Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0067 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0067 | 0 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0069 | 0.0177 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0067 | 0 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0176 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0067 | 0 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0176 | 1 | 0.5 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0067 | 0 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0176 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0176 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0176 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0176 | 1 | 1 |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | 0.0069 | 0.0177 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0069 | 0.0177 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0067 | 0 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0176 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (ADMET) | = 5.3 | Ratio of drug level in tumor to skin of C3H mouse bearing RIF tumors after 24 hrs by IRS | ChEMBL. | 17371002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.