Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0114 | 0.141 | 0.141 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0114 | 0.141 | 0.5 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0114 | 0.141 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0246 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0114 | 0.141 | 0.141 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0114 | 0.141 | 0.141 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Onchocerca volvulus | Sodium\/hydrogen exchanger homolog | 0.0114 | 0.141 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0114 | 0.141 | 0.141 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0114 | 0.141 | 0.141 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0114 | 0.141 | 0.141 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 1 | 1 |
Giardia lamblia | Sodium/hydrogen exchanger 3 | 0.0114 | 0.141 | 0.5 |
Echinococcus granulosus | sodium:hydrogen exchanger | 0.0114 | 0.141 | 0.141 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0246 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger 2 (nhe2) | 0.0114 | 0.141 | 0.141 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Echinococcus multilocularis | sodium:hydrogen exchanger | 0.0114 | 0.141 | 0.141 |
Echinococcus multilocularis | acetylcholinesterase | 0.0246 | 1 | 1 |
Echinococcus granulosus | sodium:hydrogen exchanger 2 nhe2 | 0.0114 | 0.141 | 0.141 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 19 nM | Inhibition of human serum BChE | ChEMBL. | 16279781 |
IC50 (binding) | = 19 nM | Inhibition of human serum BChE | ChEMBL. | 16279781 |
IC50 (binding) | = 36 nM | Inhibition of AchE in bovine erythrocytes | ChEMBL. | 16279781 |
IC50 (binding) | = 36 nM | Inhibition of AchE in bovine erythrocytes | ChEMBL. | 16279781 |
IC50 (binding) | = 36 nM | Inhibition of AChE | ChEMBL. | 20053484 |
Ratio IC50 (binding) | = 1.9 | Selectivity for human BChE over boviine AChE | ChEMBL. | 16279781 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.