TDR Targets

Basic information

Technical information

TDR Targets ID: 418069
Name: 1-[(3R,3aS)-3-(4-fluorophenyl)-8-methyl-3a,4- dihydro-3H-chromeno[4,3-c]pyrazol-2-yl]ethano ne
MW: 324.349 | Formula: C19H17FN2O2
H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)[C@@H]1N(N=C2[C@H]1COc1c2cc(cc1)C)C(=O)C
InChi: 1S/C19H17FN2O2/c1-11-3-8-17-15(9-11)18-16(10-24-17)19(22(21-18)12(2)23)13-4-6-14(20)7-5-13/h3-9,16,19H,10H2,1-2H3/t16-,19+/m1/s1
InChiKey: RXIKMWLNXUCMHZ-APWZRJJASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(3R,3aS)-3-(4-fluorophenyl)-8-methyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]pyrazol-2-yl]ethanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0139	0.0139
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Plasmodium falciparum	histone deacetylase 1	0.0282	1	1
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0014	0.0142	0.0142
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0016	0.0204	0.0204
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Onchocerca volvulus		0.003	0.0716	0.2343
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Leishmania major	cytochrome p450-like protein	0.0017	0.0255	0.0255
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.2025	0.2025
Echinococcus multilocularis	Ras protein Rap 1b	0.0051	0.15	0.15
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Entamoeba histolytica	histone deacetylase, putative	0.0282	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0716	0.0716
Schistosoma mansoni	histone deacetylase	0.0282	1	1
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0662	0.0662
Brugia malayi	nuclear receptor NHR-67	0.0014	0.0142	0.0142
Schistosoma mansoni	histone deacetylase hda2	0.008	0.2589	0.2589
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0114	0.3804	0.3804
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0139	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0139	0.0139
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0014	0.0142	0.0142
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	serine/threonine-protein kinase, putative	0.0014	0.0137	0.0137
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0479	0.0479
Schistosoma mansoni	histone deacetylase hda2	0.008	0.2589	0.2589
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0716	0.0716
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0023	0.0479	0.0479
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0716	0.0716
Schistosoma mansoni	zinc finger protein	0.0014	0.0142	0.0142
Trypanosoma brucei	histone deacetylase, putative	0.008	0.2589	0.2589
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.01	0.3296	0.3296
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Trypanosoma cruzi	histone deacetylase 1, putative	0.0282	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0014	0.0142	0.0142
Echinococcus granulosus	histone deacetylase 8	0.008	0.2589	0.2589
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0014	0.0139	0.0139
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.2025	1
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0014	0.0139	0.0139
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0017	0.0255	0.126
Loa Loa (eye worm)	hypothetical protein	0.0051	0.15	0.15
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.2025	0.2025
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0204	0.0204
Loa Loa (eye worm)	PDE1B protein	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Brugia malayi	nuclear hormone receptor	0.0014	0.0142	0.0142
Trichomonas vaginalis	Rab6, putative	0.0051	0.15	0.15
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Schistosoma mansoni	histone deacetylase 1 2 3	0.008	0.2589	0.2589
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Schistosoma mansoni	nuclear receptor nhr-48	0.0014	0.0142	0.0142
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0142	0.0142
Trypanosoma cruzi	histone deacetylase, putative	0.008	0.2589	0.2589
Schistosoma mansoni	hypothetical protein	0.004	0.1107	0.1107
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0716	0.0716
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Toxoplasma gondii	histone deacetylase HDAC4	0.008	0.2589	0.2589
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0087	0.2814	0.2814
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0114	0.3804	0.3804
Brugia malayi	hypothetical protein	0.0016	0.0204	0.0204
Schistosoma mansoni	histone deacetylase 4 5	0.008	0.2589	0.2589
Trypanosoma brucei	histone deacetylase 4	0.008	0.2589	0.2589
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0071	0.2241	0.2241
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0204	0.0204
Brugia malayi	conserved hypotetical protein	0.0014	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0139	0.0139
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0114	0.3804	0.3804
Brugia malayi	Histone deacetylase 1	0.0282	1	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0139	0.0139
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.003	0.0716	0.2343
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0716	0.0716
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Onchocerca volvulus	Histone deacetylase 10 homolog	0.008	0.2589	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0014	0.0139	0.0139
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0479	0.0479
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0014	0.0139	0.0139
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0014	0.0139	0.0139
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0716	0.0716
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0716	0.0716
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0479	0.0479
Giardia lamblia	Histone deacetylase	0.0282	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0716	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0114	0.3804	0.3804
Schistosoma mansoni	coup transcription factor	0.003	0.0716	0.0716
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0204	0.0204
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0014	0.0139	0.0139
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Plasmodium falciparum	phosphodiesterase delta, putative	0.0014	0.0139	0.0139
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Plasmodium falciparum	histone deacetylase, putative	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Entamoeba histolytica	hypothetical protein	0.004	0.1107	0.1107
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0114	0.3804	0.3804
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0716	0.0716
Loa Loa (eye worm)	histone deacetylase 1	0.0282	1	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	cAMP-dependent protein kinase catalytic subunit, putative	0.0014	0.0137	0.0137
Loa Loa (eye worm)	histone deacetylase 7A	0.008	0.2589	0.2589
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.2025	0.2025
Toxoplasma gondii	histone deacetylase HDAC1	0.008	0.2589	0.2589
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0716	0.0716
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0716	0.0716
Toxoplasma gondii	histone deacetylase HDAC3	0.0282	1	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	ecdysone receptor	0.0014	0.0142	0.0142
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.2025	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0014	0.0139	0.0139
Schistosoma mansoni	nuclear receptor	0.0014	0.0142	0.0142
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0716	0.0716
Loa Loa (eye worm)	histone deacetylase 11	0.008	0.2589	0.2589
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0255	0.0255
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0014	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Echinococcus multilocularis	histone deacetylase 6	0.008	0.2589	0.2589
Brugia malayi	orphan nuclear receptor NR2E1	0.0014	0.0142	0.0142
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0716	0.0716
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Schistosoma mansoni	thyroid hormone receptor	0.017	0.5882	0.5882
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0114	0.3804	0.3804
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0716	0.0716
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0139	0.0139
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0204	0.0204
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0139	0.0139
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0051	0.15	0.15
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0204	0.0204
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.01	0.3296	0.3296
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.15	0.15
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0014	0.0142	0.0142
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0014	0.0142	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0014	0.0142	0.0142
Onchocerca volvulus		0.0051	0.15	0.5551
Schistosoma mansoni	hypothetical protein	0.0141	0.4797	0.4797
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0139	0.0139
Brugia malayi	nuclear receptor RXR	0.0016	0.0204	0.0204
Trypanosoma cruzi	histone deacetylase, putative	0.008	0.2589	0.2589
Echinococcus multilocularis	histone deacetylase 7	0.008	0.2589	0.2589
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0014	0.0139	0.0139
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0139	0.0139
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.2025	0.2025
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0014	0.0139	0.0139
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0142	0.0142
Brugia malayi	hypothetical protein	0.0014	0.0142	0.0142
Schistosoma mansoni	nuclear receptor	0.0014	0.0142	0.0142
Brugia malayi	nuclear hormone receptor family member odr-7	0.0014	0.0142	0.0142
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0716	0.0716
Echinococcus granulosus	Ras protein Rap 1b	0.0051	0.15	0.15
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0716	0.0716
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	hypothetical protein	0.004	0.1107	0.1107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0014	0.0139	0.0139
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0716	0.0716
Plasmodium vivax	histone deacetylase, putative	0.008	0.2589	0.2589
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0255	0.0255
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0716	0.0716
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0014	0.0142	0.0142
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	histone deacetylase 3	0.0282	1	1
Plasmodium vivax	phosphodiesterase gamma, putative	0.0014	0.0139	0.0139
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0087	0.2814	0.2814
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0016	0.0204	0.0204
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.001	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.0017	0.0255	0.0255
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.01	0.3296	0.3296
Entamoeba histolytica	Ras family GTPase	0.0051	0.15	0.15
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Brugia malayi	nuclear receptor RXR	0.0014	0.0142	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Echinococcus granulosus	histone deacetylase 6	0.008	0.2589	0.2589
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0716	0.0716
Giardia lamblia	Hypothetical protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trypanosoma brucei	cytochrome P450, putative	0.0017	0.0255	0.0255
Giardia lamblia	hypothetical protein	0.0014	0.0139	0.0139
Brugia malayi	histone deacetylase 11	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0282	1	1
Trypanosoma cruzi	histone deacetylase, putative	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Plasmodium vivax	histone deacetylase 2, putative	0.008	0.2589	0.2589
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0014	0.0142	0.0142
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Plasmodium vivax	histone deacetylase 1, putative	0.0282	1	1
Trypanosoma brucei	histone deacetylase 1	0.0282	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0255	0.0255
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0716	0.0716
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0716	0.0716
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.01	0.3296	0.3296
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Brugia malayi	ecdysteroid receptor	0.003	0.0716	0.0716
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0716	0.0716
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.2025	0.2025
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0716	0.0716
Loa Loa (eye worm)	cytochrome P450 family protein	0.0017	0.0255	0.0255
Onchocerca volvulus	Protein ultraspiracle homolog	0.003	0.0716	0.2343
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	histone deacetylase 6	0.008	0.2589	0.2589
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0716	0.0716
Echinococcus granulosus	histone deacetylase	0.008	0.2589	0.2589
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0014	0.0142	0.0142
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0716	0.0716
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0716	0.0716
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Echinococcus granulosus	thyroid hormone receptor alpha	0.0014	0.0142	0.0142
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Toxoplasma gondii	histone deacetylase HDAC5	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Brugia malayi	nuclear hormone receptor	0.003	0.0716	0.0716
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0114	0.3804	0.3804
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0014	0.0142	0.0142
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0016	0.0204	0.0204
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0141	0.4797	0.4797
Echinococcus multilocularis	histone deacetylase 8	0.008	0.2589	0.2589
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.2025	1
Leishmania major	histone deacetylase, putative	0.008	0.2589	0.2589
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0014	0.0139	0.0139
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0716	0.0716
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0014	0.0142	0.0142
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0662	0.0662
Echinococcus multilocularis	histone deacetylase	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Schistosoma mansoni	histone deacetylase 4 5	0.008	0.2589	0.2589
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0114	0.3804	0.3804
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trypanosoma brucei	histone deacetylase 3	0.008	0.2589	0.2589
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Plasmodium falciparum	histone deacetylase 2	0.008	0.2589	0.2589
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Brugia malayi	histone deacetylase 1 (HD1)	0.0282	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0017	0.0255	0.0255
Trypanosoma cruzi	histone deacetylase 1, putative	0.0282	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Brugia malayi	RAP1B, member of RAS oncogene family	0.0051	0.15	0.15
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0142	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0087	0.2814	0.2814
Brugia malayi	nuclear receptor NHR-88	0.0014	0.0142	0.0142
Treponema pallidum	exodeoxyribonuclease (exoA)	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Brugia malayi	hypothetical protein	0.0014	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0204	0.0204
Schistosoma mansoni	hypothetical protein	0.0058	0.1753	0.1753
Entamoeba histolytica	hypothetical protein	0.004	0.1107	0.1107
Schistosoma mansoni	thyroid hormone receptor	0.017	0.5882	0.5882
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0141	0.4797	0.4797
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Echinococcus granulosus	histone deacetylase 7	0.008	0.2589	0.2589
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0014	0.0139	0.0139
Brugia malayi	Histone deacetylase family protein	0.008	0.2589	0.2589
Trypanosoma cruzi	histone deacetylase, putative	0.008	0.2589	0.2589
Plasmodium vivax	histone deacetylase, putative	0.008	0.2589	0.2589
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.1107	0.1107
Echinococcus multilocularis	Ras protein Rap 1b	0.0051	0.15	0.15
Entamoeba histolytica	hypothetical protein	0.004	0.1107	0.1107
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Toxoplasma gondii	histone deacetylase HDAC2	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0716	0.0716
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0716	0.0716
Leishmania major	hypothetical protein, conserved	0.0014	0.0139	0.0139
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0716	0.0716
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus granulosus	histone deacetylase 6	0.008	0.2589	0.2589
Schistosoma mansoni	nuclear hormone receptor	0.0014	0.0142	0.0142
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.1107	0.1107
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0716	0.0716
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Onchocerca volvulus	Bile acid receptor homolog	0.003	0.0716	0.2343
Brugia malayi	Histone deacetylase family protein	0.008	0.2589	0.2589
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0716	0.0716
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0016	0.0204	0.0204
Echinococcus multilocularis	histone deacetylase 3	0.0282	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	histone deacetylase, putative	0.0282	1	1
Loa Loa (eye worm)	histone deacetylase 3	0.0282	1	1
Trypanosoma cruzi	histone deacetylase, putative	0.008	0.2589	0.2589
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0716	0.0716
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0014	0.0142	0.0142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0716	0.0716
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0014	0.0139	0.0139
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0282	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0023	0.0479	0.0479
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0087	0.2814	0.2814
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0716	0.0716
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0716	0.0716
Trypanosoma brucei	histone deacetylase 2	0.008	0.2589	0.2589
Echinococcus multilocularis	histone deacetylase 1	0.0282	1	1
Brugia malayi	hypothetical protein	0.0016	0.0204	0.0204
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0014	0.0139	0.0139
Leishmania major	histone deacetylase, putative	0.008	0.2589	0.2589
Schistosoma mansoni	rap1 and	0.0051	0.15	0.15
Echinococcus multilocularis	histone deacetylase 6	0.008	0.2589	0.2589
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	serine/threonine-protein kinase ypk, putative	0.0014	0.0137	0.0137
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0716	0.0716
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Leishmania major	histone deacetylase, putative	0.0282	1	1
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.1107	0.1107
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.2025	1
Echinococcus multilocularis	rho GTPase activating protein 190	0.0051	0.15	0.15
Leishmania major	histone deacetylase, putative	0.0282	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Loa Loa (eye worm)	CYP4Cod1	0.0017	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Echinococcus multilocularis	nuclear receptor nhr 48	0.0014	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Entamoeba histolytica	hypothetical protein	0.004	0.1107	0.1107
Leishmania major	hypothetical protein, conserved	0.0014	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Brugia malayi	steroid hormone receptor	0.003	0.0716	0.0716
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.2025	0.2025
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0014	0.0139	0.0139
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0139	0.0139
Brugia malayi	nuclear receptor NHR-88	0.003	0.0716	0.0716
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Schistosoma mansoni	histone deacetylase	0.0282	1	1
Echinococcus granulosus	rho GTPase activating protein 190	0.0051	0.15	0.15
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0023	0.0471	0.0471
Brugia malayi	Nuclear hormone receptor E75	0.0014	0.0142	0.0142
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0014	0.0142	0.0142
Brugia malayi	tailless protein	0.0014	0.0142	0.0142
Loa Loa (eye worm)	DR-78	0.0014	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0282	1	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0204	0.0204
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0014	0.0139	0.0139
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0716	0.0716
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0014	0.0139	0.0139
Echinococcus granulosus	histone deacetylase 1	0.0282	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0014	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Schistosoma mansoni	nuclear hormone receptor	0.0014	0.0142	0.0142
Schistosoma mansoni	rap1 and	0.0051	0.15	0.15
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0716	0.0716
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.5882	0.5882
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0142	0.0142
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Echinococcus granulosus	Ras protein Rap 1b	0.0051	0.15	0.15
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.003	0.0716	0.0716
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0014	0.0137	0.0137
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0014	0.0139	0.0139
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0716	0.0716
Echinococcus granulosus	histone deacetylase 6	0.008	0.2589	0.2589
Trichomonas vaginalis	AGC family protein kinase	0.0014	0.0137	0.0137
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0014	0.0139	0.0139
Loa Loa (eye worm)	histone deacetylase	0.008	0.2589	0.2589
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0014	0.0139	0.0139

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 100 uM	Inhibition of TNF alpha-induced necroptosis in FADD-deficient variant human Jurkat T cells assessed as cell viability after 24 hrs	ChEMBL.	17361994
EC50 (functional)	> 100 uM	Inhibition of TNF alpha-induced necroptosis in FADD-deficient variant human Jurkat T cells assessed as cell viability after 24 hrs	ChEMBL.	17361994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 16204019

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 418069