Detailed information for compound 419772

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 349.297 | Formula: C19H22Cl2N2
  • H donors: 1 H acceptors: 1 LogP: 4.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cn1)[C@H]1CC2[C@H](C1CC2)NCc1ccccc1.Cl
  • InChi: 1S/C19H21ClN2.ClH/c20-18-9-7-15(12-21-18)17-10-14-6-8-16(17)19(14)22-11-13-4-2-1-3-5-13;/h1-5,7,9,12,14,16-17,19,22H,6,8,10-11H2;1H/t14?,16?,17-,19-;/m1./s1
  • InChiKey: PGMOPMSLFHJZGQ-INPIPGCJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, nicotinic, alpha 7 (neuronal) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative Get druggable targets OG5_130932 All targets in OG5_130932
Brugia malayi Cation transporter family protein Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) Get druggable targets OG5_130932 All targets in OG5_130932
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi acetylcholine receptor alpha subunit precursor, putative cholinergic receptor, nicotinic, alpha 7 (neuronal) 502 aa 513 aa 33.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0112 0.0117
Onchocerca volvulus 0.0071 0.057 0.0607
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus neuropeptide receptor 0.0036 0.0112 0.0146
Echinococcus granulosus somatostatin receptor 0.0036 0.0112 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0075 0.0614 0.0642
Brugia malayi G-protein coupled receptor 0.0036 0.0112 0.0117
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0429 0.0556
Echinococcus multilocularis mitogen activated protein kinase 14 0.0626 0.7711 0.7711
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Schistosoma mansoni hypothetical protein 0.0164 0.1759 0.4157
Onchocerca volvulus Tyrosine kinase homolog 0.0721 0.8933 0.951
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0846 0.2731
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0112 0.0117
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0426 0.1006
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0138 0.0138
Schistosoma mansoni sodium/chloride dependent transporter 0.0071 0.057 0.1347
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0038 0.0138 0.0138
Echinococcus granulosus neuropeptide s receptor 0.0544 0.6653 0.8629
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0034 0.0091 0.0091
Echinococcus multilocularis mitogen activated protein kinase 11 0.0626 0.7711 0.7711
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0112 0.0117
Loa Loa (eye worm) solute carrier family 6 member 4 0.0071 0.057 0.0596
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0846 0.2731
Brugia malayi Nuclear hormone receptor-like 1 0.0075 0.0614 0.0642
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0112 0.0112
Toxoplasma gondii ABC1 family protein 0.004 0.0166 0.296
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Schistosoma mansoni cell adhesion molecule 0.0068 0.0535 0.1263
Onchocerca volvulus Bile acid receptor homolog 0.0757 0.9394 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0112 0.0146
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0138 0.0179
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0038 0.0138 0.0144
Loa Loa (eye worm) norepinephrine transporter 0.0071 0.057 0.0596
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0168 0.3016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0214 0.0505
Echinococcus granulosus twitchin 0.006 0.0431 0.0559
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0124 0.013
Brugia malayi Cation transporter family protein 0.0123 0.1237 0.1293
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0083 0.0726 0.2313
Loa Loa (eye worm) hypothetical protein 0.0044 0.0214 0.0224
Mycobacterium tuberculosis Probable reductase 0.0083 0.0726 0.2313
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0075 0.0614 0.0642
Schistosoma mansoni myosin xvIII 0.0036 0.0112 0.0265
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.0034 0.0091 0.0095
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.006 0.0427 0.0427
Mycobacterium tuberculosis Conserved protein 0.004 0.0166 0.0353
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0112 0.0112
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi Melatonin receptor type 1A 0.0036 0.0112 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0075 0.0614 0.0642
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0168 1
Onchocerca volvulus 0.0104 0.0994 0.1058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0166 0.1677
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0112 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0075 0.0614 0.0642
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus orexin receptor type 2 0.0036 0.0112 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0075 0.0614 0.0642
Echinococcus multilocularis somatostatin receptor 0.0036 0.0112 0.0112
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0138 0.0179
Echinococcus granulosus raf serine:threonine protein kinase 0.0239 0.2729 0.3539
Echinococcus granulosus tyrosine protein kinase Lyn 0.0062 0.0456 0.0592
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0054 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.0426 0.0445
Echinococcus multilocularis Immunoglobulin 0.0046 0.0249 0.0249
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0138 0.0179
Onchocerca volvulus 0.0038 0.0138 0.0147
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0356 0.4233 0.5489
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0166 0.9617
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0046 0.0249 0.0589
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Echinococcus granulosus tyrosine kinase 0.0042 0.0192 0.0249
Brugia malayi Fibronectin type III domain containing protein 0.0053 0.0341 0.0356
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0429 0.0429
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Brugia malayi Immunoglobulin I-set domain containing protein 0.0771 0.9571 1
Onchocerca volvulus 0.0042 0.0192 0.0205
Brugia malayi mbt repeat family protein 0.0053 0.0332 0.0347
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0112 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0214 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus c src tyrosine kinase 0.006 0.0427 0.0554
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0043 0.0207 0.049
Schistosoma mansoni inositol monophosphatase 0.0036 0.0113 0.0267
Loa Loa (eye worm) hypothetical protein 0.0053 0.0341 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0075 0.0614 0.0642
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0332 0.0332
Brugia malayi hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0112 0.0117
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi Protein kinase domain containing protein 0.0042 0.0192 0.0201
Echinococcus granulosus GPCR family 2 0.0033 0.0079 0.0103
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0264 0.3047 0.3184
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0038 0.0138 0.0138
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0038 0.0138 0.0138
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0075 0.0614 0.0796
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0075 0.0614 0.0614
Schistosoma mansoni opsin-like receptor 0.0036 0.0112 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0113 0.0146
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0043 0.0207 0.0207
Echinococcus granulosus tyrosine protein kinase Src64B 0.006 0.0427 0.0554
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0079 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0075 0.0614 0.1451
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0168 0.0175
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0214 0.0214
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0038 0.0138 0.0179
Entamoeba histolytica hypothetical protein 0.004 0.0165 0.6633
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0138 0.0326
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi photoreceptor-specific nuclear receptor 0.0075 0.0614 0.0642
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.0075 0.0614 0.1451
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0626 0.7711 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.006 0.0427 0.0554
Schistosoma mansoni amine GPCR 0.0036 0.0112 0.0265
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0071 0.057 0.1347
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0214 0.0505
Echinococcus multilocularis geminin 0.0164 0.1759 0.1759
Echinococcus granulosus FTZ F1 alpha 0.0075 0.0614 0.0796
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0112 0.0112
Echinococcus granulosus neuropeptide receptor 0.0036 0.0112 0.0146
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0044 0.0214 0.0224
Onchocerca volvulus 0.0687 0.8484 0.9031
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0038 0.0138 0.0144
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0427 0.0427
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0168 1
Echinococcus multilocularis serotonin receptor 0.0036 0.0112 0.0112
Brugia malayi sulfakinin receptor protein 0.0036 0.0112 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0846 0.2731
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0124 0.0207
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0112 0.0112
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0427 0.0427
Schistosoma mansoni tyrosine kinase 0.0042 0.0192 0.0454
Brugia malayi ecdysone receptor 0.0031 0.0054 0.0056
Mycobacterium tuberculosis Probable dehydrogenase 0.0083 0.0726 0.2313
Onchocerca volvulus 0.0036 0.0112 0.0119
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0073 0.0595 0.0622
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0112 0.0112
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0429 0.1013
Echinococcus multilocularis tyrosine protein kinase Fgr 0.006 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Schistosoma mansoni vesicular amine transporter 0.0046 0.0249 0.0589
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Onchocerca volvulus 0.0169 0.1829 0.1947
Schistosoma mansoni biogenic amine receptor 0.0036 0.0112 0.0265
Brugia malayi SH2 domain containing protein 0.0042 0.0192 0.0201
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0112 0.0117
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0112 0.0146
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0054 0.0054
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0112 0.0265
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0356 0.4233 0.4422
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0138 0.0326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0046 0.0249 0.026
Brugia malayi Thioredoxin reductase 0.0037 0.0124 0.013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0113 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0075 0.0614 0.0642
Brugia malayi Protein kinase domain containing protein 0.0042 0.0192 0.0201
Trichomonas vaginalis esterase, putative 0.004 0.0166 0.9617
Brugia malayi protein-tyrosine kinase 0.0042 0.0192 0.0201
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0166 0.0173
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0166 0.0166
Onchocerca volvulus 0.004 0.0166 0.0177
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0332 0.0785
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0075 0.0614 0.1451
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0042 0.0192 0.0192
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0429 0.0488
Echinococcus granulosus hypothetical protein 0.0036 0.0112 0.0146
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0028 0.0011 0.0011
Schistosoma mansoni amine GPCR 0.0036 0.0112 0.0265
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0079 0.0083
Loa Loa (eye worm) hypothetical protein 0.0046 0.0249 0.026
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0036 0.0121 0.0126
Echinococcus granulosus roundabout 2 0.008 0.0687 0.089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Entamoeba histolytica hypothetical protein 0.004 0.0165 0.6633
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.197 0.2059
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1176 0.1229
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0075 0.0614 0.0614
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0054 0.007
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0046 0.0249 0.0249
Echinococcus multilocularis roundabout 2 0.008 0.0687 0.0687
Echinococcus granulosus ecdysone induced protein 78C 0.0075 0.0614 0.0796
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0426 0.0552
Brugia malayi conserved hypotetical protein 0.0031 0.0054 0.0056
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0112 0.0112
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis tyrosine protein kinase Abl 0.006 0.0427 0.0427
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0166 0.0353
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0043 0.0207 0.0269
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0138 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0075 0.0614 0.1451
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0214 0.0277
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0038 0.0138 0.0179
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0054 0.0128
Brugia malayi Protein kinase domain containing protein 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0123 0.1237 0.1293
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0083 0.0726 0.2313
Schistosoma mansoni nuclear receptor 0.0031 0.0054 0.0128
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0112 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0168 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0112 0.0146
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0037 0.013 0.0135
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.004 0.0165 0.0391
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0319 0.0333
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.0011 0.0014
Echinococcus granulosus defective proboscis extension response 0.0046 0.0249 0.0323
Onchocerca volvulus 0.0036 0.0112 0.0119
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0042 0.0192 0.0249
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni hypothetical protein 0.0036 0.0112 0.0265
Brugia malayi beta-lactamase 0.004 0.0166 0.0173
Brugia malayi G-protein coupled receptor 0.0036 0.0112 0.0117
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0614 0.0642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0319 0.0753
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0113 0.1541
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0166 0.0353
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0187
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0112 0.0146
Brugia malayi nuclear hormone receptor 0.0031 0.0054 0.0056
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0103 0.0108
Echinococcus granulosus serotonin receptor 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0053 0.0341 0.0356
Echinococcus granulosus tyrosine protein kinase shark 0.0042 0.0192 0.0249
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0054 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0075 0.0614 0.0614
Onchocerca volvulus 0.0036 0.0112 0.0119
Trypanosoma brucei glucosidase, putative 0.004 0.0168 0.0072
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0138 0.0179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0091 0.0095
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0112 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0998 0.1043
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0573 0.0599
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0028 0.0011 0.0026
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0332 0.0354
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.197 0.2059
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0054 0.007
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0112 0.0112
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0168 0.0168
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0626 0.7711 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni hypothetical protein 0.0071 0.0573 0.1354
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0112 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0614 0.0642
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Echinococcus granulosus tyrosine protein kinase Src42A 0.006 0.0427 0.0554
Brugia malayi P38 map kinase family protein 2 0.0626 0.7711 0.8057
Toxoplasma gondii thioredoxin reductase 0.0037 0.0124 0.1838
Echinococcus multilocularis mitogen activated protein kinase 14 0.0626 0.7711 0.7711
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0138 0.0138
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0054 0.0056
Brugia malayi beta-lactamase family protein 0.004 0.0166 0.0173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0341 0.0356
Mycobacterium ulcerans hypothetical protein 0.004 0.0166 0.1677
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0112 0.0112
Onchocerca volvulus 0.0123 0.1237 0.1317
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0112 0.0112
Schistosoma mansoni tyrosine kinase 0.006 0.0427 0.1009
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0054 0.0054
Brugia malayi GnHR receptor homolog 0.0036 0.0112 0.0117
Echinococcus granulosus roundabout 2 0.0034 0.0091 0.0118
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.013 0.0306
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0075 0.0614 0.1451
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus tyrosine protein kinase Btk29A 0.006 0.0427 0.0554
Loa Loa (eye worm) LGC-31 protein 0.0038 0.0138 0.0144
Schistosoma mansoni neuropeptide receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) beta-lactamase 0.004 0.0166 0.0173
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0192 0.0249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0998 0.1043
Leishmania major trypanothione reductase 0.0037 0.0124 0.009
Onchocerca volvulus 0.0075 0.0614 0.0654
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0192 0.0192
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Brugia malayi Raf kinase 0.0232 0.2632 0.275
Schistosoma mansoni alpha glucosidase 0.004 0.0168 0.0397
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0166 0.0392
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0038 0.0138 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0075 0.0614 0.0642
Brugia malayi nuclear receptor NHR-88 0.0031 0.0054 0.0056
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0112 0.0112
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0112 0.0117
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0166 0.9617
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0042 0.0192 0.0192
Brugia malayi hypothetical protein 0.0042 0.0192 0.0201
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0112 0.0146
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0038 0.0138 0.0144
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0112 0.0117
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0112 0.0146
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0054 0.0128
Schistosoma mansoni tyrosine kinase 0.006 0.0427 0.1009
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.2326 0.2326
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0054 0.0128
Echinococcus multilocularis neuroglian 0.0058 0.0401 0.0401
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0112 0.0117
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0168 1
Echinococcus granulosus mitogen activated protein kinase 14 0.0626 0.7711 1
Echinococcus granulosus roundabout 2 0.0034 0.0091 0.0118
Mycobacterium tuberculosis Conserved protein 0.004 0.0166 0.0353
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0112 0.0146
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0083 0.0726 0.2313
Echinococcus granulosus contactin 0.0034 0.0091 0.0118
Schistosoma mansoni nephrin 0.0034 0.0091 0.0216
Brugia malayi hypothetical protein 0.0169 0.1829 0.1911
Brugia malayi MH2 domain containing protein 0.0118 0.1176 0.1229
Entamoeba histolytica hypothetical protein 0.004 0.0165 0.6633
Onchocerca volvulus 0.0036 0.0112 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0771 0.9571 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0614 0.0614
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0426 0.0426
Brugia malayi Cation transporter family protein 0.0038 0.0138 0.0144
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0166 0.007
Brugia malayi Variant SH3 domain containing protein 0.0037 0.013 0.0135
Brugia malayi hypothetical protein 0.004 0.0165 0.0173
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Plasmodium falciparum thioredoxin reductase 0.0037 0.0124 0.5
Onchocerca volvulus 0.0038 0.0138 0.0147
Schistosoma mansoni neuropeptide receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0105 0.0998 0.1043
Brugia malayi SH2 domain containing protein 0.0042 0.0192 0.0201
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0165 0.0215
Trypanosoma brucei trypanothione reductase 0.0037 0.0124 0.0015
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0112 0.0265
Echinococcus multilocularis neuropeptide s receptor 0.0544 0.6653 0.6653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0614 0.0642
Brugia malayi Dopamine receptor protein 2 0.0036 0.0112 0.0117
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0427 0.0554
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0112 0.0265
Schistosoma mansoni growth factor receptor-bound protein 0.0037 0.013 0.0306
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0112 0.0146
Onchocerca volvulus 0.004 0.0166 0.0177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0166 0.0353
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0112 0.0117
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0112 0.0146
Brugia malayi mbt repeat family protein 0.0053 0.0332 0.0347
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Schistosoma mansoni neuroglian 0.0034 0.0091 0.0216
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0112 0.0112
Onchocerca volvulus 0.0036 0.0112 0.0119
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0075
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0112 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0166 0.0215
Brugia malayi glutathione reductase 0.0037 0.0124 0.013
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0165 0.0391
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0079 0.0083
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0112 0.0265
Leishmania major DNA polymerase eta, putative 0.0044 0.0225 0.0222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0054 0.007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0112 0.0146
Schistosoma mansoni hypothetical protein 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0426 0.0552
Loa Loa (eye worm) hypothetical protein 0.0044 0.0214 0.0224
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0187
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Echinococcus multilocularis tyrosine protein kinase Src64B 0.006 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Echinococcus granulosus mitogen activated protein kinase 11 0.0626 0.7711 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0106 0.1014 0.106
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0034 0.0091 0.0095
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0054 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0166 0.9617
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0112 0.0117
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni nephrin 0.0065 0.0493 0.1164
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0112 0.0146
Schistosoma mansoni alpha-glucosidase 0.0155 0.1648 0.3893
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0083 0.0726 0.2313
Brugia malayi hypothetical protein 0.0044 0.0214 0.0224
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.013 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0075 0.0614 0.0642
Brugia malayi Dopamine receptor 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0054 0.0057
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0112 0.0265
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0075 0.0614 0.0614
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0225 0.0235
Schistosoma mansoni neuropeptide receptor 0.0036 0.0112 0.0265
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0426 0.0445
Schistosoma mansoni thyroid hormone receptor 0.0075 0.0614 0.1451
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0112 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0075 0.0614 0.0642
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0054 0.0128
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.006 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0112 0.0117
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0075 0.0614 0.0796
Loa Loa (eye worm) hypothetical protein 0.0046 0.0249 0.026
Brugia malayi hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0054 0.0056
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Schistosoma mansoni nuclear hormone receptor 0.0075 0.0614 0.1451
Schistosoma mansoni thyroid hormone receptor 0.0075 0.0614 0.1451
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0044 0.0214 0.0224
Brugia malayi excitatory GABA receptor EXP-1A 0.0038 0.0138 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Loa Loa (eye worm) TK/ABL protein kinase 0.0042 0.0192 0.0201
Mycobacterium leprae Probable lipase LipE 0.004 0.0166 0.1294
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0112 0.0112
Onchocerca volvulus 0.0042 0.0192 0.0205
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0113 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.006 0.0427 0.1009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0091 0.0095
Schistosoma mansoni tyrosine kinase 0.006 0.0427 0.1009
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0075 0.0614 0.0796
Mycobacterium tuberculosis Conserved protein 0.004 0.0166 0.0353
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0112 0.0265
Echinococcus granulosus neuroglian 0.0058 0.0401 0.052
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0028 0.0011 0.0014
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.0011 0.0011
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0168 0.0218
Loa Loa (eye worm) inositol-1 0.0036 0.0113 0.0118
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0356 0.4233 0.4422
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0429 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0038 0.0138 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Loa Loa (eye worm) hypothetical protein 0.0061 0.0443 0.0463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0998 0.1043
Schistosoma mansoni inositol monophosphatase 0.0036 0.0113 0.0267
Entamoeba histolytica hypothetical protein 0.004 0.0165 0.6633
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0028 0.0011 0.0011
Loa Loa (eye worm) MBCTL1 0.006 0.0426 0.0445
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0426 0.0426
Treponema pallidum sodium- and chloride- dependent transporter 0.0071 0.057 0.5
Echinococcus multilocularis dna polymerase eta 0.0044 0.0225 0.0225
Loa Loa (eye worm) steroid hormone receptor 0.0075 0.0614 0.0642
Brugia malayi Dopamine receptor protein 1 0.0036 0.0112 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0075 0.0614 0.0642
Echinococcus multilocularis tyrosine protein kinase shark 0.0042 0.0192 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0075
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0356 0.4233 1
Echinococcus multilocularis FTZ F1 alpha 0.0075 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.0053 0.0341 0.0356
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.2729 0.6447
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0254 0.2924 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Schistosoma mansoni DNA polymerase eta 0.0044 0.0225 0.0532
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0166 0.9617
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0083 0.0726 0.8468
Brugia malayi Protein kinase domain containing protein 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0038 0.0138 0.0144
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0112 0.0265
Plasmodium falciparum glutathione reductase 0.0037 0.0124 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0113 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0112 0.0146
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0043 0.0207 0.0207
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1176 0.1229
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0038 0.0138 0.0144
Echinococcus multilocularis roundabout 2 0.0034 0.0091 0.0091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0319 0.0333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus serotonin transporter 0.0071 0.057 0.074
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.013 0.013
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0192 0.0192
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0038 0.0138 0.0144
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0038 0.0138 0.0326
Echinococcus granulosus tyrosine protein kinase Srms 0.0042 0.0192 0.0249
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0427 0.0554
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0038 0.0138 0.0144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0168 0.6948
Brugia malayi neuropeptide F receptor 0.0036 0.0112 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0319 0.0319
Onchocerca volvulus 0.0036 0.0112 0.0119
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0112 0.0265
Echinococcus multilocularis mitogen activated protein kinase 11 0.0626 0.7711 0.7711
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0075 0.0614 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0075 0.0614 0.0642
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0079 0.0103
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0138 0.0144
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Echinococcus multilocularis GPCR, family 2 0.0033 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0429 0.1013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0054 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0214 0.0224
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0112 0.0146
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0075 0.0614 0.0642
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0037 0.013 0.0306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0112 0.0265
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0038 0.0138 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) SRC-1 0.006 0.0427 0.0446
Brugia malayi Serotonin receptor 0.0578 0.7086 0.7404
Onchocerca volvulus 0.0036 0.0112 0.0119
Mycobacterium leprae conserved hypothetical protein 0.004 0.0166 0.1294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0166 0.0353
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Brugia malayi Cation transporter family protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Schistosoma mansoni ephrin receptor 0.003 0.0043 0.0101
Echinococcus multilocularis serotonin transporter 0.0071 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi Sex muscle abnormal protein 5 0.0037 0.013 0.0135
Schistosoma mansoni nck2/grb4 0.0037 0.013 0.0306
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0035 0.0103 0.0134
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0332 0.0347
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0166 0.1677
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Schistosoma mansoni coup transcription factor 0.0075 0.0614 0.1451
Brugia malayi putative neuropeptide receptor 0.0036 0.0112 0.0117
Brugia malayi G protein-coupled receptor 0.0036 0.0112 0.0117
Echinococcus granulosus allatostatin A receptor 0.0036 0.0112 0.0146
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0112 0.0112
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0429 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0192 0.0192
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0145 0.152 0.1588
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0038 0.0138 0.0138
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0112 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0038 0.0138 0.0179
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0168 1
Echinococcus granulosus NCK adaptor protein 0.0037 0.013 0.0168
Echinococcus granulosus neuropeptide receptor A26 0.0544 0.6653 0.8629
Echinococcus granulosus nAChR subunit 0.0038 0.0138 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0168 0.0147
Loa Loa (eye worm) hypothetical protein 0.0123 0.1237 0.1293
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0626 0.7711 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0054 0.0128
Schistosoma mansoni biogenic amine receptor 0.0036 0.0112 0.0265
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0319 0.0414
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0112 0.0265
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0038 0.0138 0.0138
Plasmodium vivax hypothetical protein, conserved 0.004 0.0166 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0166 0.0144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0164 0.1759 0.4157
Schistosoma mansoni amine GPCR 0.0036 0.0112 0.0265
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0186 0.044
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0054 0.0054
Schistosoma mansoni adapter molecule crk 0.0037 0.013 0.0306
Brugia malayi Variant SH3 domain containing protein 0.0037 0.013 0.0135
Loa Loa (eye worm) hypothetical protein 0.0071 0.057 0.0596
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0112 0.0265
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0225 0.0222
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0166 0.0392
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus fmrfamide receptor 0.0036 0.0112 0.0146
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0054 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0124 0.009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0166 0.0173
Schistosoma mansoni hypothetical protein 0.0321 0.3777 0.8923
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Schistosoma mansoni biogenic amine receptor 0.0036 0.0112 0.0265
Echinococcus granulosus geminin 0.0164 0.1759 0.2282
Loa Loa (eye worm) hypothetical protein 0.0044 0.0225 0.0235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni adenoreceptor 0.0036 0.0112 0.0265
Echinococcus multilocularis growth factor receptor bound protein 2 0.0037 0.013 0.013
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0166 0.0353
Brugia malayi ecdysteroid receptor 0.0757 0.9394 0.9815
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0112 0.0112
Onchocerca volvulus 0.0038 0.0138 0.0147
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Brugia malayi steroid hormone receptor 0.0075 0.0614 0.0642
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0138 0.0179
Brugia malayi AKH receptor 0.0036 0.0112 0.0117
Leishmania major hypothetical protein, conserved 0.004 0.0166 0.0144
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0028 0.0011 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0033 0.0079 0.0083
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0319 0.0753
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Mycobacterium ulcerans lipase LipD 0.004 0.0166 0.1677
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0319 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0075 0.0614 0.0642
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.2326 0.3017
Echinococcus multilocularis raf serine:threonine protein kinase 0.0239 0.2729 0.2729
Schistosoma mansoni cell adhesion molecule 0.0034 0.0091 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0319 0.0753
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0112 0.0146
Loa Loa (eye worm) hypothetical protein 0.0071 0.057 0.0596
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0168 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0112 0.0146
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0038 0.0138 0.0144
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Schistosoma mansoni opsin-like receptor 0.0036 0.0112 0.0265
Echinococcus granulosus glycine receptor subunit beta 0.0038 0.0138 0.0179
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0071 0.057 0.0596
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0061 0.0443 0.0575
Brugia malayi tailless protein 0.0031 0.0054 0.0056
Echinococcus multilocularis glycine receptor subunit beta 0.0038 0.0138 0.0138
Schistosoma mansoni histamine h1 receptor 0.0036 0.0112 0.0265
Brugia malayi ORL1-like opioid receptor 0.0036 0.0112 0.0117
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0075 0.0614 0.0796
Brugia malayi Immunoglobulin I-set domain containing protein 0.0034 0.0091 0.0095
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0112 0.0146
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.006 0.0427 0.0427
Echinococcus multilocularis c src tyrosine kinase 0.006 0.0427 0.0427
Echinococcus granulosus sex peptide receptor 0.0036 0.0112 0.0146
Loa Loa (eye worm) TK protein kinase 0.0035 0.0103 0.0108
Brugia malayi follicle stimulating hormone receptor 0.0264 0.3047 0.3184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni cell adhesion molecule 0.0034 0.0091 0.0216
Schistosoma mansoni tyrosine kinase 0.0042 0.0192 0.0454
Echinococcus multilocularis Immunoglobulin 0.0046 0.0249 0.0249
Loa Loa (eye worm) serotonin transporter b 0.0071 0.057 0.0596
Loa Loa (eye worm) ACC-1 protein 0.0038 0.0138 0.0144
Brugia malayi Serotonin receptor 0.0036 0.0112 0.0117
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0075 0.0614 0.0796
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0429 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0054 0.007
Loa Loa (eye worm) glutathione reductase 0.0037 0.0124 0.013
Schistosoma mansoni alpha-glucosidase 0.0155 0.1648 0.3893
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0112 0.0265
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0168 0.0147
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0356 0.4233 0.4233
Echinococcus multilocularis tyrosine protein kinase Src42A 0.006 0.0427 0.0427
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0166 0.0353
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni steroid hormone receptor ad4bp 0.0075 0.0614 0.1451
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Onchocerca volvulus 0.0123 0.1237 0.1317
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0112 0.0265
Schistosoma mansoni neuropeptide receptor 0.0036 0.0112 0.0265
Schistosoma mansoni amine GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0192 0.0249
Schistosoma mansoni amine GPCR 0.0036 0.0112 0.0265
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0112 0.0112
Onchocerca volvulus 0.0036 0.0112 0.0119
Brugia malayi hypothetical protein 0.0044 0.0214 0.0224
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Echinococcus multilocularis sex peptide receptor 0.0036 0.0112 0.0112
Echinococcus multilocularis NCK adaptor protein 0.0037 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0044 0.0214 0.0224
Schistosoma mansoni opsin-like receptor 0.0036 0.0112 0.0265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0054 0.0054
Echinococcus granulosus Immunoglobulin 0.0046 0.0249 0.0323
Onchocerca volvulus 0.0123 0.1237 0.1317
Schistosoma mansoni zinc finger protein 0.0031 0.0054 0.0128
Brugia malayi RE15519p 0.0036 0.0112 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0075 0.0614 0.0642
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0038 0.0138 0.0138
Onchocerca volvulus 0.0036 0.0112 0.0119
Onchocerca volvulus Putative nachr subunit 0.0038 0.0138 0.0147
Loa Loa (eye worm) hypothetical protein 0.0757 0.9394 0.9815
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.197 0.197
Brugia malayi Tyrosine-protein kinase abl-1 0.006 0.0427 0.0446
Loa Loa (eye worm) hypothetical protein 0.0071 0.057 0.0596
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0166 0.9617
Schistosoma mansoni tyrosine kinase 0.006 0.0427 0.1009
Brugia malayi Protein kinase domain containing protein 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0112 0.0112
Onchocerca volvulus Protein ultraspiracle homolog 0.0075 0.0614 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0075 0.0614 0.0642
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0038 0.0138 0.0138
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0166 0.0144
Onchocerca volvulus 0.0053 0.0332 0.0354
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0168 0.6948
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0079 0.0079
Echinococcus granulosus g protein coupled receptor 0.0036 0.0112 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0042 0.0192 1
Echinococcus granulosus g protein coupled receptor 0.0036 0.0112 0.0146
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0054 0.0056
Echinococcus multilocularis tyrosine kinase 0.0042 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0054 0.0056
Loa Loa (eye worm) TK protein kinase 0.0042 0.0192 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0214 0.0224
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0112 0.0146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0075 0.0614 0.1451
Brugia malayi nuclear receptor RXR 0.0031 0.0054 0.0056
Brugia malayi hypothetical protein 0.0053 0.0341 0.0356
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0614 0.0796
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0112 0.0117
Brugia malayi larval opioid receptor 0.0036 0.0112 0.0117
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0332 0.0785
Echinococcus multilocularis neuroglian 0.0034 0.0091 0.0091
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0169 0.1829 0.1911
Loa Loa (eye worm) hypothetical protein 0.0053 0.0332 0.0347
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.0614 0.0614
Echinococcus granulosus insulin growth factor 1 receptor beta 0.003 0.0043 0.0055
Brugia malayi beta-lactamase family protein 0.004 0.0166 0.0173
Echinococcus multilocularis roundabout 2 0.0034 0.0091 0.0091
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.013 0.0169
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0225 0.0148
Loa Loa (eye worm) hypothetical protein 0.0071 0.0573 0.0599
Onchocerca volvulus 0.0036 0.0112 0.0119
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0112 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0112 0.0265
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0112 0.0112
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0054 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0112 0.0117
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0332 0.0332
Onchocerca volvulus 0.0042 0.0192 0.0205
Schistosoma mansoni hypothetical protein 0.0036 0.0112 0.0265
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0427 0.0554
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0112 0.0112
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.006 0.0427 0.0427
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0138 0.0138
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0075 0.0614 0.0654
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Echinococcus granulosus neuroglian 0.0034 0.0091 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0079 0.0083
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0123 0.1237 0.2923
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0429 0.1272
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0103 0.0108
Echinococcus multilocularis serotonin receptor 0.0036 0.0112 0.0112
Schistosoma mansoni nuclear receptor 0.0031 0.0054 0.0128
Mycobacterium ulcerans beta-lactamase 0.004 0.0166 0.1677
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0038 0.0138 0.0144
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0112 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.0144
Loa Loa (eye worm) raf kinase 0.0216 0.2432 0.2541
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Onchocerca volvulus 0.0036 0.0112 0.0119
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Loa Loa (eye worm) hypothetical protein 0.0031 0.0054 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0075 0.0614 0.0642
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0038 0.0138 0.0144
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0038 0.0138 0.0138
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0112 0.0119
Onchocerca volvulus 0.0036 0.0112 0.0119
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0043 0.0207 0.0207
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0112 0.0146
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0626 0.7711 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0166 0.0173
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0075 0.0614 0.0614
Brugia malayi nuclear receptor NHR-88 0.0075 0.0614 0.0642
Schistosoma mansoni tyrosine kinase 0.005 0.0297 0.0703
Brugia malayi nuclear receptor RXR 0.0044 0.0214 0.0224
Onchocerca volvulus 0.0042 0.0192 0.0205
Schistosoma mansoni hypothetical protein 0.0033 0.0079 0.0187
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.006 0.0427 0.0554
Brugia malayi neuropeptide F receptor 0.0036 0.0112 0.0117
Onchocerca volvulus 0.0042 0.0192 0.0205
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0168 1
Echinococcus multilocularis neuropeptide receptor A26 0.0544 0.6653 0.6653
Echinococcus multilocularis nAChR subunit 0.0038 0.0138 0.0138
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0332 0.0431
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Echinococcus granulosus tyrosine protein kinase ABL1 0.0042 0.0192 0.0249
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0427 0.0427
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0165 0.0165
Echinococcus multilocularis ecdysone induced protein 78C 0.0075 0.0614 0.0614
Brugia malayi Inositol-1 0.0036 0.0113 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.0595 0.0622
Brugia malayi nuclear hormone receptor 0.0075 0.0614 0.0642
Onchocerca volvulus 0.0042 0.0192 0.0205
Schistosoma mansoni hypothetical protein 0.0036 0.0112 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0075 0.0614 0.0642
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0626 0.7711 0.8057
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0037 0.013 0.0135
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0168 0.0175
Echinococcus granulosus tyrosine kinase 0.0042 0.0192 0.0249
Brugia malayi hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0038 0.0138 0.0144
Schistosoma mansoni nAChR subunit 0.0038 0.0138 0.0326
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0054 0.007
Echinococcus granulosus dna polymerase eta 0.0044 0.0225 0.0292
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0046 0.0249 0.0589
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0079 0.0079
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0112 0.0146
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.197 0.2555
Brugia malayi SRC-1 0.006 0.0427 0.0446
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0035 0.0103 0.0103
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.197 0.197
Onchocerca volvulus 0.004 0.0166 0.0177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0075 0.0614 0.1451
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0846 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0332 0.0431
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0054 0.0056
Loa Loa (eye worm) DR-78 0.0031 0.0054 0.0056
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0332 0.0785
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0112 0.0146
Echinococcus granulosus glycine receptor subunit alpha 1 0.0038 0.0138 0.0179
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0038 0.0138 0.0326
Echinococcus granulosus growth factor receptor bound protein 2 0.0037 0.013 0.0168
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0123 0.1237 0.2923
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0038 0.0138 0.0144
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0166 0.0353
Onchocerca volvulus 0.0031 0.0054 0.0057
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0112 0.0265
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.003 0.0043 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0319 0.0414
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0038 0.0138 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0168 0.0147
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117
Brugia malayi nuclear receptor NHR-67 0.0031 0.0054 0.0056
Onchocerca volvulus 0.0031 0.0054 0.0057
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0112 0.0119
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0168 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0112 0.0265
Loa Loa (eye worm) TK/FER protein kinase 0.0042 0.0192 0.0201
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0075 0.0614 0.1451
Echinococcus granulosus g protein coupled receptor 0.0036 0.0112 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.0614 0.0796
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0117

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) Effect on locomotor activity in sc dosed mouse ChEMBL. 16279810
ED50 (functional) Antinociceptive activity in sc dosed mouse by hot-plate method ChEMBL. 16279810
ED50 (functional) Activity in sc dosed mouse by hypothermia test ChEMBL. 16279810
ED50 (functional) Antinociceptive activity in sc dosed mouse by tail-flick method ChEMBL. 16279810
ED50 (functional) 0 Antinociceptive activity in sc dosed mouse by tail-flick method ChEMBL. 16279810
ED50 (functional) 0 Antinociceptive activity in sc dosed mouse by hot-plate method ChEMBL. 16279810
ED50 (functional) 0 Activity in sc dosed mouse by hypothermia test ChEMBL. 16279810
ED50 (functional) 0 Effect on locomotor activity in sc dosed mouse ChEMBL. 16279810
Ki (binding) > 200 nM Displacement of [125]iodoMLA from alpha7 nAChR ChEMBL. 16279810
Ki (binding) > 200 nM Displacement of [125]iodoMLA from alpha7 nAChR ChEMBL. 16279810
Ki (binding) > 1000 nM Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex ChEMBL. 16279810
Ki (binding) > 1000 nM Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex ChEMBL. 16279810

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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