Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0055 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0055 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0055 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0055 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0055 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.5 | 0.5 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0055 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0055 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0055 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0055 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0055 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0055 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0055 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | 0 | Displacement of [3H]GABA from GABAB receptor in Sprague-Dawley rat brain synaptic membrane at 100 uM | ChEMBL. | 17375905 |
Ki (functional) | = 427 nM | Antagonist activity at human GABAA alpha1beta3gamma2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology | ChEMBL. | 17375905 |
Ki (binding) | = 955 nM | Displacement of [3H]muscimol from GABAA receptor in Sprague-Dawley rat brain synaptic membrane | ChEMBL. | 17375905 |
Log Ki (binding) | = 6.02 | Displacement of [3H]muscimol from GABAA receptor in Sprague-Dawley rat brain synaptic membrane | ChEMBL. | 17375905 |
Log Ki (functional) | = 6.32 | Antagonist activity at human GABAA alpha1beta3gamma2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiology | ChEMBL. | 17375905 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.