Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0146 | 0.0582 | 0.2606 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0623 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0209 | 0.1828 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0209 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0209 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0209 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0209 | 0.1828 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0209 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0209 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0623 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0229 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0146 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | fibroinase | 0.0209 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0209 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0146 | 0.0582 | 0.2606 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0209 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0146 | 0.0582 | 0.3182 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0209 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0209 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0209 | 0.1828 | 1 |
Toxoplasma gondii | cathepsin B | 0.0229 | 0.2232 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0209 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0209 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0209 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0209 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cysteine protease | 0.0209 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0146 | 0.0582 | 0.0582 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0229 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0623 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0623 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0623 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0209 | 0.1828 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0209 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0229 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0623 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.0623 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0623 | 1 | 1 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0229 | 0.2232 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0146 | 0.0582 | 0.0582 |
Giardia lamblia | Cathepsin B precursor | 0.0229 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0229 | 0.2232 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0146 | 0.0582 | 0.0582 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0209 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0209 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0209 | 0.1828 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0209 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0229 | 0.2232 | 1 |
Onchocerca volvulus | 0.0209 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin b | 0.0623 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0229 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0209 | 0.1828 | 0.1323 |
Brugia malayi | cathepsin L-like precursor | 0.0146 | 0.0582 | 0.0582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0209 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0209 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cathepsin B | 0.0229 | 0.2232 | 0.1752 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0209 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0146 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0146 | 0.0582 | 0.0582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
BP (functional) | > 40 mmHg | Antihypertensive effect in spontaneously hypertensive rat (SHR), expressed as fall in blood pressure (BP) at 50 mg/kg dose given orally | ChEMBL. | 7452695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.