Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0058 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0058 | 1 | 1 |
Brugia malayi | Dopamine receptor protein 2 | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0058 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0033 | 0.0603 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0044 | 0.4733 | 0.4733 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0058 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | sulfakinin receptor protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0058 | 1 | 1 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0058 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0058 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0058 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | nuclear hormone receptor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | putative neuropeptide receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0058 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0058 | 1 | 1 |
Brugia malayi | G protein-coupled receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | nuclear receptor NHR-88 | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0058 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0033 | 0.0603 | 0.0603 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0058 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0058 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | AKH receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Dopamine receptor | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | coup transcription factor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0058 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0044 | 0.4733 | 0.4733 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0058 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | thyroid hormone receptor | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0044 | 0.4733 | 0.4733 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0058 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Dopamine receptor protein 1 | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0058 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0058 | 1 | 1 |
Brugia malayi | ORL1-like opioid receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | thyroid hormone receptor | 0.0058 | 1 | 1 |
Brugia malayi | Melatonin receptor type 1A | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Echinococcus granulosus | FTZ F1 alpha | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0058 | 1 | 1 |
Brugia malayi | GnHR receptor homolog | 0.0044 | 0.4733 | 0.4733 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0058 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0058 | 1 | 1 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | neuropeptide F receptor | 0.0044 | 0.4733 | 0.4733 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0058 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Leishmania major | cytochrome p450-like protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0058 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | steroid hormone receptor | 0.0058 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 1 |
Brugia malayi | G-protein coupled receptor | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Serotonin receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | larval opioid receptor | 0.0044 | 0.4733 | 0.4733 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0058 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0058 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0044 | 0.4733 | 0.4733 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.4733 | 0.4733 |
Brugia malayi | RE15519p | 0.0044 | 0.4733 | 0.4733 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 17 s | Antinociceptive effect in Swiss Albino mouse assessed as licking latency at 50 mg/kg, sc after 15 mins by hot-plate test | ChEMBL. | 17373780 |
Activity (functional) | = 17 s | Antinociceptive effect in Swiss Albino mouse assessed as licking latency at 50 mg/kg, sc after 15 mins by hot-plate test | ChEMBL. | 17373780 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.