Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transient receptor potential channel | 0.0008 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | gliotactin | 0.0041 | 0.1423 | 0.1423 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.1423 | 0.1412 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.1423 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0008 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.1423 | 0.1412 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0041 | 0.1423 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Onchocerca volvulus | 0.0041 | 0.1423 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1423 | 0.1412 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.1423 | 0.1412 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0008 | 0.0012 | 0.0012 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Onchocerca volvulus | 0.0041 | 0.1423 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0041 | 0.1423 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0041 | 0.1423 | 0.1423 |
Echinococcus multilocularis | neuroligin | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0041 | 0.1423 | 0.1423 |
Onchocerca volvulus | 0.0041 | 0.1423 | 0.5 | |
Onchocerca volvulus | 0.0041 | 0.1423 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0008 | 0.0012 | 0.0012 |
Brugia malayi | Carboxylesterase family protein | 0.0041 | 0.1423 | 0.1412 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0041 | 0.1423 | 0.1423 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0008 | 0.0012 | 0.0012 |
Onchocerca volvulus | 0.0041 | 0.1423 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0041 | 0.1423 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0041 | 0.1423 | 0.1423 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0041 | 0.1423 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0041 | 0.1423 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1423 | 0.1423 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0041 | 0.1423 | 0.1423 |
Echinococcus granulosus | neuroligin | 0.0041 | 0.1423 | 0.1423 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 18 nM | Inhibition of AchE in bovine erythrocytes | ChEMBL. | 16279781 |
IC50 (binding) | = 18 nM | Inhibition of AchE in bovine erythrocytes | ChEMBL. | 16279781 |
IC50 (binding) | = 18 nM | Inhibition of AChE | ChEMBL. | 20053484 |
IC50 (binding) | = 77 nM | Inhibition of human serum BChE | ChEMBL. | 16279781 |
IC50 (binding) | = 77 nM | Inhibition of human serum BChE | ChEMBL. | 16279781 |
Ratio IC50 (binding) | = 0.2 | Selectivity for human BChE over boviine AChE | ChEMBL. | 16279781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.