Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nitric oxide synthase 2, inducible | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | p450 reductase, putative | 0.0032 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.0355 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0029 | 0.7743 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0017 | 0.0355 | 0.0355 |
Leishmania major | p450 reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0017 | 0.0355 | 0.0355 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.0355 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.002 | 0.2407 | 0.2128 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0017 | 0.0355 | 0.0355 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0016 | 0 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0.0355 | 0.5 | |
Chlamydia trachomatis | sulfite reductase | 0.002 | 0.2407 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.002 | 0.2407 | 0.2128 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0029 | 0.7743 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0032 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0032 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0017 | 0.0355 | 0.0355 |
Schistosoma mansoni | coup transcription factor | 0.0017 | 0.0355 | 0.0355 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0355 | 0.0355 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0017 | 0.0355 | 0.0355 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0017 | 0.0355 | 0.0355 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0016 | 0.0151 | 0.0151 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0017 | 0.0355 | 0.0355 |
Brugia malayi | FAD binding domain containing protein | 0.002 | 0.2407 | 0.2128 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0032 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.002 | 0.2407 | 0.2407 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0017 | 0.0355 | 0.0355 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.0355 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0355 | 0.0355 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0355 | 0.0355 |
Echinococcus granulosus | methionine synthase reductase | 0.002 | 0.2407 | 0.2128 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0032 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0032 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0355 | 0.0355 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0032 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0032 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0032 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 | |
Activity (binding) | 0 | Activity against rat cerebellum iNOS upto 1 uM | ChEMBL. | 17315988 |
IC50 (binding) | 0 | Inhibition of vaccinia virus system-induced human NOS expressed in BSC1 cells | ChEMBL. | 17315988 |
IC50 (binding) | > 100 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
IC50 (binding) | > 100 nM | Inhibition of cytokine-induced iNOS expressed in human A172 cells assessed as inhibition of NO formation | ChEMBL. | 17315988 |
Ratio IC50 (binding) | 0 | Selectivity ratio, IC50 for ecNOS/IC50 for iNOS using vaccinia virus-induced system in BSC1 cells | ChEMBL. | 17315988 |
Ratio IC50 (binding) | 0 | Selectivity ratio, IC50 for bcNOS/IC50 for iNOS using vaccinia virus-induced system in BSC1 cells | ChEMBL. | 17315988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.