Detailed information for compound 417111

Basic information

Technical information
  • TDR Targets ID: 417111
  • Name: (2S)-2-amino-N-(2,6-dimethylphenyl)-N-methylp ropanamide
  • MW: 206.284 | Formula: C12H18N2O
  • H donors: 1 H acceptors: 1 LogP: 1.5 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)N(c1c(C)cccc1C)C)N
  • InChi: 1S/C12H18N2O/c1-8-6-5-7-9(2)11(8)14(4)12(15)10(3)13/h5-7,10H,13H2,1-4H3/t10-/m0/s1
  • InChiKey: WAZVWEIMFJYUIF-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-N-(2,6-dimethylphenyl)-N-methyl-propanamide
  • (2S)-2-azanyl-N-(2,6-dimethylphenyl)-N-methyl-propanamide
  • (2S)-2-amino-N-(2,6-dimethylphenyl)-N-methyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0156 0.064
Trypanosoma brucei DNA polymerase IV, putative 0.0159 0.1047 0.3423
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.2249
Mycobacterium tuberculosis Probable oxidoreductase 0.1101 0.7928 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0005 0.0016
Brugia malayi steroid hormone receptor 0.0037 0.0158 0.0261
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0158 0.0158
Echinococcus granulosus lamin dm0 0.0033 0.0128 0.0418
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.004 0.0182 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0158 0.0261
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0161
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0134 0.0333
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0158 0.0158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0164 0.109 0.1798
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0019 0.0032 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0182 0.0594
Plasmodium vivax ferrodoxin reductase, putative 0.004 0.0182 0.0491
Brugia malayi glutathione reductase 0.0434 0.306 0.505
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0032 0.0032
Schistosoma mansoni cpg binding protein 0.0029 0.0099 0.0099
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.004 0.0182 0.1466
Onchocerca volvulus 0.0237 0.1621 0.7776
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0439
Echinococcus multilocularis glutamate synthase 0.004 0.0182 0.0594
Brugia malayi MH1 domain containing protein 0.0058 0.031 0.0512
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0158 0.0158
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0017 0.0054
Onchocerca volvulus 0.0037 0.0158 0.0687
Echinococcus granulosus intermediate filament protein 0.0033 0.0128 0.0418
Brugia malayi hypothetical protein 0.0017 0.0017 0.0028
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.004 0.0182 0.0928
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0149 0.0383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0202
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0158 0.0261
Giardia lamblia Thioredoxin reductase 0.004 0.0182 0.0772
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1247 0.6365
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0111 0.0697 0.115
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0434 0.306 0.3834
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0017 0.0017 0.0054
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0128 0.0211
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0991 0.7121 0.8958
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Schistosoma mansoni disulfide oxidoreductase 0.004 0.0182 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0112
Schistosoma mansoni glutamate synthase 0.004 0.0182 0.0182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1412 0.233
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0848 0.2772
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.004 0.0182 0.0594
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.0158 0.0517
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0028
Loa Loa (eye worm) nuclear hormone receptor 0.0017 0.0017 0.0028
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.004 0.0182 0.1556
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.2249
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0158 0.0517
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0218 0.0359
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0158 0.0517
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0159 0.1047 0.1047
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0017 0.0017 0.0028
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0091 0.0299
Schistosoma mansoni smad1 5 8 and 0.0058 0.031 0.031
Echinococcus granulosus mothers against decapentaplegic 6 0.0026 0.0078 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0112 0.0367
Mycobacterium ulcerans DNA polymerase IV 0.0159 0.1047 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0362 0.0597
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1958 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0053
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0848 0.4331
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Brugia malayi nuclear hormone receptor 0.0037 0.0158 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Loa Loa (eye worm) programmed cell death 8 0.004 0.0182 0.03
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0149 0.0383
Schistosoma mansoni ap endonuclease 0.002 0.0033 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0158 0.0158
Brugia malayi nuclear receptor RXR 0.0019 0.0032 0.0053
Plasmodium vivax DNA repair protein REV1, putative 0.0049 0.0249 0.0715
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Trypanosoma cruzi NADH dehydrogenase, putative 0.004 0.0182 0.0594
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.004 0.0182 0.0594
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.004 0.0182 0.0594
Echinococcus granulosus TGF beta signal transducer SmadC 0.0058 0.031 0.1015
Brugia malayi nuclear receptor NHR-67 0.0017 0.0017 0.0028
Leishmania major hypothetical protein, conserved 0.004 0.0182 0.0594
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Onchocerca volvulus 0.003 0.0112 0.0464
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0249 0.0815
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0249 0.0815
Echinococcus multilocularis nuclear receptor nhr 48 0.0017 0.0017 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0158 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0033 0.0108
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0158 0.0517
Loa Loa (eye worm) MH2 domain-containing protein 0.0845 0.606 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0128 0.0128
Trypanosoma brucei trypanothione reductase 0.0434 0.306 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0109 0.0688 0.2249
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0249 0.0815
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0078 0.0129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1247 0.6365
Brugia malayi nuclear hormone receptor family member nhr-6 0.0017 0.0017 0.0028
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0156 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0158 0.0261
Schistosoma mansoni Smad4 0.0026 0.0078 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1047 0.1285
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0033 0.0108
Schistosoma mansoni alpha-glucosidase 0.0141 0.0923 0.0923
Loa Loa (eye worm) glutathione reductase 0.0434 0.306 0.505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0158 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.011 0.0561
Brugia malayi hypothetical protein 0.03 0.208 0.3433
Entamoeba histolytica thioredoxin reductase, putative 0.004 0.0182 0.0772
Leishmania major hypothetical protein, conserved 0.004 0.0182 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0158 0.0261
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0017
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Leishmania major NADH dehydrogenase, putative 0.004 0.0182 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0149 0.0602
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Brugia malayi nuclear hormone receptor family member odr-7 0.0017 0.0017 0.0028
Brugia malayi hypothetical protein 0.0102 0.0633 0.1045
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.01 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Echinococcus multilocularis lamin 0.0033 0.0128 0.0418
Schistosoma mansoni DNA polymerase IV / kappa 0.0049 0.0249 0.0249
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.004 0.0182 0.0491
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0158 0.0517
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0848 0.4234
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Leishmania major DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0149 0.0383
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0151 0.0493
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0156 0.0798
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0267
Entamoeba histolytica glutamate synthase beta subunit, putative 0.004 0.0182 0.0772
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0091 0.0462
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0058 0.031 0.1015
Brugia malayi 6-phosphofructokinase 0.0131 0.0848 0.14
Echinococcus granulosus muscleblind protein 0.0306 0.2125 0.6942
Schistosoma mansoni hypothetical protein 0.0036 0.0152 0.0152
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.004 0.0182 0.0594
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.004 0.0182 0.0594
Loa Loa (eye worm) hypothetical protein 0.0306 0.2125 0.3506
Loa Loa (eye worm) hypothetical protein 0.004 0.0182 0.03
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.004 0.0182 0.0188
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.004 0.0182 0.1466
Brugia malayi orphan nuclear receptor NR2E1 0.0017 0.0017 0.0028
Echinococcus granulosus cpg binding protein 0.003 0.0111 0.0364
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0159 0.1047 0.5348
Trypanosoma cruzi trypanothione reductase, putative 0.0151 0.0989 0.3231
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1958 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0151 0.0989 0.3231
Brugia malayi hypothetical protein 0.0019 0.0032 0.0053
Trypanosoma brucei unspecified product 0.0109 0.0688 0.2249
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0158 0.0517
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0991 0.7121 0.8978
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0218 0.0359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0341
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0158 0.0517
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0218 0.0711
Entamoeba histolytica deoxycytidyl transferase, putative 0.0159 0.1047 0.5268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0158 0.0261
Schistosoma mansoni eyes absent homolog 0.0102 0.0633 0.0633
Echinococcus granulosus thioredoxin glutathione reductase 0.0434 0.306 1
Trypanosoma brucei DNA polymerase IV, putative 0.0159 0.1047 0.3423
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0158 0.0517
Toxoplasma gondii NADPH-glutathione reductase 0.0151 0.0989 0.3157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0341
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0033 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0156 0.0511
Toxoplasma gondii selenide, water dikinase 0.004 0.0182 0.0491
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0159 0.1047 0.1285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Brugia malayi polk-prov protein 0.0049 0.0249 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0158 0.0261
Loa Loa (eye worm) hypothetical protein 0.0102 0.0633 0.1045
Brugia malayi CXXC zinc finger family protein 0.0029 0.0099 0.0164
Schistosoma mansoni smad1 5 8 and 0.0058 0.031 0.031
Echinococcus multilocularis thioredoxin glutathione reductase 0.0434 0.306 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0017 0.0017 0.0054
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.004 0.0182 0.0594
Loa Loa (eye worm) nuclear receptor NHR-67 0.0017 0.0017 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0848 0.2772
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Mycobacterium ulcerans ferredoxin reductase 0.004 0.0182 0.1466
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0091 0.0296
Loa Loa (eye worm) hypothetical protein 0.0102 0.0633 0.1045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Schistosoma mansoni cpg binding protein 0.003 0.0111 0.0111
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0164 0.109 0.1798
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0147
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.004 0.0182 0.0491
Schistosoma mansoni smad 0.0058 0.031 0.031
Treponema pallidum oxidoreductase 0.004 0.0182 0.0772
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0159 0.1047 0.3423
Brugia malayi hypothetical protein 0.0026 0.0082 0.0135
Echinococcus granulosus Smad4 0.0058 0.031 0.1015
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0158 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0218 0.1112
Schistosoma mansoni DNA polymerase eta 0.0159 0.1047 0.1047
Trichomonas vaginalis set domain proteins, putative 0.0237 0.1621 0.8279
Onchocerca volvulus 0.03 0.208 1
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.004 0.0182 0.1466
Echinococcus multilocularis dna polymerase kappa 0.0159 0.1047 0.3423
Trypanosoma brucei DNA damage repair protein, putative 0.0049 0.0249 0.0815
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0017 0.0054
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0149 0.0383
Plasmodium falciparum flap endonuclease 1 0.0027 0.0091 0.019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0249 0.0715
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0158 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0158 0.0261
Trypanosoma brucei NADH dehydrogenase 0.004 0.0182 0.0594
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.004 0.0182 0.0188
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.004 0.0182 0.1466
Leishmania major hypothetical protein, conserved 0.0026 0.0082 0.0267
Trichomonas vaginalis DNA polymerase eta, putative 0.0159 0.1047 0.5348
Schistosoma mansoni flap endonuclease-1 0.0025 0.0071 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.004 0.0182 0.0594
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0156 0.0258
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.004 0.0182 0.0772
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Echinococcus multilocularis musashi 0.0033 0.0128 0.0418
Mycobacterium ulcerans NADH dehydrogenase 0.004 0.0182 0.1466
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Brugia malayi hypothetical protein 0.0122 0.0777 0.1283
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Mycobacterium ulcerans DNA polymerase IV 0.0159 0.1047 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0159 0.1047 0.3423
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0151 0.0769
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Loa Loa (eye worm) Smad1 0.0058 0.031 0.0512
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0156 0.0258
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0082 0.0267
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0848 0.4234
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0991 0.7121 0.8978
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1958 1
Loa Loa (eye worm) transcription factor SMAD2 0.0845 0.606 1
Brugia malayi phosphofructokinase 0.0131 0.0848 0.14
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1177 0.5624
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0151 0.0989 0.1632
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0017 0.0017 0.0028
Mycobacterium tuberculosis Probable dehydrogenase 0.0991 0.7121 0.8978
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0158 0.0261
Plasmodium falciparum thioredoxin reductase 0.0434 0.306 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0156 0.0511
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0151 0.0989 0.9421
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0156 0.0511
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0151 0.0989 0.3231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0158 0.0261
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0033 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0158 0.0517
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0033 0.0168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Leishmania major DNA polymerase eta, putative 0.0159 0.1047 0.3423
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.109 0.356
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0218 0.0959
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Echinococcus multilocularis lysosomal alpha glucosidase 0.0164 0.109 0.356
Echinococcus granulosus mothers against decapentaplegic 2 0.0026 0.0078 0.0255
Loa Loa (eye worm) nuclear factor I 0.0032 0.0123 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0158 0.0261
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0058 0.031 0.031
Schistosoma mansoni alpha-glucosidase 0.0141 0.0923 0.0923
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0151 0.0769
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0156 0.0798
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1101 0.7928 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0901 0.8552
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0156 0.0511
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.004 0.0182 0.0188
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0158 0.0158
Brugia malayi MH2 domain containing protein 0.0026 0.0078 0.0129
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1047 0.1729
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0128 0.0211
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.0848 0.086
Trichomonas vaginalis glutamate synthase, putative 0.004 0.0182 0.0928
Brugia malayi ecdysteroid receptor 0.0037 0.0158 0.0261
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.0848 0.1032
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0306 0.212 0.3499
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.062
Onchocerca volvulus 0.0033 0.0128 0.0539
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0019 0.0032 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0848 0.8036
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.004 0.0182 0.0491
Mycobacterium ulcerans hypothetical protein 0.0049 0.0249 0.2133
Toxoplasma gondii thioredoxin reductase 0.0434 0.306 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0156 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0151 0.0769
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0218 0.0711
Echinococcus granulosus smad 0.0058 0.031 0.1015
Mycobacterium ulcerans hypothetical protein 0.004 0.0182 0.1466
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Schistosoma mansoni glutamate synthase 0.004 0.0182 0.0182
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0151 0.0989 0.3157
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0026 0.0086
Brugia malayi nuclear receptor NHR-88 0.0037 0.0158 0.0261
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0159 0.1047 0.1729
Brugia malayi Flap endonuclease-1 0.0027 0.0091 0.0149
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.004 0.0182 0.0594
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0033 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0249 0.0815
Brugia malayi glutamate synthase 0.004 0.0182 0.03
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0033 0.0054
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0033 0.0108
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0159 0.1047 0.3423
Trypanosoma brucei unspecified product 0.0159 0.1047 0.3423
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0156 0.0798
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0158 0.0517
Schistosoma mansoni hypothetical protein 0.0409 0.2872 0.2872
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0091 0.0149
Trichomonas vaginalis glutamate synthase, putative 0.004 0.0182 0.0928
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0249 0.0815
Echinococcus granulosus dna polymerase eta 0.0159 0.1047 0.3423
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1101 0.7928 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0111 0.0697 0.115
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.004 0.0182 0.0188
Brugia malayi MH1 domain containing protein 0.0032 0.0123 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0249 0.0815
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0158 0.0158
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0151 0.0989 0.3231
Leishmania major DNA polymerase kappa, putative 0.0049 0.0249 0.0815
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0017 0.0017
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.004 0.0182 0.1556
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0848 0.2772
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.004 0.0182 0.0772
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0182 0.0594
Schistosoma mansoni nuclear receptor 0.0017 0.0017 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0099 0.0164
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.1852 0.3056
Echinococcus multilocularis Smad4 0.0058 0.031 0.1015
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0156 0.0798
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.004 0.0182 0.0491
Echinococcus granulosus glutamate synthase 0.004 0.0182 0.0594
Trypanosoma cruzi DNA damage repair protein, putative 0.0049 0.0249 0.0815
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0158 0.0261
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0156 0.0798
Giardia lamblia NADH oxidase lateral transfer candidate 0.0151 0.0989 0.4963
Trypanosoma brucei unspecified product 0.0109 0.0688 0.2249
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0848 0.0848
Echinococcus granulosus Nuclear hormone receptor HR96 0.0017 0.0017 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0112 0.0185
Onchocerca volvulus 0.0095 0.0584 0.2749
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.004 0.0182 0.0188
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0049 0.0249 0.0715
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0218 0.0959
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0151 0.0989 0.3231
Brugia malayi MH1 domain containing protein 0.0058 0.031 0.0512
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.062
Plasmodium falciparum glutathione reductase 0.0434 0.306 1
Schistosoma mansoni glutamate synthase 0.004 0.0182 0.0182
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.004 0.0182 0.0594
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.004 0.0182 0.0594
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0091 0.019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0158 0.0517
Echinococcus multilocularis muscleblind protein 1 0.0306 0.2125 0.6942
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0017 0.0054
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.004 0.0182 0.0594
Brugia malayi nuclear hormone receptor 0.0017 0.0017 0.0028
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0158 0.0517
Treponema pallidum NADH oxidase 0.0151 0.0989 0.4963
Brugia malayi MH2 domain containing protein 0.0845 0.606 1
Brugia malayi Nuclear hormone receptor E75 0.0017 0.0017 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0082 0.0161
Plasmodium vivax SET domain protein, putative 0.003 0.0112 0.0262
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0158 0.0261
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0159 0.1047 0.1729
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0032 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0218 0.1112
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0218 0.0711
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0249 0.0815
Schistosoma mansoni smad1 5 8 and 0.0058 0.031 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1177 0.6011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0159 0.1047 0.1047
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.004 0.0182 0.0491
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Echinococcus multilocularis smad 0.0058 0.031 0.1015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0151 0.0989 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0158 0.0261
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.004 0.0182 0.0594
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0848 0.4331
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Schistosoma mansoni alpha glucosidase 0.0036 0.0156 0.0156
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.004 0.0182 0.0772
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0211
Mycobacterium tuberculosis Probable reductase 0.0991 0.7121 0.8978
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.004 0.0182 0.0928
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0032 0.0053
Giardia lamblia DINP protein human, muc B family 0.0159 0.1047 0.5268
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.004 0.0182 0.0188
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0078 0.0129
Schistosoma mansoni hypothetical protein 0.004 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Giardia lamblia DNA damage repair protein 0.0049 0.0249 0.1123
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0033 0.0168
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0151 0.0989 0.9421
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1047 0.1729
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0182 0.0594
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.004 0.0182 0.1466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0112 0.0112
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0158 0.0158
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.1852 0.3056
Onchocerca volvulus 0.0033 0.0128 0.0539
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0156 0.0798
Echinococcus granulosus nuclear receptor nhr 48 0.0017 0.0017 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0037 0.0158 0.0158
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.004 0.0182 0.0594
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Echinococcus multilocularis cpg binding protein 0.003 0.0111 0.0364
Schistosoma mansoni Smad4 0.0058 0.031 0.031
Echinococcus multilocularis lamin dm0 0.0033 0.0128 0.0418
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0151 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0204
Leishmania major hypothetical protein, conserved 0.004 0.0182 0.0594
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0158 0.0261
Plasmodium vivax glutathione reductase, putative 0.0434 0.306 1
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0848 0.4234
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0129
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.2872 0.9384
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0848 0.14
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0033 0.0108
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0848 0.4331
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0158 0.0261
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0151 0.0989 0.3157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0218 0.1112
Trypanosoma cruzi NADH dehydrogenase, putative 0.004 0.0182 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0084 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0151 0.0769
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0151 0.0989 0.3157
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0218 0.0711
Schistosoma mansoni zinc finger protein 0.0017 0.0017 0.0017
Brugia malayi Pre-SET motif family protein 0.003 0.0112 0.0185
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.004 0.0182 0.0594
Loa Loa (eye worm) MH1 domain-containing protein 0.0058 0.031 0.0512
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.004 0.0182 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0342
Loa Loa (eye worm) hypothetical protein 0.0129 0.0834 0.1377
Loa Loa (eye worm) hypothetical protein 0.03 0.208 0.3433
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0151 0.0989 0.3157
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0991 0.7121 0.8978
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0149 0.0602
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0019 0.0032 0.0104
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0005 0.0016
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0017 0.0017 0.0054
Mycobacterium ulcerans dehydrogenase 0.004 0.0182 0.1466
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0218 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0439
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0218 0.0711
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0082 0.0161
Brugia malayi MH1 domain containing protein 0.0032 0.0123 0.0202
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0112 0.0262
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Onchocerca volvulus 0.004 0.0182 0.08
Brugia malayi MH2 domain containing protein 0.0058 0.031 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Schistosoma mansoni ap endonuclease 0.002 0.0033 0.0033
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.004 0.0182 0.0594
Loa Loa (eye worm) DR-78 0.0017 0.0017 0.0028
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.004 0.0182 0.0772
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0158 0.0261
Plasmodium falciparum thioredoxin reductase 0.0151 0.0989 0.3157
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0151 0.0989 0.3231
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.0135
Brugia malayi hypothetical protein 0.0019 0.0032 0.0053
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.004 0.0182 0.0594
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0091 0.0296
Schistosoma mansoni sulfide quinone reductase 0.004 0.0182 0.0182
Echinococcus granulosus mothers against decapentaplegic 5 0.0058 0.031 0.1015
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.004 0.0182 0.03
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0218 0.0218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0128 0.0211
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0091 0.0299
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0091 0.0296
Trichomonas vaginalis apoptosis inducing factor, putative 0.004 0.0182 0.0928
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0017 0.0017 0.0017
Brugia malayi tailless protein 0.0017 0.0017 0.0028
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0151 0.0989 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0026 0.0078 0.0297
Brugia malayi MH2 domain containing protein 0.0058 0.031 0.0512
Trypanosoma cruzi DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0158 0.0687
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Brugia malayi Smad1 0.0058 0.031 0.0512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Echinococcus multilocularis mothers against decapentaplegic 6 0.0026 0.0078 0.0255
Mycobacterium ulcerans glutamate synthase subunit beta 0.004 0.0182 0.1466
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0156 0.0511
Leishmania major trypanothione reductase 0.0434 0.306 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.004 0.0182 0.0594
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0149 0.0383
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0151 0.0493
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0112 0.0367
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Echinococcus granulosus lamin 0.0033 0.0128 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0103 0.0525
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0151 0.0989 0.3231
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.004 0.0182 0.0491
Schistosoma mansoni smad 0.0026 0.0078 0.0078
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0848 0.0848
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0082 0.0267
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0019 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0151 0.0989 0.3231
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.0411
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.004 0.0182 0.1466
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.004 0.0182 0.0928
Echinococcus granulosus flap endonuclease 1 0.0027 0.0091 0.0296
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0017 0.0029
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1958 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0084 0.0429
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.004 0.0182 0.03
Trichomonas vaginalis disulfide oxidoreductase, putative 0.004 0.0182 0.0928
Giardia lamblia GTOR 0.0045 0.0218 0.0959
Echinococcus granulosus thyroid hormone receptor alpha 0.0017 0.0017 0.0054
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0151 0.0989 1
Brugia malayi intermediate filament protein 0.0033 0.0128 0.0211
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0149 0.0602
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0017 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0991 0.7121 0.8978
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1852 0.9456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0158 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0158 0.0261
Brugia malayi hypothetical protein 0.0036 0.0152 0.0251
Brugia malayi hypothetical protein 0.0017 0.0017 0.0028
Leishmania major DNA damage repair protein, putative 0.0049 0.0249 0.0815
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1101 0.7928 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.004 0.0182 0.1466
Schistosoma mansoni lamin 0.0033 0.0128 0.0128
Schistosoma mansoni nuclear receptor nhr-48 0.0017 0.0017 0.0017
Brugia malayi mothers against decapentaplegic homolog 3 0.0026 0.0078 0.0129
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0149 0.0383
Echinococcus multilocularis mothers against decapentaplegic 2 0.0026 0.0078 0.0255
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0149 0.0383
Brugia malayi ecdysone receptor 0.0017 0.0017 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0342
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.004 0.0182 0.03
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0017 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1958 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0158 0.0261
Echinococcus granulosus dnaJ subfamily B 0.0409 0.2872 0.9384
Schistosoma mansoni sulfide quinone reductase 0.004 0.0182 0.0182
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0901 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0158 0.0261
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0151 0.0493
Trypanosoma brucei glucosidase, putative 0.0036 0.0156 0.0511
Brugia malayi hypothetical protein 0.0017 0.0014 0.0023
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0151 0.0989 0.121
Echinococcus granulosus sulfide:quinone oxidoreductase 0.004 0.0182 0.0594
Brugia malayi nuclear receptor RXR 0.0017 0.0017 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0249 0.0815
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0151 0.0989 0.3157
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0053
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0156 0.0407
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0848 0.14
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0049 0.0249 0.0715
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0158 0.0261
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0156 0.0798
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0158 0.0687
Brugia malayi conserved hypotetical protein 0.0017 0.0017 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0159 0.1047 0.3423
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0156 0.0798
Chlamydia trachomatis thioredoxin reductase 0.004 0.0182 0.039
Echinococcus multilocularis muscleblind protein 0.0306 0.2125 0.6942
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0151 0.0989 0.9421
Leishmania major DNA polymerase eta, putative 0.0049 0.0249 0.0815
Loa Loa (eye worm) hypothetical protein 0.0306 0.2125 0.3506
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.004 0.0182 0.0594
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0151 0.0989 0.3231
Loa Loa (eye worm) MH2 domain-containing protein 0.0058 0.031 0.0512
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0111 0.0703 0.0703
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0091 0.0296
Entamoeba histolytica glutamate synthase beta subunit, putative 0.004 0.0182 0.0772
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0158 0.0158
Entamoeba histolytica disulphide oxidoreductase, putative 0.004 0.0182 0.0772
Brugia malayi 6-phosphofructokinase 0.0131 0.0848 0.14
Schistosoma mansoni Smad4 0.0026 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0086 0.0439
Brugia malayi Thioredoxin reductase 0.0434 0.306 0.505
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0158 0.0687
Echinococcus multilocularis mothers against decapentaplegic 5 0.0058 0.031 0.1015
Schistosoma mansoni coup transcription factor 0.0037 0.0158 0.0158
Trypanosoma brucei chrX additional, unordered contigs 0.0049 0.0249 0.0815
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0151 0.0989 0.3231
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0158 0.0517
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0082 0.0161
Giardia lamblia Glutamate synthase 0.004 0.0182 0.0772
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0158 0.0517
Echinococcus multilocularis dna polymerase eta 0.0159 0.1047 0.3423
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.004 0.0182 0.0594
Plasmodium vivax thioredoxin reductase, putative 0.0434 0.306 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.004 0.0182 0.0594
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.004 0.0182 0.0594
Onchocerca volvulus 0.0029 0.0099 0.0401
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0159 0.1047 0.3423
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0151 0.0989 0.3231
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0218 0.0711
Echinococcus granulosus lysosomal alpha glucosidase 0.0164 0.109 0.356
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.004 0.0182 0.0491
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.004 0.0182 0.0928
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0218 0.0711
Loa Loa (eye worm) hypothetical protein 0.0317 0.2203 0.3635
Trypanosoma cruzi DNA polymerase eta, putative 0.0159 0.1047 0.3423
Brugia malayi Muscleblind-like protein 0.0306 0.2125 0.3506
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0295 0.0865
Trypanosoma brucei DNA polymerase eta, putative 0.0159 0.1047 0.3423
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.004 0.0182 0.0594
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0001
Brugia malayi Pre-SET motif family protein 0.0208 0.1412 0.233
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0848 0.14
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0151 0.0989 0.3231
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0158 0.0261
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Trichomonas vaginalis glutathione reductase, putative 0.0151 0.0989 0.5048
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0848 0.4331
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0848 0.2772
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0158 0.0261
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0848 0.2772
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0151 0.0769
Treponema pallidum thioredoxin reductase (trxB) 0.004 0.0182 0.0772
Loa Loa (eye worm) hypothetical protein 0.0241 0.1647 0.2719
Plasmodium falciparum ferrodoxin reductase-like protein 0.004 0.0182 0.0491
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0017 0.0017 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0134 0.0683
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0149 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0158 0.0261
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.004 0.0182 0.03
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0901 0.1099
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0149 0.0761
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0249 0.0815
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.004 0.0182 0.1556
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0342 0.0342
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0158 0.0517
Loa Loa (eye worm) hypothetical protein 0.0037 0.0158 0.0261
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0091 0.019
Entamoeba histolytica hypothetical protein 0.0036 0.0152 0.062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.017 0.0867
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0848 0.4234
Trypanosoma cruzi trypanothione reductase, putative 0.0434 0.306 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0342
Brugia malayi nuclear receptor NHR-88 0.0017 0.0017 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0152 0.0498
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0017 0.0054
Schistosoma mansoni lamin 0.0033 0.0128 0.0128
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0112 0.0367
Trichomonas vaginalis mercuric reductase, putative 0.0151 0.0989 0.5048
Loa Loa (eye worm) thioredoxin reductase 0.0434 0.306 0.505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0067 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0112 0.0112
Plasmodium falciparum DNA repair protein REV1, putative 0.0049 0.0249 0.0715
Mycobacterium ulcerans monoxygenase 0.004 0.0182 0.1466
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0152 0.0498
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0158 0.0517
Echinococcus granulosus dna polymerase kappa 0.0159 0.1047 0.3423
Plasmodium falciparum glutathione reductase 0.0151 0.0989 0.3157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0158 0.0517

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 16.7 s Antinociceptive effect in Swiss Albino mouse assessed as licking latency at 10 mg/kg, sc after 15 mins by hot-plate test ChEMBL. 17373780
Activity (functional) = 16.7 s Antinociceptive effect in Swiss Albino mouse assessed as licking latency at 10 mg/kg, sc after 15 mins by hot-plate test ChEMBL. 17373780

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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