Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth hormone secretagogue receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | growth hormone secretagogue receptor | 289 aa | 243 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0013 | 0.5 | 0.5 | |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0013 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0013 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0013 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0013 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -55 % | Stimulation of cumulative food intake in Sprague-Dawley rat at 160 ug/kg, sc at 6 hrs relative to 80 ug/kg hexarelin | ChEMBL. | 17375904 |
Activity (functional) | = 16 % | Activity at human GHS1a receptor expressed in CHO cells assessed as intracellular calcium mobilization relative to 0.1 uM ghrelin | ChEMBL. | 17375904 |
Activity (functional) | = 16 % | Activity at human GHS1a receptor expressed in CHO cells assessed as intracellular calcium mobilization relative to 0.1 uM ghrelin | ChEMBL. | 17375904 |
Activity (functional) | = 0.74 g | Stimulation of cumulative food intake per 100 g body weight in Sprague-Dawley rat at 160 ug/kg, sc at 6 hrs | ChEMBL. | 17375904 |
EC50 (functional) | = 12 nM | Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization | ChEMBL. | 17375904 |
EC50 (functional) | = 12 nM | Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization | ChEMBL. | 17375904 |
IC50 (binding) | = 21 nM | Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells | ChEMBL. | 17375904 |
IC50 (binding) | = 21 nM | Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells | ChEMBL. | 17375904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.