Detailed information for compound 416796

Basic information

Technical information
  • TDR Targets ID: 416796
  • Name: 2-benzyl-N-hydroxy-N'-[3-(N-methylanilino)pro pyl]propanediamide
  • MW: 355.431 | Formula: C20H25N3O3
  • H donors: 3 H acceptors: 3 LogP: 2.66 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C(C(=O)NCCCN(c1ccccc1)C)Cc1ccccc1
  • InChi: 1S/C20H25N3O3/c1-23(17-11-6-3-7-12-17)14-8-13-21-19(24)18(20(25)22-26)15-16-9-4-2-5-10-16/h2-7,9-12,18,26H,8,13-15H2,1H3,(H,21,24)(H,22,25)
  • InChiKey: SUVYEXLYYNZZGT-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-benzyl-3-(hydroxyamino)-N-[3-(N-methylanilino)propyl]-3-oxo-propanamide
  • 2-benzyl-3-(hydroxyamino)-N-[3-(N-methylanilino)propyl]-3-oxopropanamide
  • N-hydroxy-N'-[3-[methyl(phenyl)amino]propyl]-2-(phenylmethyl)propanediamide
  • 2-benzyl-3-(hydroxyamino)-3-keto-N-[3-(N-methylanilino)propyl]propionamide
  • N-hydroxy-N'-[3-(methyl-phenylamino)propyl]-2-(phenylmethyl)propanediamide
  • 3-(hydroxyamino)-N-[3-(methyl-phenyl-amino)propyl]-3-oxo-2-(phenylmethyl)propanamide
  • 3-(hydroxyamino)-N-[3-(methyl-phenylamino)propyl]-3-oxo-2-(phenylmethyl)propanamide
  • 2-(benzyl)-3-(hydroxyamino)-3-keto-N-[3-(methyl-phenyl-amino)propyl]propionamide
  • N-hydroxy-N'-[3-(methyl-phenyl-amino)propyl]-2-(phenylmethyl)propanediamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0068 0.2907 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0043 0.1781 0.4253
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.007 0.2981 0.297
Giardia lamblia ABC transporter, putative 0.0021 0.0799 1
Brugia malayi chromobox protein homolog 3 0.0018 0.0664 0.1981
Brugia malayi CXXC zinc finger family protein 0.0016 0.0552 0.1615
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.0059 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.0059 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.0059 0.0044
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0799 0.2543
Echinococcus granulosus chromobox protein 1 0.0033 0.1311 0.1298
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.002 0.0765 0.2631
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Loa Loa (eye worm) multidrug resistance protein 3 0.0068 0.2907 0.9293
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0043 0.1781 0.1768
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0072 0.3109 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0799 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.3124 0.3113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0022 0.084 0.0825
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0799 0.2747
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.002 0.0732 0.0718
Entamoeba histolytica P-glycoprotein 6, putative 0.0021 0.0799 0.2543
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0043 0.1781 0.6018
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0021 0.0799 0.2419
Leishmania major p-glycoprotein 0.0068 0.2907 0.9127
Toxoplasma gondii ABC transporter family protein 0.0021 0.0799 0.2543
Echinococcus multilocularis peptidase Clp (S14 family) 0.0028 0.1112 0.1098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0008 0.0184 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Echinococcus multilocularis 0.0021 0.0799 0.0784
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0073 0.3124 0.3113
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0068 0.2907 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0043 0.1781 0.1768
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0006 0.0095 0.008
Trichomonas vaginalis ABC transporter, putative 0.0068 0.2907 1
Echinococcus multilocularis dnaJ subfamily B 0.0225 1 1
Trichomonas vaginalis chromobox protein, putative 0.002 0.0727 0.25
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0021 0.0799 0.2543
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.0059 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.0059 0.0044
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0068 0.2907 0.9127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0022 0.084 0.0825
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0068 0.2907 0.2896
Entamoeba histolytica P-glycoprotein 6, putative 0.0021 0.0799 0.2543
Trichomonas vaginalis ABC transporter, putative 0.0068 0.2907 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0008 0.0184 0.0406
Entamoeba histolytica hypothetical protein 0.002 0.0732 0.2308
Entamoeba histolytica P-glycoprotein-2 0.0068 0.2907 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0079 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0033 0.1352 0.1338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0028 0.1112 0.4744
Echinococcus multilocularis potassium voltage gated channel protein 0.0006 0.0106 0.009
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0006 0.0106 0.009
Trichomonas vaginalis chromobox protein, putative 0.0005 0.0079 0.0273
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0067 0.2874 0.9183
Schistosoma mansoni hypothetical protein 0.0008 0.0184 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0022 0.084 0.0825
Loa Loa (eye worm) ABC transporter 0.0021 0.0799 0.2412
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0043 0.1781 0.6018
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.002 0.0765 0.0751
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Schistosoma mansoni cpg binding protein 0.0016 0.0552 0.0537
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.0059 0.0044
Echinococcus multilocularis chromobox protein 1 0.0033 0.1311 0.1298
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0006 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Loa Loa (eye worm) helicase 0.0005 0.0079 0.0066
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.1981 0.1968
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0799 0.2543
Entamoeba histolytica P-glycoprotein 5, putative 0.002 0.0765 0.2424
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0043 0.1781 0.6018
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0799 0.0784
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0021 0.0799 0.2543
Trichomonas vaginalis Heterochromatin protein, putative 0.0005 0.0079 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Echinococcus multilocularis potassium voltage gated channel protein 0.0073 0.3124 0.3113
Echinococcus granulosus GPCR family 2 0.0008 0.0184 0.0168
Schistosoma mansoni chromobox protein 0.0033 0.1311 0.1298
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0799 0.0784
Brugia malayi ABC transporter family protein 0.0021 0.0799 0.2419
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0059 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0068 0.2907 0.2896
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0006 0.0106 0.009
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0005 0.0079 0.0064
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.0059 0.0044
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0799 0.2412
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0068 0.2907 0.2896
Loa Loa (eye worm) hypothetical protein 0.0017 0.0584 0.1714
Brugia malayi P-glycoprotein-like protein 0.0021 0.0799 0.2419
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Schistosoma mansoni multidrug resistance protein 0.0068 0.2907 0.2896
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0664 0.2284
Loa Loa (eye worm) hypothetical protein 0.0018 0.0664 0.1974
Trichomonas vaginalis abcb9, putative 0.0068 0.2907 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0799 0.0784
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.0059 0.0044
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0068 0.2907 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0059 0.0044
Echinococcus granulosus ATP binding cassette sub family B 0.0021 0.0799 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0006 0.0106 0.0161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.0059 0.0044
Schistosoma mansoni hypothetical protein 0.0005 0.0079 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0486 0.1392
Brugia malayi multidrug resistance related protein 1 0.0021 0.0799 0.2419
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.2303
Brugia malayi multidrug resistance protein 3 0.0068 0.2907 0.9293
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0015 0.0508 0.1514
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0015 0.0508 0.1514
Echinococcus multilocularis chromobox protein 1 0.0033 0.1311 0.1298
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Schistosoma mansoni hypothetical protein 0.0225 1 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.0021 0.0799 0.2543
Schistosoma mansoni chromobox protein 0.0005 0.0079 0.0064
Echinococcus granulosus voltage gated potassium channel 0.0006 0.0106 0.009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.0059 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.0059 0.0044
Schistosoma mansoni coup transcription factor 0.0005 0.0059 0.0044
Schistosoma mansoni multidrug resistance protein 0.0021 0.0799 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.0017 0.0584 0.1721
Echinococcus granulosus peptidase Clp S14 family 0.0028 0.1112 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.0059 0.0009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.002 0.0727 0.2344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0059 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0423 0.1455
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0008 0.0184 0.0168
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.0059 0.0044
Plasmodium falciparum ABC transporter B family member 6, putative 0.0021 0.0799 0.2543
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0021 0.0799 0.2284
Schistosoma mansoni multidrug resistance protein 0.0068 0.2907 0.2896
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0664 0.2284
Loa Loa (eye worm) hypothetical protein 0.0021 0.0799 0.2412
Plasmodium falciparum multidrug resistance protein 2 0.0021 0.0799 0.2543
Plasmodium falciparum ABC transporter B family member 3, putative 0.0021 0.0799 0.2543
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.0059 0.0009
Echinococcus multilocularis Chromobox protein 3 0.0005 0.0079 0.0064
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.0059 0.0044
Entamoeba histolytica hypothetical protein 0.002 0.0732 0.2308
Brugia malayi SET domain containing protein 0.0006 0.0095 0.0126
Onchocerca volvulus 0.0014 0.0486 0.1498
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Schistosoma mansoni multidrug resistance protein 0.0021 0.0799 0.0784
Plasmodium vivax ABC transporter B family member 4, putative 0.0021 0.0799 0.2543
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0068 0.2907 1
Trichomonas vaginalis abcb9, putative 0.0068 0.2907 1
Schistosoma mansoni hypothetical protein 0.0008 0.0184 0.0168
Echinococcus granulosus shaker cognate 0.0006 0.0106 0.009
Loa Loa (eye worm) ABC transporter 0.0021 0.0799 0.2412
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0022 0.084 0.2547
Brugia malayi ABC transporter family protein 0.0021 0.0799 0.2419
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.0059 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0033 0.1311 0.4511
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0072 0.3109 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0068 0.2907 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0423 0.1455
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0059 0.0009
Schistosoma mansoni multidrug resistance protein 0.002 0.0765 0.0751
Echinococcus granulosus multidrug resistance protein 1 0.0047 0.1981 0.1968
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0005 0.0079 0.0273
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0068 0.2907 0.2896
Loa Loa (eye worm) hypothetical protein 0.0006 0.0106 0.0152
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0005 0.0079 0.0064
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0006 0.0106 0.009
Schistosoma mansoni multidrug resistance protein 0.0068 0.2907 0.2896
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0059 0.0044
Echinococcus granulosus potassium voltage gated channel protein 0.0006 0.0106 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.1781 0.5618
Loa Loa (eye worm) hypothetical protein 0.0073 0.3124 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0043 0.1781 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0068 0.2907 0.2896
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0799 0.2412
Loa Loa (eye worm) CHromoDomain protein family member 0.0006 0.012 0.0199
Echinococcus multilocularis shaker cognate 0.0006 0.0106 0.009
Trichomonas vaginalis taga, putative 0.0068 0.2907 1
Schistosoma mansoni transcription factor LCR-F1 0.002 0.0732 0.0718
Loa Loa (eye worm) CXXC zinc finger family protein 0.0016 0.0552 0.1608
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.0059 0.0044
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0068 0.2907 0.2896
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0005 0.0079 0.0076
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0006 0.0106 0.0161
Toxoplasma gondii hypothetical protein 0.0015 0.0508 0.1514
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0005 0.0079 0.0064
Plasmodium falciparum multidrug resistance-associated protein 2 0.0021 0.0799 0.2543
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0073 0.3124 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.002 0.0732 0.0718
Echinococcus multilocularis geminin 0.0093 0.4048 0.4039
Brugia malayi Valyl-tRNA synthetase 0.0005 0.0079 0.0076
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0021 0.0799 0.0784
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0008 0.0184 0.0168
Echinococcus multilocularis multidrug resistance protein 1 0.0068 0.2907 0.2896
Brugia malayi Associated with TFs and helicases family protein 0.0005 0.0079 0.0076
Entamoeba histolytica P-glycoprotein-2 0.0068 0.2907 1
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.3124 0.3113
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.0059 0.0009
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0068 0.2907 1
Schistosoma mansoni hypothetical protein 0.002 0.0732 0.0718
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Entamoeba histolytica ABC transporter, putative 0.0021 0.0799 0.2543
Loa Loa (eye worm) voltage-gated potassium channel 0.0006 0.0106 0.0152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0008 0.0184 0.0415
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0241 0.0829
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0166 0.0572
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.0059 0.0044
Echinococcus granulosus chromobox protein 2 0.0005 0.0079 0.0064
Echinococcus granulosus ATP binding cassette sub family B 0.0021 0.0799 0.0784
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.0059 0.0044
Onchocerca volvulus 0.0005 0.0079 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.0059 0.0044
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0765 0.2631
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0067 0.2874 0.2863
Echinococcus multilocularis cpg binding protein 0.0017 0.0593 0.0578
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0006 0.0106 0.009
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0006 0.0106 0.009
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0068 0.2907 0.9127
Schistosoma mansoni hypothetical protein 0.0008 0.0184 0.0168
Schistosoma mansoni hypothetical protein 0.0008 0.0184 0.0168
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Onchocerca volvulus 0.0005 0.0079 0.0071
Echinococcus granulosus Chromobox protein 3 0.0005 0.0079 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.0059 0.0044
Toxoplasma gondii histone lysine methyltransferase SET1 0.003 0.119 0.3927
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0059 0.0044
Brugia malayi hypothetical protein 0.002 0.0732 0.2203
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0024 0.093 0.2847
Echinococcus granulosus ATP binding cassette sub family B 0.002 0.0765 0.0751
Echinococcus multilocularis voltage gated potassium channel 0.0006 0.0106 0.009
Brugia malayi nuclear receptor NHR-88 0.0005 0.0059 0.0009
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0765 0.2303
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.0059 0.0009
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0018 0.0664 0.2124
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.0059 0.0044
Echinococcus granulosus geminin 0.0093 0.4048 0.4039
Entamoeba histolytica hypothetical protein 0.002 0.0732 0.2308
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0059 0.0009
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0799 0.0784
Plasmodium vivax multidrug resistance protein 2, putative 0.0021 0.0799 0.2543
Brugia malayi CHD4 protein 0.0006 0.012 0.0208
Onchocerca volvulus 0.0006 0.0095 0.0126
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0765 0.231
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0021 0.0799 0.2284
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0068 0.2907 0.2896
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0059 0.0044
Schistosoma mansoni cpg binding protein 0.0017 0.0593 0.0578
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Schistosoma mansoni hypothetical protein 0.0093 0.4048 0.4039
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0765 0.2631
Trichomonas vaginalis chromobox protein, putative 0.002 0.0727 0.25
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0021 0.0799 0.2543
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0059 0.0044
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Trichomonas vaginalis abcb9, putative 0.0068 0.2907 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0043 0.1781 0.6018
Echinococcus granulosus Chromo domain 0.0005 0.0079 0.0064
Echinococcus granulosus multidrug resistance protein 1 0.0068 0.2907 0.2896
Schistosoma mansoni smdr2 0.0068 0.2907 0.2896
Brugia malayi ABC transporter 0.0021 0.0799 0.2419
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0005 0.0079 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.0059 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0022 0.084 0.0825
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0072 0.3109 1
Echinococcus granulosus chromobox protein 1 0.0033 0.1311 0.1298
Plasmodium vivax ABC transporter B family member 5, putative 0.0021 0.0799 0.2543
Schistosoma mansoni multidrug resistance protein 0.0021 0.0799 0.0784
Plasmodium falciparum multidrug resistance protein 1 0.0068 0.2907 1
Schistosoma mansoni vesicular amine transporter 0.0006 0.0106 0.009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0024 0.093 0.284
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Entamoeba histolytica hypothetical protein 0.0021 0.0799 0.2543
Entamoeba histolytica P-glycoprotein-2, putative 0.002 0.0765 0.2424
Echinococcus granulosus potassium voltage gated channel protein 0.0006 0.0106 0.009
Loa Loa (eye worm) heterochromatin protein 1 0.0033 0.1311 0.4086
Onchocerca volvulus 0.0016 0.0552 0.173
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0059 0.0009
Trichomonas vaginalis ABC transporter, putative 0.0068 0.2907 1
Entamoeba histolytica hypothetical protein 0.002 0.0732 0.2308
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0009 0.0241 0.0829
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Schistosoma mansoni chromobox protein 0.0033 0.1311 0.1298
Echinococcus granulosus multidrug resistance protein 1 0.0068 0.2907 0.2896
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0068 0.2907 1
Echinococcus multilocularis multidrug resistance protein 1 0.0047 0.1981 0.1968
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0068 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0799 0.2412
Trichomonas vaginalis chromobox protein, putative 0.0005 0.0079 0.0273
Loa Loa (eye worm) hypothetical protein 0.0068 0.2907 0.9293
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0059 0.0044
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0043 0.1781 1
Echinococcus multilocularis GPCR, family 2 0.0008 0.0184 0.0168
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0799 0.2543
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.0059 0.0044
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0043 0.1781 1
Trichomonas vaginalis ABC transporter, putative 0.0068 0.2907 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0021 0.0799 0.0784
Brugia malayi Probable ClpP-like protease 0.0043 0.1781 0.5623
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0006 0.012 0.0105
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0047 0.1981 0.6813
Echinococcus multilocularis transfer RNA-Gly 0.0006 0.0106 0.009
Entamoeba histolytica P-glyco protein 6, putative 0.0068 0.2907 1
Schistosoma mansoni cpg binding protein 0.0017 0.0593 0.0578
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0799 0.2543
Trichomonas vaginalis chromobox protein, putative 0.0033 0.1311 0.4511
Loa Loa (eye worm) hypothetical protein 0.0068 0.2907 0.9293
Schistosoma mansoni hypothetical protein 0.0093 0.4048 0.4039
Brugia malayi Protein cec-1. 0.0005 0.0079 0.0076
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0799 0.2543
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0059 0.0044
Schistosoma mansoni hypothetical protein 0.0017 0.0584 0.057
Plasmodium vivax ABC transporter B family member 6, putative 0.0021 0.0799 0.2543
Entamoeba histolytica P-glycoprotein-1 0.0068 0.2907 1
Brugia malayi ABC transporter 0.002 0.0765 0.231
Loa Loa (eye worm) hypothetical protein 0.0024 0.093 0.284
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0068 0.2907 1
Brugia malayi ABC transporter family protein 0.0068 0.2907 0.9293
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.0059 0.0044
Echinococcus multilocularis Chromo domain 0.0005 0.0079 0.0064
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0005 0.0079 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0059 0.0009
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0006 0.0106 0.009
Schistosoma mansoni chromobox protein 0.0005 0.0079 0.0064
Brugia malayi Heterochromatin protein 1 0.0033 0.1311 0.4092
Trichomonas vaginalis hypothetical protein 0.0005 0.0079 0.0273
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0068 0.2907 1
Entamoeba histolytica P-glycoprotein-5 0.0068 0.2907 1
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0059 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0154 0.0531
Giardia lamblia MRP-like ABC transporter 0.0021 0.0799 1
Toxoplasma gondii ABC transporter, putative 0.0021 0.0799 0.2543
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0068 0.2907 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.0021 0.0799 0.2543
Schistosoma mansoni multidrug resistance protein 0.0021 0.0799 0.0784
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0022 0.084 0.0825
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0799 0.2419
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0072 0.3109 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0005 0.0079 0.0273
Schistosoma mansoni smdr1 0.0021 0.0799 0.0784
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Brugia malayi hypothetical protein 0.0021 0.0799 0.2419
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Echinococcus multilocularis chromobox protein 2 0.0005 0.0079 0.0064
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0068 0.2907 1
Plasmodium falciparum ABC transporter B family member 4, putative 0.0021 0.0799 0.2543
Echinococcus multilocularis multidrug resistance protein 1 0.0068 0.2907 0.2896
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0006 0.012 0.0105
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.0059 0.0044
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0799 0.2419
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0799 0.0784
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0028 0.1112 0.1356
Echinococcus granulosus potassium voltage gated channel protein 0.0073 0.3124 0.3113
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0043 0.1781 0.4253
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0068 0.2907 0.2896
Brugia malayi nuclear hormone receptor 0.0005 0.0059 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0022 0.084 0.0825
Entamoeba histolytica P-glycoprotein-2, putative 0.0068 0.2907 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0799 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0008 0.0184 0.0168
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0068 0.2907 0.2896
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Echinococcus granulosus cpg binding protein 0.0017 0.0593 0.0578
Brugia malayi ecdysteroid receptor 0.0005 0.0059 0.0009
Loa Loa (eye worm) ABC transporter 0.0021 0.0799 0.2412
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0022 0.084 0.2554
Echinococcus multilocularis potassium voltage gated channel protein 0.0006 0.0106 0.009
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0072 0.3109 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.002 0.0765 0.2631
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0072 0.3109 1
Brugia malayi ABC transporter family protein 0.0021 0.0799 0.2419
Plasmodium vivax ABC transporter B family member 3, putative 0.0021 0.0799 0.2543
Echinococcus multilocularis ATP binding cassette sub family B 0.0067 0.2874 0.2863
Trichomonas vaginalis chromobox protein, putative 0.0005 0.0079 0.0273
Echinococcus granulosus FTZ F1 alpha 0.0005 0.0059 0.0044
Loa Loa (eye worm) hypothetical protein 0.0005 0.0079 0.0066
Brugia malayi hypothetical protein 0.0005 0.0079 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.0059 0.0009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0068 0.2907 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0184 0.0406
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0799 1
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0106 0.009
Brugia malayi Latrophilin receptor protein 2 0.0008 0.0184 0.0415
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0166 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0079 0.0273
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0006 0.0106 0.009
Echinococcus granulosus multidrug resistance protein 1 0.0068 0.2907 0.2896
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0009 0.0241 0.0829
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0043 0.1781 0.1768
Brugia malayi steroid hormone receptor 0.0005 0.0059 0.0009
Brugia malayi M-phase phosphoprotein, mpp8 0.0005 0.0079 0.0076
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0068 0.2907 0.9293
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0028 0.1112 0.1356
Plasmodium vivax multidrug resistance protein 1, putative 0.0068 0.2907 1
Plasmodium falciparum ABC transporter B family member 7, putative 0.0021 0.0799 0.2543
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0799 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0059 0.0009
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0799 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0022 0.084 0.0825
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0059 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0024 0.093 0.2847
Plasmodium vivax ABC transporter B family member 7, putative 0.0021 0.0799 0.2543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0059 0.0044
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0799 0.2543
Onchocerca volvulus 0.0068 0.2907 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 46 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615
Inhibition (binding) = 46 % Inhibition of pig kidney microsomal APN at 10 uM ChEMBL. 17326615
Inhibition (binding) = 67 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615
Inhibition (binding) = 67 % Inhibition of Plasmodium falciparum FcB1 M1 aminopeptidase at 10 uM ChEMBL. 17326615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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