Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Variant SH3 domain containing protein | 0.0193 | 0.3088 | 0.3088 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.3088 | 0.3088 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0152 | 0.1217 | 0.1217 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0221 | 0.4336 | 0.4336 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0193 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0193 | 0.3088 | 0.3088 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.0221 | 0.4336 | 0.4336 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0193 | 0.3088 | 0.3088 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0193 | 0.3088 | 0.3088 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.025 | 0.5664 | 0.5664 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0345 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.025 | 0.5664 | 0.5664 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0345 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0345 | 1 | 1 |
Echinococcus multilocularis | NCK adaptor protein | 0.0193 | 0.3088 | 0.3088 |
Brugia malayi | protein-tyrosine kinase | 0.025 | 0.5664 | 0.5664 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.025 | 0.5664 | 0.5664 |
Echinococcus granulosus | NCK adaptor protein | 0.0193 | 0.3088 | 0.3088 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0193 | 0.3088 | 0.3088 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0345 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0152 | 0.1217 | 0.1217 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0221 | 0.4336 | 0.4336 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0222 | 0.4415 | 0.4415 |
Loa Loa (eye worm) | TK protein kinase | 0.0152 | 0.1217 | 0.1217 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.025 | 0.5664 | 0.5664 |
Schistosoma mansoni | nck2/grb4 | 0.0193 | 0.3088 | 0.3088 |
Schistosoma mansoni | tyrosine kinase | 0.0221 | 0.4336 | 0.4336 |
Loa Loa (eye worm) | SRC-1 | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0221 | 0.4336 | 0.4336 |
Schistosoma mansoni | adapter molecule crk | 0.0193 | 0.3088 | 0.3088 |
Brugia malayi | Variant SH3 domain containing protein | 0.0193 | 0.3088 | 0.3088 |
Entamoeba histolytica | protein kinase, putative | 0.0152 | 0.1217 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0345 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0345 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0345 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0221 | 0.4336 | 0.4336 |
Schistosoma mansoni | tyrosine kinase | 0.0345 | 1 | 1 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0193 | 0.3088 | 0.3088 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0345 | 1 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0193 | 0.3088 | 0.3088 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0221 | 0.4336 | 0.4336 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0221 | 0.4336 | 0.4336 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0193 | 0.3088 | 0.3088 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0221 | 0.4336 | 0.4336 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.025 | 0.5664 | 0.5664 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0345 | 1 | 1 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0345 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0345 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.025 | 0.5664 | 0.5664 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.025 | 0.5664 | 0.5664 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0222 | 0.4415 | 0.4415 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 56 % | Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation at 10 uM relative control | ChEMBL. | 17341062 |
Activity (binding) | = 56 % | Inhibition of BCRP expressed in human HEK293 cells assessed as maximal mitoxantrone accumulation at 10 uM relative control | ChEMBL. | 17341062 |
IC50 (binding) | = 23.9 uM | Inhibition of ovine COX1 assessed as PGF2alpha production by reduction of PGH2 with stannous chloride by enzyme immunoassay | ChEMBL. | 23914900 |
Inhibition (binding) | = 61.5 % | Inhibition of ovine COX2 assessed as PGF2alpha production by reduction of PGH2 with stannous chloride at 40 uM by enzyme immunoassay relative to control | ChEMBL. | 23914900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.