Detailed information for compound 419346

Basic information

Technical information
  • TDR Targets ID: 419346
  • Name: 3-[2-[3-(anthracene-9-carbonyloxy)propyl-meth ylamino]ethyl-methylamino]propyl anthracene-9 -carboxylate
  • MW: 612.757 | Formula: C40H40N2O4
  • H donors: 0 H acceptors: 2 LogP: 9.11 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(CCN(CCCOC(=O)c1c2ccccc2cc2c1cccc2)C)CCCOC(=O)c1c2ccccc2cc2c1cccc2
  • InChi: 1S/C40H40N2O4/c1-41(21-11-25-45-39(43)37-33-17-7-3-13-29(33)27-30-14-4-8-18-34(30)37)23-24-42(2)22-12-26-46-40(44)38-35-19-9-5-15-31(35)28-32-16-6-10-20-36(32)38/h3-10,13-20,27-28H,11-12,21-26H2,1-2H3
  • InChiKey: JRQDOTIBLCQSDH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[3-(anthracene-9-carbonyloxy)propyl-methyl-amino]ethyl-methyl-amino]propyl anthracene-9-carboxylate
  • 9-anthracenecarboxylic acid 3-[2-[3-[9-anthryl(oxo)methoxy]propyl-methylamino]ethyl-methylamino]propyl ester
  • 3-[2-[3-anthracen-9-ylcarbonyloxypropyl(methyl)amino]ethyl-methyl-amino]propyl anthracene-9-carboxylate
  • anthracene-9-carboxylic acid 3-[2-[3-(anthracene-9-carbonyloxy)propyl-methyl-amino]ethyl-methyl-amino]propyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi G protein-coupled receptor F59B2.13 0.0149 0.0654 0.0925
Schistosoma mansoni opsin-like receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus beta-adrenergic receptor kinase 0.01 0.0289 0.0289
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0134 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus granulosus g protein coupled receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Plasmodium falciparum SET domain protein, putative 0.0066 0.004 1
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0289 0.0289
Echinococcus granulosus biogenic amine 5HT receptor 0.0149 0.0654 0.0654
Trypanosoma brucei mitotic cyclin 6 0.0126 0.0483 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Echinococcus multilocularis neuropeptide receptor 0.1412 1 1
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Echinococcus granulosus tachykinin peptides receptor 99D 0.0149 0.0654 0.0654
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0149 0.0654 0.0925
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Schistosoma mansoni histamine h1 receptor 0.0149 0.0654 0.0654
Plasmodium vivax SET domain protein, putative 0.0066 0.004 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0727 0.4933 0.4933
Echinococcus multilocularis cyclin B 0.0126 0.0483 0.0483
Trichomonas vaginalis cyclin B, putative 0.0126 0.0483 0.1121
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Brugia malayi neuropeptide F receptor 0.0149 0.0654 0.0925
Loa Loa (eye worm) neuropeptide F receptor 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Echinococcus granulosus neuropeptide receptor A26 0.0149 0.0654 0.0654
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0149 0.0654 0.0925
Echinococcus multilocularis neuropeptides capa receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0126 0.0483 0.7392
Schistosoma mansoni hypothetical protein 0.0149 0.0654 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0074 0.0094 0.0133
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0066 0.004 0.004
Echinococcus granulosus hypothetical protein 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0079 0.0133 0.0133
Echinococcus multilocularis G protein coupled receptor 139 0.1412 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0149 0.0654 0.0925
Schistosoma mansoni biogenic amine (5HT) receptor 0.0149 0.0654 0.0654
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus g-protein coupled receptor 0.0149 0.0654 0.0654
Brugia malayi Dopamine receptor protein 1 0.0149 0.0654 0.0925
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0149 0.0654 0.0654
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0149 0.0654 0.0654
Echinococcus granulosus biogenic amine 5HT receptor 0.0149 0.0654 0.0654
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0149 0.0654 0.0654
Brugia malayi follicle stimulating hormone receptor 0.0149 0.0654 0.0925
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.01 0.0289 0.0409
Echinococcus multilocularis 0.0587 0.3892 0.3892
Brugia malayi ORL1-like opioid receptor 0.0149 0.0654 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0845 0.5806 0.5806
Echinococcus granulosus integrin alpha 3 0.0117 0.0413 0.0413
Echinococcus granulosus cyclin B 0.0126 0.0483 0.0483
Echinococcus multilocularis neuropeptide Y receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni hypothetical protein 0.0149 0.0654 0.0654
Echinococcus multilocularis neuroendocrine convertase 2 0.0457 0.2933 0.2933
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0141 0.0591 0.1531
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0149 0.0654 0.0654
Echinococcus granulosus sex peptide receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0133 0.0189
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) TYRA-2 protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.0654 0.0654
Echinococcus multilocularis g-protein coupled receptor 0.0149 0.0654 0.0654
Echinococcus granulosus neuroendocrine convertase 2 0.0457 0.2933 0.2933
Trichomonas vaginalis cyclins, putative 0.0126 0.0483 0.1121
Schistosoma mansoni hypothetical protein 0.0079 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0126 0.0483 0.0684
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0149 0.0654 0.0654
Echinococcus granulosus neuropeptides capa receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis orexin receptor type 2 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Onchocerca volvulus 0.0149 0.0654 1
Echinococcus multilocularis serotonin receptor 0.0149 0.0654 0.0654
Schistosoma mansoni biogenic amine receptor 0.0149 0.0654 0.0654
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0149 0.0654 0.0925
Echinococcus multilocularis g protein coupled receptor 0.0149 0.0654 0.0654
Brugia malayi putative neuropeptide receptor NPR1 0.0149 0.0654 0.0925
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0133 0.0189
Schistosoma mansoni neuropeptide f receptor 76f 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni amine GPCR 0.0149 0.0654 0.0654
Brugia malayi AKH receptor 0.0149 0.0654 0.0925
Trichomonas vaginalis cyclins, putative 0.0126 0.0483 0.1121
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Echinococcus granulosus neuropeptide Y receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.0654 0.0654
Echinococcus multilocularis GPCR, family 2 0.0079 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0442 0.2822 0.2822
Brugia malayi larval opioid receptor 0.0149 0.0654 0.0925
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.0654 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) melatonin receptor type 1A 0.0149 0.0654 0.0925
Echinococcus multilocularis fmrfamide receptor 0.0149 0.0654 0.0654
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0811 0.1147
Schistosoma mansoni amine GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis somatostatin receptor 0.0149 0.0654 0.0654
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.0654 0.0654
Schistosoma mansoni myosin xvIII 0.0149 0.0654 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Brugia malayi endoprotease bli-4 precursor 0.0727 0.4933 0.6982
Brugia malayi neuroendocrine convertase 1 precursor 0.0457 0.2933 0.4151
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.2822 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Onchocerca volvulus 0.0149 0.0654 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0133 0.0189
Brugia malayi Protein set-1 0.0066 0.004 0.0057
Echinococcus multilocularis integrin alpha ps 0.0068 0.0055 0.0055
Trypanosoma cruzi cyclin 6, putative 0.0126 0.0483 0.5
Schistosoma mansoni biogenic amine receptor 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni hypothetical protein 0.0149 0.0654 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.017 0.0811 0.0811
Echinococcus granulosus dro:myosuppressin receptor 0.0149 0.0654 0.0654
Schistosoma mansoni alpha-1 adrenergic receptor 0.0149 0.0654 0.0654
Entamoeba histolytica cyclin, putative 0.0126 0.0483 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0079 0.0133 0.0133
Schistosoma mansoni neuropeptide F-like receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) G-protein coupled receptor 0.0149 0.0654 0.0925
Brugia malayi putative neuropeptide receptor 0.0149 0.0654 0.0925
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Schistosoma mansoni neuropeptide receptor 0.1412 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0149 0.0654 0.0654
Schistosoma mansoni growth hormone secretagogue receptor 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Brugia malayi Melatonin receptor type 1A 0.0149 0.0654 0.0925
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0066 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Toxoplasma gondii histone lysine methyltransferase SET8 0.0066 0.004 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0149 0.0654 0.0654
Brugia malayi GnHR receptor homolog 0.0149 0.0654 0.0925
Brugia malayi G-protein coupled receptor 0.0149 0.0654 0.0925
Schistosoma mansoni adenoreceptor 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0141 0.0591 0.0591
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus granulosus allatostatin A receptor 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0285 0.1662 0.2351
Onchocerca volvulus 0.0149 0.0654 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0149 0.0654 0.0654
Echinococcus granulosus peptide allatostatin:somatostatin 0.0149 0.0654 0.0654
Schistosoma mansoni neuropeptide receptor 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis protein will die slowly 0.0134 0.054 0.054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0149 0.0654 0.0654
Echinococcus multilocularis sex peptide receptor 0.0149 0.0654 0.0654
Echinococcus granulosus neuropeptides capa receptor 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Echinococcus multilocularis integrin alpha 3 0.0117 0.0413 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Loa Loa (eye worm) integrin alpha pat-2 0.0234 0.1285 0.1818
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) WD40 repeat protein 0.0134 0.054 0.0764
Brugia malayi Integrin alpha pat-2 precursor 0.0152 0.0675 0.0956
Loa Loa (eye worm) endoprotease bli-4 0.0727 0.4933 0.6982
Schistosoma mansoni cyclin B 0.0126 0.0483 0.0483
Brugia malayi RE15519p 0.0149 0.0654 0.0925
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0149 0.0654 0.0654
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus granulosus serotonin receptor 0.0149 0.0654 0.0654
Schistosoma mansoni amine GPCR 0.0149 0.0654 0.0654
Leishmania major cyclin 0.0126 0.0483 0.5
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.1016 0.7066 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0149 0.0654 0.0654
Echinococcus multilocularis neuropeptide receptor A26 0.0149 0.0654 0.0654
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.0654 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Trichomonas vaginalis cyclins, putative 0.0126 0.0483 0.1121
Echinococcus granulosus integrin alpha ps 0.0068 0.0055 0.0055
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0172 0.0821 0.0821
Brugia malayi G-protein coupled receptor 0.0149 0.0654 0.0925
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0149 0.0654 0.0654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Brugia malayi celfurPC protein 0.0587 0.3892 0.5508
Loa Loa (eye worm) hypothetical protein 0.0126 0.0483 0.0684
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0149 0.0654 0.0654
Brugia malayi Serotonin receptor 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis neuropeptides capa receptor 0.0149 0.0654 0.0654
Brugia malayi Will die slowly protein 0.0134 0.054 0.0764
Echinococcus granulosus G protein coupled receptor kinase 1 0.009 0.0213 0.0213
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0066 0.004 0.0057
Echinococcus multilocularis serotonin receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis dro:myosuppressin receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis neuropeptide Y receptor 0.0149 0.0654 0.0654
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0133 0.0189
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Echinococcus granulosus protein will die slowly 0.0134 0.054 0.054
Schistosoma mansoni opsin-like receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0126 0.0483 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0149 0.0654 0.0654
Brugia malayi Tachykinin-like peptides receptor 99D 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Schistosoma mansoni furin-1 (S08 family) 0.0316 0.1892 0.1892
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0172 0.0821 0.2405
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Echinococcus multilocularis neuropeptide FF receptor 2 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0115 0.0401 0.0568
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus alpha 1A adrenergic receptor 0.0149 0.0654 0.0654
Echinococcus granulosus fmrfamide receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0727 0.4933 0.6982
Loa Loa (eye worm) proprotein convertase 2 0.0172 0.0821 0.1162
Trichomonas vaginalis cyclin A, putative 0.0126 0.0483 0.1121
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0149 0.0654 0.0654
Brugia malayi G protein-coupled receptor 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0149 0.0654 1
Brugia malayi Dopamine receptor 0.0149 0.0654 0.0925
Trypanosoma cruzi cyclin, putative 0.0126 0.0483 0.5
Giardia lamblia Furin precursor putative serine protease 0.0141 0.0591 0.1013
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Schistosoma mansoni neuropeptide receptor 0.0149 0.0654 0.0654
Schistosoma mansoni hypothetical protein 0.0079 0.0133 0.0133
Brugia malayi Cyclin, N-terminal domain containing protein 0.0126 0.0483 0.0684
Trichomonas vaginalis hypothetical protein 0.0141 0.0591 0.1531
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni integrin alpha 0.0152 0.0675 0.0675
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0149 0.0654 0.0654
Echinococcus granulosus neuropeptide Y receptor 0.0149 0.0654 0.0654
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0149 0.0654 0.0925
Echinococcus granulosus GPCR family 2 0.0079 0.0133 0.0133
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0149 0.0654 0.0925
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0141 0.0591 0.1531
Schistosoma mansoni hypothetical protein 0.0149 0.0654 0.0654
Echinococcus multilocularis neuropeptide s receptor 0.0149 0.0654 0.0654
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0149 0.0654 0.0654
Schistosoma mansoni amine GPCR 0.0149 0.0654 0.0654
Brugia malayi Serotonin receptor 0.0149 0.0654 0.0925
Trichomonas vaginalis cyclin B, putative 0.0126 0.0483 0.1121
Echinococcus multilocularis g protein coupled receptor 0.0149 0.0654 0.0654
Echinococcus granulosus 7tm_1 domain containing protein 0.0149 0.0654 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Trichomonas vaginalis cyclin B, putative 0.0126 0.0483 0.1121
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis neuropeptide receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0149 0.0654 0.0654
Onchocerca volvulus Neuropeptide F receptor homolog 0.0149 0.0654 1
Echinococcus granulosus neuropeptide s receptor 0.0149 0.0654 0.0654
Onchocerca volvulus 0.0134 0.054 0.8255
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0149 0.0654 1
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Brugia malayi Dopamine receptor protein 2 0.0149 0.0654 0.0925
Schistosoma mansoni biogenic amine (5HT) receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis fmrfamide receptor 0.0149 0.0654 0.0654
Brugia malayi proprotein convertase 2 0.0457 0.2933 0.4151
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0149 0.0654 0.0925
Echinococcus granulosus g protein coupled receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis allatostatin A receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0149 0.0654 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.1394 0.1973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.1394 0.1973
Echinococcus granulosus neuropeptide FF receptor 2 0.0149 0.0654 0.0654
Echinococcus granulosus somatostatin receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus orexin receptor type 2 0.0149 0.0654 0.0654
Trichomonas vaginalis WD repeat domain, putative 0.0134 0.054 0.1335
Echinococcus multilocularis Furin 1 0.0172 0.0821 0.0821
Loa Loa (eye worm) neuropeptide F receptor 0.0149 0.0654 0.0925
Loa Loa (eye worm) G-protein coupled receptor 0.0149 0.0654 0.0925
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus multilocularis integrin alpha ps 0.0068 0.0055 0.0055
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0149 0.0654 0.0654
Schistosoma mansoni opsin-like receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0133 0.0133
Trypanosoma cruzi CYC2-like cyclin, putative 0.0126 0.0483 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0149 0.0654 0.0925
Echinococcus granulosus g protein coupled receptor 0.0149 0.0654 0.0654
Brugia malayi hypothetical protein 0.0149 0.0654 0.0925
Brugia malayi sulfakinin receptor protein 0.0149 0.0654 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0289 0.0289
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0845 0.5806 0.5806
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Schistosoma mansoni integrin alpha-ps 0.0068 0.0055 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1016 0.7066 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0149 0.0654 0.0925
Onchocerca volvulus 0.0149 0.0654 1
Echinococcus granulosus furin 0.0727 0.4933 0.4933
Trichomonas vaginalis cyclin B, putative 0.0126 0.0483 0.1121
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0115 0.0401 0.0568
Onchocerca volvulus 0.0149 0.0654 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Brugia malayi Cyclin, N-terminal domain containing protein 0.0126 0.0483 0.0684
Echinococcus multilocularis g protein coupled receptor 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0084 0.0171 0.0242
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.0654 0.0654
Echinococcus granulosus Furin 1 0.0172 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0149 0.0654 0.0654
Echinococcus multilocularis rhodopsin orphan GPCR 0.0149 0.0654 0.0654
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0442 0.2822 0.2822
Schistosoma mansoni amine GPCR 0.0149 0.0654 0.0654
Schistosoma mansoni neuropeptide receptor 0.0149 0.0654 0.0654
Schistosoma mansoni biogenic amine receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0149 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Giardia lamblia High cysteine membrane protein Group 2 0.027 0.155 1
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0066 0.004 0.004
Brugia malayi neuropeptide F receptor 0.0149 0.0654 0.0925
Echinococcus multilocularis G protein coupled receptor kinase 1 0.009 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0149 0.0654 0.0925
Echinococcus granulosus neuropeptide receptor 0.0149 0.0654 0.0654
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.2822 1
Onchocerca volvulus 0.0149 0.0654 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0434 0.0614
Loa Loa (eye worm) hypothetical protein 0.017 0.0811 0.1147
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0141 0.0591 0.1531
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0149 0.0654 0.0654
Schistosoma mansoni neuropeptide F-like receptor 0.0149 0.0654 0.0654
Echinococcus multilocularis beta adrenergic receptor kinase 0.01 0.0289 0.0289
Echinococcus granulosus tm gpcr rhodopsin 0.0149 0.0654 0.0654
Trichomonas vaginalis cyclins, putative 0.0126 0.0483 0.1121
Trypanosoma cruzi cyclin, putative 0.0126 0.0483 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.0591 0.1531

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0.8 uM Reversal of P-gp-mediated multidrug resistance in human K562 cells assessed as drug concentration causing 40% increase in nuclear pirarubicin concentration ChEMBL. 16279802
Activity (binding) = 0.8 uM Reversal of P-gp-mediated multidrug resistance in human K562 cells assessed as drug concentration causing 40% increase in nuclear pirarubicin concentration ChEMBL. 16279802
Alpha max (binding) = 0.5 Reversal of P-gp-mediated multidrug resistance in doxorubicin-resistant human K562 cells assessed as increase in nuclear pirarubicin concentration ChEMBL. 16279802

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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