Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Mus musculus | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0107 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0107 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0066 | 0.1198 | 0.1198 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0107 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0107 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0066 | 0.1198 | 0.1198 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Brugia malayi | FAD binding domain containing protein | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0107 | 1 | 1 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0061 | 0 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0107 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0107 | 1 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0107 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0061 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0095 | 0.7384 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0107 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0066 | 0.1198 | 0.1198 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0066 | 0.1198 | 0.1198 |
Giardia lamblia | Hypothetical protein | 0.0095 | 0.7384 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0107 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0107 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0107 | 1 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Chlamydia trachomatis | sulfite reductase | 0.0066 | 0.1198 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.4872 | 0.4872 |
Leishmania major | p450 reductase, putative | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0107 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0107 | 1 | 1 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Brugia malayi | FAD binding domain containing protein | 0.0066 | 0.1198 | 0.1198 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Trypanosoma cruzi | p450 reductase, putative | 0.0107 | 1 | 0.5 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Onchocerca volvulus | 0.0061 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14.8 nM | Displacement of [3H]CP55940 from CB1 receptor in CD1 mouse brain | ChEMBL. | 16279795 |
Ki (binding) | = 15 nM | Binding affinity to CB1 receptor | ChEMBL. | 18512901 |
Ki (binding) | = 227 nM | Displacement of [3H]CP55940 from CB2 receptor in CD1 mouse spleen | ChEMBL. | 16279795 |
Ki (binding) | = 230 nM | Binding affinity to CB2 receptor | ChEMBL. | 18512901 |
Ratio Ki (binding) | = 15.3 | Selectivity for CB1 receptor over CB2 receptor in CD1 mouse | ChEMBL. | 16279795 |
Ratio Ki (binding) | = 15.3 | Selectivity for CB1 receptor over CB2 receptor in CD1 mouse | ChEMBL. | 16279795 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.