Detailed information for compound 419007

Basic information

Technical information
  • TDR Targets ID: 419007
  • Name: N-[3-(4-methoxyphenoxy)pyridin-4-yl]methanesu lfonamide
  • MW: 294.326 | Formula: C13H14N2O4S
  • H donors: 1 H acceptors: 3 LogP: 1.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Oc1cnccc1NS(=O)(=O)C
  • InChi: 1S/C13H14N2O4S/c1-18-10-3-5-11(6-4-10)19-13-9-14-8-7-12(13)15-20(2,16)17/h3-9H,1-2H3,(H,14,15)
  • InChiKey: SJQYXSIKYYHNSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(4-methoxyphenoxy)-4-pyridyl]methanesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References
Homo sapiens prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei trypanothione reductase 0.0047 0.0066 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0122 0.0219 0.0218
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0054 0.008 0.0079
Schistosoma mansoni DNA topoisomerase type I 0.3601 0.7336 0.7336
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.029
Brugia malayi DNA topoisomerase III 0.0245 0.0471 0.0471
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0028 0.0027
Onchocerca volvulus Huntingtin homolog 0.0122 0.0219 0.4832
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0178 0.0177
Leishmania major DNA topoisomerase type IB small subunit 0.2678 0.5448 0.7426
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0028 0.0027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.0554 1
Schistosoma mansoni survival motor neuron protein 0.0095 0.0163 0.0163
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.0027
Trypanosoma cruzi DNA topoisomerase III, putative 0.0245 0.0471 0.0641
Loa Loa (eye worm) DNA topoisomerase I 0.4903 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Brugia malayi MH2 domain containing protein 0.0232 0.0445 0.0445
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0089 0.0088
Onchocerca volvulus Huntingtin homolog 0.0122 0.0219 0.4832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0093 0.0093
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0134 0.2381
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0056 0.0971
Treponema pallidum DNA topoisomerase I (topA) 0.0279 0.054 0.9756
Echinococcus multilocularis lysosomal alpha glucosidase 0.0147 0.027 0.027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0029
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0011 0.0011
Onchocerca volvulus 0.0017 0.0003 0.0057
Onchocerca volvulus 0.0021 0.0011 0.0232
Brugia malayi Dopamine receptor 0.0015 0.0001 0.0001
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0008 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0099 0.0099
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.0189 0.74
Echinococcus granulosus caspase 0.0113 0.0201 0.0201
Loa Loa (eye worm) glutathione reductase 0.0047 0.0066 0.0065
Brugia malayi G-protein coupled receptor 0.0015 0.0001 0.0001
Schistosoma mansoni kinase 0.0047 0.0065 0.0065
Schistosoma mansoni caspase-7 (C14 family) 0.0113 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Echinococcus multilocularis geminin 0.0499 0.099 0.0989
Plasmodium falciparum glutathione reductase 0.0047 0.0066 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0066 0.0088
Mycobacterium tuberculosis Probable reductase 0.0108 0.0189 0.74
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0032 0.0042
Plasmodium falciparum metacaspase 1 0.0043 0.0057 0.0056
Echinococcus multilocularis expressed protein 0.0372 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0052 0.0075 0.0074
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0007 0.0089
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0008
Brugia malayi PXA domain containing protein 0.0019 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0054 0.008 0.0107
Entamoeba histolytica hypothetical protein 0.0146 0.0267 0.4798
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.0035 0.0034
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma brucei DNA topoisomerase III, putative 0.0245 0.0471 0.0641
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0165 0.0306 0.0305
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Onchocerca volvulus Putative cubilin 0.0021 0.0011 0.0232
Brugia malayi ecdysteroid receptor 0.0061 0.0093 0.0093
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0014
Brugia malayi tailless protein 0.0029 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0028 0.0028
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0099 0.0099
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0265 0.0264
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0157 0.2803
Plasmodium falciparum topoisomerase I 0.4903 1 1
Schistosoma mansoni inositol monophosphatase 0.0073 0.0118 0.0117
Trypanosoma brucei metacaspase MCA3 0.0043 0.0057 0.0076
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0028 0.0598
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.001 0.0009
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0119 0.0119
Giardia lamblia DINP protein human, muc B family 0.0019 0.0007 0.0089
Onchocerca volvulus 0.0063 0.0099 0.2178
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0037 0.0036
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.0033 0.0037 0.0037
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0003 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Onchocerca volvulus Peroxidasin homolog 0.0064 0.0099 0.2183
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0003 0.0001
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.0554 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0093 0.0093
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0267 0.0267
Schistosoma mansoni hypothetical protein 0.0033 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0003 0.0002
Loa Loa (eye worm) TOPoisomerase family member 0.0054 0.008 0.0079
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.2678 0.5448 0.7426
Echinococcus multilocularis cysteine protease 0.0017 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0064 0.0099 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0093 0.0093
Brugia malayi Pre-SET motif family protein 0.003 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0054 0.008 0.0079
Onchocerca volvulus 0.0017 0.0003 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0311 0.031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0021 0.0011 0.0232
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0007 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Brugia malayi Cadherin domain containing protein 0.0021 0.0011 0.0011
Schistosoma mansoni notch 0.0021 0.0011 0.001
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0058 0.0058
Brugia malayi ORL1-like opioid receptor 0.0015 0.0001 0.0001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0157 0.0157
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0018 0.0603
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0056 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0061 0.1057
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0178 0.0177
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0239 0.0457 1
Brugia malayi Muscle positioning protein 4 0.0021 0.0011 0.0011
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0108 0.1921
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.0295 0.0572 0.0572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0093 0.0092
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0239 0.0457 0.8254
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0042 0.0716
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0118 0.0159
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0139 0.0138
Schistosoma mansoni intermediate filament proteins 0.0027 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0042 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0096 0.0095
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0093 0.0093
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0107
Onchocerca volvulus Peroxidase homolog 0.0063 0.0099 0.2178
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0008 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0017 0.0003 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Echinococcus granulosus neutral alpha glucosidase AB 0.0045 0.0061 0.0061
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0003 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Loa Loa (eye worm) DNA topoisomerase III 0.0245 0.0471 0.047
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0003 0.0002
Brugia malayi Cytochrome P450 family protein 0.0031 0.0033 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0093 0.0093
Brugia malayi Peroxidasin 0.0064 0.0099 0.0099
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0061 0.0081
Brugia malayi TAR-binding protein 0.0062 0.0096 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0042 0.0716
Schistosoma mansoni ran 0.0021 0.0011 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0007 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0124 0.0223 0.0223
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0002
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0011 0.001
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0018 0.0017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0118 0.0159
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0011
Brugia malayi neuropeptide F receptor 0.0015 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0093 0.0093
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.0035 0.0034
Loa Loa (eye worm) inositol-1 0.0073 0.0118 0.0117
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.003 0.0029
Trypanosoma cruzi metacaspase, putative 0.0043 0.0057 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Trichomonas vaginalis alpha-glucosidase, putative 0.0017 0.0003 0.0016
Leishmania major glycosyl hydrolase-like protein 0.0017 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Echinococcus multilocularis conserved hypothetical protein 0.0688 0.1376 0.1376
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0088 0.0118
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0011 0.0011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0002 0.0001
Schistosoma mansoni zinc finger protein 0.0029 0.0028 0.0027
Echinococcus multilocularis protein jagged 1 0.0021 0.0011 0.001
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0255 0.5543
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0054 0.008 0.008
Brugia malayi Serotonin receptor 0.0015 0.0001 0.0001
Brugia malayi Muscleblind-like protein 0.0295 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Mycobacterium tuberculosis DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (nicking-c 0.0114 0.0203 0.7951
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0008 0.0008
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0028 0.0027
Brugia malayi hypothetical protein 0.0032 0.0035 0.0035
Onchocerca volvulus 0.0061 0.0093 0.2048
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0391 0.0532
Echinococcus granulosus neurogenic locus notch protein 4 0.0021 0.0011 0.001
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0008 0.0008
Leishmania major cytochrome p450-like protein 0.0031 0.0033 0.0044
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0018 0.0276
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0061 0.0081
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0008 0.0008
Onchocerca volvulus 0.0124 0.0223 0.4932
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.0496 0.0495
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0008 0.0008
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0061 0.1045
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0094 0.0127
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Onchocerca volvulus 0.0021 0.0011 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0061 0.006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0032 0.0042
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0016 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Echinococcus granulosus caspase 8 0.0043 0.0057 0.0056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.058 0.0579
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0121 0.0163
Leishmania major cathepsin L-like protease 0.0017 0.0003 0.0003
Brugia malayi Globin family protein 0.0017 0.0003 0.0003
Schistosoma mansoni lamin 0.0027 0.0024 0.0023
Schistosoma mansoni single-minded 0.0048 0.0068 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0003 0.0002
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0021 0.0011 0.001
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0167 0.0311 0.031
Brugia malayi G protein-coupled receptor 0.0015 0.0001 0.0001
Trypanosoma cruzi metacaspase, putative 0.0043 0.0057 0.0076
Schistosoma mansoni importin beta-1 0.0028 0.0026 0.0026
Loa Loa (eye worm) RNA binding protein 0.0062 0.0096 0.0095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Echinococcus multilocularis cysteine protease 0.0017 0.0003 0.0003
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0061 0.0081
Leishmania major cathepsin L-like protease 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.004 0.0051 0.0051
Trichomonas vaginalis sucrase-isomaltase, putative 0.0045 0.0061 0.1066
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0003 0.0003
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0028 0.0027
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0093 0.2048
Toxoplasma gondii DNA topoisomerase I, putative 0.4903 1 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0018 0.0334
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0093 0.0093
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0011 0.0011
Plasmodium falciparum DNA topoisomerase 3, putative 0.0239 0.0457 0.0456
Brugia malayi Hypothetical 22.2 kDa protein C28F5.2 in chromosome II, putative 0.0017 0.0003 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0058 0.0078
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0028 0.0027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0045 0.0061 0.1054
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0093 0.0093
Schistosoma mansoni nuclear receptor 0.0029 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0121 0.0163
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0003 0.0003
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0099 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0061 0.1066
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0032 0.0031
Brugia malayi hypothetical protein 0.0163 0.0302 0.0302
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0003 0.0058
Echinococcus granulosus flap endonuclease 1 0.0025 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Brugia malayi Serotonin receptor 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0093 0.0093
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0018 0.0334
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0057 0.0056
Echinococcus multilocularis musashi 0.0027 0.0024 0.0023
Plasmodium falciparum importin beta, putative 0.0028 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0026 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0093 0.1988
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.3601 0.7336 1
Trypanosoma brucei Metacaspase-4 0.0043 0.0057 0.0076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0035 0.0034
Giardia lamblia Kinase, PLK 0.0092 0.0157 0.2812
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0099 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0003 0.0003
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0033 0.0044
Schistosoma mansoni peroxidasin 0.0064 0.0099 0.0099
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0178 0.0177
Plasmodium vivax metacaspase 1, putative 0.0043 0.0057 0.0056
Leishmania major hypothetical protein, conserved 0.0206 0.0391 0.0532
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0157 0.3472
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0042 0.0056
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0011 0.001
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0139 0.3055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Echinococcus granulosus protein jagged 2 0.0021 0.0011 0.001
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0028 0.0027
Entamoeba histolytica DNA topoisomerase III, putative 0.0239 0.0457 0.8251
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0099 0.0134
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0089 0.0088
Trypanosoma brucei DNA topoisomerase ii 0.0054 0.008 0.0107
Echinococcus multilocularis rho GTPase activating protein 20 0.0245 0.0471 0.047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0061 0.006
Brugia malayi hypothetical protein 0.0063 0.0099 0.0099
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0017 0.0003 0.0016
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0147 0.027 0.027
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0113 0.0201 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0093 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0017 0.0003 0.0016
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0028 0.0027
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0093 0.2048
Plasmodium vivax importin-beta 2, putative 0.0028 0.0026 0.0025
Mycobacterium tuberculosis Probable monooxygenase 0.0017 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Leishmania major hypothetical protein, conserved 0.0074 0.0121 0.0163
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0056 0.0055
Trypanosoma brucei polo-like protein kinase 0.0092 0.0157 0.0213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0043 0.0058 0.0057
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.0099 0.2178
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0017 0.0003 0.0003
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.001 0.0009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0028 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0121 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0089 0.0088
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0008 0.0008
Echinococcus multilocularis notch 0.0021 0.0011 0.001
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0049 0.084
Entamoeba histolytica DNA topoisomerase II, putative 0.0054 0.008 0.1392
Trypanosoma brucei unspecified product 0.0019 0.0007 0.0009
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0028 0.0027
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.0102 0.3952
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0118 0.0159
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Echinococcus granulosus lysosomal alpha glucosidase 0.0147 0.027 0.027
Echinococcus granulosus expressed protein 0.0372 0.073 0.073
Leishmania major cathepsin L-like protease 0.0064 0.0099 0.0134
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0099 0.0134
Echinococcus multilocularis Smad4 0.0016 0.0002 0.0001
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0033 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Brugia malayi hypothetical protein 0.0146 0.0267 0.0267
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0028 0.0027
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.0921 0.092
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0008
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0094 0.0094
Loa Loa (eye worm) Notch2 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0054 0.008 0.0107
Giardia lamblia DNA topoisomerase II 0.0054 0.008 0.1403
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0267 0.0267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0093 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Brugia malayi RE15519p 0.0015 0.0001 0.0001
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.0189 0.74
Onchocerca volvulus 0.0021 0.0011 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0061 0.0082
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0054 0.008 0.1403
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0054 0.008 0.1438
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0018 0.0334
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0061 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.003 0.0029
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.0496 0.0496
Schistosoma mansoni hypothetical protein 0.0146 0.0267 0.0267
Trypanosoma cruzi metacaspase, putative 0.0043 0.0057 0.0076
Brugia malayi nuclear receptor NHR-88 0.0029 0.0028 0.0028
Schistosoma mansoni myoglobin 1 0.0017 0.0003 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0028 0.0027
Echinococcus granulosus microtubule associated protein 2 0.0674 0.1349 0.1348
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0043 0.0042
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0032 0.0032
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Brugia malayi Melatonin receptor type 1A 0.0015 0.0001 0.0001
Echinococcus multilocularis lamin 0.0027 0.0024 0.0023
Echinococcus granulosus peroxidasin 0.0064 0.0099 0.0099
Schistosoma mansoni DNA topoisomerase II 0.0054 0.008 0.0079
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0066 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0024 0.0387
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.1349 0.1348
Brugia malayi hypothetical protein 0.0048 0.0067 0.0067
Plasmodium vivax glutathione reductase, putative 0.0047 0.0066 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0093 0.0092
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0061 0.1066
Leishmania major trypanothione reductase 0.0047 0.0066 0.0088
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.1349 0.1348
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0096 0.0095
Echinococcus granulosus dna polymerase kappa 0.0019 0.0007 0.0007
Trypanosoma brucei DNA topoisomerase III, putative 0.0124 0.0223 0.0303
Schistosoma mansoni cell polarity protein 0.0021 0.0011 0.001
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0043 0.0043
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0032 0.0031
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0021 0.002
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0032 0.1171
Schistosoma mansoni alpha-glucosidase 0.0119 0.0212 0.0212
Echinococcus granulosus dna polymerase eta 0.0043 0.0058 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0061 0.006
Giardia lamblia GTOR 0.0045 0.0061 0.1057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0032 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0093 0.0093
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0028 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0093 0.0093
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.0554 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Schistosoma mansoni notch 0.0021 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0118 0.2091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0094 0.0093
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0017 0.0003 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Leishmania major DNA topoisomerase IB, large subunit 0.3601 0.7336 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.003 0.0029
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0056 0.0055
Schistosoma mansoni alpha glucosidase 0.0045 0.0061 0.0061
Echinococcus granulosus single minded 2 0.0036 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0465 0.0921 0.092
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Onchocerca volvulus 0.0017 0.0003 0.0058
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0011 0.001
Mycobacterium ulcerans DNA gyrase subunit B 0.0054 0.008 0.17
Plasmodium vivax SET domain protein, putative 0.003 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0064 0.0099 0.0099
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0037 0.0037
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0008 0.0103
Echinococcus granulosus fibropellin Ia 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0028 0.0027
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.007 0.0113 0.2
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0018 0.0017
Brugia malayi PAS domain containing protein 0.0048 0.0068 0.0068
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0214 0.3139
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0113 0.0201 0.0201
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.007 0.0069
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0028 0.0027
Echinococcus granulosus Smad4 0.0016 0.0002 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0093 0.0093
Onchocerca volvulus 0.0017 0.0003 0.0058
Echinococcus granulosus tumor protein p63 0.0337 0.0658 0.0658
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0003 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.0391 0.0532
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0096 0.0095
Toxoplasma gondii thioredoxin reductase 0.0047 0.0066 0.0064
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0028 0.0027
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0119 0.0119
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0008 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.0391 0.0532
Echinococcus granulosus cathepsin l1 0.0017 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Trypanosoma cruzi metacaspase, putative 0.0043 0.0057 0.0076
Brugia malayi GRF zinc finger family protein 0.0061 0.0094 0.0094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0054 0.008 0.1754
Schistosoma mansoni alpha-glucosidase 0.0119 0.0212 0.0212
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Echinococcus multilocularis smad 0.0016 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0095 0.0163 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Echinococcus multilocularis 0.0383 0.0753 0.0753
Schistosoma mansoni flap endonuclease-1 0.0023 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0061 0.0061
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0157 0.0213
Loa Loa (eye worm) hypothetical protein 0.0122 0.0219 0.0218
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Loa Loa (eye worm) globin family protein 0.0017 0.0003 0.0003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Echinococcus multilocularis lysosomal alpha glucosidase 0.0147 0.027 0.027
Plasmodium vivax vivapain-2 0.0017 0.0003 0.0002
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Echinococcus granulosus slit 2 protein 0.0021 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0003 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Leishmania major metacaspase, putative 0.0043 0.0057 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0099 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Brugia malayi hypothetical protein 0.0029 0.0028 0.0028
Brugia malayi MH2 domain containing protein 0.0016 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0008 0.0008
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0028 0.0028
Brugia malayi Pre-SET motif family protein 0.0207 0.0394 0.0394
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0094 0.3628
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0074 0.0121 0.012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0093 0.0093
Onchocerca volvulus Peroxidasin homolog 0.0063 0.0099 0.2178
Schistosoma mansoni laminin gamma-3 chain 0.0021 0.0011 0.001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0032 0.0031
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0042 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0146 0.0267 0.4798
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0028 0.0028
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0028 0.0028
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0051 0.005
Brugia malayi hypothetical protein 0.0122 0.0219 0.0219
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0009
Onchocerca volvulus 0.0063 0.0099 0.2178
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0061 0.006
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0223
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0286 0.0554 0.0553
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Mycobacterium tuberculosis Conserved protein 0.0024 0.0018 0.0603
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0276 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0008 0.0008
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0003 0.0002
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0008 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0255 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0032 0.0031
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0058 0.0078
Onchocerca volvulus 0.0017 0.0003 0.0058
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0002 0.0001
Toxoplasma gondii EGF family domain-containing protein 0.0021 0.0011 0.001
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0028 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0093 0.0093
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0061 0.0081
Schistosoma mansoni hypothetical protein 0.0499 0.099 0.0989
Giardia lamblia DNA topoisomerase III 0.0124 0.0223 0.401
Brugia malayi Melibiase family protein 0.0068 0.0108 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0157 0.0157
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0099 0.0099
Plasmodium vivax DNA topoisomerase II, putative 0.0054 0.008 0.0079
Leishmania major DNA polymerase eta, putative 0.0031 0.0032 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0017 0.0003 0.0003
Brugia malayi Smad1 0.0016 0.0002 0.0002
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.2678 0.5448 0.7426
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0096 0.0095
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0032 0.0042
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0017 0.0003 0.0003
Echinococcus granulosus snurportin 1 0.0299 0.058 0.0579
Schistosoma mansoni notch 0.0021 0.0011 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0093 0.0092
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0008 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.0445 0.0444
Leishmania major cathepsin L-like protease 0.0017 0.0003 0.0003
Brugia malayi hypothetical protein 0.0074 0.0121 0.0121
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0118 0.208
Loa Loa (eye worm) globin family protein 0.0017 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Onchocerca volvulus 0.0021 0.0011 0.0232
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0032 0.0042
Echinococcus granulosus tar DNA binding protein 0.0062 0.0096 0.0095
Entamoeba histolytica DNA topoisomerase III, putative 0.0124 0.0223 0.4002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0093 0.0093
Onchocerca volvulus 0.0236 0.0452 1
Echinococcus granulosus lamin 0.0027 0.0024 0.0023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0061 0.006
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0028 0.0598
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0255 0.4293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0378
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0093 0.0093
Echinococcus granulosus lamin dm0 0.0027 0.0024 0.0023
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0057 0.0056
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0096 0.0096
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0021 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0118 0.2533
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0093 0.0093
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0056 0.0971
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0093 0.2048
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0033 0.0032
Schistosoma mansoni notch 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0068 0.0068
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0018 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0045 0.0061 0.1066
Brugia malayi jmjC domain containing protein 0.0059 0.0089 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0063 0.1094
Brugia malayi Dopamine receptor protein 1 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.052 0.1034 0.1033
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0033 0.0671
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0002 0.0001
Brugia malayi Importin beta-1 subunit 0.0028 0.0026 0.0026
Echinococcus granulosus intermediate filament protein 0.0027 0.0024 0.0023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0037 0.0036
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0026 0.0026
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0003 0.0001
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0026 0.0025
Brugia malayi nuclear receptor RXR 0.0029 0.0028 0.0028
Brugia malayi nuclear receptor RXR 0.0032 0.0035 0.0035
Brugia malayi Probable DNA topoisomerase II 0.0054 0.008 0.008
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0029 0.0473
Trypanosoma brucei metacaspase 0.0043 0.0057 0.0076
Schistosoma mansoni notch 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0239 0.0457 0.0622
Leishmania major DNA topoisomerase 1A 0.0239 0.0457 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Echinococcus multilocularis fat cadherin tumor suppressor 0.0021 0.0011 0.001
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.0334
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0093 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0061 0.1057
Brugia malayi Pax transcription factor protein 2 0.0235 0.045 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0047 0.0814
Plasmodium vivax topoisomerase I, putative 0.4903 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0096 0.0095
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.001 0.0009
Brugia malayi Thioredoxin reductase 0.0047 0.0066 0.0066
Schistosoma mansoni lamin 0.0027 0.0024 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0001 0.0001
Brugia malayi RNA, U transporter 1 0.008 0.0132 0.0132
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0158
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0108 0.0108
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Echinococcus multilocularis caspase 0.0113 0.0201 0.0201
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0003 0.0003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0093 0.0093
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0021 0.0339
Onchocerca volvulus 0.0049 0.007 0.1535
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0089 0.0088
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0002 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.0921 0.092
Brugia malayi intermediate filament protein 0.0027 0.0024 0.0024
Brugia malayi Inositol-1 0.0073 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0037 0.0631
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0021 0.0021
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0003 0.0001
Brugia malayi Blistered cuticle protein 3 0.0063 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0178 0.0177
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0118 0.2091
Brugia malayi Protein kinase domain containing protein 0.0167 0.0311 0.0311
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0096 0.0095
Echinococcus multilocularis lamin dm0 0.0027 0.0024 0.0023
Onchocerca volvulus 0.0017 0.0003 0.0057
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0007 0.0089
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0089 0.0088
Echinococcus multilocularis DNA topoisomerase 1 0.4903 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.0035 0.0034
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0214 0.8374
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0003 0.0003
Trypanosoma cruzi DNA topoisomerase III, putative 0.0124 0.0223 0.0303
Brugia malayi glutathione reductase 0.0047 0.0066 0.0066
Onchocerca volvulus 0.0017 0.0003 0.0058
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.0445 0.0444
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Leishmania major mitochondrial DNA topoisomerase II 0.0054 0.008 0.0107
Mycobacterium ulcerans DNA topoisomerase I 0.0239 0.0457 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0093 0.1988
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Trichomonas vaginalis ran, putative 0.0021 0.0011 0.0158
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0032 0.0042
Leishmania major cathepsin L-like protease 0.0017 0.0003 0.0003
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0021 0.0339
Echinococcus granulosus geminin 0.0499 0.099 0.0989
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Echinococcus multilocularis caspase 2 0.0083 0.0139 0.0138
Echinococcus multilocularis slit 2 protein 0.0021 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Echinococcus multilocularis muscleblind protein 1 0.0295 0.0572 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0023 0.0378
Loa Loa (eye worm) hypothetical protein 0.0068 0.0108 0.0108
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0093 0.3587
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0239 0.0457 0.0622
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0003 0.0003
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0124 0.0223 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Schistosoma mansoni Smad4 0.0016 0.0002 0.0001
Trypanosoma cruzi DNA topoisomerase III, putative 0.0245 0.0471 0.0641
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0032 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0093 0.0093
Brugia malayi AKH receptor 0.0015 0.0001 0.0001
Onchocerca volvulus 0.0235 0.045 0.9955
Schistosoma mansoni ran 0.0021 0.0011 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0093 0.0093
Onchocerca volvulus 0.0017 0.0003 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0017 0.0003 0.0016
Echinococcus multilocularis neurogenic locus protein delta 0.0021 0.0011 0.001
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0049 0.0827
Brugia malayi Glycosyl hydrolases family 31 protein 0.0147 0.027 0.027
Schistosoma mansoni smad 0.0016 0.0002 0.0001
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0094 0.2011
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0054 0.008 0.3067
Onchocerca volvulus 0.0017 0.0003 0.0057
Brugia malayi Flap endonuclease-1 0.0025 0.0021 0.0021
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Echinococcus granulosus notch 0.0021 0.0011 0.001
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0008 0.0008
Plasmodium falciparum metacaspase-like protein 0.0043 0.0057 0.0056
Echinococcus multilocularis neurogenic locus notch protein 0.0021 0.0011 0.001
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0003 0.0002
Echinococcus granulosus protein jagged 1 0.0021 0.0011 0.001
Chlamydia trachomatis DNA topoisomerase I 0.0279 0.054 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0081 0.0134 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0061 0.0082
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0099 0.0098
Loa Loa (eye worm) pax transcription factor protein 2 0.0235 0.045 0.045
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0061 0.0081
Toxoplasma gondii DNA topoisomerase family protein 0.0239 0.0457 0.0456
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0016 0.0003 0.0001
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0032 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0096 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0029
Plasmodium vivax DNA topoisomerase 3, putative 0.0239 0.0457 0.0456
Echinococcus multilocularis caspase 3 0.0071 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0045 0.0061 0.1066
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0093 0.0093
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0057 0.0056
Schistosoma mansoni DNA topoisomerase type I 0.3601 0.7336 0.7336
Echinococcus multilocularis neutral alpha glucosidase AB 0.0045 0.0061 0.0061
Brugia malayi Dopamine receptor protein 2 0.0015 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.0061 0.0093 0.0093
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0008 0.0008
Brugia malayi hypothetical protein 0.0032 0.0035 0.0035
Leishmania major DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Schistosoma mansoni DNA polymerase eta 0.0043 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1601 0.3244 0.3244
Echinococcus multilocularis neurogenic locus notch protein 4 0.0021 0.0011 0.001
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0008 0.0008
Toxoplasma gondii SWI2/SNF2-containing protein 0.004 0.0052 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0118 0.0117
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0042 0.0716
Giardia lamblia DNA topoisomerase III 0.0239 0.0457 0.8254
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0045 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0093 0.0093
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0054 0.008 0.1754
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0061 0.006
Leishmania major DNA topoisomerase III, putative 0.0124 0.0223 0.0303
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0315 0.6951
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0003 0.0013
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0157 0.0213
Chlamydia trachomatis DNA gyrase subunit B 0.0054 0.008 0.1438
Echinococcus granulosus importin subunit beta 1 0.0028 0.0026 0.0026
Schistosoma mansoni inositol monophosphatase 0.0073 0.0118 0.0117
Schistosoma mansoni coup transcription factor 0.0061 0.0093 0.0093
Onchocerca volvulus Globin homolog 0.0017 0.0003 0.0057
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0279 0.054 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.0189 0.2447
Echinococcus granulosus protein jagged 2 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Echinococcus granulosus delta-like protein 1 0.0021 0.0011 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0003 0.0001
Onchocerca volvulus Peroxidase homolog 0.0063 0.0099 0.2178
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0003 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0003 0.0058
Brugia malayi larval opioid receptor 0.0015 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0024 0.0387
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0042 0.0056
Trypanosoma brucei glucosidase, putative 0.0045 0.0061 0.0082
Brugia malayi ecdysone receptor 0.0029 0.0028 0.0028
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0093 0.0093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.0099 0.0098
Plasmodium falciparum glutathione reductase 0.0016 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0299 0.058 0.0579
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0093 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0061 0.1057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0093 0.0093
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0094 0.0093
Chlamydia trachomatis DNA gyrase subunit B 0.0054 0.008 0.1438
Trichomonas vaginalis alpha-glucosidase, putative 0.0017 0.0003 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0089 0.0088
Leishmania major cathepsin L-like protease 0.0017 0.0003 0.0003
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0008 0.0008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0066 0.25
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0003 0.0001
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0239 0.0457 0.8254
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Loa Loa (eye worm) fibroinase 0.0017 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0093 0.0093
Leishmania major DNA topoisomerase III, putative 0.0286 0.0554 0.0754
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Echinococcus granulosus hypothetical protein 0.0703 0.1408 0.1407
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0016 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0002 0.0001
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0061 0.0093 0.0093
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0011 0.0011
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0032 0.003
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0061 0.1066
Brugia malayi nuclear receptor NHR-67 0.0029 0.0028 0.0028
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0018 0.0023
Plasmodium falciparum flap endonuclease 1 0.0025 0.0021 0.002
Onchocerca volvulus 0.0017 0.0003 0.0057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0094 0.2011
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.0334
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0021 0.0021
Brugia malayi neuropeptide F receptor 0.0015 0.0001 0.0001
Echinococcus multilocularis dna polymerase eta 0.0043 0.0058 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0033 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.052 0.1034 0.1034
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0027 0.0024 0.052
Plasmodium vivax vivapain-2 0.0017 0.0003 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0093 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.0496 0.8951
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0093 0.0093
Loa Loa (eye worm) cysteine protease 0.0017 0.0003 0.0003
Loa Loa (eye worm) Smad1 0.0016 0.0002 0.0001
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0008 0.0008
Plasmodium vivax DNA gyrase subunit B, putative 0.0054 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Plasmodium falciparum DNA gyrase subunit B 0.0054 0.008 0.0079
Brugia malayi hypothetical protein 0.0029 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0028 0.0027
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0001 0.0001
Brugia malayi notch-like transmembrane receptor 0.0021 0.0011 0.0011
Brugia malayi hypoxia-induced factor 1 0.015 0.0276 0.0276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0031 0.0509
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0032 0.0031
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0061 0.006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0009
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0024 0.0023
Leishmania major adenylate cyclase-like protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0008 0.0008
Brugia malayi hypothetical protein 0.0019 0.0008 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Loa Loa (eye worm) notch protein 0.0021 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0042 0.0716
Brugia malayi hypothetical protein 0.0465 0.0921 0.0921
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0004
Onchocerca volvulus Dual oxidase homolog 0.0063 0.0099 0.2178
Schistosoma mansoni notch 0.0021 0.0011 0.001
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0157 0.0157
Loa Loa (eye worm) acetyltransferase 0.0144 0.0265 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0292
Brugia malayi RNA binding protein 0.0062 0.0096 0.0096
Onchocerca volvulus 0.0029 0.0028 0.0598
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0452 0.816
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0315 0.5665
Brugia malayi sulfakinin receptor protein 0.0015 0.0001 0.0001
Echinococcus multilocularis peroxidasin 0.0064 0.0099 0.0099
Brugia malayi G-protein coupled receptor 0.0015 0.0001 0.0001
Mycobacterium ulcerans monooxygenase 0.0017 0.0003 0.0015
Brugia malayi hypothetical protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Brugia malayi DNA topoisomerase III beta-1 0.0124 0.0223 0.0223
Echinococcus granulosus neural cadherin 0.0021 0.0011 0.001
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0023
Echinococcus multilocularis tumor protein p63 0.0337 0.0658 0.0658
Brugia malayi nuclear hormone receptor 0.0061 0.0093 0.0093
Trypanosoma brucei DNA topoisomerase IA, putative 0.0239 0.0457 0.0622
Onchocerca volvulus 0.0062 0.0095 0.2094
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0163 0.0302 0.0301
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0178 0.0177
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.0189 0.74
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0214 0.8374
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.001 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Echinococcus multilocularis protein jagged 1 0.0021 0.0011 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.003 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Schistosoma mansoni nuclear receptor 0.0029 0.0028 0.0027
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0008 0.0008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0007
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0178 0.0177
Onchocerca volvulus 0.0029 0.0028 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Echinococcus granulosus caspase 3 0.0071 0.0113 0.0113
Schistosoma mansoni caspase-3 (C14 family) 0.0113 0.0201 0.0201
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0001 0.0001
Schistosoma mansoni globin X 0.0017 0.0003 0.0003
Onchocerca volvulus 0.0027 0.0024 0.052
Trichomonas vaginalis maltase-glucoamylase, putative 0.0017 0.0003 0.0016
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0054 0.008 0.008
Trichomonas vaginalis maltase-glucoamylase, putative 0.0045 0.0061 0.1066
Brugia malayi Glycosyl hydrolases family 31 protein 0.0045 0.0061 0.0061
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0017 0.0003 0.0062
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0032 0.0031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0007 0.0007
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0028 0.0027
Schistosoma mansoni peroxidasin 0.0063 0.0099 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0063 0.1094
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0061 0.006
Onchocerca volvulus 0.0095 0.0163 0.3598
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.007 0.0069
Toxoplasma gondii DNA topoisomerase 2, putative 0.0054 0.008 0.0079
Brugia malayi Cathepsin L-like precursor 0.0017 0.0003 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0093 0.0093
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0028 0.0027
Brugia malayi Cell death protein 3 precursor 0.0083 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Trypanosoma brucei glycosyl hydrolase-like protein 0.0017 0.0003 0.0003
Onchocerca volvulus 0.0017 0.0003 0.0057
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0267 0.0267
Trichomonas vaginalis DNA topoisomerase II, putative 0.0054 0.008 0.1403
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0333 0.6002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.001
Schistosoma mansoni thyroid hormone receptor 0.0061 0.0093 0.0093
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0026 0.0034
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0118 0.0117
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0057 0.0076
Onchocerca volvulus 0.0036 0.0043 0.0928
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0008 0.0008
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.003 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0061 0.0061
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0057 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Brugia malayi MH1 domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.002 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Echinococcus multilocularis protein jagged 2 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.029
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0118 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0093 0.0093
Echinococcus granulosus neurogenic locus protein delta 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.0189 0.74
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Echinococcus multilocularis neural cadherin 0.0021 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0061 0.006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0214 0.8374
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0045 0.0061 0.1054
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.009
Echinococcus multilocularis caspase 8 0.0043 0.0057 0.0056
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0093 0.0093
Onchocerca volvulus 0.003 0.003 0.065
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0066 0.0065
Brugia malayi MH1 domain containing protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0093 0.0093
Echinococcus granulosus neurogenic locus notch protein 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0008 0.0103
Brugia malayi PXA domain containing protein 0.0019 0.0008 0.0008
Brugia malayi MH2 domain containing protein 0.0016 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Brugia malayi conserved hypotetical protein 0.0029 0.0028 0.0028
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0093 0.0093
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0061 0.1066
Schistosoma mansoni DNA topoisomerase type I 0.4903 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.0554 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0009
Brugia malayi isocitrate dehydrogenase 0.0031 0.0032 0.0032
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0061 0.1045
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0011 0.0011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.0189 0.74
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0061 0.0081
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0256 0.0256
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0033 0.0044
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0094 0.0093
Brugia malayi Cytochrome P450 family protein 0.0031 0.0033 0.0033
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0054 0.008 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0118 0.2091
Echinococcus multilocularis snurportin 1 0.0299 0.058 0.0579
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0265 0.0264
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0032 0.0042
Leishmania major alpha glucosidase II subunit, putative 0.0045 0.0061 0.0082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Echinococcus multilocularis thyroid hormone receptor alpha 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0089 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Brugia malayi GCC2 and GCC3 family protein 0.0021 0.0011 0.0011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0089 0.0088
Schistosoma mansoni hypothetical protein 0.0499 0.099 0.0989
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0157 0.0213
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0021 0.0011 0.0011
Trypanosoma brucei metacaspase MCA2 0.0043 0.0057 0.0076
Brugia malayi steroid hormone receptor 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0034
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0124 0.0223 0.0223
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0032 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0061 0.006
Echinococcus granulosus caspase 2 0.0083 0.0139 0.0138
Giardia lamblia High cysteine protein 0.0021 0.0011 0.0155
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0024 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0292
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0043 0.088
Echinococcus granulosus muscleblind protein 0.0295 0.0572 0.0572
Echinococcus granulosus DNA topoisomerase 1 0.4903 1 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0139 0.0138
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0093 0.0093
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Leishmania major DNA polymerase eta, putative 0.0043 0.0058 0.0078
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0008 0.0008
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.0099 0.0098
Brugia malayi nuclear hormone receptor 0.0029 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0021 0.0027
Toxoplasma gondii cathepsin CPL 0.0017 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0057 0.0056
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0066 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0032 0.0031
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0057 0.0056
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0049 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0099 0.0134
Entamoeba histolytica hypothetical protein 0.0019 0.0008 0.009
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0045 0.0061 0.0061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0093 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0035 0.0035
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0035 0.0035
Brugia malayi Animal haem peroxidase family protein 0.0063 0.0099 0.0099
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0118 0.0159
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Schistosoma mansoni septate junction protein 0.0021 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0024 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0014
Brugia malayi putative neuropeptide receptor 0.0015 0.0001 0.0001
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0008 0.0008
Plasmodium falciparum DNA topoisomerase 2 0.0054 0.008 0.0079
Entamoeba histolytica hypothetical protein 0.0146 0.0267 0.4798
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0003 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0007
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0028 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0099 0.0134
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0001 0.0001
Echinococcus granulosus smad 0.0016 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.004 0.0051 0.005
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0121 0.012
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0093 0.0093
Brugia malayi GnHR receptor homolog 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0024 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0121 0.012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0093 0.0093
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0003 0.0013
Onchocerca volvulus Slit protein homolog 0.0021 0.0011 0.0237
Leishmania major GTP-binding protein, putative 0.0021 0.0011 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.0554 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0003 0.0002
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0134 0.2381
Loa Loa (eye worm) ctsf protein 0.0017 0.0003 0.0003
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0057 0.0986
Echinococcus granulosus protein jagged 1 0.0021 0.0011 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0066 0.0065
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0157 0.2812
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0178 0.0177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0093 0.1988
Onchocerca volvulus Neurogenic locus notch homolog 0.0021 0.0011 0.0237
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0003 0.0003
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0008 0.0008
Onchocerca volvulus 0.0021 0.0011 0.0232
Leishmania major importin beta-1 subunit, putative 0.0023 0.0016 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0028 0.0027
Brugia malayi Cadherin domain containing protein 0.0021 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0118 0.2143
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0093 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0121 0.012
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0003 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0096 0.0095
Brugia malayi Delta serrate ligand family protein 0.0021 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0333 0.6002
Onchocerca volvulus 0.004 0.0051 0.1112
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0057 0.0056
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0017 0.0003 0.0003
Plasmodium falciparum thioredoxin reductase 0.0047 0.0066 0.0064
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0107
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0146 0.0267 0.4798
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0016 0.0002 0.0001
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0054 0.008 0.1754
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0057 0.0986
Loa Loa (eye worm) DR-78 0.0029 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0295 0.0572 0.0572
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0121 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0292
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0245 0.0471 0.047
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0002 0.0001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0003 0.0002
Schistosoma mansoni slit 0.0021 0.0011 0.0011
Entamoeba histolytica Ran family GTPase 0.0021 0.0011 0.0145
Brugia malayi EGF-like domain containing protein 0.0021 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0064 0.0099 0.0134
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0008 0.0008
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0008 0.0008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0011 0.0014
Echinococcus multilocularis muscleblind protein 0.0295 0.0572 0.0572
Onchocerca volvulus 0.0017 0.0003 0.0058
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0124 0.0223 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0045 0.0061 0.1066
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.3601 0.7336 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.0035 0.0034
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0071 0.0096
Onchocerca volvulus 0.0063 0.0099 0.2178
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0093 0.0093
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0178 0.0177
Loa Loa (eye worm) hypothetical protein 0.0063 0.0099 0.0098
Brugia malayi Globin family protein 0.0017 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.002 0.001 0.0009
Echinococcus multilocularis fibropellin Ia 0.0021 0.0011 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0394 0.0393
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0003 0.0003
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0265 0.0265
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0059 0.0089 0.0089
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.002 0.001 0.0009
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0008 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0061 0.006
Brugia malayi Globin family protein 0.0017 0.0003 0.0003
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0007 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0011 0.0011
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0007 0.0193

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.81 uM Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A23187-stimulated platelet aggregation by measuring TXB2 production ChEMBL. 15615524
IC50 (binding) = 1.81 uM Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A23187-stimulated platelet aggregation by measuring TXB2 production ChEMBL. 15615524
IC50 (binding) = 2.36 uM Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production ChEMBL. 15615524
IC50 (binding) = 2.36 uM Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production ChEMBL. 15615524
Ratio IC50 (binding) = 0.76 Selectivity ratio of IC50 for human COX1 to IC50 for human COX2 ChEMBL. 15615524

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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