Detailed information for compound 418265

Basic information

Technical information
  • TDR Targets ID: 418265
  • Name: 4-[3-[[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy ]methyl]-5-phenylpyrazol-1-yl]benzenesulfonam ide
  • MW: 537.602 | Formula: C28H28FN3O5S
  • H donors: 1 H acceptors: 3 LogP: 3.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC1(CCOCC1)c1cc(OCc2cc(n(n2)c2ccc(cc2)S(=O)(=O)N)c2ccccc2)cc(c1)F
  • InChi: 1S/C28H28FN3O5S/c1-35-28(11-13-36-14-12-28)21-15-22(29)17-25(16-21)37-19-23-18-27(20-5-3-2-4-6-20)32(31-23)24-7-9-26(10-8-24)38(30,33)34/h2-10,15-18H,11-14,19H2,1H3,(H2,30,33,34)
  • InChiKey: GUQAIXOPXQIGPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-[[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)phenoxy]methyl]-5-phenyl-pyrazol-1-yl]benzenesulfonamide
  • 4-[3-[[3-fluoro-5-(4-methoxy-4-tetrahydropyranyl)phenoxy]methyl]-5-phenyl-1-pyrazolyl]benzenesulfonamide
  • 4-[3-[[3-fluoro-5-(4-methoxyoxan-4-yl)phenoxy]methyl]-5-phenyl-pyrazol-1-yl]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis insulin receptor 0.0051 0.0341 0.051
Echinococcus multilocularis 0.0046 0.028 0.0419
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1012 0.1012
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1012 0.0999
Onchocerca volvulus 0.0047 0.0291 0.2876
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0047 0.0291 0.0432
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0047 0.0291 0.0432
Echinococcus multilocularis Pleckstrin y 0.0047 0.0291 0.0435
Entamoeba histolytica PH domain containing protein kinase, putative 0.0174 0.1913 0.1902
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1318 0.1971
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.1624 0.2428
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0447 0.016
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0283 0.3308 0.3308
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0447 0.0243
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0109 0.1092 0.1092
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0269 0.312 0.312
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Onchocerca volvulus Putative zinc finger protein 0.0047 0.0291 0.2876
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0447 0.0668
Entamoeba histolytica protein kinase, putative 0.0761 0.9405 0.9405
Onchocerca volvulus 0.0047 0.0291 0.2876
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0195 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0502 0.6094 1
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0447 0.0668
Echinococcus granulosus serine:threonine protein kinase N2 0.0269 0.312 0.4637
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0103 0.1012 0.7015
Schistosoma mansoni peroxidasin 0.0032 0.0101 0.0151
Brugia malayi Dynamin 0.0047 0.0291 0.0291
Entamoeba histolytica hypothetical protein 0.0047 0.0291 0.0278
Echinococcus granulosus serine/threonine protein kinase 0.0548 0.6688 0.994
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0103 0.1012 0.1513
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0127 0.1318 0.1318
Schistosoma mansoni tyrosine kinase 0.0079 0.0699 0.1045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus multilocularis actin binding protein anillin 0.0047 0.0291 0.0435
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0047 0.0291 0.0478
Echinococcus multilocularis peroxidasin 0.0032 0.0101 0.0151
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.0751 0.1117
Echinococcus multilocularis serine:threonine protein kinase 38 0.0269 0.312 0.4665
Onchocerca volvulus 0.006 0.0463 0.4576
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0101 0.0101
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.1624 0.1624
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0101 0.1
Brugia malayi Syntrophin-1 0.0047 0.0291 0.0291
Brugia malayi Pleckstrin Homology Domain 0.006 0.0463 0.0463
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0047 0.0291 0.0435
Schistosoma mansoni lipoxygenase 0.01 0.0966 0.1444
Loa Loa (eye worm) hypothetical protein 0.006 0.0463 0.0463
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0447 0.016
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1971
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0127 0.1318 0.1606
Echinococcus granulosus serine threonine protein kinase nrc 0.0502 0.6094 0.9057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Schistosoma mansoni oxysterol-binding protein 1 0.0047 0.0291 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.312 0.4665
Brugia malayi Protein kinase domain containing protein 0.0269 0.312 0.312
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0307 0.0307
Loa Loa (eye worm) AGC/PKN protein kinase 0.0269 0.312 0.312
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0047 0.0291 0.0291
Giardia lamblia Kinase, AGC PKA 0.0127 0.1318 0.1544
Schistosoma mansoni oxysterol-binding protein 1 0.0047 0.0291 0.0435
Echinococcus multilocularis Oxysterol binding protein 11 0.0047 0.0291 0.0435
Trichomonas vaginalis AGC family protein kinase 0.0269 0.312 0.2914
Echinococcus multilocularis pdz domain containing protein 0.0047 0.0291 0.0435
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1971
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0403 0.0175
Echinococcus granulosus nervana 2 0.0493 0.5982 0.889
Toxoplasma gondii AGC kinase 0.0127 0.1318 0.1127
Echinococcus multilocularis nervana 2 0.0493 0.5982 0.8944
Entamoeba histolytica protein kinase, putative 0.0269 0.312 0.3111
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0269 0.312 0.312
Schistosoma mansoni goodpasture antigen-binding protein 0.0047 0.0291 0.0435
Echinococcus multilocularis oxysterol binding protein 3 0.0047 0.0291 0.0435
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1318 0.1971
Loa Loa (eye worm) rho-GTPase-activating 0.0047 0.0291 0.0291
Schistosoma mansoni tyrosine kinase 0.0079 0.0699 0.1045
Echinococcus granulosus Pleckstrin y 0.0047 0.0291 0.0432
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0047 0.0291 0.0432
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0055 0.0403 0.0123
Loa Loa (eye worm) hypothetical protein 0.0127 0.1318 0.1318
Echinococcus multilocularis myotubularin protein 13 0.006 0.0463 0.0692
Echinococcus granulosus nervana 2 0.0493 0.5982 0.889
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Leishmania major protein kinase A catalytic subunit 0.0127 0.1318 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0502 0.6094 0.9057
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0447 0.016
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0047 0.0291 0.0478
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0055 0.0403 0.0661
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Schistosoma mansoni vav2 0.006 0.0463 0.0692
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0051 0.0341 0.051
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0055 0.0403 0.1089
Onchocerca volvulus 0.0047 0.0291 0.2876
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0047 0.0291 0.0435
Leishmania major serine/threonine-protein kinase a, putative 0.0055 0.0403 0.1089
Trypanosoma cruzi Protein kinase B 0.0548 0.6688 1
Brugia malayi TBC domain containing protein 0.0047 0.0291 0.0291
Entamoeba histolytica hypothetical protein 0.0047 0.0291 0.0278
Leishmania major protein kinase A catalytic subunit isoform 1 0.0127 0.1318 1
Entamoeba histolytica protein kinase, putative 0.0055 0.0403 0.039
Entamoeba histolytica protein kinase, putative 0.0808 1 1
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0055 0.0403 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus multilocularis DCC interacting protein 13 beta 0.0047 0.0291 0.0435
Leishmania major protein kinase, putative 0.0055 0.0403 0.1089
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0101 0.1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0118 0.1206 0.1793
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus multilocularis Rho GTPase activating protein 24 0.0047 0.0291 0.0435
Toxoplasma gondii AGC kinase 0.0127 0.1318 0.1127
Onchocerca volvulus Peroxidase homolog 0.0032 0.0101 0.1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0447 0.0447
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1959
Schistosoma mansoni hypothetical protein 0.0047 0.0291 0.0435
Echinococcus multilocularis cytohesin 1 0.0047 0.0291 0.0435
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0403 0.039
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0055 0.0403 0.0115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0447 0.0243
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0548 0.6688 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0047 0.0291 0.0435
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0291 0.0291
Entamoeba histolytica hypothetical protein 0.0047 0.0291 0.0278
Loa Loa (eye worm) hypothetical protein 0.0039 0.0195 0.0195
Brugia malayi hypothetical protein 0.0032 0.0101 0.0101
Echinococcus granulosus peroxidasin 0.0032 0.0101 0.015
Echinococcus granulosus oxysterol binding protein 1 0.0047 0.0291 0.0432
Giardia lamblia Kinase, AGC PKA 0.0502 0.6094 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1971
Loa Loa (eye worm) AGC/PKA protein kinase 0.0127 0.1318 0.1318
Echinococcus granulosus twitchin 0.0024 0.0004 0.0006
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1959
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0047 0.0291 0.0291
Echinococcus granulosus Pleckstrin y 0.0047 0.0291 0.0432
Entamoeba histolytica PH domain containing protein kinase, putative 0.0174 0.1913 0.1902
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0047 0.0291 0.0278
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0403 0.0175
Schistosoma mansoni tyrosine kinase 0.0083 0.0751 0.1123
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0125 0.1289 0.1289
Toxoplasma gondii AGC kinase 0.0761 0.9405 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1512 0.2261
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0447 0.016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Leishmania major folate/biopterin transporter, putative 0.0055 0.0403 0.1089
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0101 0.0101
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Onchocerca volvulus 0.0103 0.1012 1
Echinococcus multilocularis calcium dependent secretion activator 1 0.0047 0.0291 0.0435
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1012 0.1001
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0103 0.1012 0.0791
Brugia malayi protein kinase C II. 0.0283 0.3308 0.3308
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0403 0.0175
Loa Loa (eye worm) cytohesin 3 0.0047 0.0291 0.0291
Plasmodium vivax PH domain containing protein 0.0047 0.0291 0.0478
Echinococcus granulosus beta 1 syntrophin 0.0047 0.0291 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0101 0.0101
Entamoeba histolytica PH domain containing protein kinase, putative 0.0548 0.6688 0.6684
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus multilocularis protein kinase c iota type 0.0282 0.3292 0.4922
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0101 0.0101
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0307 0.0307
Loa Loa (eye worm) AGC/AKT protein kinase 0.0808 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.312 0.4665
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0447 0.016
Entamoeba histolytica hypothetical protein 0.0055 0.0403 0.039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0291 0.0478
Echinococcus multilocularis serine:threonine protein kinase N2 0.0269 0.312 0.4665
Echinococcus multilocularis protein kinase shaggy 0.0103 0.1012 0.1513
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Brugia malayi Cytohesin 3 0.0047 0.0291 0.0291
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0055 0.0403 0.0115
Loa Loa (eye worm) syntrophin-1 0.0047 0.0291 0.0291
Brugia malayi Hr1 repeat family protein 0.0269 0.312 0.312
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0101 0.1
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1971
Echinococcus multilocularis serine threonine protein kinase 0.0309 0.3635 0.5434
Schistosoma mansoni goodpasture antigen-binding protein 0.0047 0.0291 0.0435
Schistosoma mansoni tyrosine kinase 0.0051 0.0341 0.051
Echinococcus granulosus Pleckstrin y 0.0047 0.0291 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0283 0.3308 0.4946
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0403 0.039
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0047 0.0291 0.0435
Onchocerca volvulus 0.0047 0.0291 0.2876
Entamoeba histolytica protein kinase 2, putative 0.0502 0.6094 0.6088
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.0751 0.1117
Schistosoma mansoni dynamin 0.0047 0.0291 0.0435
Toxoplasma gondii protein kinase domain-containing protein 0.0055 0.0403 0.0123
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus multilocularis protein kinase c epsilon type 0.0283 0.3308 0.4946
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0101 0.0101
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0047 0.0291 0.0435
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0502 0.6094 0.9071
Brugia malayi Oxysterol-binding protein 0.0047 0.0291 0.0291
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0127 0.1318 0.1058
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0047 0.0291 0.0435
Schistosoma mansoni dynamin 0.0047 0.0291 0.0435
Loa Loa (eye worm) raf kinase 0.022 0.2498 0.2498
Brugia malayi Uncoordinated protein 104 0.0047 0.0291 0.0291
Echinococcus multilocularis oxysterol binding protein 1 0.0047 0.0291 0.0435
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Trypanosoma brucei rac serine-threonine kinase, putative 0.0808 1 1
Entamoeba histolytica protein kinase, putative 0.0055 0.0403 0.039
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0047 0.0291 0.0278
Entamoeba histolytica PH domain containing protein 0.0047 0.0291 0.0278
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0269 0.312 0.4637
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.3806 0.5691
Brugia malayi probable spectrin beta chain 0.0047 0.0291 0.0291
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0051 0.0341 0.0506
Schistosoma mansoni tyrosine kinase 0.0151 0.1624 0.2428
Loa Loa (eye worm) hypothetical protein 0.0269 0.312 0.312
Loa Loa (eye worm) hypothetical protein 0.0053 0.0367 0.0367
Brugia malayi Blistered cuticle protein 3 0.0032 0.0101 0.0101
Entamoeba histolytica protein kinase, putative 0.0055 0.0403 0.039
Echinococcus granulosus pdz domain containing protein 0.0047 0.0291 0.0432
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0447 0.0668
Schistosoma mansoni protein kinase 0.0133 0.1394 0.2084
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.026 0.3008 0.2799
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Plasmodium vivax glycogen synthase kinase 3, putative 0.0103 0.1012 0.166
Entamoeba histolytica PH domain containing protein 0.0047 0.0291 0.0278
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0047 0.0291 0.0278
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0403 0.0175
Echinococcus granulosus Glutaredoxin protein 5 0.0493 0.5982 0.889
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.1624 0.2413
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0047 0.0291 0.0291
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0493 0.5982 0.8944
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0109 0.1092 0.1092
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Schistosoma mansoni tyrosine kinase 0.0079 0.0699 0.1045
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Onchocerca volvulus 0.0032 0.0101 0.1
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.312 0.4665
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0047 0.0291 0.2876
Entamoeba histolytica protein kinase domain containing protein 0.0103 0.1012 0.0999
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Plasmodium falciparum PH domain-containing protein, putative 0.0047 0.0291 0.0478
Brugia malayi Protein kinase domain containing protein 0.0269 0.312 0.312
Plasmodium falciparum glycogen synthase kinase 3 0.0103 0.1012 0.166
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.006 0.0463 0.0463
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0502 0.6094 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0447 0.1515
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0447 0.0243
Echinococcus granulosus dynamin 1 0.0047 0.0291 0.0432
Schistosoma mansoni tyrosine kinase 0.0051 0.0341 0.051
Brugia malayi Protein kinase domain containing protein 0.0051 0.0341 0.0341
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.0751 0.1123
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0101 0.0101
Trypanosoma brucei protein kinase, putative 0.0055 0.0403 0.0115
Schistosoma mansoni hypothetical protein 0.0047 0.0291 0.0435
Echinococcus granulosus protein kinase c iota type 0.0282 0.3292 0.4893
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0055 0.0403 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0047 0.0291 0.0432
Entamoeba histolytica hypothetical protein, conserved 0.0047 0.0291 0.0278
Echinococcus multilocularis raf serine:threonine protein kinase 0.0224 0.2551 0.3814
Loa Loa (eye worm) PH domain-containing protein 0.0047 0.0291 0.0291
Brugia malayi intracellular kinase 0.0103 0.1012 0.1012
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0291 0.0435
Echinococcus granulosus pleckstrin y domain containing family A 0.0047 0.0291 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0133 0.1394 0.2084
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0055 0.0403 0.0115
Echinococcus granulosus DCC interacting protein 13 beta 0.0047 0.0291 0.0432
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0502 0.6094 0.9111
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0447 0.1515
Trichomonas vaginalis AGC family protein kinase 0.0269 0.312 0.2914
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus multilocularis pleckstrin y domain containing family A 0.0047 0.0291 0.0435
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0103 0.1012 0.1127
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0269 0.312 0.4637
Entamoeba histolytica hypothetical protein 0.0047 0.0291 0.0278
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0047 0.0291 0.0432
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0133 0.1394 0.2072
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0047 0.0291 0.0435
Schistosoma mansoni tyrosine kinase 0.0083 0.0751 0.1123
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0551 0.6728 1
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0047 0.0291 0.0435
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0322 0.3806 0.5691
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.0291 0.0478
Trypanosoma brucei protein kinase, putative 0.0103 0.1012 0.0742
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0127 0.1318 0.1127
Echinococcus granulosus GRB2 associated binding protein 3 0.0047 0.0291 0.0432
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Schistosoma mansoni serine/threonine kinase 0.0269 0.312 0.4665
Loa Loa (eye worm) TK/INSR protein kinase 0.0051 0.0341 0.0341
Entamoeba histolytica protein kinase, putative 0.0055 0.0403 0.039
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0047 0.0291 0.0278
Brugia malayi Plekhf2 protein 0.0047 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0047 0.0291 0.0435
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0447 0.0664
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0103 0.1012 0.1012
Echinococcus granulosus Protein kinase C brain isozyme 0.0322 0.3806 0.5657
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0761 0.9405 0.9405
Entamoeba histolytica protein kinase, putative 0.0808 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0548 0.6688 0.6684
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0269 0.312 0.4665
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0403 0.0175
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0101 0.1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.0291 0.0478
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0127 0.1318 0.2163
Brugia malayi hypothetical protein 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0127 0.1318 0.2163
Entamoeba histolytica protein kinase, putative 0.0103 0.1012 0.0999
Leishmania major protein kinase A catalytic subunit isoform 2 0.0127 0.1318 1
Brugia malayi MAP kinase sur-1 0.0059 0.0447 0.0447
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0047 0.0291 0.0291
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0055 0.0403 0.0115
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0047 0.0291 0.0432
Loa Loa (eye worm) oxysterol binding protein 0.0047 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.0047 0.0291 0.0435
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0101 0.0101
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0047 0.0291 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1512 0.2248
Echinococcus granulosus raf serine:threonine protein kinase 0.0224 0.2551 0.3791
Schistosoma mansoni serine/threonine protein kinase 0.0269 0.312 0.4665
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Schistosoma mansoni syntrophin 0.0047 0.0291 0.0435
Echinococcus multilocularis nervana 2 0.0493 0.5982 0.8944
Echinococcus granulosus cytohesin 1 0.0047 0.0291 0.0432
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0047 0.0291 0.0435
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0127 0.1318 0.1606
Brugia malayi Oxysterol binding protein 0.0047 0.0291 0.0291
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0127 0.1318 0.1606
Echinococcus multilocularis dynamin 1 0.0047 0.0291 0.0435
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Loa Loa (eye worm) AGC/PKA protein kinase 0.0127 0.1318 0.1318
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Echinococcus granulosus protein kinase c epsilon type 0.0283 0.3308 0.4916
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0101 0.0101
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0049 0.0323 0.0323
Echinococcus multilocularis Pleckstrin y 0.0047 0.0291 0.0435
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0493 0.5982 0.889
Echinococcus granulosus myotubularin protein 13 0.006 0.0463 0.0688
Echinococcus granulosus protein kinase shaggy 0.0103 0.1012 0.1504
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Loa Loa (eye worm) AGC/NDR protein kinase 0.0269 0.312 0.312
Schistosoma mansoni myotubularin-related protein 0.0047 0.0291 0.0435
Onchocerca volvulus outspread protein homolog 0.0047 0.0291 0.2876
Schistosoma mansoni hypothetical protein 0.0047 0.0291 0.0435
Schistosoma mansoni serine/threonine-protein kinase 0.0548 0.6688 1
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0103 0.1012 0.1504
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0447 0.0243
Trichomonas vaginalis AGC family protein kinase 0.0269 0.312 0.2914
Brugia malayi Dynamin 0.0047 0.0291 0.0291
Echinococcus granulosus protein kinase C gamma type 0.0309 0.3635 0.5402
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0101 0.0101
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0055 0.0403 0.1089
Brugia malayi Raf kinase 0.021 0.2379 0.2379
Echinococcus multilocularis serine:threonine protein kinase N2 0.0269 0.312 0.4665
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Entamoeba histolytica hypothetical protein 0.0055 0.0403 0.039
Echinococcus granulosus Rho GTPase activating protein 24 0.0047 0.0291 0.0432
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0047 0.0291 0.0432
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0047 0.0291 0.0291
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0047 0.0291 0.0435
Onchocerca volvulus 0.0032 0.0101 0.1
Schistosoma mansoni centaurin alpha 0.0047 0.0291 0.0435
Loa Loa (eye worm) hypothetical protein 0.0032 0.0101 0.0101
Loa Loa (eye worm) Plekhf2 protein 0.0047 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0269 0.312 0.4665
Echinococcus multilocularis Glutaredoxin protein 5 0.0493 0.5982 0.8944
Onchocerca volvulus Peroxidase homolog 0.0032 0.0101 0.1
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0127 0.1318 0.1058
Entamoeba histolytica hypothetical protein 0.0047 0.0291 0.0278
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0447 0.0171
Brugia malayi p70 ribosomal S6 kinase beta 0.0761 0.9405 0.9405
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0127 0.1318 0.1058
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0127 0.1318 0.1606
Echinococcus multilocularis Ras associated and pleckstrin y 0.0047 0.0291 0.0435
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0195 0.0291
Echinococcus multilocularis rac serine:threonine kinase 0.0548 0.6688 1
Schistosoma mansoni peroxidasin 0.0032 0.0101 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Entamoeba histolytica p21-activated kinase 0.0055 0.0403 0.039
Echinococcus granulosus Oxysterol binding protein 11 0.0047 0.0291 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Onchocerca volvulus 0.0047 0.0291 0.2876
Giardia lamblia Kinase, CMGC GSK 0.0103 0.1012 0.1001
Echinococcus multilocularis Pleckstrin y 0.0047 0.0291 0.0435
Brugia malayi PH domain containing protein 0.0047 0.0291 0.0291
Entamoeba histolytica protein kinase, putative 0.0055 0.0403 0.039
Schistosoma mansoni serine/threonine-protein kinase 0.0548 0.6688 1
Brugia malayi MAX-1A 0.0047 0.0291 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0403 0.0115
Schistosoma mansoni rho gtpase activating protein 0.0047 0.0291 0.0435
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0047 0.0291 0.0478
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0047 0.0291 0.0435
Trypanosoma brucei protein kinase, putative 0.0059 0.0447 0.016
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0047 0.0291 0.2876
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1012 0.0742
Echinococcus multilocularis oxysterol binding protein 9 0.0047 0.0291 0.0435
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0047 0.0291 0.0278
Entamoeba histolytica PH domain containing protein 0.0047 0.0291 0.0278
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0447 0.0664
Onchocerca volvulus 0.0047 0.0291 0.2876
Onchocerca volvulus 0.0032 0.0101 0.1
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0195 0.029
Onchocerca volvulus Protein melted homolog 0.0047 0.0291 0.2876
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0055 0.0403 0.0175
Echinococcus multilocularis beta 1 syntrophin 0.0047 0.0291 0.0435
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0103 0.1012 0.1513
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.1012 0.0742
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Schistosoma mansoni zinc finger protein 0.0047 0.0291 0.0435
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.1624 0.1624
Trichomonas vaginalis AGC family protein kinase 0.0315 0.3715 0.3526
Trichomonas vaginalis AGC family protein kinase 0.0808 1 1
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0047 0.0291 0.0435
Echinococcus granulosus insulin receptor 0.0051 0.0341 0.0506
Entamoeba histolytica ARF GTPase activating protein, putative 0.0047 0.0291 0.0278
Plasmodium falciparum oxysterol-binding protein, putative 0.0047 0.0291 0.0478
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0055 0.0403 0.0115
Leishmania major protein kinase, putative 0.0055 0.0403 0.1089
Schistosoma mansoni zinc finger protein 0.0047 0.0291 0.0435
Echinococcus granulosus calcium dependent secretion activator 1 0.0047 0.0291 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.3806 0.5691
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0055 0.0403 0.0115
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0269 0.312 0.4637
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0269 0.312 0.312
Schistosoma mansoni lipoxygenase 0.0142 0.1512 0.2261
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0047 0.0291 0.0278
Brugia malayi Protein kinase c protein 2 0.0063 0.0495 0.0495
Echinococcus granulosus NDR protein kinase 0.0269 0.312 0.4637
Schistosoma mansoni atypical protein kinase C 0.0282 0.3292 0.4922
Brugia malayi Peroxidasin 0.0032 0.0101 0.0101
Echinococcus granulosus oxysterol binding protein 9 0.0047 0.0291 0.0432
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0269 0.312 0.4665
Trichomonas vaginalis AGC family protein kinase 0.0127 0.1318 0.1058
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0047 0.0291 0.0278
Echinococcus granulosus oxysterol binding protein 3 0.0047 0.0291 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.2551 0.3814
Loa Loa (eye worm) hypothetical protein 0.0047 0.0291 0.0291
Echinococcus multilocularis GRB2 associated binding protein 3 0.0047 0.0291 0.0435
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0047 0.0291 0.0478
Plasmodium falciparum calcium-dependent protein kinase 7 0.0055 0.0403 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0127 0.1318 0.1971
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0055 0.0403 0.0175
Schistosoma mansoni protein kinase 0.0133 0.1394 0.2084
Loa Loa (eye worm) uncoordinated protein 104 0.0047 0.0291 0.0291
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0118 0.1206 0.1804
Brugia malayi Cadps2 protein 0.0047 0.0291 0.0291
Schistosoma mansoni protein kinase 0.0133 0.1394 0.2084
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0403 0.0175
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0127 0.1318 0.1959

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of MMP9 secretion in androgen-independent human PC3 cells ChEMBL. 15566290
Activity (functional) = 2.1 % Cell cycle arrest in human PC3 cells by accumulation at subG1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 2.1 % Cell cycle arrest in human PC3 cells by accumulation at subG1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 6.6 % Cell cycle arrest in human PC3 cells by accumulation at S phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 6.6 % Cell cycle arrest in human PC3 cells by accumulation at S phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 6.9 % Cell cycle arrest in human LNCaP cells by accumulation at S phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 6.9 % Cell cycle arrest in human LNCaP cells by accumulation at S phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 8.2 % Cell cycle arrest in human LNCaP cells by accumulation at G2M phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 8.2 % Cell cycle arrest in human LNCaP cells by accumulation at G2M phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 10.8 % Cell cycle arrest in human LNCaP cells by accumulation at subG1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 10.8 % Cell cycle arrest in human LNCaP cells by accumulation at subG1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 19.5 % Cell cycle arrest in human PC3 cells by accumulation at G2M phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 19.5 % Cell cycle arrest in human PC3 cells by accumulation at G2M phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 71.5 % Cell cycle arrest in human PC3 cells by accumulation at G1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 71.5 % Cell cycle arrest in human PC3 cells by accumulation at G1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 74.2 % Cell cycle arrest in human LNCaP cells by accumulation at G1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
Activity (functional) = 74.2 % Cell cycle arrest in human LNCaP cells by accumulation at G1 phase at 10 uM after 72 hrs by FACS flow cytometry ChEMBL. 15566290
IC50 (functional) = 0.1 uM Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay ChEMBL. 15566290
IC50 (functional) = 0.1 uM Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay ChEMBL. 15566290
IC50 (functional) = 0.74 uM Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysis ChEMBL. 15566290
IC50 (functional) = 0.74 uM Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysis ChEMBL. 15566290
IC50 (functional) = 25.7 uM Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay ChEMBL. 15566290
IC50 (functional) = 25.7 uM Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay ChEMBL. 15566290
IC50 (functional) = 45.9 uM Antiproliferative activity against androgen-independent human PC3 cells after 72 hrs by MTT test ChEMBL. 15566290
IC50 (functional) = 45.9 uM Antiproliferative activity against androgen-independent human PC3 cells after 72 hrs by MTT test ChEMBL. 15566290
IC50 (functional) = 49.7 uM Antiproliferative activity against androgen-sensitive human LNCaP cells after 72 hrs by MTT test ChEMBL. 15566290
IC50 (functional) = 49.7 uM Antiproliferative activity against androgen-sensitive human LNCaP cells after 72 hrs by MTT test ChEMBL. 15566290
Selectivity ratio (binding) = 257 Selectivity for COX2 over COX1 ChEMBL. 15566290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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