Detailed information for compound 41900

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.521 | Formula: C21H27N3O5S
  • H donors: 2 H acceptors: 3 LogP: 1.33 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1C(=O)NCC1OCCN(C1)Cc1ccccc1)S(=O)(=O)N
  • InChi: 1S/C21H27N3O5S/c1-2-28-20-9-8-18(30(22,26)27)12-19(20)21(25)23-13-17-15-24(10-11-29-17)14-16-6-4-3-5-7-16/h3-9,12,17H,2,10-11,13-15H2,1H3,(H,23,25)(H2,22,26,27)
  • InChiKey: YBZPDDBNKAIVSE-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0787 0.162
Brugia malayi follicle stimulating hormone receptor 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.018
Brugia malayi hypothetical protein 0.004 0.0216 0.0715
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0151 0.1091 0.3964
Plasmodium falciparum polyprenol reductase, putative 0.0021 0.0072 0.1572
Giardia lamblia Synaptic glycoprotein SC2 0.0021 0.0072 0.0038
Brugia malayi NADH dehydrogenase subunit 1, identical 0.004 0.0216 0.0715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0116
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0787 0.162
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0321 0.2428 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.0787 0.2836
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0787 0.162
Onchocerca volvulus 0.0112 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0787 0.451
Loa Loa (eye worm) hypothetical protein 0.0183 0.1342 0.4896
Echinococcus granulosus sex peptide receptor 0.0112 0.0787 0.162
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0151 0.1091 0.1091
Brugia malayi hypothetical protein 0.0025 0.0103 0.0295
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 0.0072 0.0361
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Brugia malayi neuropeptide F receptor 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.0787 0.451
Schistosoma mansoni opsin-like receptor 0.0112 0.0787 0.451
Echinococcus granulosus somatostatin receptor 0.0112 0.0787 0.162
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0186 0.0604
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0103 0.2855
Schistosoma mansoni myosin xvIII 0.0112 0.0787 0.451
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.0787 0.162
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0038
Schistosoma mansoni adenoreceptor 0.0112 0.0787 0.451
Brugia malayi Dopamine receptor protein 2 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Brugia malayi Thioredoxin reductase 0.0047 0.0276 0.0939
Onchocerca volvulus 0.0112 0.0787 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.0787 0.162
Onchocerca volvulus 0.0112 0.0787 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.0787 0.2836
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.0787 0.162
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 0.0072 0.0361
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0276 0.0536
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.0787 0.162
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0072 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0787 0.162
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Brugia malayi neuropeptide F receptor 0.0112 0.0787 0.2836
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0038
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Brugia malayi putative neuropeptide receptor 0.0112 0.0787 0.2836
Onchocerca volvulus 0.0112 0.0787 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0752 0.1696
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0072 0.018
Giardia lamblia NADPH oxidoreductase, putative 0.1285 1 1
Trypanosoma brucei trypanothione reductase 0.0047 0.0276 0.0939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0258 0.0258
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Schistosoma mansoni opsin-like receptor 0.0112 0.0787 0.451
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0752 0.1696
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.0787 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Schistosoma mansoni hypothetical protein 0.0112 0.0787 0.451
Onchocerca volvulus 0.0112 0.0787 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0258 0.0497
Giardia lamblia NADPH oxidoreductase, putative 0.1285 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0052 0.0105
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0295
Schistosoma mansoni biogenic amine (5HT) receptor 0.0231 0.1717 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.0787 1
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0787 0.451
Brugia malayi Synaptic glycoprotein SC2 0.0021 0.0072 0.018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Onchocerca volvulus 0.0112 0.0787 1
Onchocerca volvulus 0.0112 0.0787 1
Echinococcus granulosus neuropeptide s receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0276 0.0939
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0258 0.0871
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0024
Echinococcus multilocularis serotonin receptor 0.0231 0.1717 0.3593
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0787 0.451
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0186 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0321 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.0787 0.162
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.0787 0.162
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0846 0.1919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0787 0.162
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0147 0.106 1
Brugia malayi GnHR receptor homolog 0.0112 0.0787 0.2836
Echinococcus multilocularis somatostatin receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0151 0.1091 0.1091
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0103 0.2855
Schistosoma mansoni amine GPCR 0.0112 0.0787 0.451
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0787 0.162
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Schistosoma mansoni neuropeptide receptor 0.0112 0.0787 0.451
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.0787 0.162
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0024
Echinococcus multilocularis sex peptide receptor 0.0112 0.0787 0.162
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0321 0.2428 0.2428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0787 0.451
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Plasmodium falciparum thioredoxin reductase 0.0047 0.0276 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0147 0.106 0.2198
Onchocerca volvulus 0.0112 0.0787 1
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0787 0.162
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.0787 0.451
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0072 0.1572
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0021 0.0072 0.0103
Brugia malayi Dopamine receptor 0.0112 0.0787 0.2836
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.0787 0.2836
Leishmania major hypothetical protein, conserved 0.0025 0.0103 0.0295
Brugia malayi Melatonin receptor type 1A 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Schistosoma mansoni amine GPCR 0.0112 0.0787 0.451
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.0787 0.162
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.0787 0.451
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0072 0.0072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.0787 0.162
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0034 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0787 0.162
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0072 0.018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0258 0.0871
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0787 0.162
Schistosoma mansoni NADH dehydrogenase subunit 1 0.004 0.0216 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Schistosoma mansoni amine GPCR 0.0112 0.0787 0.451
Brugia malayi ORL1-like opioid receptor 0.0112 0.0787 0.2836
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Onchocerca volvulus 0.0112 0.0787 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Brugia malayi G-protein coupled receptor 0.0112 0.0787 0.2836
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Schistosoma mansoni neuropeptide receptor 0.0112 0.0787 0.451
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Mycobacterium ulcerans hypothetical protein 0.0151 0.1091 0.2496
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0258 0.0871
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0103 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0116
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.0787 0.162
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0186 0.0186
Mycobacterium tuberculosis Probable reductase 0.0108 0.0752 0.1696
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.0787 0.162
Brugia malayi G protein-coupled receptor 0.0112 0.0787 0.2836
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0358 0.2716 1
Schistosoma mansoni amine GPCR 0.0112 0.0787 0.451
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus granulosus neuropeptide receptor 0.0112 0.0787 0.162
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Echinococcus multilocularis serotonin receptor 0.0231 0.1717 0.3593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0295
Leishmania major trypanothione reductase 0.0047 0.0276 0.0939
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0787 0.2836
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0258 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.0787 0.2836
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.0787 0.451
Schistosoma mansoni hypothetical protein 0.0112 0.0787 0.451
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0168 0.1265
Onchocerca volvulus 0.0112 0.0787 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0258 0.079
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0103 0.0295
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0358 0.2716 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0072 0.0072
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0034 0.0038
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus granulosus g-protein coupled receptor 0.0112 0.0787 0.162
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0034 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.0787 0.162
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.0787 0.451
Brugia malayi NADH dehydrogenase subunit 1 0.004 0.0216 0.0715
Schistosoma mansoni hypothetical protein 0.0147 0.106 0.6118
Giardia lamblia GTOR 0.0045 0.0258 0.0225
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0034 0.0038
Echinococcus multilocularis synaptic glycoprotein sc2 0.0021 0.0072 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0787 0.162
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.0787 0.162
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0787 0.162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Brugia malayi RE15519p 0.0112 0.0787 0.2836
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0258 0.1384
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0151 0.1091 0.4325
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0787 0.162
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0787 0.162
Onchocerca volvulus 0.0112 0.0787 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0787 0.451
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0615 0.4737 1
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.004 0.0216 0.043
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Plasmodium vivax polyprenol reductase, putative 0.0021 0.0072 0.1572
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis allatostatin A receptor 0.0112 0.0787 0.162
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0034 0.0038
Treponema pallidum NADH oxidase 0.0016 0.0034 0.5
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0021 0.0072 0.0286
Trypanosoma brucei C-8 sterol isomerase, putative 0.0358 0.2716 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.0787 0.451
Echinococcus granulosus g protein coupled receptor 0.0112 0.0787 0.162
Brugia malayi Serotonin receptor 0.0112 0.0787 0.2836
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0151 0.1091 0.3964
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0787 0.2836
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.0787 0.451
Onchocerca volvulus 0.0112 0.0787 1
Brugia malayi G-protein coupled receptor 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0358 0.2716 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0024
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.0787 0.162
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0321 0.2428 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0258 0.0871
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0186 0.0604
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0752 0.1696
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0147 0.106 0.2423
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0787 0.162
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0072 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0022
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.0787 0.451
Mycobacterium ulcerans short chain dehydrogenase 0.0555 0.4267 1
Entamoeba histolytica hypothetical protein 0.0321 0.2428 1
Echinococcus granulosus fmrfamide receptor 0.0112 0.0787 0.162
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1285 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0151 0.1091 0.1091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0258 0.0871
Echinococcus granulosus hypothetical protein 0.0112 0.0787 0.162
Schistosoma mansoni biogenic amine receptor 0.0112 0.0787 0.451
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Onchocerca volvulus 0.0112 0.0787 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0752 0.1696
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Schistosoma mansoni opsin-like receptor 0.0112 0.0787 0.451
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.0787 0.2836
Brugia malayi hypothetical protein 0.0016 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0072 0.018
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0787 0.162
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0034 0.0038
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0022
Echinococcus granulosus allatostatin A receptor 0.0112 0.0787 0.162
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.0787 0.162
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0787 0.451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0024
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0034 0.0038
Plasmodium falciparum glutathione reductase 0.0047 0.0276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0116 0.0116
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0276 0.0573
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0103 0.0655
Echinococcus granulosus biogenic amine 5HT receptor 0.0231 0.1717 0.3593
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0034 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0021 0.0072 0.0286
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0787 0.162
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0258 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0142 0.0142
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.0787 0.162
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0846 0.1919
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0034 0.0038
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.0787 0.451
Onchocerca volvulus 0.0112 0.0787 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Brugia malayi sulfakinin receptor protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0258 0.0871
Echinococcus granulosus orexin receptor type 2 0.0112 0.0787 0.162
Onchocerca volvulus 0.0112 0.0787 1
Onchocerca volvulus 0.0112 0.0787 1
Brugia malayi Serotonin receptor 0.0112 0.0787 0.2836
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.0787 0.162
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0752 0.1696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0186 0.0186
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0846 1
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0147 0.106 0.2423
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0276 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1285 1 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0151 0.1091 0.3964
Loa Loa (eye worm) hypothetical protein 0.0151 0.1091 0.3964
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Brugia malayi Dopamine receptor protein 1 0.0112 0.0787 0.2836
Schistosoma mansoni amine GPCR 0.0112 0.0787 0.451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0151 0.1091 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Mycobacterium tuberculosis Probable oxidoreductase 0.0555 0.4267 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0034 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.0787 0.162
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.0787 0.2836
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0787 0.162
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.0787 0.162
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0103 0.2855
Echinococcus granulosus g protein coupled receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Onchocerca volvulus 0.004 0.0216 0.2013
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0321 0.2428 0.2428
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0072 0.1572
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0258 0.0871
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.0787 0.2836
Schistosoma mansoni histamine h1 receptor 0.0112 0.0787 0.451
Schistosoma mansoni neuropeptide receptor 0.0112 0.0787 0.451
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.0787 0.162
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0787 0.162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Trichomonas vaginalis conserved hypothetical protein 0.0964 0.7478 0.7478
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0096 0.0096
Toxoplasma gondii thioredoxin reductase 0.0047 0.0276 0.2295
Echinococcus granulosus neuropeptide receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.0787 0.162
Brugia malayi larval opioid receptor 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0207 0.0207
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0787 0.162
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0034 0.0061
Schistosoma mansoni biogenic amine receptor 0.0112 0.0787 0.451
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0021 0.0072 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis orexin receptor type 2 0.0112 0.0787 0.162
Echinococcus granulosus synaptic glycoprotein sc2 0.0021 0.0072 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0134 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0787 0.162
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.0787 0.2836
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0186 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0276 0.0939
Mycobacterium ulcerans formate hydrogenlyase HycD 0.004 0.0216 0.043
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0787 0.2836
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0846 0.1919
Brugia malayi AKH receptor 0.0112 0.0787 0.2836
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0787 0.162
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0151 0.1091 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.0787 0.451
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.0787 0.2836
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0258 0.079
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.0787 0.451
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.1285 1 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.1285 1 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.0787 0.162
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.0787 0.162
Echinococcus granulosus tm gpcr rhodopsin 0.0615 0.4737 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.0787 0.2836
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0186 0.0186
Onchocerca volvulus 0.004 0.0216 0.2013
Loa Loa (eye worm) hypothetical protein 0.0231 0.1717 0.6289
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Plasmodium vivax glutathione reductase, putative 0.0047 0.0276 1
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0787 0.162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0034 0.0038
Brugia malayi hypothetical protein 0.0112 0.0787 0.2836
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0151 0.1091 0.3964
Leishmania major C-8 sterol isomerase-like protein 0.0358 0.2716 1
Schistosoma mansoni biogenic amine receptor 0.0112 0.0787 0.451
Schistosoma mansoni neuropeptide receptor 0.0112 0.0787 0.451
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0276 0.0536
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.0787 0.451
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.004 0.0216 0.0715
Echinococcus granulosus serotonin receptor 0.0112 0.0787 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0114 0.0114
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0321 0.2428 0.2428
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Loa Loa (eye worm) hypothetical protein 0.0112 0.0787 0.2836
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.0787 0.162
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0034 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0787 0.451
Schistosoma mansoni hypothetical protein 0.0112 0.0787 0.451
Trichomonas vaginalis modulator of drug activity B, putative 0.0321 0.2428 0.2428
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.0787 0.2836
Brugia malayi glutathione reductase 0.0047 0.0276 0.0939
Schistosoma mansoni hypothetical protein 0.0112 0.0787 0.451
Echinococcus granulosus g protein coupled receptor 0.0112 0.0787 0.162
Loa Loa (eye worm) glutathione reductase 0.0047 0.0276 0.0939
Loa Loa (eye worm) hypothetical protein 0.0231 0.1717 0.6289
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0787 0.451
Onchocerca volvulus 0.0112 0.0787 1

Activities

Activity type Activity value Assay description Source Reference
GE (functional) = 19 % Evaluated for the effects on the gastric emptying rates of phenol red semisolid meal through the stomach in rats, at a dose of 2.0 mg/Kg administered perorally. ChEMBL. 2139471

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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