Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0083 | 0.547 | 0.5368 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.2311 | 0.2138 |
Echinococcus granulosus | delta-like protein 1 | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | norepinephrine transporter | 0.0132 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | fibropellin Ia | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | peroxidasin | 0.0083 | 0.547 | 0.547 |
Trypanosoma brucei | prostaglandin f synthase | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | serotonin transporter | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | slit 2 protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Echinococcus granulosus | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 0.0933 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0132 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | notch | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | serotonin transporter | 0.0132 | 1 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Leishmania major | aldo-keto reductase-like protein | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | notch | 0.0027 | 0.0219 | 0.0219 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | fibropellin Ia | 0.0027 | 0.0219 | 0.0219 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 0.0933 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0132 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.0034 | 0.0933 | 0.0729 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Onchocerca volvulus | Peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Peroxidasin | 0.0083 | 0.547 | 0.5368 |
Leishmania major | prostaglandin f synthase, putative | 0.0034 | 0.0933 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Onchocerca volvulus | Peroxidasin homolog | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Blistered cuticle protein 3 | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | neural cadherin | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Schistosoma mansoni | peroxidasin | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | Peroxidasin homolog | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0027 | 0.0219 | 0.0219 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0132 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.0933 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0083 | 0.547 | 0.547 |
Onchocerca volvulus | Peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.2311 | 0.2138 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0132 | 1 | 1 |
Echinococcus multilocularis | slit 2 protein | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | neural cadherin | 0.0027 | 0.0219 | 0.0219 |
Trypanosoma cruzi | aldo-keto reductase | 0.0034 | 0.0933 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.0933 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | hypothetical protein | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Toxoplasma gondii | aldose reductase, putative | 0.0034 | 0.0933 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0034 | 0.0933 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | < 0.1 | Oral bioavailability in mouse at 40 mg/kg, po relative to AVP13358 | ChEMBL. | 15588078 |
IC50 (functional) | = 5 nM | Ex vivo inhibition of IgE production in spleen cells from antigen sensitized BALB/c mouse | ChEMBL. | 15588078 |
IC50 (functional) | = 8 nM | Inhibition of IgE production in B lymphocytes from BALB/c mouse | ChEMBL. | 15588078 |
IC50 (functional) | = 20 nM | Antiviral activity against mouse hepatitis virus-infected NCTC clone-1469 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 35 nM | Antiviral activity against California encephalitis virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | = 70 nM | Inhibition of IgE production in antigen-sensitised BALB/c mouse spleen cells | ChEMBL. | 17973358 |
IC50 (functional) | = 130 nM | Antiviral activity against San Angelo virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | > 600 nM | Antiviral activity against Modoc virus-infected HeLa-H1 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 600 nM | Antiviral activity against Rhinovirus-infected HeLa-H1 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 2000 nM | Antiviral activity against HSV2-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | = 2000 nM | Antiviral activity against Vaccinia virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | > 2000 nM | Antiviral activity against VSV-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | > 2000 nM | Antiviral activity against SV40-infected Vero cells | ChEMBL. | 17973358 |
Relative Bioavailability (ADMET) | < 0.1 | Oral bioavailability in mouse at 40 mg/kg, po relative to AVP13358 | ChEMBL. | 15588078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.