Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.1222 | 0.0237 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0367 | 0.7365 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0255 | 0.4521 | 0.6094 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0367 | 0.7365 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0367 | 0.7365 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0255 | 0.4521 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0215 | 0.3498 | 0.4721 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.025 | 0.4393 | 0.5965 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0255 | 0.4521 | 0.6118 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0184 | 0.27 | 0.427 |
Leishmania major | hypothetical protein, conserved | 0.0078 | 0 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0152 | 0.1886 | 0.2519 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0239 | 0.4113 | 0.4113 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0241 | 0.4162 | 0.4137 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0185 | 0.2742 | 0.3724 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0215 | 0.3498 | 0.4689 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0239 | 0.4113 | 0.5585 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0465 | 0.9872 | 1 |
Giardia lamblia | Methyltransferase like 2 | 0.0078 | 0 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0255 | 0.4521 | 0.6094 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0255 | 0.4521 | 0.6139 |
Brugia malayi | AMP-binding enzyme family protein | 0.0241 | 0.4162 | 0.4162 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0239 | 0.4113 | 0.556 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0239 | 0.4101 | 1 |
Onchocerca volvulus | 0.0449 | 0.9463 | 0.9285 | |
Brugia malayi | AMP-binding enzyme family protein | 0.0079 | 0.0041 | 0.0041 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0189 | 0.2828 | 0.3806 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0152 | 0.1886 | 0.2519 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0215 | 0.3498 | 0.475 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0147 | 0.1757 | 0.2386 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0152 | 0.1886 | 0.2474 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0193 | 0.2928 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0367 | 0.7365 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0189 | 0.2828 | 0.3806 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0239 | 0.4113 | 0.5533 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0079 | 0.0041 | 0.0055 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0189 | 0.2828 | 0.3769 |
Loa Loa (eye worm) | fatty acid synthase | 0.0255 | 0.4507 | 0.4594 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.8583 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0239 | 0.4113 | 0.556 |
Mycobacterium ulcerans | polyketide synthase | 0.0255 | 0.4521 | 0.6118 |
Mycobacterium ulcerans | polyketide synthase | 0.0239 | 0.4113 | 0.556 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0255 | 0.4521 | 0.6094 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0255 | 0.4521 | 0.6139 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0239 | 0.4113 | 0.556 |
Mycobacterium ulcerans | thioesterase | 0.0215 | 0.3498 | 0.4721 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0081 | 0.0085 | 0.006 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0255 | 0.4521 | 0.6139 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.017 | 0.2355 | 0.5682 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0239 | 0.4113 | 0.556 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0239 | 0.4113 | 0.5585 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0081 | 0.0085 | 0.0115 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0104 | 0.0678 | 0.0921 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.025 | 0.4393 | 0.5965 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0159 | 0.2062 | 0.4956 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0239 | 0.4101 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0241 | 0.4162 | 0.5652 |
Echinococcus granulosus | nmda type glutamate receptor | 0.017 | 0.2355 | 0.1439 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0239 | 0.4113 | 0.5585 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0239 | 0.4113 | 0.5533 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0255 | 0.4521 | 0.6118 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0192 | 0.2915 | 0.3958 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0167 | 0.2285 | 0.2964 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (ADMET) | = 12.2 uM | Cytotoxicity against plated MRC5 cells by neutral red uptake assay | ChEMBL. | 17130297 |
CC50 (ADMET) | = 12.2 uM | Cytotoxicity against human MRC5 cells by neutral red uptake assay | ChEMBL. | 17166725 |
CC50 (ADMET) | = 12.2 uM | Cytotoxicity against plated MRC5 cells by neutral red uptake assay | ChEMBL. | 17130297 |
CC50 (ADMET) | = 12.2 uM | Cytotoxicity against human MRC5 cells by neutral red uptake assay | ChEMBL. | 17166725 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against HFF cells by neutral red uptake assay | ChEMBL. | 17130297 |
CC50 (ADMET) | > 100 uM | Cytotoxicity against HFF cells by neutral red uptake assay | ChEMBL. | 17130297 |
CC50 (ADMET) | = 929 uM | Cytotoxicity against Huh7 cells | ChEMBL. | 17130297 |
CC50 (ADMET) | > 1000 uM | Cytotoxicity against HepG2 2.2.15 cells assessed as inhibition of uptake of neutral red dye after 24 hrs | ChEMBL. | 17130297 |
EC50 (functional) | = 1.8 uM | Antiviral activity against HCMV AD169 in HFF cells by plaque reduction assay | ChEMBL. | 17130297 |
EC50 (functional) | = 2.4 uM | Antiviral activity against HBV in HepG2 2.2.15 cells after 24 hrs by DNA reduction assay | ChEMBL. | 17130297 |
EC50 (functional) | = 5.8 uM | Antiviral activity against HSV1 in MRC5 cells by DNA reduction assay | ChEMBL. | 17130297 |
EC50 (functional) | = 5.8 uM | Antiviral activity against HSV1 in MRC5 cells after 20 to 24 hrs by DNA reduction assay | ChEMBL. | 17166725 |
EC50 (functional) | = 6.3 uM | Antiviral activity against HBV with adenofir-resistant polymerase N236T mutant in Huh7 cells after 5 days | ChEMBL. | 17130297 |
EC50 (functional) | = 7.5 uM | Antiviral activity against Vaccinia virus Copenhagen in HFF cells by plaque reduction assay | ChEMBL. | 17130297 |
EC50 (functional) | = 8.8 uM | Antiviral activity against wild type HBV in Huh7 cells after 5 days | ChEMBL. | 17130297 |
EC50 (functional) | = 11 uM | Antiviral activity against Cowpox virus Brighton in HFF cells by plaque reduction assay | ChEMBL. | 17130297 |
EC50 (functional) | = 12.2 uM | Antiviral activity against VZV Ellen in HFF cell by CPE assay | ChEMBL. | 17130297 |
EC50 (functional) | = 13 uM | Antiviral activity against HBV with lamivudine-resistant polymerase M204I mutant in Huh7 cells after 5 days | ChEMBL. | 17130297 |
EC50 (functional) | = 16 uM | Antiviral activity against HBV with lamivudine-resistant polymerase M204V mutant in Huh7 cells after 5 days | ChEMBL. | 17130297 |
EC50 (functional) | = 48 uM | Antiviral activity against EBV in Daudi cells by ELISA | ChEMBL. | 17130297 |
EC50 (functional) | > 100 uM | Antiviral activity against HBV with lamivudine-resistant polymerase L180M mutant in Huh7 cells after 5 days | ChEMBL. | 17130297 |
EC50 (functional) | > 100 uM | Antiviral activity against HBV with lamivudine-resistant polymerase L180M/M204V double mutant in Huh7 cells after 5 days | ChEMBL. | 17130297 |
Ratio CC50/EC50 (functional) | > 417 | Selectivity index, ratio of CC50 for HepG2 2.2.15 cells to EC50 for HBV | ChEMBL. | 17130297 |
Selectivity index (functional) | = 2.1 | Specificity index, Ratio of CC50 for MCR5 cells to EC50 for HSV1 | ChEMBL. | 17166725 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.