092 0.1401 0.1401
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.113 0.2325
Plasmodium falciparum endoplasmin, putative 0.0039 0.0413 0.1112
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.1639 0.1639
Echinococcus multilocularis RUN 0.0104 0.1639 0.1639
Loa Loa (eye worm) steroid hormone receptor 0.0173 0.2934 0.6036
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0522 0.0522
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0688 0.8459
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0276 0.0567
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.08 0.7008
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0268 0.2701
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.1639 0.1639
Schistosoma mansoni heat shock protein 0.0054 0.0688 0.0688
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.000000018241 0.000000018241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0173 0.2934 0.6036
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0237 0.0603
Onchocerca volvulus 0.0031 0.0276 0.0939
Echinococcus multilocularis jun protein 0.0098 0.1523 0.1523
Schistosoma mansoni steroid hormone receptor ad4bp 0.0173 0.2934 0.2934
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0276 0.0567
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Schistosoma mansoni RAR-like nuclear receptor 0.0173 0.2934 0.2934
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0265 0.0545
Brugia malayi intermediate filament protein 0.0031 0.0276 0.0567
Schistosoma mansoni hypothetical protein 0.0042 0.0473 0.0473
Trypanosoma cruzi heat shock protein, putative 0.0036 0.0352 0.2932
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0071 0.0071
Entamoeba histolytica hypothetical protein 0.0042 0.0473 0.3791
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0029 0.0029
Schistosoma mansoni nuclear hormone receptor 0.0173 0.2934 0.2934
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.113 0.113
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0031 0.0031
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.055 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0173 0.2934 0.2934
Loa Loa (eye worm) RNA binding protein 0.0074 0.1072 0.2205
Loa Loa (eye worm) nuclear hormone receptor 0.0082 0.1218 0.2506
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0031 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0092 0.1401 0.1401
Schistosoma mansoni jun-related protein 0.008 0.1179 0.1179
Brugia malayi Nuclear hormone receptor-like 1 0.0173 0.2934 0.6036
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0355 0.0355
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0431 0.0887
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0173 0.2934 0.2934
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0543 0.4673
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0173 0.2934 0.2934
Plasmodium vivax heat shock protein 86, putative 0.0054 0.0688 0.1908
Loa Loa (eye worm) hypothetical protein 0.0191 0.3257 0.6701
Entamoeba histolytica hypothetical protein 0.0042 0.0473 0.3791
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0972 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0173 0.2934 0.6036
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0355 0.0731
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Echinococcus multilocularis heat shock protein 90 0.0046 0.0543 0.0543
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0972 0.0972
Trichomonas vaginalis heat shock protein, putative 0.005 0.0626 0.7614
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0355 0.0731
Schistosoma mansoni endoplasmin 0.0054 0.0688 0.0688
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.113 0.113
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0355 0.0945
Onchocerca volvulus 0.0082 0.1218 0.4151
Trichomonas vaginalis CMGC family protein kinase 0.006 0.08 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0355 0.0355
Schistosoma mansoni single-minded 0.0057 0.075 0.075
Brugia malayi RNA binding protein 0.0074 0.1072 0.2205
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0618 0.7499
Brugia malayi tailless protein 0.0082 0.1218 0.2506
Brugia malayi hypothetical protein 0.0276 0.486 1
Brugia malayi nuclear receptor RXR 0.0092 0.1401 0.2884
Echinococcus granulosus lamin 0.0031 0.0276 0.0276
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.1639 0.1639
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0173 0.2934 0.6036
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0104 0.1639 0.1639
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0173 0.2934 0.2934
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0029 0.0029
Brugia malayi heat shock protein 90 0.0054 0.0688 0.1416
Schistosoma mansoni hypothetical protein 0.0121 0.1961 0.1961
Brugia malayi Death domain containing protein 0.0017 0.000000018241 0.000000037533
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0972 0.2001
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0688 0.5988
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2934 0.2934
Echinococcus granulosus FTZ F1 alpha 0.0173 0.2934 0.2934
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.005 0.0626 0.5429
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0618 0.7499
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0029 0.0029
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0543 0.6472
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Echinococcus multilocularis Polycystic kidney disease protein 0.0104 0.1639 0.1639
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0082 0.1218 0.1218
Brugia malayi nuclear hormone receptor family member odr-7 0.0082 0.1218 0.2506
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.054 0.1481
Trichomonas vaginalis endoplasmin, putative 0.0039 0.0413 0.4687
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0972 0.0972
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0688 0.5988
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0173 0.2934 0.2934
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.113 1
Brugia malayi hypothetical protein 0.0019 0.0041 0.0085
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0092 0.1401 0.2884
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.08 0.7008
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0237 0.0603
Schistosoma mansoni hypothetical protein 0.004 0.0431 0.0431
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.1401 0.2884
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0082 0.1218 0.2506
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0173 0.2934 0.6036
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0082 0.1218 0.1218
Echinococcus granulosus tar DNA binding protein 0.0074 0.1072 0.1072
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi jmjC domain containing protein 0.0018 0.0029 0.0059
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0029 0.0029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0776 0.1597
Trypanosoma cruzi Heat shock protein 83, putative 0.0054 0.0688 0.5988
Onchocerca volvulus 0.0104 0.1639 0.5588
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0355 0.0355
Echinococcus granulosus endoplasmin 0.005 0.0626 0.0626
Leishmania major heat shock protein, putative 0.0036 0.0352 0.2932
Loa Loa (eye worm) hypothetical protein 0.0104 0.1639 0.3373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0173 0.2934 0.6036
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1072 0.2205
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0173 0.2934 0.6036
Brugia malayi jmjC domain containing protein 0.0069 0.0972 0.2001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0031 0.0063
Entamoeba histolytica hypothetical protein 0.0042 0.0473 0.3791
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0618 0.1705
Toxoplasma gondii heat shock protein 90, putative 0.0054 0.0688 0.1908
Brugia malayi Doublecortin family protein 0.0104 0.1639 0.3373
Echinococcus granulosus heat shock protein 90 0.0046 0.0543 0.0543
Schistosoma mansoni rab6-interacting 0.0104 0.1639 0.1639
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0972 0.0972
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi nuclear hormone receptor 0.0082 0.1218 0.2506
Brugia malayi nuclear receptor NHR-88 0.0173 0.2934 0.6036
Echinococcus multilocularis musashi 0.0031 0.0276 0.0276
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.113 1
Onchocerca volvulus Bile acid receptor homolog 0.0173 0.2934 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.08 0.7008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0173 0.2934 0.2934
Loa Loa (eye worm) heat shock protein 75 0.0036 0.0352 0.0723
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.054 0.4431
Plasmodium vivax endoplasmin, putative 0.0054 0.0688 0.1908
Loa Loa (eye worm) nuclear receptor NHR-67 0.0082 0.1218 0.2506
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0543 0.6472
Loa Loa (eye worm) hypothetical protein 0.0058 0.0776 0.1597
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0776 0.1597
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0029 0.0029
Schistosoma mansoni nuclear receptor 0.0082 0.1218 0.1218
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.08 0.2233
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.005 0.0626 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0173 0.2934 0.2934
Brugia malayi conserved hypotetical protein 0.0082 0.1218 0.2506
Brugia malayi hypothetical protein 0.0082 0.1218 0.2506
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0046 0.0543 0.0543
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0355 0.2967
Leishmania major hypothetical protein, conserved 0.0029 0.0237 0.1892
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.113 1
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0618 0.1705
Schistosoma mansoni hypothetical protein 0.008 0.1179 0.1179
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0398 0.7141 0.7141
Brugia malayi hypothetical protein 0.0191 0.3257 0.6701
Brugia malayi Nuclear hormone receptor E75 0.0082 0.1218 0.2506
Schistosoma mansoni nuclear hormone receptor 0.0082 0.1218 0.1218
Brugia malayi ecdysteroid receptor 0.0173 0.2934 0.6036
Echinococcus multilocularis survival motor neuron protein 1 0.0276 0.486 0.486
Echinococcus granulosus jun protein 0.0098 0.1523 0.1523
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.1297 0.1297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0031 0.0031
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0105 0.0696
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0776 0.1597
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Plasmodium falciparum heat shock protein 90, putative 0.0203 0.3486 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Echinococcus multilocularis heat shock protein 90 0.0054 0.0688 0.0688
Echinococcus multilocularis heat shock protein 0.0054 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0355 0.2967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0173 0.2934 0.6036
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.08 0.7008
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Echinococcus granulosus Polycystic kidney disease protein 0.0104 0.1639 0.1639
Onchocerca volvulus 0.0031 0.0276 0.0939
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0522 0.0522
Echinococcus granulosus Ankyrin 0.0017 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2934 0.2934
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0473 0.724
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0173 0.2934 0.2934
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.2768 0.2768
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0768 0.0768
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0002 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.006 0.08 0.08
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0173 0.2934 0.2934
Brugia malayi jmjC domain containing protein 0.0069 0.0972 0.2001
Loa Loa (eye worm) hypothetical protein 0.004 0.0431 0.0887
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0173 0.2934 0.2934
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0688 0.5988
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.113 0.2325
Echinococcus multilocularis geminin 0.0398 0.7141 0.7141
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0276 0.0567
Echinococcus multilocularis lamin dm0 0.0031 0.0276 0.0276
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0029 0.0029
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0173 0.2934 0.6036
Echinococcus granulosus heat shock protein 0.0054 0.0688 0.0688
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0036 0.0352 0.0352
Brugia malayi bZIP transcription factor family protein 0.0098 0.1523 0.3134
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Entamoeba histolytica hypothetical protein 0.0042 0.0473 0.3791
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0237 0.1892
Trichomonas vaginalis CMGC family protein kinase 0.006 0.08 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0173 0.2934 0.2934
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0029 0.0029
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0413 0.4687
Loa Loa (eye worm) hypothetical protein 0.0092 0.1401 0.2884
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0082 0.1218 0.4151
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0173 0.2934 0.2934
Giardia lamblia Kinase, CMGC MAPK 0.006 0.08 1
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0355 0.0945
Echinococcus granulosus Nuclear hormone receptor HR96 0.0082 0.1218 0.1218
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0688 0.8459
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0173 0.2934 0.6036
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0003 0.0003
Trypanosoma brucei heat shock protein 84, putative 0.0036 0.0352 0.2932
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1072 0.2205
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.2857 0.2857
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0031 0.0031
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0473 0.0473
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.08 0.08
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0173 0.2934 0.6036
Brugia malayi hypothetical protein 0.0092 0.1401 0.2884
Brugia malayi jmjC domain containing protein 0.0018 0.0029 0.0059
Echinococcus granulosus lamin dm0 0.0031 0.0276 0.0276
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0082 0.1218 0.1218
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.08 0.7008
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Loa Loa (eye worm) doublecortin family protein 0.0104 0.1639 0.3373
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.000000018241 0.000000018241
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0173 0.2934 0.2934
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Schistosoma mansoni lamin 0.0031 0.0276 0.0276
Brugia malayi isocitrate dehydrogenase 0.0036 0.0355 0.0731
Brugia malayi photoreceptor-specific nuclear receptor 0.0173 0.2934 0.6036
Brugia malayi hypothetical protein 0.0029 0.0237 0.0488
Echinococcus granulosus phd:f box containing protein 0.0018 0.0029 0.0029
Echinococcus granulosus tumor protein p63 0.0395 0.7079 0.7079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0173 0.2934 0.2934
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0029 0.0059
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0059
Brugia malayi Uncoordinated protein 44 0.0017 0.000000018241 0.000000037533
Brugia malayi PAS domain containing protein 0.0057 0.075 0.1543
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Echinococcus granulosus heat shock protein 90 0.0054 0.0688 0.0688
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0173 0.2934 0.6036
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0082 0.1218 0.1218
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.113 1
Treponema pallidum heat shock protein 90 0.005 0.0626 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0092 0.1401 0.1401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.1218 0.1218
Loa Loa (eye worm) transcription factor SMAD2 0.0141 0.2326 0.4785
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0029 0.0029
Toxoplasma gondii Hsp90 domain-containing protein 0.0203 0.3486 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0473 0.0473
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0972 0.0972
Brugia malayi jmjC domain containing protein 0.0018 0.0029 0.0059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0473 0.0473
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.1297 0.1297
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.2934 0.2934
Toxoplasma gondii heat shock protein 75, putative 0.0036 0.0352 0.0934
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0741 0.1524
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0237 0.0603
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0355 0.2967
Onchocerca volvulus 0.0082 0.1218 0.4151
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.113 1
Brugia malayi nuclear hormone receptor 0.0173 0.2934 0.6036
Schistosoma mansoni hypothetical protein 0.0056 0.0741 0.0741
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0543 0.4673
Schistosoma mansoni nuclear receptor 0.0082 0.1218 0.1218
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0618 0.0618
Brugia malayi hypothetical protein 0.0077 0.1128 0.2322
Echinococcus granulosus GPCR family 2 0.0018 0.0031 0.0031
Mycobacterium ulcerans heat shock protein 90 0.005 0.0626 1
Trichomonas vaginalis CMGC family protein kinase 0.006 0.08 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0173 0.2934 0.6036
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.1639 0.1639
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.054 0.6433
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0173 0.2934 0.6036
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1072 0.1072
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0029 0.0059
Brugia malayi ecdysone receptor 0.0082 0.1218 0.2506
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0036 0.0352 0.2646
Trichomonas vaginalis heat shock protein, putative 0.005 0.0626 0.7614
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.08 0.08
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0173 0.2934 0.2934
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0173 0.2934 0.2934
Schistosoma mansoni lipoxygenase 0.0363 0.6483 0.6483
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Onchocerca volvulus 0.0077 0.1128 0.3846
Plasmodium falciparum heat shock protein 90, putative 0.0031 0.0268 0.0693
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0173 0.2934 0.6036
Plasmodium vivax heat shock protein 90, putative 0.0036 0.0352 0.0934
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0029 0.0029
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0029 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.006 0.08 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0082 0.1218 0.1218
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0355 0.0945
Brugia malayi Steroid receptor seven-up type 2 0.0173 0.2934 0.6036
Toxoplasma gondii exonuclease III APE 0.0021 0.0071 0.0124
Echinococcus granulosus nuclear receptor nhr 48 0.0082 0.1218 0.1218
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0058 0.0768 0.158
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi Protein kinase domain containing protein 0.0017 0.001 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0173 0.2934 0.6036
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0029 0.0059
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0082 0.1218 0.4151
Schistosoma mansoni rab6-interacting 0.0104 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Schistosoma mansoni heat shock protein 0.0054 0.0688 0.0688
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0071 0.0124
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0237 0.0603
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.08 0.7008
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0022 0.0107 0.5
Onchocerca volvulus 0.0104 0.1639 0.5588
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0355 0.2967
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0688 0.5988
Onchocerca volvulus 0.0173 0.2934 1
Echinococcus granulosus single minded 2 0.0042 0.0473 0.0473
Echinococcus multilocularis Ankyrin 0.0017 0.0003 0.0003
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0092 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Loa Loa (eye worm) hypoxia-induced factor 1 0.0176 0.298 0.6132
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0071 0.0388
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0031
Brugia malayi Hsp90 protein 0.0036 0.0352 0.0723
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0355 0.0355
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0173 0.2934 0.2934
Loa Loa (eye worm) hypothetical protein 0.0092 0.1401 0.2884
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0029 0.0029
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0237 0.1892
Loa Loa (eye worm) hypothetical protein 0.0104 0.1639 0.3373
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0031 0.0063
Echinococcus granulosus RUN 0.0104 0.1639 0.1639
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0688 0.5826
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.005 0.0626 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0972 0.0972
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.113 0.113
Schistosoma mansoni endoplasmin 0.0054 0.0688 0.0688
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0388
Trypanosoma brucei protein kinase, putative 0.006 0.08 0.7008
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0092 0.1401 0.2884
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0071 0.0388
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.1401 0.2884
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi hypothetical protein 0.0104 0.1639 0.3373
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.08 0.08
Plasmodium falciparum heat shock protein 90 0.0054 0.0688 0.1908
Brugia malayi hypoxia-induced factor 1 0.0176 0.298 0.6132
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0355 0.5116
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0473 0.0473
Trypanosoma brucei heat shock protein, putative 0.0054 0.0688 0.5988
Brugia malayi MAP kinase sur-1 0.006 0.08 0.1647
Schistosoma mansoni lipoxygenase 0.055 1 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0082 0.1218 0.1218
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.08 0.7008
Schistosoma mansoni polycystin 1-related 0.0104 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Loa Loa (eye worm) hypothetical protein 0.0276 0.486 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0071 0.0388
Schistosoma mansoni zinc finger protein 0.0082 0.1218 0.1218
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0173 0.2934 0.2934
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0082 0.1218 0.1218
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0031 0.0031
Schistosoma mansoni heat shock protein 0.0036 0.0352 0.0352
Brugia malayi orphan nuclear receptor NR2E1 0.0082 0.1218 0.2506
Echinococcus multilocularis GPCR, family 2 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0173 0.2934 0.6036
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0276 0.0567
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0173 0.2934 0.6036
Echinococcus granulosus thyroid hormone receptor alpha 0.0082 0.1218 0.1218
Echinococcus multilocularis FTZ F1 alpha 0.0173 0.2934 0.2934
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1072 0.2205
Schistosoma mansoni hypothetical protein 0.0398 0.7141 0.7141
Brugia malayi hypothetical protein 0.0092 0.1401 0.2884
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Brugia malayi nuclear receptor RXR 0.0082 0.1218 0.2506
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0355 0.2967
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0688 0.5988
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0688 0.5988
Plasmodium vivax heat shock protein, putative 0.0203 0.3486 1
Echinococcus multilocularis lamin 0.0031 0.0276 0.0276
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0688 0.5826
Schistosoma mansoni ap endonuclease 0.0021 0.0071 0.0071
Schistosoma mansoni intermediate filament proteins 0.0031 0.0276 0.0276
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Brugia malayi MH2 domain containing protein 0.0141 0.2326 0.4785
Plasmodium falciparum LCCL domain-containing protein 0.0104 0.1639 0.4659
Loa Loa (eye worm) acetyltransferase 0.0169 0.2857 0.5879
Schistosoma mansoni nuclear receptor nhr-48 0.0082 0.1218 0.1218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0071 0.0147
Brugia malayi nuclear receptor NHR-88 0.0082 0.1218 0.2506
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.08 0.1647
Schistosoma mansoni survival motor neuron protein 0.0056 0.0741 0.0741
Giardia lamblia Grp94/Hsp90 0.005 0.0626 0.7614
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0618 0.1705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0173 0.2934 0.6036
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1072 0.1072
Plasmodium vivax multidomain scavenger receptor, putative 0.0104 0.1639 0.4659
Echinococcus granulosus intermediate filament protein 0.0031 0.0276 0.0276
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0972 0.0972
Schistosoma mansoni coup transcription factor 0.0173 0.2934 0.2934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0173 0.2934 0.6036
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0098 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.0095 0.1473 0.303
Brugia malayi hypothetical protein 0.0104 0.1639 0.3373
Echinococcus multilocularis endoplasmin 0.005 0.0626 0.0626
Trypanosoma brucei Heat shock protein 83, putative 0.0054 0.0688 0.5988
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0173 0.2934 0.2934
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.075 0.075
Echinococcus multilocularis ecdysone induced protein 78C 0.0173 0.2934 0.2934
Echinococcus granulosus ecdysone induced protein 78C 0.0173 0.2934 0.2934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0173 0.2934 0.6036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0098 0.1523 0.1523
Loa Loa (eye worm) heat shock protein 90 0.0054 0.0688 0.1416
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0036 0.0352 0.1198
Loa Loa (eye worm) hypothetical protein 0.0082 0.1218 0.2506
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0082 0.1218 0.1218
Brugia malayi Nuclear hormone receptor E75 0.0082 0.1218 0.2506
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Loa Loa (eye worm) DR-78 0.0082 0.1218 0.2506
Leishmania major heat shock protein 83-1 0.0054 0.0688 0.5988
Loa Loa (eye worm) hypothetical protein 0.0018 0.0029 0.0059
Loa Loa (eye worm) hypothetical protein 0.0092 0.1401 0.2884
Echinococcus granulosus Nuclear hormone receptor HR96 0.0082 0.1218 0.1218
Echinococcus granulosus geminin 0.0398 0.7141 0.7141
Onchocerca volvulus Protein ultraspiracle homolog 0.0173 0.2934 1
Brugia malayi hypothetical protein 0.0082 0.1218 0.2506
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0063
Brugia malayi hypothetical protein 0.0042 0.0473 0.0973
Brugia malayi jmjC domain containing protein 0.0018 0.0029 0.0059
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0082 0.1218 0.2506
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.2857 0.2857
Loa Loa (eye worm) hypothetical protein 0.0029 0.0237 0.0488
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0071 0.0071
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0036 0.0352 0.0352

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) 0 Hydrolysis half life in RPMI-1650/FCS medium at pH 7.6 ChEMBL. 17335187
Activity (ADMET) 0 Hydrolysis half life in human serum at pH 6.8 ChEMBL. 17335187
EC50 (functional) = 0.26 uM Antiviral activity against HIV1 in CEM/0 cells ChEMBL. 17335187
EC50 (functional) = 0.6 uM Antiviral activity against HIV2 ROD in CEM/0 cells ChEMBL. 17335187
EC50 (functional) = 1.73 uM Antiviral activity against HIV2 ROD in CEM/TK- cells ChEMBL. 17335187
t1/2 (ADMET) = 0.9 hr Hydrolysis half life in CEM cell extracts at pH 6.9 ChEMBL. 17335187
T1/2 (ADMET) = 0.9 hr Hydrolysis half life in CEM cell extracts at pH 6.9 ChEMBL. 17335187
t1/2 = 3.9 hr Chemical stability in phosphate buffer at pH 7.3 ChEMBL. 17335187

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.