TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 521.99 | Formula: C25H32ClN3O7
H donors: 3 H acceptors: 5 LogP: 0.98 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(=O)O.CCOc1cc(N(C)C)c(cc1C(=O)NCC1OCCN(C1)Cc1ccccc1)Cl
InChi: 1S/C23H30ClN3O3.C2H2O4/c1-4-29-22-13-21(26(2)3)20(24)12-19(22)23(28)25-14-18-16-27(10-11-30-18)15-17-8-6-5-7-9-17;3-1(4)2(5)6/h5-9,12-13,18H,4,10-11,14-16H2,1-3H3,(H,25,28);(H,3,4)(H,5,6)
InChiKey: IMXAZVRLMLHYLQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serotonin receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Schistosoma mansoni	lipoxygenase	0.0039	0.0209	0.0206
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0017	0.001	0.0009
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.1104	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.1104	1	1
Echinococcus granulosus	7tm_1 domain containing protein	0.1104	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0122	0.2928
Brugia malayi	Serotonin receptor	0.1104	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0239	0.1163
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0017	0.001	0.0009
Schistosoma mansoni	rab6-interacting	0.0039	0.0209	0.0206
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.0852	0.0852
Echinococcus granulosus	expressed conserved protein	0.0093	0.0703	0.0703
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0241	0.1173
Echinococcus granulosus	hypothetical protein	0.1104	1	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0411	0.4803
Echinococcus multilocularis	neuropeptides capa receptor	0.1104	1	1
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0296	0.0293
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1104	1	1
Brugia malayi	6-phosphofructokinase	0.0109	0.0852	0.0851
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0122	0.0589
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.1104	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0088	0.0078
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2028	0.2028
Onchocerca volvulus		0.1104	1	1
Echinococcus multilocularis	serotonin receptor	0.1104	1	1
Echinococcus multilocularis	somatostatin receptor	0.1104	1	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0758	0.8709
Loa Loa (eye worm)	heterochromatin protein 1	0.007	0.0493	0.0484
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Schistosoma mansoni	neuropeptide receptor	0.1104	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0433	0.0433
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0321	0.0318
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0122	0.2928
Echinococcus granulosus	G protein coupled receptor 139	0.1104	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0003	0.5
Echinococcus granulosus	neuropeptide receptor	0.1104	1	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.01	0.0772	0.077
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0017	0.001	0.0009
Brugia malayi	jmjC domain containing protein	0.0059	0.0393	0.0392
Brugia malayi	putative neuropeptide receptor	0.1104	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Brugia malayi	Serotonin receptor	0.1104	1	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0321	0.3745
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0321	0.3745
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0017	0.001	0.0009
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0411	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0393	0.0393
Echinococcus granulosus	fmrfamide receptor	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0017	0.001	0.0009
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0852	0.4187
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0321	0.1568
Echinococcus granulosus	CREB binding protein	0.0098	0.0754	0.0754
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0107	0.0511
Brugia malayi	Dopamine receptor	0.1104	1	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0321	0.0321
Echinococcus multilocularis	neuropeptide receptor	0.1104	1	1
Brugia malayi	Dopamine receptor protein 1	0.1104	1	1
Schistosoma mansoni	neuropeptide receptor	0.1104	1	1
Echinococcus multilocularis		0.0017	0.001	0.001
Brugia malayi	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	g protein coupled receptor	0.1104	1	1
Brugia malayi	Thioredoxin reductase	0.0047	0.0287	0.0285
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0109	0.0852	0.1119
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0179	0.0233
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0017	0.001	0.0079
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.0852	0.0852
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Leishmania major	cytochrome p450-like protein	0.0017	0.001	0.0079
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0017	0.001	0.0009
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0845	0.1116
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0411	0.0408
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0287	0.697
Echinococcus multilocularis	RUN	0.0039	0.0209	0.0209
Leishmania major	hypothetical protein, conserved	0.0025	0.0084	0.0956
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0017	0.001	0.0009
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2028	0.2028
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0209	0.0209
Brugia malayi	hypothetical protein	0.1104	1	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0239	0.0106
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0287	0.0287
Onchocerca volvulus		0.0039	0.0209	0.0076
Echinococcus multilocularis	Niemann Pick C1 protein	0.0141	0.1147	0.1147
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0017	0.001	0.0165
Echinococcus multilocularis	neuropeptide Y receptor	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0017	0.001	0.0009
Brugia malayi	Heterochromatin protein 1	0.007	0.0493	0.0492
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Plasmodium falciparum	glutathione reductase	0.0047	0.0287	1
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0852	0.085
Echinococcus multilocularis	g-protein coupled receptor	0.1104	1	1
Schistosoma mansoni	biogenic amine receptor	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0017	0.001	0.0009
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0017	0.001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0241	0.0232
Echinococcus granulosus	RUN	0.0039	0.0209	0.0209
Schistosoma mansoni	hypothetical protein	0.1104	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0321	0.1568
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0088	0.0086
Echinococcus granulosus	tumor protein p63	0.0338	0.2962	0.2962
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0211	0.0202
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0411	0.0541
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0393	0.0391
Schistosoma mansoni	hypothetical protein	0.0041	0.0227	0.0224
Echinococcus granulosus	neuropeptide s receptor	0.1104	1	1
Brugia malayi	AKH receptor	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Brugia malayi	Pre-SET motif family protein	0.003	0.0127	0.0125
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Brugia malayi	neuropeptide F receptor	0.1104	1	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.0852	0.1127
Brugia malayi	follicle stimulating hormone receptor	0.1104	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0017	0.001	0.0009
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0852	0.0844
Plasmodium falciparum	LCCL domain-containing protein	0.0039	0.0209	0.725
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0393	0.0384
Onchocerca volvulus		0.1104	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0039	0.0209	0.0209
Brugia malayi	hypothetical protein	0.1104	1	1
Mycobacterium tuberculosis	Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular	0.0036	0.0179	0.0233
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0433	0.057
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0122	0.4201
Echinococcus granulosus	g protein coupled receptor	0.1104	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0127	0.0124
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0084	0.0956
Mycobacterium tuberculosis	Probable conserved exported protein	0.0036	0.0179	0.0233
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0845	0.1116
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0127	0.0127
Schistosoma mansoni	cytochrome P450	0.0017	0.001	0.0007
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0493	0.2417
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0059	0.0393	0.0393
Trichomonas vaginalis	chromobox protein, putative	0.0042	0.0239	0.1163
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0003	0.0001
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0321	0.3745
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.1104	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0393	0.0391
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0017	0.001	0.0079
Echinococcus multilocularis	neuropeptide FF receptor 2	0.1104	1	1
Schistosoma mansoni	amine GPCR	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0003	0.5
Loa Loa (eye worm)	doublecortin family protein	0.0039	0.0209	0.02
Brugia malayi	phosphofructokinase	0.0109	0.0852	0.0851
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0241	0.0241
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.1104	1	1
Brugia malayi	RE15519p	0.1104	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0127	0.3037
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0179	0.0233
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0211	0.1028
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1104	1	1
Echinococcus multilocularis	chromobox protein 1	0.007	0.0493	0.0493
Brugia malayi	Pre-SET motif family protein	0.0208	0.1767	0.1766
Mycobacterium leprae	SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C)	0.0837	0.7544	1
Echinococcus granulosus	dro:myosuppressin receptor	0.1104	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Echinococcus multilocularis	chromobox protein 1	0.007	0.0493	0.0493
Schistosoma mansoni	hypothetical protein	0.1104	1	1
Brugia malayi	neuropeptide F receptor	0.1104	1	1
Mycobacterium tuberculosis	Possible conserved membrane protein	0.0036	0.0179	0.0233
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0127	0.0127
Schistosoma mansoni	CREB-binding protein 2	0.0098	0.0754	0.0752
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Trypanosoma brucei	protein kinase, putative	0.0051	0.0321	0.3745
Onchocerca volvulus		0.1104	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.1104	1	1
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0852	0.085
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Entamoeba histolytica	endo-1,4-beta-xylanase, putative	0.0036	0.0179	0.0774
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0098	0.0754	0.0752
Plasmodium vivax	SET domain protein, putative	0.003	0.0127	0.4358
Onchocerca volvulus		0.1104	1	1
Onchocerca volvulus		0.0039	0.0209	0.0076
Schistosoma mansoni	chromobox protein	0.007	0.0493	0.0491
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0017	0.001	0.0009
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.1104	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.1104	1	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.1104	1	1
Echinococcus granulosus	neuropeptide receptor	0.1104	1	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0003	0.0003
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0321	0.0321
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.1104	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0955	0.1263
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0017	0.001	0.0009
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0017	0.001	0.0009
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0017	0.001	0.0009
Loa Loa (eye worm)	G-protein coupled receptor	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0017	0.001	0.0009
Loa Loa (eye worm)	CYP4Cod1	0.0026	0.0088	0.0078
Mycobacterium ulcerans	secreted antigen 85-A FbpA	0.0036	0.0179	0.0233
Echinococcus granulosus	neuropeptides capa receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	esterase D	0.0036	0.0179	0.0169
Brugia malayi	hypothetical protein	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0017	0.001	0.0009
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0321	0.1568
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0017	0.001	0.0079
Echinococcus granulosus	g-protein coupled receptor	0.1104	1	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0411	0.0408
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0059	0.0393	0.0393
Echinococcus multilocularis	g protein coupled receptor	0.1104	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.0433	0.5059
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0134	0.0124
Echinococcus granulosus	g protein coupled receptor	0.1104	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0141	0.1147	0.1147
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0127	0.0127
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0321	0.3745
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0321	0.0312
Onchocerca volvulus		0.1104	1	1
Schistosoma mansoni	myosin xvIII	0.1104	1	1
Echinococcus granulosus	serotonin receptor	0.1104	1	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.0433	0.043
Echinococcus multilocularis	S formylglutathione hydrolase	0.0036	0.0179	0.0179
Trichomonas vaginalis	conserved hypothetical protein	0.0028	0.0107	0.0511
Echinococcus granulosus	neuropeptide Y receptor	0.1104	1	1
Echinococcus multilocularis	orexin receptor type 2	0.1104	1	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.1104	1	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0017	0.001	0.0009
Echinococcus multilocularis	neuropeptide receptor A26	0.1104	1	1
Onchocerca volvulus		0.0237	0.2032	0.1924
Brugia malayi	G-protein coupled receptor	0.1104	1	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0039	0.0209	0.0209
Brugia malayi	cytochrome P450	0.0017	0.001	0.0008
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.1104	1	1
Mycobacterium tuberculosis	Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	0.0036	0.0179	0.0233
Echinococcus granulosus	neuropeptides capa receptor	0.1104	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1104	1	1
Brugia malayi	glutathione reductase	0.0047	0.0287	0.0285
Brugia malayi	Dopamine receptor protein 2	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0017	0.001	0.0009
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0084	0.2855
Brugia malayi	Cytochrome P450 family protein	0.0054	0.0349	0.0348
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0026	0.0088	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0758	0.0749
Schistosoma mansoni	hypothetical protein	0.0041	0.0227	0.0224
Echinococcus granulosus	biogenic amine 5HT receptor	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0209	0.0209
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1104	1	1
Mycobacterium leprae	SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR	0.0036	0.0179	0.0225
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.1104	1	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0017	0.001	0.0079
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0017	0.001	0.0009
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0411	0.0541
Onchocerca volvulus		0.005	0.0307	0.0176
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0433	0.057
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0017	0.001	0.0009
Brugia malayi	larval opioid receptor	0.1104	1	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0852	0.4187
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0017	0.001	0.0009
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0758	0.0758
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0117	0.0117
Echinococcus granulosus	S formylglutathione hydrolase	0.0036	0.0179	0.0179
Echinococcus multilocularis	fmrfamide receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0433	0.0433
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.0852	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0017	0.001	0.0009
Echinococcus granulosus	sex peptide receptor	0.1104	1	1
Leishmania major	cytochrome p450-like protein	0.0017	0.001	0.0079
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	CREB binding protein	0.0061	0.0409	0.0409
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0127	0.0124
Schistosoma mansoni	chromobox protein	0.007	0.0493	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0209	0.02
Brugia malayi	Doublecortin family protein	0.0039	0.0209	0.0207
Echinococcus granulosus	7TM GPCR rhodopsin	0.1104	1	1
Brugia malayi	chromobox protein homolog 3	0.0039	0.0211	0.021
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0088	0.0997
Trichomonas vaginalis	chromobox protein, putative	0.007	0.0493	0.2417
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0287	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.1104	1	1
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0852	1
Echinococcus granulosus	chromobox protein 1	0.007	0.0493	0.0493
Echinococcus granulosus	orexin receptor type 2	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0307	0.0298
Schistosoma mansoni	hypothetical protein	0.0041	0.0227	0.0224
Brugia malayi	Esterase D	0.0036	0.0179	0.0177
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.1104	1	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.1104	1	1
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.0852	0.0844
Echinococcus multilocularis	g protein coupled receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0852	0.0844
Brugia malayi	hypothetical protein	0.0122	0.0972	0.0971
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0122	1
Echinococcus multilocularis	neuropeptides capa receptor	0.1104	1	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0017	0.001	0.0009
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	fmrfamide receptor	0.1104	1	1
Leishmania major	trypanothione reductase	0.0047	0.0287	0.3347
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0017	0.001	0.0079
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0703	0.0703
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0122	0.4201
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0179	0.0233
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0852	1
Brugia malayi	hypothetical protein	0.0237	0.2028	0.2027
Leishmania major	cytochrome p450-like protein	0.0026	0.0088	0.0997
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0241	0.0232
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0852	1
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0017	0.001	0.0009
Echinococcus granulosus	g protein coupled receptor	0.1104	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.1104	1	1
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0287	0.0278
Echinococcus granulosus	cytochrome P450 2K1	0.0017	0.001	0.001
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0017	0.001	0.0009
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0029	0.0122	1
Brugia malayi	hypothetical protein	0.0025	0.0084	0.0082
Loa Loa (eye worm)	cytochrome P450 family protein	0.0054	0.0349	0.034
Echinococcus multilocularis	protein patched	0.0042	0.0241	0.0241
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0029	0.0122	0.1406
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0276	0.0266
Echinococcus multilocularis	neuropeptide Y receptor	0.1104	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.1104	1	1
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0122	0.2928
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0287	1
Brugia malayi	hypothetical protein	0.1104	1	1
Schistosoma mansoni	amine GPCR	0.1104	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Mycobacterium ulcerans	secreted antigen 85-C FbpC	0.0837	0.7544	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0955	0.1263
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0209	0.02
Echinococcus granulosus	Polycystic kidney disease protein	0.0039	0.0209	0.0209
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2028	0.2021
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0084	0.2855
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0955	0.1263
Mycobacterium ulcerans	secreted Mpt51/Mpb51 antigen protein FbpD	0.0036	0.0179	0.0233
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.1104	1	1
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0296	0.0296
Schistosoma mansoni	patched 1	0.0042	0.0241	0.0238
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0845	0.1108
Onchocerca volvulus		0.1104	1	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0955	0.1255
Schistosoma mansoni	amine GPCR	0.1104	1	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.1104	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0026	0.0088	0.0997
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.1104	1	1
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0321	0.3745
Schistosoma mansoni	loxhd1	0.0039	0.0209	0.0206
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0084	0.0956
Schistosoma mansoni	biogenic amine receptor	0.1104	1	1
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0321	0.0321
Brugia malayi	hypothetical protein	0.0039	0.0209	0.0207
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0852	0.4187
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0084	0.199
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.1104	1	1
Brugia malayi	hypothetical protein	0.1104	1	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0211	0.0079
Schistosoma mansoni	lipoxygenase	0.0109	0.0852	0.0849
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1104	1	1
Schistosoma mansoni	opsin-like receptor	0.1104	1	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0845	0.1116
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0039	0.0209	0.0209
Onchocerca volvulus		0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.1104	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.1104	1	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0321	0.0321
Schistosoma mansoni	histamine h1 receptor	0.1104	1	1
Schistosoma mansoni	hypothetical protein	0.1104	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.001	0.0007
Echinococcus granulosus	peptide allatostatin:somatostatin	0.1104	1	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0122	0.4201
Schistosoma mansoni	neuropeptide receptor	0.1104	1	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0321	0.7797
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0017	0.001	0.0009
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0003	0.0003
Echinococcus multilocularis	lysine specific demethylase 5A	0.0059	0.0393	0.0393
Brugia malayi	MAP kinase sur-1	0.0051	0.0321	0.0319
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0017	0.001	0.0009
Loa Loa (eye worm)	G-protein coupled receptor	0.1104	1	1
Trypanosoma brucei	trypanothione reductase	0.0047	0.0287	0.3347
Echinococcus multilocularis	sex peptide receptor	0.1104	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0017	0.001	0.0009
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0845	0.1116
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Schistosoma mansoni	polycystin 1-related	0.0039	0.0209	0.0206
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0017	0.001	0.0009
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0127	0.0124
Schistosoma mansoni	growth hormone secretagogue receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.2772	0.2765
Echinococcus multilocularis	tumor protein p63	0.0338	0.2962	0.2962
Mycobacterium leprae	Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A)	0.0036	0.0179	0.0225
Schistosoma mansoni	alpha-1 adrenergic receptor	0.1104	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0812	0.7315	0.7315
Loa Loa (eye worm)	melatonin receptor type 1A	0.1104	1	1
Onchocerca volvulus		0.1104	1	1
Brugia malayi	Cytochrome P450 family protein	0.0017	0.001	0.0008
Brugia malayi	GnHR receptor homolog	0.1104	1	1
Brugia malayi	6-phosphofructokinase	0.0109	0.0852	0.0851
Brugia malayi	hypothetical protein	0.1104	1	1
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0321	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1104	1	1
Brugia malayi	hypothetical protein	0.1104	1	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0122	0.4201
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0307	0.0304
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0287	0.0278
Echinococcus granulosus	neuropeptide receptor A26	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Brugia malayi	hypothetical protein	0.0039	0.0209	0.0207
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.0852	0.1127
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0287	0.3347
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0296	0.0294
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0109	0.0852	0.0852
Schistosoma mansoni	opsin-like receptor	0.1104	1	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0758	0.0756
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0017	0.001	0.0009
Echinococcus granulosus	allatostatin A receptor	0.1104	1	1
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0088	0.0086
Brugia malayi	hypothetical protein	0.1104	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0041	0.0232	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0328	0.0319
Onchocerca volvulus		0.0041	0.0232	0.0099
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0321	0.3745
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.0433	0.0431
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0287	0.0377
Echinococcus multilocularis	G protein coupled receptor 139	0.1104	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0411	0.0411
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1104	1	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0411	0.0541
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0084	0.2855
Brugia malayi	Melatonin receptor type 1A	0.1104	1	1
Schistosoma mansoni	jumonji domain containing protein	0.0059	0.0393	0.0391
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.1104	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0411	0.0541
Brugia malayi	sulfakinin receptor protein	0.1104	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.1104	1	1
Echinococcus multilocularis	allatostatin A receptor	0.1104	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.1104	1	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.1104	1	1
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0017	0.001	0.0009
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0179	0.0233
Schistosoma mansoni	adenoreceptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0127	0.0117
Brugia malayi	G-protein coupled receptor	0.1104	1	1
Schistosoma mansoni	hypothetical protein	0.1104	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0321	0.3745
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0852	1
Schistosoma mansoni	amine GPCR	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0017	0.001	0.0009
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0017	0.001	0.0009
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0852	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.1104	1	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0296	0.0293
Echinococcus granulosus	somatostatin receptor	0.1104	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0433	0.057
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.1104	1	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0845	0.1116
Echinococcus granulosus	tachykinin peptides receptor 99D	0.1104	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0211	0.1028
Schistosoma mansoni	hypothetical protein	0.0039	0.0209	0.0206
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.1104	1	1
Onchocerca volvulus		0.0048	0.0296	0.0164
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0017	0.001	0.0009
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0017	0.001	0.0009
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0122	0.0589
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0084	0.0075
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0852	0.4187
Onchocerca volvulus		0.1104	1	1
Brugia malayi	G protein-coupled receptor	0.1104	1	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0179	0.0233
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0109	0.0852	0.0852
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.1104	1	1
Trypanosoma brucei	cytochrome P450, putative	0.0026	0.0088	0.0997
Mycobacterium tuberculosis	Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind	0.0036	0.0179	0.0233
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.1767	0.176
Mycobacterium tuberculosis	Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C)	0.0837	0.7544	1
Echinococcus multilocularis	CREB binding protein	0.0067	0.0471	0.0471
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.1104	1	1
Schistosoma mansoni	rab6-interacting	0.0039	0.0209	0.0206
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Echinococcus granulosus	chromobox protein 1	0.007	0.0493	0.0493
Schistosoma mansoni	biogenic amine receptor	0.1104	1	1
Schistosoma mansoni	amine GPCR	0.1104	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Brugia malayi	jmjC domain containing protein	0.0059	0.0393	0.0392
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0029	0.0122	0.3755
Onchocerca volvulus		0.1104	1	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1104	1	1
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0017	0.001	0.0009
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Brugia malayi	TAZ zinc finger family protein	0.0098	0.0754	0.0753
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0017	0.001	0.0009
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0241	0.0241
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.1104	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.1104	1	1
Brugia malayi	CHE-14 protein	0.0042	0.0241	0.0239
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0017	0.001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.1104	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.1104	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0321	0.1568
Trichomonas vaginalis	set domain proteins, putative	0.0237	0.2032	1
Brugia malayi	ORL1-like opioid receptor	0.1104	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0084	0.0956
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0328	0.0319
Brugia malayi	putative neuropeptide receptor NPR1	0.1104	1	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.1104	1	1
Schistosoma mansoni	opsin-like receptor	0.1104	1	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.1104	1	1
Echinococcus multilocularis	neuropeptide receptor	0.1104	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0758	0.0758
Schistosoma mansoni	neuropeptide receptor	0.1104	1	1
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0036	0.0179	0.0233
Loa Loa (eye worm)	neuropeptide F receptor	0.1104	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0227	0.0224
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0287	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0411	0.0411
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0088	0.0078
Onchocerca volvulus		0.1104	1	1
Mycobacterium ulcerans	secreted antigen 85-B FbpB	0.0036	0.0179	0.0233
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0845	0.1116
Loa Loa (eye worm)	CBP-B	0.0068	0.0479	0.047
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0017	0.001	0.0009
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.0852	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0039	0.0209	0.725

Activities

Activity type	Activity value	Assay description	Source	Reference
GE (functional)	= 51 %	Evaluated for the effects on the gastric emptying rates of phenol red semisolid meal through the stomach in rats, at a dose of 2.0 mg/Kg administered perorally.	ChEMBL.	2139471

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 41842