Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0054 | 0.4608 | 0.6179 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0051 | 0.4207 | 0.568 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4207 | 0.568 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0038 | 0.2657 | 0.4063 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0077 | 0.7407 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4207 | 0.5656 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0038 | 0.2699 | 0.3644 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4207 | 0.5656 |
Brugia malayi | AMP-binding enzyme family protein | 0.0016 | 0.004 | 0.004 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4207 | 0.5656 |
Schistosoma mansoni | methyltransferase-related | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0022 | 0.0667 | 0.0901 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.005 | 0.4096 | 0.405 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0035 | 0.2248 | 0.2821 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0077 | 0.7407 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0077 | 0.7407 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.4608 | 0.6202 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.003 | 0.1729 | 0.2335 |
Onchocerca volvulus | 0.0093 | 0.9312 | 0.9285 | |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0016 | 0.004 | 0.0054 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.4608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.1362 | 0.0443 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0054 | 0.4608 | 0.6222 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0051 | 0.4207 | 0.563 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0054 | 0.4608 | 0.6179 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0033 | 0.2015 | 0.2638 |
Brugia malayi | AMP-binding enzyme family protein | 0.005 | 0.4096 | 0.4096 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.4608 | 0.6202 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0052 | 0.4323 | 0.5836 |
Mycobacterium ulcerans | polyketide synthase | 0.0051 | 0.4207 | 0.5656 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0051 | 0.4207 | 0.4207 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0041 | 0.3028 | 0.4088 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0051 | 0.4207 | 0.563 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0054 | 0.4608 | 0.6179 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.005 | 0.4096 | 0.553 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.004 | 0.2942 | 0.394 |
Loa Loa (eye worm) | fatty acid synthase | 0.0053 | 0.4435 | 0.4497 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0077 | 0.7407 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0045 | 0.3442 | 0.4619 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0033 | 0.2015 | 0.2681 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0051 | 0.4207 | 0.568 |
Giardia lamblia | Methyltransferase like 2 | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0017 | 0.0083 | 0.0112 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0054 | 0.4608 | 0.6222 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0045 | 0.3442 | 0.4587 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.4608 | 0.6222 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.004 | 0.2942 | 0.394 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0033 | 0.2015 | 0.2681 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4207 | 0.5656 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.004 | 0.2942 | 0.3904 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.4608 | 0.6202 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.8606 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0016 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0045 | 0.3442 | 0.4648 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0052 | 0.4323 | 0.5836 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0017 | 0.0083 | 0.0059 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0096 | 0.9714 | 1 |
Mycobacterium ulcerans | thioesterase TesA | 0.0045 | 0.3442 | 0.4619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.