Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Mycobacterium ulcerans | oxidoreductase | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | serotonin transporter b | 0.0132 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Trypanosoma cruzi | aldo-keto reductase | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | neural cadherin | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | slit 2 protein | 0.0027 | 0.0219 | 0.0219 |
Toxoplasma gondii | aldose reductase, putative | 0.0034 | 0.0933 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0034 | 0.0933 | 0.5 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.0933 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | hypothetical protein | 0.0034 | 0.0933 | 0.0933 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0027 | 0.0219 | 0.0219 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0132 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | peroxidasin | 0.0083 | 0.547 | 0.547 |
Giardia lamblia | Aldose reductase | 0.0034 | 0.0933 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 0.0933 | 0.0729 |
Onchocerca volvulus | Peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Cytochrome P450 family protein | 0.0049 | 0.2311 | 0.2138 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Onchocerca volvulus | Peroxidasin homolog | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | Blistered cuticle protein 3 | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | neural cadherin | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Schistosoma mansoni | peroxidasin | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | protein jagged 1 | 0.0027 | 0.0219 | 0.0219 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Schistosoma mansoni | pol-related | 0.0034 | 0.0933 | 0.0729 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0132 | 1 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Entamoeba histolytica | aldose reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0034 | 0.0933 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Leishmania major | prostaglandin f synthase, putative | 0.0034 | 0.0933 | 0.5 |
Brugia malayi | Peroxidasin | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | notch | 0.0027 | 0.0219 | 0.0219 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0083 | 0.547 | 0.5368 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0034 | 0.0933 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | fibropellin Ia | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0034 | 0.0933 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Onchocerca volvulus | 0.0132 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | notch | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Leishmania major | aldo-keto reductase-like protein | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0933 | 0.0729 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | serotonin transporter | 0.0132 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus multilocularis | aldo keto reductase | 0.0034 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Brugia malayi | Animal haem peroxidase family protein | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0083 | 0.547 | 0.5368 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0027 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Echinococcus granulosus | protein jagged 2 | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | slit 2 protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0083 | 0.547 | 0.5368 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0132 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0034 | 0.0933 | 0.5 |
Brugia malayi | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | Dual oxidase homolog | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0083 | 0.547 | 0.5368 |
Onchocerca volvulus | 0.0034 | 0.0933 | 0.0729 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0049 | 0.2311 | 0.2138 |
Echinococcus granulosus | delta-like protein 1 | 0.0027 | 0.0219 | 0.0219 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0034 | 0.0933 | 0.0933 |
Echinococcus granulosus | fibropellin Ia | 0.0027 | 0.0219 | 0.0219 |
Echinococcus granulosus | peroxidasin | 0.0083 | 0.547 | 0.547 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0132 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0034 | 0.0933 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0132 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0027 | 0.0219 | 0.0219 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0132 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0034 | 0.0933 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Trypanosoma brucei | prostaglandin f synthase | 0.0034 | 0.0933 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.547 | 0.5368 |
Loa Loa (eye worm) | oxidoreductase | 0.0034 | 0.0933 | 0.0729 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | < 0.1 | Oral bioavailability in mouse at 40 mg/kg, po relative to AVP13358 | ChEMBL. | 15588078 |
IC50 (functional) | = 1 nM | Ex vivo inhibition of IgE production in spleen cells from antigen sensitized BALB/c mouse | ChEMBL. | 15588078 |
IC50 (functional) | = 2 nM | Inhibition of IgE production in B lymphocytes from BALB/c mouse | ChEMBL. | 15588078 |
IC50 (functional) | = 5 nM | Inhibition of IgE production in antigen-sensitised BALB/c mouse spleen cells | ChEMBL. | 17973358 |
IC50 (functional) | = 20 nM | Antiviral activity against San Angelo virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | = 20 nM | Antiviral activity against mouse hepatitis virus-infected NCTC clone-1469 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 20 nM | Antiviral activity against Rhinovirus-infected HeLa-H1 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 40 nM | Antiviral activity against HSV2-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | = 60 nM | Antiviral activity against California encephalitis virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | = 60 nM | Antiviral activity against Modoc virus-infected HeLa-H1 cells | ChEMBL. | 17973358 |
IC50 (functional) | = 600 nM | Antiviral activity against Vaccinia virus-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | > 2000 nM | Antiviral activity against VSV-infected Vero cells | ChEMBL. | 17973358 |
IC50 (functional) | > 2000 nM | Antiviral activity against SV40-infected Vero cells | ChEMBL. | 17973358 |
Relative Bioavailability (ADMET) | < 0.1 | Oral bioavailability in mouse at 40 mg/kg, po relative to AVP13358 | ChEMBL. | 15588078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.