Detailed information for compound 418734

Basic information

Technical information
  • TDR Targets ID: 418734
  • Name: (2S)-2-[[(1R,4S,7S,10R,13S,16R)-16-[[(2S)-2-a mino-4-hydroxy-4-oxobutanoyl]amino]-7-(3-amin opropyl)-13-benzyl-4-[(4-hydroxyphenyl)methyl ]-10-(1H-indol-3-ylmethyl)-17,17-dimethyl-3,6 ,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pe ntazacycloicosane-1-carbonyl]amino]-3-methylb utanoic acid
  • MW: 1075.26 | Formula: C51H66N10O12S2
  • H donors: 13 H acceptors: 12 LogP: -2.67 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCC[C@@H]1NC(=O)[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)C(SSC[C@H](NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)O)C(C)C)(C)C)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C51H66N10O12S2/c1-27(2)41(50(72)73)60-48(70)39-26-74-75-51(3,4)42(61-43(65)33(53)24-40(63)64)49(71)58-37(21-28-11-6-5-7-12-28)45(67)57-38(23-30-25-54-34-14-9-8-13-32(30)34)47(69)55-35(15-10-20-52)44(66)56-36(46(68)59-39)22-29-16-18-31(62)19-17-29/h5-9,11-14,16-19,25,27,33,35-39,41-42,54,62H,10,15,20-24,26,52-53H2,1-4H3,(H,55,69)(H,56,66)(H,57,67)(H,58,71)(H,59,68)(H,60,70)(H,61,65)(H,63,64)(H,72,73)/t33-,35-,36-,37-,38+,39-,41-,42+/m0/s1
  • InChiKey: VXLUBANOZQJZFE-MSYIYWSESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[(1R,4S,7S,10R,13S,16R)-16-[[(2S)-2-amino-4-hydroxy-4-oxo-butanoyl]amino]-7-(3-aminopropyl)-13-benzyl-4-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-17,17-dimethyl-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]amino]-3-methyl-butanoic acid
  • (2S)-2-[[[(1R,4S,7S,10R,13S,16R)-16-[[(2S)-2-amino-4-hydroxy-1,4-dioxobutyl]amino]-7-(3-aminopropyl)-13-benzyl-4-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-17,17-dimethyl-3,6,9,12,15-pentaoxo-18,19-dithia-2,5,8,11,14-pentazacycloicos-1-yl]-oxomethyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(1R,4S,7S,10R,13S,16R)-16-[[(2S)-2-azanyl-4-hydroxy-4-oxo-butanoyl]amino]-7-(3-azanylpropyl)-4-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-17,17-dimethyl-3,6,9,12,15-pentaoxo-13-(phenylmethyl)-18,19-dithia-2,5,8,11,14-pentazacycloicos-1-yl]carbonylamino]-3-methyl-butanoic acid
  • (2S)-2-[[(1R,4S,7S,10R,13S,16R)-16-[[(2S)-2-amino-4-hydroxy-4-keto-butanoyl]amino]-7-(3-aminopropyl)-13-benzyl-4-(4-hydroxybenzyl)-10-(1H-indol-3-ylmethyl)-3,6,9,12,15-pentaketo-17,17-dimethyl-18,19-dithia-2,5,8,11,14-pentazacycloicosane-1-carbonyl]amino]-3-methyl-butyric acid
  • (2S)-2-[[(4R,7S,10S,13R,16S,19R)-19-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-10-(3-aminopropyl)-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-16-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(4R,7S,10S,13R,16S,19R)-19-[[(2S)-2-amino-4-hydroxy-4-oxo-butanoyl]amino]-10-(3-aminopropyl)-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-16-(phenylmethyl)1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methyl-butanoic acid
  • (2S)-2-[[[(4R,7S,10S,13R,16S,19R)-19-[[(2S)-2-amino-4-hydroxy-1,4-dioxobutyl]amino]-10-(3-aminopropyl)-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicos-4-yl]-oxomethyl]amino]-3-methylbutanoic acid
  • (2S)-2-[[(4R,7S,10S,13R,16S,19R)-19-[[(2S)-2-amino-4-hydroxy-4-keto-butanoyl]amino]-10-(3-aminopropyl)-16-(benzyl)-7-(4-hydroxybenzyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaketo-20,20-dimethyl-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methyl-butyric acid
  • (2S)-2-[[(4R,7S,10S,13R,16S,19R)-19-[[(2S)-2-amino-4-hydroxy-4-oxo-butanoyl]amino]-10-(3-aminopropyl)-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentazacycloicos-4-yl]carbonylamino]-3-methyl-butanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens urotensin 2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi Dopamine receptor protein 2 0.0046 0.015 0.06
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0105 0.1457
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0218 0.0342
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) calpain family protein 1 0.0179 0.0756 0.3016
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0072 0.0441
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0151 0.0599
Brugia malayi steroid hormone receptor 0.0028 0.0072 0.0285
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0075
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.007
Giardia lamblia Kinase, PLK 0.0095 0.0376 0.4696
Onchocerca volvulus 0.0248 0.1066 0.6677
Echinococcus multilocularis muscleblind protein 0.0306 0.1328 0.1327
Echinococcus granulosus neuropeptide receptor 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Echinococcus multilocularis neuropeptide s receptor 0.0046 0.015 0.0149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0017 0.002 0.0075
Echinococcus granulosus 7TM GPCR rhodopsin 0.0046 0.015 0.0149
Echinococcus granulosus calpain 0.0068 0.025 0.0249
Echinococcus granulosus calpain A 0.0068 0.025 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Toxoplasma gondii cathepsin B 0.0187 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Brugia malayi cathepsin L-like precursor 0.0017 0.002 0.008
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0193 0.2791
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0277 0.0276
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0011 0.0039
Schistosoma mansoni hypothetical protein 0.0074 0.0277 0.0435
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0126
Echinococcus multilocularis snurportin 1 0.0321 0.1398 0.1397
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0055 0.0193 0.2661
Brugia malayi cathepsin L precursor 0.0017 0.002 0.008
Loa Loa (eye worm) glutathione reductase 0.0049 0.0167 0.0662
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0046 0.015 0.0235
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.015 0.0235
Trypanosoma brucei cysteine peptidase C (CPC) 0.0187 0.0788 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.015 0.0149
Plasmodium falciparum serine repeat antigen 1 0.0017 0.002 0.0167
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0025 0.0023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Leishmania major calpain family cysteine protease-like protein 0.002 0.0035 0.0338
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0009 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0019 0.0071
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Onchocerca volvulus 0.0015 0.0009 0.0049
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Echinococcus multilocularis sex peptide receptor 0.0046 0.015 0.0149
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0072 0.007
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0021 0.0149
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0011 0.0043
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.016 0.0668 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0105 0.0419 0.0417
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi hypothetical protein 0.0018 0.0025 0.0098
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0143 0.0142
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Entamoeba histolytica calpain family cysteine protease, putative 0.002 0.0035 0.0839
Echinococcus multilocularis muscleblind protein 1 0.0306 0.1328 0.1327
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0259 0.1033
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0046 0.015 0.0149
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1802 0.1801
Toxoplasma gondii cathepsin CPC2 0.0017 0.002 0.0141
Trypanosoma cruzi major cysteine proteinase, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Plasmodium falciparum serine repeat antigen 2 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Onchocerca volvulus 0.0046 0.015 0.0935
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0013 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0072 0.0111
Echinococcus granulosus 7tm_1 domain containing protein 0.0046 0.015 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi follicle stimulating hormone receptor 0.0046 0.015 0.06
Brugia malayi hypothetical protein 0.0015 0.0011 0.0043
Schistosoma mansoni peptidase Clp (S14 family) 0.016 0.0668 0.1052
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0021 0.0149
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0285
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Loa Loa (eye worm) fibroinase 0.0017 0.002 0.0075
Echinococcus multilocularis cpg binding protein 0.003 0.0081 0.008
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi nuclear receptor NHR-67 0.0013 0.0004 0.0014
Trichomonas vaginalis kakapo, putative 0.0015 0.001 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Brugia malayi Smad1 0.0017 0.0019 0.0075
Schistosoma mansoni pyruvate kinase 0.007 0.0259 0.0406
Schistosoma mansoni cpg binding protein 0.0029 0.0074 0.0114
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.002 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0149
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.016 0.0668 1
Schistosoma mansoni neuropeptide F-like receptor 0.0046 0.015 0.0235
Echinococcus multilocularis Smad4 0.0017 0.0019 0.0018
Brugia malayi Muscleblind-like protein 0.0306 0.1328 0.5306
Brugia malayi Importin beta-1 subunit 0.003 0.008 0.0317
Echinococcus multilocularis neuropeptide receptor A26 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Leishmania major hypothetical protein, conserved 0.002 0.0035 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0211 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0151 0.0603
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus multilocularis caspase 3 0.0076 0.0287 0.0286
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0187 0.0788 0.3145
Onchocerca volvulus 0.0015 0.001 0.0057
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.051 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.051 1
Schistosoma mansoni kinase 0.0049 0.0163 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis somatostatin receptor 0.0046 0.015 0.0149
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0668 0.8463
Trypanosoma brucei metacaspase MCA2 0.0046 0.0152 0.1839
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Toxoplasma gondii calcium binding protein precursor, putative 0.0015 0.001 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.001 0.0038
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0105 0.1457
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.015 0.0149
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0009 0.0179
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0046 0.015 0.0149
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0218 0.0342
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Onchocerca volvulus 0.0112 0.0449 0.2811
Entamoeba histolytica protein kinase, putative 0.0048 0.0159 0.3874
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0025 0.0037
Onchocerca volvulus 0.0017 0.002 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.008 0.0905
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0039 0.0154
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.015 0.0149
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0011 0.0015
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0009 0.0179
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0004 0.0014
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.3775 0.3775
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0453 0.6735
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.015 0.0596
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0004 0.0014
Schistosoma mansoni adenoreceptor 0.0046 0.015 0.0235
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Leishmania major trypanothione reductase 0.0049 0.0167 0.2024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0103 0.0409 0.1628
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0105 0.1233
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0111 0.139
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Schistosoma mansoni hypothetical protein 0.0043 0.0138 0.0216
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi hypothetical protein 0.0018 0.0025 0.0098
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Loa Loa (eye worm) calpain 0.0068 0.025 0.0994
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0169
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0072 0.007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.007
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0009 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0167 0.0668
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0075
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0072 0.0285
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0017 0.002 0.0167
Echinococcus multilocularis g-protein coupled receptor 0.0046 0.015 0.0149
Trypanosoma brucei antigen, putative 0.0068 0.025 0.3091
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0072 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi jmjC domain containing protein 0.0059 0.0211 0.0841
Brugia malayi regulator of G-protein signaling egl-10 0.0018 0.0025 0.0098
Onchocerca volvulus 0.0013 0.0004 0.0016
Trypanosoma cruzi kinesin, putative 0.0047 0.0158 0.0625
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Brugia malayi MH2 domain containing protein 0.0245 0.1054 0.421
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0075
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0017 0.002 0.0167
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0072 0.0111
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Brugia malayi nuclear hormone receptor 0.0013 0.0004 0.0014
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0044 0.0443
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus multilocularis neuropeptides capa receptor 0.0046 0.015 0.0149
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0046 0.015 0.0149
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Leishmania major calpain protease-like protein 0.002 0.0035 0.0338
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0046 0.015 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0285
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus granulosus somatostatin receptor 0.0046 0.015 0.0149
Echinococcus multilocularis programmed cell death protein 6 0.0015 0.001 0.0009
Onchocerca volvulus Cell death protein 3 homolog 0.0089 0.0347 0.2169
Schistosoma mansoni ran 0.0022 0.0044 0.0067
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0009 0.0031
Onchocerca volvulus 0.0043 0.0138 0.0858
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0004 0.0003
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1398 0.5584
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Trypanosoma brucei calpain, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0111 0.2172
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0565 0.2503 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0025 0.0023
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Brugia malayi Cell death protein 3 precursor 0.0089 0.0347 0.1386
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0152 0.0604
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Brugia malayi glutathione reductase 0.0049 0.0167 0.0666
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Echinococcus granulosus pyruvate kinase 0.007 0.0259 0.0257
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0285
Trichomonas vaginalis calmodulin, putative 0.0015 0.001 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis neuropeptide FF receptor 2 0.0046 0.015 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Onchocerca volvulus 0.0028 0.0072 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0214 0.3115
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0021 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Echinococcus granulosus serotonin receptor 0.0046 0.015 0.0149
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0021 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0054 0.021
Echinococcus granulosus cathepsin L 0.0017 0.002 0.0019
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0009 0.0179
Onchocerca volvulus 0.0017 0.002 0.0118
Entamoeba histolytica hypothetical protein 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi AKH receptor 0.0046 0.015 0.06
Schistosoma mansoni myosin xvIII 0.0046 0.015 0.0235
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.015 0.0596
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0214 0.2636
Brugia malayi Thioredoxin reductase 0.0049 0.0167 0.0666
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0218 0.0217
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.1054 0.4207
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi calpain 7 0.0068 0.025 0.0997
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0018 0.0025 0.0146
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0376 0.0374
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Plasmodium falciparum serine repeat antigen 3 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0259 0.3203
Brugia malayi DIX domain containing protein 0.0018 0.0025 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0285
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0167 0.3283
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.0019
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0167 0.3283
Trypanosoma cruzi centrin, putative 0.0023 0.0047 0.0183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0453 0.8885
Trichomonas vaginalis calmodulin, putative 0.0023 0.0047 0.043
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0319 0.7791
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0019 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0285
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.0019
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Echinococcus granulosus neuropeptide FF receptor 2 0.0046 0.015 0.0149
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0004 0.001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0035 0.0137
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0035 0.0338
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Leishmania major pyruvate kinase 0.007 0.0259 0.3203
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Echinococcus granulosus cathepsin b 0.0565 0.2503 0.2502
Echinococcus multilocularis pyruvate kinase 0.0055 0.0192 0.0191
Echinococcus granulosus pyruvate kinase 0.007 0.0259 0.0257
Mycobacterium ulcerans hypothetical protein 0.0049 0.0167 0.2401
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0075
Schistosoma mansoni cathepsin C 0.0017 0.002 0.003
Brugia malayi conserved hypotetical protein 0.0013 0.0004 0.0014
Plasmodium vivax vivapain-3 0.0017 0.002 0.0167
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0046 0.015 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Loa Loa (eye worm) neuropeptide F receptor 0.0046 0.015 0.0596
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0376 0.1496
Schistosoma mansoni calpain-2 (C02 family) 0.002 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0158 0.0657 0.2623
Brugia malayi ecdysteroid receptor 0.0028 0.0072 0.0285
Onchocerca volvulus 0.0158 0.0657 0.4117
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0111 0.1542
Plasmodium falciparum thioredoxin reductase 0.0017 0.0021 0.0177
Echinococcus granulosus tachykinin peptides receptor 99D 0.0046 0.015 0.0149
Brugia malayi N-terminal motif family protein 0.0013 0.0001 0.0004
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.015 0.0149
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0167
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0004 0.0003
Onchocerca volvulus 0.0015 0.0009 0.0049
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0046 0.015 0.0149
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.0021
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0143 0.0142
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0167 0.2032
Echinococcus multilocularis neuropeptide Y receptor 0.0046 0.015 0.0149
Entamoeba histolytica grainin 2 0.0023 0.0047 0.1125
Echinococcus multilocularis neuropeptide receptor 0.0046 0.015 0.0149
Leishmania major kinesin, putative 0.0047 0.0158 0.1908
Loa Loa (eye worm) pyruvate kinase-PB 0.0049 0.0163 0.0647
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0015 0.001 0.0057
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.002 0.0019
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0072 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0187 0.0788 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0105 0.0419 0.6211
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0072 0.0111
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0167 0.0662
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0046 0.0152 0.1839
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0017 0.002 0.0167
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0072 0.0285
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0214 0.0856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0046 0.015 0.0235
Leishmania major cysteine peptidase A (CPA) 0.0017 0.002 0.0141
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0025 0.0023
Echinococcus granulosus importin subunit beta 1 0.003 0.008 0.0078
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0072 0.0111
Trypanosoma brucei trypanothione reductase 0.0049 0.0167 0.2024
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0167 0.4079
Trypanosoma brucei Metacaspase-4 0.0046 0.0152 0.1839
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0013
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0017 0.002 0.0075
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.002 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0167 0.3271
Plasmodium falciparum centrin-4 0.0015 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0259 0.1029
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0017 0.002 0.0167
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0565 0.2503 1
Schistosoma mansoni coup transcription factor 0.0028 0.0072 0.0111
Brugia malayi hypothetical protein 0.0015 0.0011 0.0043
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0046 0.015 0.06
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.015 0.0149
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.008 0.0905
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0072 0.0285
Brugia malayi larval opioid receptor 0.0046 0.015 0.06
Chlamydia trachomatis pyruvate kinase 0.007 0.0259 0.3673
Trypanosoma brucei hypothetical protein 0.002 0.0035 0.0338
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0122 0.0496 0.0495
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Loa Loa (eye worm) calpain D 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.1248
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Echinococcus multilocularis pyruvate kinase 0.007 0.0259 0.0257
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0214 0.0213
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0259 0.1029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0453 0.8885
Trypanosoma brucei Calpain-like protein 1.1 0.002 0.0035 0.0338
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0072 0.0111
Plasmodium falciparum calpain 0.002 0.0035 0.04
Entamoeba histolytica hypothetical protein 0.0074 0.0277 0.6765
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0004 0.0003
Echinococcus multilocularis neuropeptide receptor 0.0046 0.015 0.0149
Echinococcus multilocularis serotonin receptor 0.0046 0.015 0.0149
Schistosoma mansoni Smad4 0.0017 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0365 0.1595 0.6372
Trichomonas vaginalis calcium binding protein, putative 0.0015 0.001 0.0085
Brugia malayi nuclear receptor NHR-88 0.0013 0.0004 0.0014
Echinococcus multilocularis G-protein coupled receptor, putative 0.0046 0.015 0.0149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Onchocerca volvulus 0.0019 0.0027 0.0164
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0072 0.0441
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0017 0.002 0.0167
Onchocerca volvulus 0.0029 0.0074 0.0455
Schistosoma mansoni Mername-AA248 (C02 family) 0.0068 0.025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trypanosoma brucei polo-like protein kinase 0.0095 0.0376 0.4704
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0409 0.1632
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0218 0.0866
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0017 0.002 0.0177
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0149
Brugia malayi nuclear receptor RXR 0.0013 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0214 0.4205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0025 0.0023
Brugia malayi Tachykinin-like peptides receptor 99D 0.0046 0.015 0.06
Leishmania major metacaspase, putative 0.0046 0.0152 0.1839
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0214 0.0213
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0044 0.0042
Onchocerca volvulus 0.0017 0.002 0.0118
Brugia malayi Probable ClpP-like protease 0.016 0.0668 0.2669
Loa Loa (eye worm) hypothetical protein 0.003 0.008 0.0313
Loa Loa (eye worm) hypothetical protein 0.0112 0.0449 0.1791
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0453 0.8885
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0017 0.002 0.008
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0167 0.2401
Schistosoma mansoni z-protein (S1r protein) 0.0018 0.0025 0.0037
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Echinococcus multilocularis caspase 8 0.0046 0.0152 0.0151
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0004 0.0014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0046 0.015 0.0149
Giardia lamblia Hypothetical protein 0.0017 0.002 0.0126
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0211 0.0209
Echinococcus granulosus cathepsin l1 0.0017 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0177 0.0744 0.1172
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0021 0.0149
Echinococcus multilocularis Calcium binding protein 0.0015 0.001 0.0009
Giardia lamblia Cathepsin L-like protease 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.016 0.0668 0.0667
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0453 0.8885
Echinococcus granulosus geminin 0.0177 0.0744 0.0743
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Plasmodium falciparum metacaspase-like protein 0.0046 0.0152 0.2173
Trypanosoma cruzi centrin-3 0.0023 0.0047 0.0183
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0009 0.0074
Brugia malayi tailless protein 0.0013 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0196 0.2396
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.0791
Trypanosoma brucei caltractin, putative 0.0023 0.0047 0.0488
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Toxoplasma gondii hypothetical protein 0.002 0.0035 0.0338
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.002 0.008
Schistosoma mansoni myosin regulatory light chain 0.0015 0.001 0.0014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0087 0.1003
Loa Loa (eye worm) hypothetical protein 0.0043 0.0138 0.0547
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0046 0.015 0.0149
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0017 0.002 0.0126
Onchocerca volvulus 0.0046 0.015 0.0935
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.008 0.0905
Brugia malayi nuclear hormone receptor 0.0028 0.0072 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis ran, putative 0.0022 0.0044 0.0398
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0021 0.0177
Echinococcus multilocularis caspase 2 0.0089 0.0347 0.0346
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.002 0.0035 0.0338
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0179 0.0756 0.119
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus multilocularis smad 0.0017 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus hypothetical protein 0.0046 0.015 0.0149
Mycobacterium tuberculosis Probable reductase 0.0113 0.0453 0.8885
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0105 0.0419 0.8207
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0138 0.0137
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0188 0.0793 0.1248
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0409 0.0407
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Onchocerca volvulus 0.0046 0.015 0.0935
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0167 0.2401
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0009 0.0036
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0137
Schistosoma mansoni nuclear receptor nhr-48 0.0013 0.0004 0.0004
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Schistosoma mansoni nuclear receptor 0.0013 0.0004 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0054 0.0494
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0196 0.0779
Echinococcus multilocularis calcyphosin protein 0.0015 0.001 0.0009
Echinococcus granulosus caspase 0.0122 0.0496 0.0495
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0068 0.025 0.0994
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0167 0.2392
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.016 0.0668 0.8463
Loa Loa (eye worm) myosin Light Chain family member 0.0015 0.001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Giardia lamblia Cathepsin B precursor 0.0187 0.0788 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0072 0.007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0046 0.015 0.06
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Loa Loa (eye worm) cathepsin B 0.0187 0.0788 0.3145
Entamoeba histolytica Ran family GTPase 0.0022 0.0044 0.1039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0072 0.0111
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Plasmodium vivax vivapain-2 0.0017 0.002 0.0167
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Echinococcus multilocularis protein dispatched 1 0.005 0.0171 0.017
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0009 0.0031
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Onchocerca volvulus 0.0017 0.002 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma brucei calpain, putative 0.002 0.0035 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi hypothetical protein 0.0043 0.0138 0.0551
Echinococcus granulosus neuropeptide receptor 0.0046 0.015 0.0149
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0054 0.0494
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0046 0.015 0.0596
Onchocerca volvulus 0.0046 0.015 0.0935
Giardia lamblia Hypothetical protein 0.0017 0.002 0.0126
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0167 0.4079
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0017 0.002 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0376 0.1496
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0167 0.4079
Echinococcus granulosus neuropeptide s receptor 0.0046 0.015 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0259 0.1033
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0647
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0087 0.0136
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0017 0.002 0.003
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0087 0.0086
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0111 0.1542
Onchocerca volvulus Cathepsin F homolog 0.0017 0.002 0.0118
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0523
Schistosoma mansoni cathepsin B (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis orexin receptor type 2 0.0046 0.015 0.0149
Loa Loa (eye worm) G-protein coupled receptor 0.0046 0.015 0.0596
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Plasmodium falciparum serine repeat antigen 8 0.0017 0.002 0.0167
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0004 0.001
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.0021
Echinococcus multilocularis allatostatin A receptor 0.0046 0.015 0.0149
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0046 0.015 0.0149
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Schistosoma mansoni survival motor neuron protein 0.005 0.0171 0.0268
Toxoplasma gondii preprocathepsin c precursor, putative 0.0017 0.002 0.0141
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0565 0.2503 0.3946
Loa Loa (eye worm) hypothetical protein 0.0306 0.1328 0.5304
Brugia malayi hypothetical protein 0.0013 0.0004 0.0014
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0105 0.0419 0.8207
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0009 0.0179
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni dishevelled 0.0018 0.0025 0.0037
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0281
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0167 0.0662
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0059 0.0636
Entamoeba histolytica pyruvate kinase, putative 0.0049 0.0163 0.3976
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0259 0.3785
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0102 0.1993
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Plasmodium vivax unspecified product 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0187 0.0788 0.1241
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0046 0.015 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Schistosoma mansoni growth hormone secretagogue receptor 0.0046 0.015 0.0235
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Echinococcus granulosus neuropeptides capa receptor 0.0046 0.015 0.0149
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0025 0.0037
Echinococcus granulosus caspase 2 0.0089 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0025 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0151 0.015
Echinococcus granulosus cathepsin l1 0.0017 0.002 0.0019
Toxoplasma gondii thioredoxin reductase 0.0049 0.0167 0.2024
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0009 0.0012
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0021 0.0177
Echinococcus granulosus orexin receptor type 2 0.0046 0.015 0.0149
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0017 0.002 0.0167
Echinococcus granulosus neuropeptide receptor A26 0.0046 0.015 0.0149
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Echinococcus granulosus cysteine protease 0.0017 0.002 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0072 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0087 0.0086
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.002 0.0075
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0021 0.0082
Echinococcus granulosus calcyphosin protein 0.0015 0.001 0.0009
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0004 0.001
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.002 0.0462
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0004 0.0016
Giardia lamblia Pyruvate kinase 0.0036 0.0105 0.122
Trypanosoma cruzi kinesin, putative 0.0047 0.0158 0.0625
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0167 0.0166
Brugia malayi neuropeptide F receptor 0.0046 0.015 0.06
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0068 0.025 0.3091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0214 0.0336
Trypanosoma cruzi conserved protein 0.002 0.0035 0.0137
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0009 0.0179
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus granulosus programmed cell death protein 0.0023 0.0047 0.0046
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0046 0.015 0.0235
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0021 0.0183
Echinococcus granulosus Smad4 0.0017 0.0019 0.0018
Trypanosoma brucei cysteine peptidase, putative 0.002 0.0035 0.0338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Plasmodium vivax importin-beta 2, putative 0.003 0.008 0.1069
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0046 0.015 0.0149
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0211 0.0209
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Schistosoma mansoni hypothetical protein 0.0177 0.0744 0.1172
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Plasmodium vivax pyruvate kinase, putative 0.007 0.0259 0.3785
Loa Loa (eye worm) hypothetical protein 0.0089 0.0347 0.1382
Trichomonas vaginalis set domain proteins, putative 0.0248 0.1066 1
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0072 0.0111
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Plasmodium vivax vivapain-1 0.0017 0.002 0.0167
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.015 0.0235
Echinococcus granulosus allatostatin A receptor 0.0046 0.015 0.0149
Echinococcus multilocularis calpain 5 0.0068 0.025 0.0249
Brugia malayi Dopamine receptor protein 1 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0031
Schistosoma mansoni calpain (C02 family) 0.0068 0.025 0.0392
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Plasmodium falciparum serine repeat antigen 5 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0344
Loa Loa (eye worm) melatonin receptor type 1A 0.0046 0.015 0.0596
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0443
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2221 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0046 0.015 0.0149
Onchocerca volvulus Neuropeptide F receptor homolog 0.0046 0.015 0.0935
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0021 0.0177
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0011 0.0043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0072 0.007
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.015 0.0149
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0046 0.015 0.06
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0046 0.015 0.0235
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0021 0.0408
Loa Loa (eye worm) cysteine protease 0.0017 0.002 0.0075
Schistosoma mansoni dishevelled 0.0018 0.0025 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.3091
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Echinococcus multilocularis cathepsin b 0.0565 0.2503 0.2502
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0376 0.15
Onchocerca volvulus 0.0017 0.002 0.0118
Loa Loa (eye worm) calpain family protein 1 0.0132 0.0541 0.216
Plasmodium falciparum thioredoxin reductase 0.0049 0.0167 0.2392
Loa Loa (eye worm) Smad1 0.0017 0.0019 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0072 0.007
Brugia malayi hypothetical protein 0.0016 0.0018 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Toxoplasma gondii centrin family protein 0.0015 0.001 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0072 0.0281
Echinococcus multilocularis serotonin receptor 0.0046 0.015 0.0149
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0019 0.0018
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.002 0.0035 0.0338
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Giardia lamblia Cathepsin L-like protease 0.0017 0.002 0.0126
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.002 0.0167
Brugia malayi fibroinase precursor 0.0017 0.002 0.008
Echinococcus multilocularis hypothetical protein 0.0068 0.025 0.0249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0021 0.0177
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Echinococcus granulosus cathepsin L 0.0017 0.002 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.1465
Schistosoma mansoni calpain-7 (C02 family) 0.0068 0.025 0.0392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Echinococcus granulosus smad 0.0017 0.0019 0.0018
Echinococcus multilocularis Myosin regulatory light chain 0.0015 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0746
Echinococcus multilocularis programmed cell death protein 0.0023 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0225 0.0353
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0072 0.0281
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0608 0.0607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus granulosus pyruvate kinase 0.0036 0.0105 0.0104
Brugia malayi cathepsin L-like cysteine proteinase 0.0017 0.002 0.008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0004 0.0003
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.002 0.0462
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0159 0.0664 0.2648
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0011 0.0015
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Brugia malayi Pre-SET motif family protein 0.0032 0.0087 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Leishmania major GTP-binding protein, putative 0.0022 0.0044 0.0443
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0072 0.007
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.0013
Echinococcus granulosus fmrfamide receptor 0.0046 0.015 0.0149
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0188 0.0793 0.0791
Echinococcus multilocularis cathepsin b 0.0565 0.2503 0.2502
Brugia malayi pyruvate kinase 0.0015 0.001 0.0038
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0214 0.3115
Onchocerca volvulus 0.0049 0.0167 0.1042
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0365 0.1595 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0167 0.2401
Brugia malayi calpain family protein 1 0.0179 0.0756 0.3019
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Echinococcus multilocularis importin subunit beta 1 0.003 0.008 0.0078
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.002 0.0075
Brugia malayi G protein-coupled receptor 0.0046 0.015 0.06
Schistosoma mansoni hypothetical protein 0.0411 0.1802 0.2841
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0018 0.0025 0.0093
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0019
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0017 0.002 0.0167
Toxoplasma gondii hypothetical protein 0.0055 0.0193 0.2362
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0259 0.2418
Entamoeba histolytica grainin 2 0.0015 0.001 0.0222
Brugia malayi hypothetical protein 0.0158 0.0657 0.2626
Loa Loa (eye worm) hypothetical protein 0.0049 0.0167 0.0664
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Trichomonas vaginalis caltractin, putative 0.0015 0.001 0.0085
Trypanosoma brucei Calpain-like protein 1.2 0.002 0.0035 0.0338
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0319 0.7791
Brugia malayi sulfakinin receptor protein 0.0046 0.015 0.06
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus multilocularis calpain 0.0068 0.025 0.0249
Schistosoma mansoni nuclear receptor 0.0013 0.0004 0.0004
Echinococcus multilocularis calpain family protein 1, d 0.0132 0.0541 0.054
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0321
Schistosoma mansoni hypothetical protein 0.005 0.0171 0.0268
Echinococcus granulosus expressed conserved protein 0.0097 0.038 0.0379
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.008
Onchocerca volvulus 0.0013 0.0004 0.0016
Trypanosoma brucei metacaspase 0.0046 0.0152 0.1839
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.051 1
Trypanosoma cruzi centrin, putative 0.0023 0.0047 0.0183
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0025 0.0023
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0053
Echinococcus multilocularis protein patched 0.0044 0.0143 0.0142
Echinococcus multilocularis cathepsin L 0.0017 0.002 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.1054 0.4207
Echinococcus granulosus microtubule associated protein 2 0.1413 0.634 0.634
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0072 0.0285
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0053
Trichomonas vaginalis centrin, putative 0.0015 0.001 0.0085
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0015 0.001 0.0085
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0055 0.0193 0.2791
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0072 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.007 0.0259 0.1029
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0019 0.0018
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Schistosoma mansoni cpg binding protein 0.003 0.0081 0.0126
Echinococcus granulosus dro:myosuppressin receptor 0.0046 0.015 0.0149
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0017 0.002 0.0167
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0376 0.059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Schistosoma mansoni myosin light chain 0.0015 0.001 0.0014
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0046 0.015 0.0149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.007
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0259 0.2418
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis calpain A 0.0188 0.0793 0.0791
Echinococcus granulosus Myosin regulatory light chain 0.0015 0.001 0.0009
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0138 0.0137
Toxoplasma gondii calmodulin CAM2 0.0015 0.001 0.0015
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0009 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0046 0.015 0.0149
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0046 0.015 0.0596
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0046 0.0152 0.0608
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0074 0.029
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0044 0.0169
Onchocerca volvulus 0.0046 0.015 0.0935
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0004 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0021 0.0149
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0608 0.0607
Loa Loa (eye worm) hypothetical protein 0.016 0.0668 0.2666
Giardia lamblia Pyruvate kinase 0.007 0.0259 0.3193
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0167 0.2401
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Onchocerca volvulus 0.0046 0.015 0.0935
Loa Loa (eye worm) calpain 5 0.0047 0.0158 0.0625
Echinococcus granulosus muscleblind protein 0.0306 0.1328 0.1327
Brugia malayi G-protein coupled receptor 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.016 0.0668 0.0667
Brugia malayi GnHR receptor homolog 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0046 0.015 0.0149
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0019 0.0028
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0025 0.0093
Brugia malayi G protein-coupled receptor F59B2.13 0.0046 0.015 0.06
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0021 0.0149
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0015 0.0053
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0072 0.0285
Trichomonas vaginalis calcium binding protein, putative 0.0023 0.0047 0.043
Echinococcus granulosus peptide allatostatin:somatostatin 0.0046 0.015 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0004 0.0014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0151 0.015
Plasmodium falciparum glutathione reductase 0.0017 0.0021 0.0177
Echinococcus granulosus biogenic amine 5HT receptor 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.002 0.0167
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0167 0.2401
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1061 0.106
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0167 0.2401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0151 0.0236
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0019 0.0018
Loa Loa (eye worm) TYRA-2 protein 0.0046 0.015 0.0596
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Onchocerca volvulus 0.005 0.0171 0.1066
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.002 0.0167
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Echinococcus multilocularis fmrfamide receptor 0.0046 0.015 0.0149
Echinococcus granulosus G protein coupled receptor 139 0.0046 0.015 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0072 0.007
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Plasmodium falciparum importin beta, putative 0.003 0.008 0.1069
Brugia malayi putative neuropeptide receptor 0.0046 0.015 0.06
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0072 0.0285
Brugia malayi nuclear receptor NHR-88 0.0028 0.0072 0.0285
Onchocerca volvulus 0.0017 0.002 0.0118
Loa Loa (eye worm) hypothetical protein 0.0044 0.0143 0.0566
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0009 0.0179
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0143 0.0142
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0416 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0072 0.0281
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0046 0.015 0.0235
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0021 0.0078
Toxoplasma gondii EF hand domain-containing protein 0.0015 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Echinococcus granulosus g protein coupled receptor 0.0046 0.015 0.0149
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0072 0.007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Schistosoma mansoni ran 0.0022 0.0044 0.0067
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.015 0.0235
Onchocerca volvulus 0.0017 0.002 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.001 0.0036
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0004 0.0003
Schistosoma mansoni pyruvate kinase 0.007 0.0259 0.0406
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0072 0.0111
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0021 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni calpain C (C02 family) 0.0068 0.025 0.0392
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Brugia malayi RasGEF domain containing protein 0.0013 0.0001 0.0004
Echinococcus multilocularis expressed conserved protein 0.0097 0.038 0.0379
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Trypanosoma cruzi cysteine protease, putative 0.0017 0.002 0.0075
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Plasmodium vivax glutathione reductase, putative 0.0049 0.0167 0.2392
Schistosoma mansoni microtubule-associated protein tau 0.1413 0.634 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Brugia malayi Pre-SET motif family protein 0.0218 0.093 0.3714
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1802 0.1801
Schistosoma mansoni biogenic amine (5HT) receptor 0.0046 0.015 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0046 0.0152 0.0238
Toxoplasma gondii cathepsin CPL 0.0017 0.002 0.0141
Echinococcus multilocularis pyruvate kinase 0.007 0.0259 0.0257
Brugia malayi neuropeptide F receptor 0.0046 0.015 0.06
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0046 0.015 0.0149
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0409 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0259 0.5072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0046 0.015 0.0235
Onchocerca volvulus 0.0015 0.0009 0.0049
Brugia malayi calpain 5 0.0047 0.0158 0.0629
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0137
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Trichomonas vaginalis caltractin, putative 0.0015 0.001 0.0085
Brugia malayi calpain 5 0.002 0.0035 0.0141
Brugia malayi CHE-14 protein 0.0044 0.0143 0.0571
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0171 0.0684
Trypanosoma cruzi metacaspase, putative 0.0046 0.0152 0.0604
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.0013
Trichomonas vaginalis hypothetical protein 0.002 0.0035 0.0321
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0259 0.3203
Echinococcus multilocularis geminin 0.0177 0.0744 0.0743
Schistosoma mansoni nuclear hormone receptor 0.0013 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.003 0.0081 0.008
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0009 0.0036
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0004 0.0014
Echinococcus granulosus g-protein coupled receptor 0.0046 0.015 0.0149
Schistosoma mansoni importin beta-1 0.003 0.008 0.0124
Brugia malayi RasGEF domain containing protein 0.0019 0.003 0.0118
Loa Loa (eye worm) oxidoreductase 0.0015 0.0009 0.0031
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0046 0.015 0.0235
Schistosoma mansoni caspase-7 (C14 family) 0.0122 0.0496 0.0781
Leishmania major hypothetical protein, unknown function 0.002 0.0035 0.0338
Echinococcus granulosus regulator of G protein signaling 7 0.0018 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0247 0.1061 0.4236
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0376 0.4704
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0017 0.002 0.0177
Loa Loa (eye worm) pyruvate kinase 0.0015 0.001 0.0034
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0235
Schistosoma mansoni calmodulin-related 0.0015 0.001 0.0014
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0409 0.0407
Schistosoma mansoni pyruvate kinase 0.0036 0.0105 0.0164
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0015 0.001 0.0018
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0376 0.2348
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0083
Brugia malayi Probable myosin regulatory light chain 0.0015 0.001 0.004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0021 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0087 0.0136
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Loa Loa (eye worm) hypothetical protein 0.0083 0.0319 0.1269
Echinococcus granulosus sex peptide receptor 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0057
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0376 0.1496
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0044 0.0523
Schistosoma mansoni hypothetical protein 0.002 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Schistosoma mansoni zinc finger protein 0.0013 0.0004 0.0004
Leishmania major importin beta-1 subunit, putative 0.0024 0.0054 0.0574
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0059 0.0636
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0022 0.0021
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0025 0.0098
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0017 0.002 0.0167
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0021 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Brugia malayi hypothetical protein 0.0013 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Entamoeba histolytica cysteine proteinase 2 0.0017 0.002 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0072 0.0285
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Onchocerca volvulus 0.0018 0.0025 0.0146
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0017 0.002 0.0462
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0143 0.0566
Plasmodium falciparum serine repeat antigen 6 0.0017 0.002 0.0167
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Trypanosoma brucei Calpain-like protein CALP1.3 0.002 0.0035 0.0338
Echinococcus multilocularis pyruvate kinase 0.0036 0.0105 0.0104
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0428
Plasmodium falciparum glutathione reductase 0.0049 0.0167 0.2392
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0068 0.025 0.0994
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0046 0.015 0.0235
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0054 0.0494
Brugia malayi G-protein coupled receptor 0.0046 0.015 0.06
Echinococcus granulosus calpain A 0.0188 0.0793 0.0791
Toxoplasma gondii hypothetical protein 0.0018 0.0025 0.0199
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0039
Schistosoma mansoni calpain-7 (C02 family) 0.0068 0.025 0.0392
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0036
Giardia lamblia Cysteine protease 0.0017 0.002 0.0126
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Schistosoma mansoni alpha-1 adrenergic receptor 0.0046 0.015 0.0235
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0046 0.015 0.0149
Brugia malayi nuclear receptor RXR 0.0015 0.0011 0.0043
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Brugia malayi cathepsin Z-like cysteine proteinase 0.0017 0.002 0.008
Brugia malayi Cathepsin L-like cysteine proteinase 0.0017 0.002 0.008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0072 0.0441
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0277 0.0276
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0046 0.015 0.0935
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0009 0.0008
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0004 0.0003
Mycobacterium ulcerans pyruvate kinase 0.007 0.0259 0.3785
Loa Loa (eye worm) hypothetical protein 0.0016 0.0015 0.0053
Loa Loa (eye worm) hypothetical protein 0.0132 0.0541 0.216
Onchocerca volvulus 0.0046 0.015 0.0935
Loa Loa (eye worm) ctsf protein 0.0017 0.002 0.0075
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0025 0.0023
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Onchocerca volvulus 0.0046 0.015 0.0935
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0177
Loa Loa (eye worm) hypothetical protein 0.0179 0.0756 0.3016
Schistosoma mansoni smad1 5 8 and 0.0017 0.0019 0.0028
Giardia lamblia Cathepsin B precursor 0.0017 0.002 0.0126
Trypanosoma brucei metacaspase 5, putative 0.0046 0.0152 0.1839
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1061 0.106
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0167 0.0166
Onchocerca volvulus 0.0046 0.015 0.0935
Brugia malayi Serotonin receptor 0.0046 0.015 0.06
Trypanosoma cruzi metacaspase 5, putative 0.0046 0.0152 0.0604
Schistosoma mansoni caspase-7 (C14 family) 0.0089 0.0347 0.0545
Plasmodium vivax SET domain protein, putative 0.0032 0.0087 0.1185
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0046 0.015 0.0596
Echinococcus multilocularis programmed cell death protein 0.0023 0.0047 0.0046
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0004 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi hypothetical protein 0.0025 0.0059 0.0234
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0035 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi Myosin regulatory light chain 1 0.0015 0.001 0.004
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0167
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.002 0.0019
Brugia malayi cathepsin B-like cysteine proteinase 0.0565 0.2503 1
Brugia malayi putative neuropeptide receptor NPR1 0.0046 0.015 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus multilocularis fmrfamide receptor 0.0046 0.015 0.0149
Plasmodium vivax unspecified product 0.0017 0.002 0.0167
Schistosoma mansoni smad 0.0017 0.0019 0.0028
Plasmodium falciparum serine repeat antigen 4 0.0017 0.002 0.0167
Brugia malayi ecdysone receptor 0.0013 0.0004 0.0014
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Plasmodium vivax calpain, putative 0.0068 0.025 0.3652
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Echinococcus multilocularis microtubule associated protein 2 0.1413 0.634 0.634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Brugia malayi calpain D 0.002 0.0035 0.0141
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.051 0.7598
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.0009 0.0074
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0035 0.0338
Schistosoma mansoni histamine h1 receptor 0.0046 0.015 0.0235
Leishmania major hypothetical protein, conserved 0.0025 0.0059 0.0636
Entamoeba histolytica calpain large subunit domain III containing protein 0.0047 0.0158 0.384
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0017 0.002 0.0167
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Echinococcus granulosus programmed cell death protein 6 0.0015 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0143 0.1331
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Schistosoma mansoni opsin-like receptor 0.0046 0.015 0.0235
Schistosoma mansoni neuropeptide f receptor 76f 0.0046 0.015 0.0235
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0009 0.0031
Trypanosoma brucei metacaspase MCA3 0.0046 0.0152 0.1839
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0072 0.0285
Echinococcus granulosus Calcium binding protein 0.0015 0.001 0.0009
Echinococcus granulosus caspase 8 0.0046 0.0152 0.0151
Brugia malayi MH1 domain containing protein 0.0017 0.0019 0.0075
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0021 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0046 0.0152 0.2173
Onchocerca volvulus 0.0015 0.001 0.0057
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0122 0.0496 0.0495
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0011 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi N-terminal motif family protein 0.0013 0.0001 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0565 0.2503 0.3946
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0157 0.1465
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0004 0.0003
Schistosoma mansoni myosin regulatory light chain 0.0015 0.001 0.0014
Onchocerca volvulus 0.0017 0.002 0.0118
Toxoplasma gondii calmodulin, putative 0.0015 0.001 0.0015
Echinococcus multilocularis caspase 0.0122 0.0496 0.0495
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.008
Trypanosoma brucei calpain-like protein, putative 0.0068 0.025 0.3091
Echinococcus granulosus calpain 5 0.0068 0.025 0.0249
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0083
Schistosoma mansoni neuropeptide receptor 0.0046 0.015 0.0235
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.007
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0025 0.0098
Trypanosoma brucei centrin-3 0.0023 0.0047 0.0488
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.002 0.0177
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.0021
Brugia malayi RNA, U transporter 1 0.0086 0.0331 0.1321
Brugia malayi hypothetical protein 0.0247 0.1061 0.4238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0046 0.015 0.0235
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0072 0.0285
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi RE15519p 0.0046 0.015 0.06
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0013
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0021 0.0134
Entamoeba histolytica calmodulin, putative 0.0015 0.001 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 0.0177
Schistosoma mansoni patched 1 0.0044 0.0143 0.0224
Plasmodium falciparum metacaspase 1 0.0046 0.0152 0.2173
Echinococcus granulosus peptidase Clp S14 family 0.0105 0.0419 0.0417
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0046 0.015 0.0149
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0046 0.0152 0.142
Echinococcus granulosus caspase 3 0.0076 0.0287 0.0286
Brugia malayi Serotonin receptor 0.0046 0.015 0.06
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0055 0.0193 0.2791
Schistosoma mansoni caspase-3 (C14 family) 0.0122 0.0496 0.0781
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0075
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0013 0.0004 0.0016
Brugia malayi N-terminal motif family protein 0.0365 0.1595 0.6373
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0017 0.002 0.003
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0075
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0111 0.1542
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0068 0.025 0.0994
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Loa Loa (eye worm) hypothetical protein 0.0306 0.1328 0.5304
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0751
Schistosoma mansoni biogenic amine receptor 0.0046 0.015 0.0235
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.016 0.0668 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0376 0.9187
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0453 0.8885
Echinococcus granulosus snurportin 1 0.0321 0.1398 0.1397
Echinococcus granulosus cathepsin b 0.0565 0.2503 0.2502
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0338
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0046 0.015 0.0149
Trichomonas vaginalis calpain, putative 0.002 0.0035 0.0321
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0211 0.033
Plasmodium vivax metacaspase 1, putative 0.0046 0.0152 0.2173
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0046 0.015 0.06
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0152 0.142
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.002 0.0075
Brugia malayi Dopamine receptor 0.0046 0.015 0.06
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.002 0.0141
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0167 0.2401
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0093
Brugia malayi MH2 domain containing protein 0.0017 0.0019 0.0075
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0021 0.0177
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0019
Onchocerca volvulus 0.0046 0.015 0.0935
Schistosoma mansoni hypothetical protein 0.0043 0.0136 0.0212
Echinococcus granulosus calpain 7 C02 family 0.0068 0.025 0.0249
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0187 0.0788 0.7391
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0046 0.015 0.0235
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0072 0.007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0019 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.0013
Plasmodium vivax vivapain-2 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.001 0.0085
Schistosoma mansoni dep domain containing protein 0.0018 0.0025 0.0037
Onchocerca volvulus 0.0032 0.0087 0.0539
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0072 0.0111
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0017 0.002 0.0167
Schistosoma mansoni cathepsin S (C01 family) 0.0017 0.002 0.003
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0044 0.0042
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0259 0.1614
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0031
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0004 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.0018 0.0025 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0046 0.015 0.0149
Loa Loa (eye worm) pyruvate kinase 0.007 0.0259 0.1029
Plasmodium falciparum pyruvate kinase 0.007 0.0259 0.3785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0072 0.0281
Loa Loa (eye worm) hypothetical protein 0.0037 0.0111 0.0438
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.003
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Brugia malayi Melatonin receptor type 1A 0.0046 0.015 0.06
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0072 0.0285
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0072 0.0281
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0013
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 0.0462
Schistosoma mansoni hypothetical protein 0.0321 0.1398 0.2203
Trypanosoma brucei kinesin, putative 0.0047 0.0158 0.1908
Plasmodium vivax serine-repeat antigen (SERA) 0.0017 0.002 0.0167
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0072 0.007
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0015 0.001 0.0057
Loa Loa (eye worm) myosin regulatory light chain 1 0.0015 0.001 0.0036
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0009 0.0179
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.0009 0.0192
Echinococcus multilocularis G protein coupled receptor 139 0.0046 0.015 0.0149
Schistosoma mansoni amine GPCR 0.0046 0.015 0.0235
Echinococcus multilocularis calpain 7 (C02 family) 0.0068 0.025 0.0249
Trypanosoma brucei Calpain-like protein 2 0.002 0.0035 0.0338
Brugia malayi jmjC domain containing protein 0.0061 0.0218 0.087
Onchocerca volvulus 0.0017 0.002 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.002 0.0167
Brugia malayi ORL1-like opioid receptor 0.0046 0.015 0.06
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0013 0.0004 0.0004
Giardia lamblia Cathepsin L precursor 0.0017 0.002 0.0126
Onchocerca volvulus 0.0046 0.015 0.0935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0046 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0281
Plasmodium falciparum serine repeat antigen 7 0.0017 0.002 0.0167
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0075
Echinococcus granulosus neuropeptide Y receptor 0.0046 0.015 0.0149
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0277 0.0435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Brugia malayi calpain family protein 1 0.0179 0.0756 0.3019
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0009 0.0008
Brugia malayi hypothetical protein 0.0074 0.0277 0.1105
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0141
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 0.0177
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0376 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0376 0.3516
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 0.0462
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0044 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0021 0.0149
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.0118
Toxoplasma gondii cathepsin CPC1 0.0017 0.002 0.0141
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.001
Echinococcus multilocularis dro:myosuppressin receptor 0.0046 0.015 0.0149
Trypanosoma brucei pyruvate kinase 1 0.007 0.0259 0.3203
Brugia malayi Neuronal calcium sensor family protein 1 0.0015 0.001 0.004
Leishmania major pyruvate kinase 0.007 0.0259 0.3203
Brugia malayi CXXC zinc finger family protein 0.0029 0.0074 0.0294
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0017 0.002 0.0126
Plasmodium falciparum serine repeat antigen 9 0.0017 0.002 0.0167
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0229
Loa Loa (eye worm) hypothetical protein 0.0046 0.015 0.0596
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.093 0.3712
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.002 0.0035 0.0137
Brugia malayi hypothetical protein 0.0046 0.015 0.06
Giardia lamblia Encystation-specific protease 0.0017 0.002 0.0126
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0604
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0009 0.0179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0079 0.0078
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.002 0.0035 0.0321
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0017 0.002 0.0167
Loa Loa (eye worm) DR-78 0.0013 0.0004 0.001

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Maximum contractile response of thoracic aorta in albino Wistar rat after 30 min ChEMBL. 16279788
Ki (binding) = -5.7 Displacement of [125I]urotensin 2 from human UT receptor expressed in CHO-K1 cells ChEMBL. 16279788
Log Ki (binding) = 5.7 Displacement of [125I]urotensin 2 from human UT receptor expressed in CHO-K1 cells ChEMBL. 16279788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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