TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.417 | Formula: C16H26N6O2
H donors: 2 H acceptors: 4 LogP: 1.87 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COCCNc1nc(nc2c1ncn2C(C)C)C(=O)NCC(C)C
InChi: 1S/C16H26N6O2/c1-10(2)8-18-16(23)14-20-13(17-6-7-24-5)12-15(21-14)22(9-19-12)11(3)4/h9-11H,6-8H2,1-5H3,(H,18,23)(H,17,20,21)
InChiKey: APKXWYGHGQKQSJ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 5	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 5	260 aa	307 aa	28.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0359	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0359	1	1
Brugia malayi	cathepsin L-like precursor	0.024	0.5946	0.5946
Trypanosoma cruzi	cysteine peptidase, putative	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.4054	0.4054
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0066	0	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0359	1	1
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0119	0.1791	0.1791
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0119	0.1791	0.1791
Echinococcus multilocularis	cysteine protease	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.024	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0359	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Giardia lamblia	Cysteine protease	0.0066	0	0.5
Leishmania major	cathepsin L-like protease	0.0359	1	1
Giardia lamblia	Encystation-specific protease	0.0066	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.4054	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0359	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.024	0.5946	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0185	0.4054	0.4054
Echinococcus granulosus	cathepsin l1	0.024	0.5946	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Leishmania major	cathepsin L-like protease	0.0359	1	1
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Loa Loa (eye worm)	fibroinase	0.0359	1	1
Toxoplasma gondii	cathepsin CPL	0.0359	1	1
Loa Loa (eye worm)	hypothetical protein	0.024	0.5946	0.5946
Plasmodium vivax	unspecified product	0.0119	0.1791	0.1791
Onchocerca volvulus		0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.024	0.5946	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0359	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Onchocerca volvulus		0.0359	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0066	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Schistosoma mansoni	cathepsin s	0.0119	0.1791	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0359	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0359	1	1
Brugia malayi	Cathepsin L-like precursor	0.0359	1	1
Giardia lamblia	Cysteine protease	0.0066	0	0.5
Schistosoma mansoni	cathepsin F (C01 family)	0.0359	1	1
Plasmodium vivax	vivapain-1	0.0185	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.024	0.5946	0.5946
Echinococcus granulosus	cathepsin L	0.0185	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0359	1	1
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0185	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1791	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0359	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Leishmania major	cathepsin L-like protease	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0359	1	1
Onchocerca volvulus		0.0359	1	1
Leishmania major	cathepsin L-like protease	0.0359	1	1
Brugia malayi	Cathepsin L-like precursor	0.0119	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.024	0.5946	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0359	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Plasmodium vivax	vivapain-3	0.0185	0.4054	0.4054
Onchocerca volvulus		0.0359	1	1
Giardia lamblia	Cysteine protease	0.0066	0	0.5
Trypanosoma cruzi	cysteine proteinase, putative	0.0185	0.4054	0.4054
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.024	0.5946	0.5946
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.0359	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Leishmania major	cathepsin L-like protease	0.0359	1	1
Leishmania major	cathepsin L-like protease	0.0359	1	1
Leishmania major	cathepsin L-like protease	0.0359	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0185	0.4054	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0185	0.4054	0.4054
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Entamoeba histolytica	cysteine proteinase 2	0.0185	0.4054	0.4054
Echinococcus multilocularis	cathepsin L	0.0185	0.4054	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0359	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0359	1	1
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0119	0.1791	0.1791
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Onchocerca volvulus	Cathepsin L homolog	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0185	0.4054	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.0359	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0359	1	1
Plasmodium vivax	vivapain-2	0.0359	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0185	0.4054	0.4054
Plasmodium vivax	unspecified product	0.0185	0.4054	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0185	0.4054	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0185	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Loa Loa (eye worm)	cysteine protease	0.0359	1	1
Loa Loa (eye worm)	ctsf protein	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0359	1	1
Brugia malayi	Cathepsin L-like precursor	0.0359	1	1
Echinococcus granulosus	cysteine protease	0.0185	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1791	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.024	0.5946	0.5946
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0066	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0119	0.1791	0.1791
Entamoeba histolytica	cysteine proteinase, putative	0.0359	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0359	1	1
Giardia lamblia	Cysteine protease	0.0066	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1791	0.1791
Giardia lamblia	Cathepsin L-like protease	0.0066	0	0.5
Brugia malayi	Cathepsin L-like precursor	0.024	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0185	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0359	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Plasmodium vivax	vivapain-2	0.0359	1	1
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0359	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0359	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0185	0.4054	0.4054
Echinococcus granulosus	cathepsin l1	0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Onchocerca volvulus		0.0359	1	1
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Entamoeba histolytica	cysteine protease, putative	0.0185	0.4054	0.4054
Echinococcus multilocularis	cysteine protease	0.0359	1	1
Onchocerca volvulus		0.0359	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0359	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0359	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.4054	0.4054
Giardia lamblia	Hypothetical protein	0.0066	0	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0359	1	1
Leishmania major	cathepsin L-like protease	0.0359	1	1
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Brugia malayi	cathepsin F-like cysteine proteinase	0.0119	0.1791	0.1791
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0066	0	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.024	0.5946	0.5946
Onchocerca volvulus		0.024	0.5946	0.5946
Onchocerca volvulus		0.0359	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0359	1	1
Giardia lamblia	Hypothetical protein	0.0066	0	0.5
Giardia lamblia	Cathepsin L precursor	0.0066	0	0.5
Giardia lamblia	Cathepsin B precursor	0.0066	0	0.5
Giardia lamblia	Cathepsin L-like protease	0.0066	0	0.5
Onchocerca volvulus	Cathepsin F homolog	0.0359	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7.2 uM	Inhibition of CDK1/Cyclin B from M phase starfish oocytes	ChEMBL.	17064911
IC50 (binding)	= 16 uM	Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coli	ChEMBL.	17064911
IC50 (binding)	= 16 uM	Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coli	ChEMBL.	17064911

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 420335