Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | lipase containing protein, putative | 0.0139 | 0.1283 | 0.1283 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0077 | 0 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.056 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.056 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0099 | 0.0455 | 0.0455 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.056 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0077 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0139 | 0.1283 | 0.1283 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0077 | 0 | 0.5 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.056 | 1 | 1 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0139 | 0.1283 | 0.1283 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.056 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.056 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.1283 | 0.1283 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.056 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0455 | 0.0455 |
Onchocerca volvulus | 0.0139 | 0.1283 | 1 | |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.056 | 1 | 1 |
Trypanosoma brucei | lipase domain protein, putative | 0.0139 | 0.1283 | 0.1283 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0077 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0099 | 0.0455 | 0.0455 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.056 | 1 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.056 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.056 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0483 | 0.8404 | 0.8404 |
Loa Loa (eye worm) | lipase | 0.0139 | 0.1283 | 0.1283 |
Schistosoma mansoni | immunophilin | 0.056 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.056 | 1 | 1 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0139 | 0.1283 | 0.1283 |
Schistosoma mansoni | immunophilin | 0.0483 | 0.8404 | 0.8404 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0139 | 0.1283 | 0.1283 |
Trichomonas vaginalis | immunophilin, putative | 0.056 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0483 | 0.8404 | 0.8404 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.056 | 1 | 1 |
Schistosoma mansoni | amidase | 0.0099 | 0.0455 | 0.0455 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.056 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.056 | 1 | 1 |
Brugia malayi | amidase | 0.0099 | 0.0455 | 0.0455 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.056 | 1 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0099 | 0.0455 | 0.0455 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0483 | 0.8404 | 0.8404 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0099 | 0.0455 | 0.0455 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.056 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.056 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0099 | 0.0455 | 0.0455 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.1283 | 0.1283 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.056 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.056 | 1 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0077 | 0 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.056 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0139 | 0.1283 | 0.1283 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.056 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.056 | 1 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.056 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.056 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.056 | 1 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.056 | 1 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0077 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.1283 | 0.1283 |
Leishmania major | fk506-binding protein 1-like protein | 0.056 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (ADMET) | = 11.6 uM | Cytotoxicity against human A459 cells after 48 hrs by MTT assay | ChEMBL. | 17070059 |
GI50 (ADMET) | = 11.7 uM | Cytotoxicity against human HT29 cells after 48 hrs by MTT assay | ChEMBL. | 17070059 |
GI50 (ADMET) | = 11.7 uM | Cytotoxicity against human HT29 cells after 48 hrs by MTT assay | ChEMBL. | 17070059 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 17070059 |
GI50 (ADMET) | > 100 uM | Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay | ChEMBL. | 17070059 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.