Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | ADAM metallopeptidase domain 17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Disintegrin family protein | ADAM metallopeptidase domain 17 | 824 aa | 724 aa | 27.4 % |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0413 | 0.2904 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.3663 | 0.35 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.108 | 1 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.108 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.108 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.0407 | 0.0161 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0413 | 0.2904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0468 | 0.3496 | 0.3329 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0163 | 0.0251 | 0.5 |
Echinococcus granulosus | adam 17 protease | 0.0245 | 0.112 | 0.112 |
Echinococcus multilocularis | dihydrofolate reductase | 0.108 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0163 | 0.0251 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0268 | 0.1362 | 0.1362 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.3663 | 0.35 |
Echinococcus granulosus | dihydrofolate reductase | 0.108 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0413 | 0.2904 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0268 | 0.1362 | 0.1362 |
Schistosoma mansoni | dihydrofolate reductase | 0.108 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.108 | 1 | 0.5 |
Echinococcus multilocularis | adam 17 protease | 0.0223 | 0.0884 | 0.0884 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.108 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0413 | 0.2904 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0413 | 0.2904 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0413 | 0.2904 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 233 nM | Inhibition of TACE | ChEMBL. | 15566296 |
IC50 (binding) | = 233 nM | Inhibition of TACE | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP1 | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP9 | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP13 | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP1 | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP9 | ChEMBL. | 15566296 |
IC50 (binding) | > 10000 nM | Inhibition of MMP13 | ChEMBL. | 15566296 |
Inhibition (functional) | = 28 % | Inhibition of LPS-stimulated TNFalpha production in human THP1 cells at 3 uM by ELISA | ChEMBL. | 15566296 |
Inhibition (functional) | = 28 % | Inhibition of LPS-stimulated TNFalpha production in human THP1 cells at 3 uM by ELISA | ChEMBL. | 15566296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.