Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | dihydrofolate reductase | 187 aa | 202 aa | 29.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.696 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0469 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0469 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0469 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.696 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.696 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0208 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.696 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.696 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.696 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0469 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0469 | 1 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.696 | 0.5 | |
Brugia malayi | thymidylate synthase | 0.0389 | 0.696 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.696 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 690 nM | Growth inhibition of human CCRF-CEM cells | ChEMBL. | 15615522 |
EC50 (functional) | = 690 nM | Growth inhibition of human CCRF-CEM cells | ChEMBL. | 15615522 |
EC50 (functional) | = 1200 nM | Growth inhibition of MTX-resistant human CCRF-CEM R30dm cells | ChEMBL. | 15615522 |
EC50 (functional) | = 1200 nM | Growth inhibition of MTX-resistant human CCRF-CEM R30dm cells | ChEMBL. | 15615522 |
EC50 (functional) | = 1900 nM | Growth inhibition of MTX-resistant human CCRF-CEM R1 cells overexpressing DHFR | ChEMBL. | 15615522 |
EC50 (functional) | = 1900 nM | Growth inhibition of MTX-resistant human CCRF-CEM R1 cells overexpressing DHFR | ChEMBL. | 15615522 |
EC50 (functional) | = 12000 nM | Growth inhibition of MTX-resistant human CCRF-CEM R2 cells | ChEMBL. | 15615522 |
EC50 (functional) | = 12000 nM | Growth inhibition of MTX-resistant human CCRF-CEM R2 cells | ChEMBL. | 15615522 |
GI50 (ADMET) | 0 | Cytotoxicity against human CCRF-CEM leukemia cells | ChEMBL. | 15615522 |
GI50 (ADMET) | < 0.01 uM | Cytotoxicity against BT549 cells | ChEMBL. | 15615522 |
GI50 (ADMET) | < 0.01 uM | Cytotoxicity against BT549 cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 0.758 uM | Cytotoxicity against human EKVX cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 0.758 uM | Cytotoxicity against human EKVX cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 1.48 uM | Cytotoxicity against HCC2998 cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 1.48 uM | Cytotoxicity against HCC2998 cells | ChEMBL. | 15615522 |
GI50 (functional) | = 7.44 uM | Cytotoxicity against SF268 cells | ChEMBL. | 15615522 |
GI50 (functional) | = 7.44 uM | Cytotoxicity against SF268 cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 8.54 uM | Cytotoxicity against NCI/ADR-RES cells | ChEMBL. | 15615522 |
GI50 (ADMET) | = 8.54 uM | Cytotoxicity against NCI/ADR-RES cells | ChEMBL. | 15615522 |
IC50 (binding) | = 51 nM | Inhibition of human thymidylate synthase | ChEMBL. | 15615522 |
IC50 (binding) | = 51 nM | Inhibition of human thymidylate synthase | ChEMBL. | 15615522 |
IC50 (binding) | = 5100 nM | Inhibition of Escherichia coli thymidylate synthase | ChEMBL. | 15615522 |
IC50 (binding) | = 5100 nM | Inhibition of Escherichia coli thymidylate synthase | ChEMBL. | 15615522 |
IC50 (binding) | = 11 uM | Inhibition of human DHFR | ChEMBL. | 15615522 |
IC50 (binding) | = 11 uM | Inhibition of human DHFR | ChEMBL. | 15615522 |
IC50 (binding) | = 40 uM | Inhibition of Escherichia coli DHFR | ChEMBL. | 15615522 |
IC50 (binding) | = 40 uM | Inhibition of Escherichia coli DHFR | ChEMBL. | 15615522 |
Inhibition (binding) | Inhibition of human thymidylate synthase | ChEMBL. | 23927969 | |
Inhibition (functional) | = 11 % | Growth inhibition of human CCRF-CEM leukemia cells at 2400 nM relative to leucovorin | ChEMBL. | 15615522 |
Inhibition (functional) | = 11 % | Growth inhibition of human CCRF-CEM leukemia cells at 2400 nM relative to leucovorin | ChEMBL. | 15615522 |
Km (binding) | <= 250 uM | Activity of human recombinant FPGS | ChEMBL. | 15615522 |
Km (binding) | <= 250 uM | Activity of human recombinant FPGS | ChEMBL. | 15615522 |
Ratio (binding) | = 0 | Ratio of relative Vmax to Km of human recombinant FPGS | ChEMBL. | 15615522 |
Vmax (binding) | = 0 | Activity of human recombinant FPGS relative to AMT | ChEMBL. | 15615522 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15615522 | |
Homo sapiens | ChEMBL23 | 15615522 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.