TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.505 | Formula: C24H32O9
H donors: 3 H acceptors: 6 LogP: 0.79 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OCC(COC(=O)/C(=C/C=C/[C@@]1(C)OC(=O)[C@]23[C@]([C@H]1CC2)(O)CCC(=CC3)C(=O)OC)/C)O
InChi: 1S/C24H32O9/c1-15(19(27)32-14-17(26)13-25)5-4-9-22(2)18-8-11-23(21(29)33-22)10-6-16(20(28)31-3)7-12-24(18,23)30/h4-6,9,17-18,25-26,30H,7-8,10-14H2,1-3H3/b9-4+,15-5+/t17?,18-,22+,23+,24-/m0/s1
InChiKey: JCLIEVRKSAIZLM-HVGAAAKNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	epidermal growth factor receptor	0.0174	0.1958	0.294
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	nervana 2	0.0476	0.5951	0.8935
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Trichomonas vaginalis	centaurin beta, putative	0.0045	0.0242	0.0242
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0118	0.1212	0.7678
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0054	0.0362	0.0187
Echinococcus granulosus	Glutaredoxin protein 5	0.0476	0.5951	0.738
Schistosoma mansoni	dynamin	0.0045	0.0242	0.0364
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.0424	0.0526
Trichomonas vaginalis	kinesin light chain, putative	0.0045	0.0242	0.0242
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0054	0.0362	0.0187
Trichomonas vaginalis	CMGC family protein kinase	0.0118	0.1212	0.1212
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0045	0.0242	0.0364
Schistosoma mansoni	protein kinase	0.0153	0.167	0.2507
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0258	0.3067	0.4605
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0118	0.1212	0.1512
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Brugia malayi	Protein kinase domain containing protein	0.0262	0.3112	0.3112
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0067	0.0537	0.0459
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0045	0.0242	0.0364
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0262	0.3112	0.4673
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Echinococcus granulosus	DCC interacting protein 13 beta	0.0045	0.0242	0.03
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0067	0.0537	0.3398
Echinococcus multilocularis	epidermal growth factor receptor	0.0095	0.0915	0.1373
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Echinococcus multilocularis	pdz domain containing protein	0.0045	0.0242	0.0364
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0045	0.0242	0.0242
Leishmania major	protein kinase, putative	0.0054	0.0362	0.2294
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0045	0.0242	0.0364
Brugia malayi	Oxysterol binding protein	0.0045	0.0242	0.0242
Echinococcus granulosus	Pleckstrin y	0.0045	0.0242	0.03
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0279	0.3337	0.3337
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0045	0.0249	0.0374
Schistosoma mansoni	hypothetical protein	0.0045	0.0242	0.0364
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0045	0.0242	0.0364
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Leishmania major	protein kinase A catalytic subunit	0.0146	0.1579	1
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0485	0.6072	0.9116
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0045	0.0242	0.0242
Entamoeba histolytica	protein kinase, putative	0.0054	0.0362	0.0362
Schistosoma mansoni	tyrosine kinase	0.0174	0.1958	0.294
Toxoplasma gondii	protein kinase domain-containing protein	0.0054	0.0362	0.0385
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0045	0.0242	0.0257
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0324	0.3933	0.5905
Entamoeba histolytica	protein kinase, putative	0.0262	0.3112	0.3112
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0054	0.0362	0.0362
Brugia malayi	Protein kinase domain containing protein	0.0262	0.3112	0.3112
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Entamoeba histolytica	protein kinase, putative	0.0783	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Brugia malayi	Dynamin	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0253	0.2992	0.2992
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0045	0.0242	0.0242
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0045	0.0242	0.0399
Brugia malayi	Dynamin	0.0045	0.0242	0.0242
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0118	0.1212	0.1997
Trichomonas vaginalis	AGC family protein kinase	0.0262	0.3112	0.3112
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0045	0.0242	0.0364
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0054	0.0362	0.0597
Brugia malayi	MAP kinase sur-1	0.0067	0.0537	0.0537
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.3112	0.4673
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Plasmodium falciparum	PH domain-containing protein, putative	0.0045	0.0242	0.0399
Schistosoma mansoni	serine/threonine kinase	0.0262	0.3112	0.4673
Entamoeba histolytica	protein kinase, putative	0.0054	0.0362	0.0362
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0485	0.6072	0.7529
Echinococcus multilocularis	Pleckstrin y	0.0045	0.0242	0.0364
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0242	0.0399
Schistosoma mansoni	oxysterol-binding protein 1	0.0045	0.0242	0.0364
Schistosoma mansoni	tyrosine kinase	0.0095	0.0915	0.1373
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0045	0.0242	0.0364
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0054	0.0362	0.0362
Echinococcus multilocularis	serine threonine protein kinase	0.0308	0.3728	0.5597
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.1579	0.1579
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus granulosus	oxysterol binding protein 9	0.0045	0.0242	0.03
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus granulosus	protein kinase c epsilon type	0.0279	0.3337	0.4138
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0045	0.0242	0.03
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0067	0.0537	0.0459
Brugia malayi	p70 ribosomal S6 kinase beta	0.0738	0.9411	0.9411
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0153	0.167	0.2507
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0045	0.0242	0.03
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0126	0.1323	0.1323
Toxoplasma gondii	hypothetical protein	0.0045	0.0242	0.0257
Entamoeba histolytica	protein kinase, putative	0.0118	0.1212	0.1212
Toxoplasma gondii	AtPH1 family protein	0.0045	0.0242	0.0257
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0054	0.0362	0.2294
Entamoeba histolytica	PH domain containing protein kinase, putative	0.019	0.2168	0.2168
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0045	0.0242	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0045	0.0242	0.0364
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Schistosoma mansoni	tyrosine kinase	0.0091	0.0852	0.1279
Entamoeba histolytica	protein kinase, putative	0.0054	0.0362	0.0362
Schistosoma mansoni	serine/threonine-protein kinase	0.053	0.6661	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0045	0.0242	0.0399
Echinococcus multilocularis	Oxysterol binding protein 11	0.0045	0.0242	0.0364
Schistosoma mansoni	atypical protein kinase C	0.0277	0.3318	0.4982
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Schistosoma mansoni	serine/threonine protein kinase	0.0279	0.3337	0.501
Trichomonas vaginalis	CMGC family protein kinase	0.0118	0.1212	0.1212
Schistosoma mansoni	tyrosine kinase	0.0095	0.0915	0.1373
Trichomonas vaginalis	centaurin alpha, putative	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0056	0.0388	0.0388
Echinococcus multilocularis	protein kinase shaggy	0.0118	0.1212	0.182
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0045	0.0242	0.03
Trypanosoma brucei	protein kinase, putative	0.0054	0.0362	0.0362
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.1579	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0067	0.0537	0.0459
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.1579	0.2083
Echinococcus granulosus	Oxysterol binding protein 11	0.0045	0.0242	0.03
Trichomonas vaginalis	alpha chimerin, putative	0.0045	0.0242	0.0242
Entamoeba histolytica	PH domain containing protein kinase, putative	0.053	0.6661	0.6661
Trypanosoma cruzi	NIMA-related kinase, putative	0.0054	0.0362	0.0187
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0045	0.0242	0.0364
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0054	0.0362	0.2294
Echinococcus multilocularis	oxysterol binding protein 9	0.0045	0.0242	0.0364
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Echinococcus multilocularis	insulin receptor	0.0058	0.0424	0.0636
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.2371
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0054	0.0362	0.0187
Brugia malayi	Plekhf2 protein	0.0045	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.0045	0.0242	0.0364
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0045	0.0242	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Entamoeba histolytica	hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0045	0.0242	0.0242
Schistosoma mansoni	serine/threonine-protein kinase	0.053	0.6661	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0448	0.0448
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0146	0.1579	1
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1579	0.2371
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0485	0.6072	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.2371
Echinococcus granulosus	cytohesin 1	0.0045	0.0242	0.03
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0045	0.0242	0.0242
Echinococcus multilocularis	oxysterol binding protein 1	0.0045	0.0242	0.0364
Schistosoma mansoni	zinc finger protein	0.0045	0.0242	0.0364
Leishmania major	folate/biopterin transporter, putative	0.0054	0.0362	0.2294
Entamoeba histolytica	hypothetical protein	0.0054	0.0362	0.0362
Echinococcus granulosus	RNA directed DNA polymerase	0.0045	0.0249	0.0309
Trichomonas vaginalis	guanyl-nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0067	0.0537	0.0537
Loa Loa (eye worm)	oxysterol binding protein	0.0045	0.0242	0.0242
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.1958
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0054	0.0362	0.0187
Entamoeba histolytica	PH domain containing protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0262	0.3112	0.4673
Schistosoma mansoni	hypothetical protein	0.0045	0.0242	0.0364
Plasmodium falciparum	oxysterol-binding protein, putative	0.0045	0.0242	0.0399
Brugia malayi	Hr1 repeat family protein	0.0262	0.3112	0.3112
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0144	0.1557	0.1557
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0045	0.0242	0.03
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0537	0.0537
Entamoeba histolytica	PH domain containing protein	0.0045	0.0242	0.0242
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0054	0.0362	0.0187
Entamoeba histolytica	protein kinase 2, putative	0.0485	0.6072	0.6072
Trypanosoma brucei	PH domain containing protein, putative	0.0045	0.0242	0.0242
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0067	0.0537	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus multilocularis		0.0053	0.0351	0.0527
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0476	0.5951	0.738
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0045	0.0242	0.0242
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0067	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1579	0.1579
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0537	0.0537
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0095	0.0915	0.1134
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0067	0.0537	0.0806
Brugia malayi	Variant SH3 domain containing protein	0.0045	0.0242	0.0242
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0067	0.0537	0.057
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0262	0.3112	0.4673
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0067	0.0537	0.3398
Brugia malayi	Protein kinase c protein 2	0.0071	0.0594	0.0594
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0045	0.0242	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.2371
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0067	0.0537	0.0806
Echinococcus granulosus	oxysterol binding protein 1	0.0045	0.0242	0.03
Brugia malayi	Syntrophin-1	0.0045	0.0242	0.0242
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0174	0.1958	0.1958
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0262	0.3112	0.3112
Loa Loa (eye worm)	syntrophin-1	0.0045	0.0242	0.0242
Echinococcus multilocularis	Pleckstrin y	0.0045	0.0242	0.0364
Schistosoma mansoni	myotubularin-related protein	0.0045	0.0242	0.0364
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0476	0.5951	0.8935
Echinococcus multilocularis	nervana 2	0.0476	0.5951	0.8935
Toxoplasma gondii	AGC kinase	0.0146	0.1579	0.1678
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.2371
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0045	0.0242	0.0399
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Schistosoma mansoni	dynamin	0.0045	0.0242	0.0364
Echinococcus granulosus	serine threonine protein kinase nrc	0.0485	0.6072	0.7529
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Toxoplasma gondii	AGC kinase	0.0146	0.1579	0.1678
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0146	0.1579	0.1579
Trichomonas vaginalis	AGC family protein kinase	0.0146	0.1579	0.1579
Echinococcus multilocularis	actin binding protein anillin	0.0045	0.0242	0.0364
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0045	0.0242	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0262	0.3112	0.3112
Trichomonas vaginalis	AGC family protein kinase	0.0262	0.3112	0.3112
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0262	0.3112	0.3112
Trichomonas vaginalis	centaurin gamma, putative	0.0045	0.0242	0.0242
Echinococcus granulosus	beta 1 syntrophin	0.0045	0.0242	0.03
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	protein transport protein sec7, putative	0.0045	0.0242	0.0242
Brugia malayi	Furin-like cysteine rich region family protein	0.0174	0.1958	0.1958
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.1579	0.1579
Entamoeba histolytica	PH domain containing protein kinase, putative	0.019	0.2168	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus granulosus	epidermal growth factor receptor	0.0095	0.0915	0.1134
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0118	0.1212	0.1504
Echinococcus granulosus	Pleckstrin y	0.0045	0.0242	0.03
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0054	0.0362	0.0362
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0118	0.1212	0.182
Echinococcus multilocularis	myotubularin protein 13	0.006	0.0448	0.0672
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0262	0.3112	0.4673
Giardia lamblia	Kinase, AGC PKA	0.0485	0.6072	1
Echinococcus granulosus	GRB2 associated binding protein 3	0.0045	0.0242	0.03
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0783	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.053	0.6661	1
Brugia malayi	intracellular kinase	0.0118	0.1212	0.1212
Entamoeba histolytica	protein kinase, putative	0.0054	0.0362	0.0362
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Echinococcus granulosus	twitchin	0.0027	0.0008	0.0009
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0262	0.3112	0.4673
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0448	0.0448
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0.1212	0.1212
Brugia malayi	protein kinase C II.	0.0279	0.3337	0.3337
Brugia malayi	Protein kinase domain containing protein	0.0058	0.0424	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Toxoplasma gondii	AGC kinase	0.0738	0.9411	1
Echinococcus granulosus	mitogen activated protein kinase	0.0067	0.0537	0.0666
Brugia malayi	Oxysterol-binding protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0146	0.1579	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0262	0.3112	0.386
Trichomonas vaginalis	development and differentiation-enhancing factor, ddef, putative	0.0045	0.0242	0.0242
Trichomonas vaginalis	centaurin/arf, putative	0.0045	0.0242	0.0242
Echinococcus multilocularis	protein kinase c iota type	0.0277	0.3318	0.4982
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.3112	0.4673
Echinococcus granulosus	mitogen activated protein kinase 3	0.0067	0.0537	0.0666
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0045	0.0242	0.0242
Entamoeba histolytica	pleckstrin homology (PH) domain containing protein	0.0045	0.0242	0.0242
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0126	0.1323	0.1323
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Schistosoma mansoni	protein kinase	0.0153	0.167	0.2507
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.1579	0.2083
Entamoeba histolytica	p21-activated kinase	0.0054	0.0362	0.0362
Brugia malayi	Uncoordinated protein 104	0.0045	0.0242	0.0242
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0146	0.1579	0.2601
Echinococcus multilocularis	dynamin 1	0.0045	0.0242	0.0364
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus granulosus	raf serine:threonine protein kinase	0.0258	0.3067	0.3804
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0045	0.0242	0.03
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1579	0.2371
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0054	0.0362	0.0187
Trichomonas vaginalis	protein transport protein sec7, putative	0.0045	0.0242	0.0242
Echinococcus granulosus	insulin receptor	0.0058	0.0424	0.0526
Loa Loa (eye worm)	cytohesin 3	0.0045	0.0242	0.0242
Echinococcus granulosus	pdz domain containing protein	0.0045	0.0242	0.03
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0045	0.0242	0.0242
Echinococcus granulosus	epidermal growth factor receptor	0.0174	0.1958	0.2429
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0045	0.0242	0.0364
Entamoeba histolytica	protein kinase domain containing protein	0.0118	0.1212	0.1212
Giardia lamblia	Kinase, CMGC GSK	0.0118	0.1212	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0118	0.1212	0.1212
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0537	0.0537
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0045	0.0242	0.0242
Trichomonas vaginalis	CMGC family protein kinase	0.0067	0.0537	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Entamoeba histolytica	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	Pleckstrin y	0.0045	0.0242	0.0364
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0054	0.0362	0.0187
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0153	0.167	0.207
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0262	0.3112	0.3112
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus granulosus	Protein kinase C brain isozyme	0.0324	0.3933	0.4878
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0262	0.3112	0.386
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0045	0.0242	0.0364
Schistosoma mansoni	centaurin alpha	0.0045	0.0242	0.0364
Trichomonas vaginalis	AGC family protein kinase	0.0783	1	1
Echinococcus granulosus	protein kinase C gamma type	0.0308	0.3728	0.4623
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0045	0.0242	0.0399
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0046	0.0261	0.0261
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0045	0.0242	0.0364
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.0424	0.0424
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0738	0.9411	0.9411
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0045	0.0242	0.0242
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0137	0.1459	0.2191
Echinococcus granulosus	Rho GTPase activating protein 24	0.0045	0.0242	0.03
Trypanosoma cruzi	Protein kinase B	0.053	0.6661	1
Echinococcus granulosus	dynamin 1	0.0045	0.0242	0.03
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0146	0.1579	0.2083
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.1958
Loa Loa (eye worm)	Plekhf2 protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	centaurin/arf, putative	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0249	0.0249
Echinococcus multilocularis	Glutaredoxin protein 5	0.0476	0.5951	0.8935
Entamoeba histolytica	PH domain containing protein	0.0045	0.0242	0.0242
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.3112	0.4673
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0045	0.0242	0.0364
Plasmodium vivax	PH domain containing protein	0.0045	0.0242	0.0399
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus granulosus	serine/threonine protein kinase	0.053	0.6661	0.826
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Echinococcus granulosus	Pleckstrin y	0.0045	0.0242	0.03
Brugia malayi	Cadps2 protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Loa Loa (eye worm)	PH domain-containing protein	0.0045	0.0242	0.0242
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0118	0.1212	0.1288
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0054	0.0362	0.0385
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	oxysterol binding protein 3	0.0045	0.0242	0.0364
Entamoeba histolytica	hypothetical protein	0.0054	0.0362	0.0362
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0306	0.3702	0.3702
Brugia malayi	TBC domain containing protein	0.0045	0.0242	0.0242
Brugia malayi	probable spectrin beta chain	0.0045	0.0242	0.0242
Schistosoma mansoni	serine/threonine protein kinase	0.0262	0.3112	0.4673
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0537	0.0806
Schistosoma mansoni	tyrosine kinase	0.0058	0.0424	0.0636
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0118	0.1212	0.182
Loa Loa (eye worm)	uncoordinated protein 104	0.0045	0.0242	0.0242
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0045	0.0242	0.0399
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0262	0.3112	0.386
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0054	0.0362	0.0362
Echinococcus multilocularis	rac serine:threonine kinase	0.053	0.6661	1
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0045	0.0242	0.0364
Entamoeba histolytica	hypothetical protein, conserved	0.0045	0.0242	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.0045	0.0242	0.0364
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0045	0.0242	0.03
Entamoeba histolytica	hypothetical protein	0.0045	0.0242	0.0242
Brugia malayi	MAX-1A	0.0045	0.0242	0.0242
Schistosoma mansoni	syntrophin	0.0045	0.0242	0.0364
Brugia malayi	Raf kinase	0.0243	0.2862	0.2862
Schistosoma mansoni	tyrosine kinase	0.0058	0.0424	0.0636
Entamoeba histolytica	protein kinase, putative	0.0028	0.0019	0.0019
Echinococcus granulosus	serine:threonine protein kinase N2	0.0262	0.3112	0.386
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0783	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	cytohesin 1	0.0045	0.0242	0.0364
Leishmania major	hypothetical protein, conserved	0.0045	0.0242	0.1533
Schistosoma mansoni	serine/threonine protein kinase	0.0146	0.1579	0.2371
Echinococcus multilocularis	protein kinase c epsilon type	0.0279	0.3337	0.501
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0146	0.1579	0.2083
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Schistosoma mansoni	goodpasture antigen-binding protein	0.0045	0.0242	0.0364
Schistosoma mansoni	zinc finger protein	0.0045	0.0242	0.0364
Echinococcus granulosus	nervana 2	0.0476	0.5951	0.738
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0146	0.1579	0.1678
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Echinococcus multilocularis	RNA directed DNA polymerase	0.0045	0.0249	0.0374
Trypanosoma brucei	protein kinase, putative	0.0118	0.1212	0.1212
Echinococcus granulosus	nervana 2	0.0476	0.5951	0.738
Trypanosoma brucei	protein kinase, putative	0.0067	0.0537	0.0537
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0045	0.0242	0.0364
Brugia malayi	Pleckstrin Homology Domain	0.006	0.0448	0.0448
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0146	0.1579	0.1958
Echinococcus granulosus	protein kinase shaggy	0.0118	0.1212	0.1504
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0045	0.0242	0.0364
Echinococcus granulosus	oxysterol binding protein 3	0.0045	0.0242	0.03
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0054	0.0362	0.0362
Brugia malayi	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0054	0.0362	0.0362
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0262	0.3112	0.3112
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0137	0.1459	0.1809
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0146	0.1579	0.1579
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0054	0.0362	0.0362
Brugia malayi	PH domain containing protein	0.0045	0.0242	0.0242
Echinococcus granulosus	pleckstrin y domain containing family A	0.0045	0.0242	0.03
Schistosoma mansoni	protein kinase	0.0153	0.167	0.2507
Entamoeba histolytica	protein kinase, putative	0.0054	0.0362	0.0362
Trichomonas vaginalis	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0262	0.3112	0.4673
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	raf kinase	0.0253	0.3005	0.3005
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0045	0.0242	0.0364
Toxoplasma gondii	Oxysterol-binding protein	0.0045	0.0242	0.0257
Entamoeba histolytica	hypothetical protein	0.0045	0.0242	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0636	0.8064	1
Echinococcus multilocularis	beta 1 syntrophin	0.0045	0.0242	0.0364
Schistosoma mansoni	tyrosine kinase	0.0091	0.0852	0.1279
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0045	0.0242	0.0242
Schistosoma mansoni	serine/threonine protein kinase	0.0324	0.3933	0.5905
Plasmodium falciparum	glycogen synthase kinase 3	0.0118	0.1212	0.1997
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0054	0.0362	0.0187
Loa Loa (eye worm)	rho-GTPase-activating	0.0045	0.0242	0.0242
Echinococcus granulosus	NDR protein kinase	0.0262	0.3112	0.386
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0146	0.1579	0.1579
Trichomonas vaginalis	AGC family protein kinase	0.0262	0.3112	0.3112
Entamoeba histolytica	ARF GTPase activating protein, putative	0.0045	0.0242	0.0242
Echinococcus granulosus	calcium dependent secretion activator 1	0.0045	0.0242	0.03
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0045	0.0242	0.0242
Schistosoma mansoni	rho gtpase activating protein	0.0045	0.0242	0.0364
Leishmania major	hypothetical protein, conserved	0.0045	0.0242	0.1533
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0242	0.0242
Entamoeba histolytica	protein kinase, putative	0.0783	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.053	0.6661	0.6661
Entamoeba histolytica	protein kinase, putative	0.0738	0.9411	0.9411
Echinococcus granulosus	myotubularin protein 13	0.006	0.0448	0.0555
Giardia lamblia	Kinase, CMGC GSK	0.0118	0.1212	0.1221
Schistosoma mansoni	serine/threonine protein kinase	0.0324	0.3933	0.5905
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.0424	0.0636
Entamoeba histolytica	hypothetical protein	0.0045	0.0242	0.0242
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0118	0.1212	0.1212
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0146	0.1579	0.2601
Leishmania major	protein kinase, putative	0.0054	0.0362	0.2294
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0262	0.3112	0.3112
Entamoeba histolytica	Rho guanine nucleotide exchange factor, putative	0.0045	0.0242	0.0242
Schistosoma mansoni	tyrosine kinase	0.0091	0.0852	0.1279
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0054	0.0362	0.0597
Brugia malayi	Variant SH3 domain containing protein	0.0046	0.0261	0.0261
Schistosoma mansoni	hypothetical protein	0.0045	0.0242	0.0364
Leishmania major	serine/threonine-protein kinase a, putative	0.0054	0.0362	0.2294
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0485	0.6072	1
Onchocerca volvulus		0.006	0.0448	0.2119
Schistosoma mansoni	oxysterol-binding protein 1	0.0045	0.0242	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0455	0.0455
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0362	0.0362
Giardia lamblia	Kinase, AGC PKA	0.0146	0.1579	0.1884
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0045	0.0242	0.0364
Toxoplasma gondii	hypothetical protein	0.0045	0.0242	0.0257
Schistosoma mansoni	vav2	0.006	0.0448	0.0672
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0485	0.6072	0.9082
Trichomonas vaginalis	ankyrin repeat and FYVE domain containing protein, putative	0.0045	0.0242	0.0242
Schistosoma mansoni	goodpasture antigen-binding protein	0.0045	0.0242	0.0364
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.3067	0.4605
Trypanosoma cruzi	NIMA-related kinase, putative	0.0054	0.0362	0.0187
Brugia malayi	Cytohesin 3	0.0045	0.0242	0.0242
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0054	0.0362	0.0362
Echinococcus granulosus	protein kinase c iota type	0.0277	0.3318	0.4115
Onchocerca volvulus		0.0118	0.1212	1
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0045	0.0242	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0242	0.0242

Activities

Activity type	Assay description	Source	Reference
Activity (ADMET)	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	ChEMBL.	17291040
Activity (ADMET)	Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay	ChEMBL.	17291040
Activity (ADMET)	Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay	ChEMBL.	17291040

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 16215032

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 418391