Detailed information for compound 420388

Basic information

Technical information
  • TDR Targets ID: 420388
  • Name: 1-bromo-2-[(E)-2-[[(E)-2-(2-bromo-4,5-dimetho xyphenyl)ethenyl]sulfonylmethylsulfonyl]ethen yl]-4,5-dimethoxybenzene
  • MW: 626.333 | Formula: C21H22Br2O8S2
  • H donors: 0 H acceptors: 4 LogP: 4.31 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc(/C=C/S(=O)(=O)CS(=O)(=O)/C=C/c2cc(OC)c(cc2Br)OC)c(cc1OC)Br
  • InChi: 1S/C21H22Br2O8S2/c1-28-18-9-14(16(22)11-20(18)30-3)5-7-32(24,25)13-33(26,27)8-6-15-10-19(29-2)21(31-4)12-17(15)23/h5-12H,13H2,1-4H3/b7-5+,8-6+
  • InChiKey: AXAHRHMMURZTDE-KQQUZDAGSA-N  

Network

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Synonyms

  • 1-bromo-2-[(E)-2-[[(E)-2-(2-bromo-4,5-dimethoxy-phenyl)vinyl]sulfonylmethylsulfonyl]vinyl]-4,5-dimethoxy-benzene
  • 1-bromo-2-[(E)-2-[[(E)-2-(2-bromo-4,5-dimethoxyphenyl)vinyl]sulfonylmethylsulfonyl]vinyl]-4,5-dimethoxybenzene
  • 1-bromo-2-[(E)-2-[[(E)-2-(2-bromo-4,5-dimethoxy-phenyl)ethenyl]sulfonylmethylsulfonyl]ethenyl]-4,5-dimethoxy-benzene
  • Benzene, 1,1'-[methylenebis[sulfonyl(E)-2,1-ethenediyl]]bis[4,5-dimethoxy-2-bromo-
  • AIDS-415740
  • AIDS415740

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0148 0.4157 0.6391
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0071 0.0123
Plasmodium vivax SET domain protein, putative 0.0028 0.0459 0.1387
Leishmania major oxidoreductase-like protein 0.0106 0.2872 1
Onchocerca volvulus Matrilysin homolog 0.0036 0.0719 0.1118
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0106 0.2872 0.4415
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0153 0.0174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0775 0.0878
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Brugia malayi MAP kinase sur-1 0.0048 0.1078 0.1657
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0071 0.0123
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0106 0.2872 0.6077
Echinococcus granulosus WW domain containing oxidoreductase 0.0106 0.2872 0.3252
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0106 0.2872 1
Entamoeba histolytica protein kinase, putative 0.0016 0.0103 0.0103
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Brugia malayi hypothetical protein 0.002 0.022 0.0338
Onchocerca volvulus 0.0038 0.0775 0.1205
Echinococcus multilocularis serine threonine protein kinase 0.0016 0.0103 0.0117
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0446 0.0505
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0071 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0775 0.1191
Brugia malayi Protein kinase domain containing protein 0.0016 0.0103 0.0158
Echinococcus granulosus beta LACTamase domain containing family member 0.0032 0.0591 0.0669
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.0338
Brugia malayi RNA recognition motif domain containing protein 0.0057 0.1345 0.2067
Entamoeba histolytica protein kinase, putative 0.0016 0.0103 0.0103
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0026 0.04 0.1285
Echinococcus granulosus oxidoreductase 0.0106 0.2872 0.3252
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0775 0.0878
Brugia malayi nuclear receptor NHR-67 0.0018 0.0153 0.0236
Giardia lamblia Reductase, putative 0.0106 0.2872 0.2821
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Brugia malayi ecdysteroid receptor 0.0038 0.0775 0.1191
Trichomonas vaginalis rheb, putative 0.0027 0.0418 0.0418
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0775 0.1191
Onchocerca volvulus 0.0106 0.2872 0.4466
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0106 0.2872 1
Echinococcus granulosus carbonyl reductase 1 0.0106 0.2872 0.3252
Brugia malayi dehydrogenases, short chain protein 9 0.0106 0.2872 0.4415
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0446 0.0505
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0071 0.008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0428 0.0484
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0775 0.1191
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0033 0.0038
Trichomonas vaginalis cation-transporting ATPase, putative 0.0026 0.04 0.04
Mycobacterium ulcerans ketoacyl reductase 0.0106 0.2872 0.6077
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.0338
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0775 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0775 0.1191
Mycobacterium ulcerans short-chain dehydrogenase 0.0106 0.2872 0.6077
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Echinococcus granulosus retinol dehydrogenase 11 0.0106 0.2872 0.3252
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0106 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0153 0.0236
Mycobacterium tuberculosis Possible oxidoreductase 0.0106 0.2872 0.4772
Onchocerca volvulus 0.0016 0.0104 0.0161
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0775 0.0878
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0148 0.4157 0.4708
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0153 0.0236
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0106 0.2872 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.468 1
Schistosoma mansoni hypothetical protein 0.0023 0.0315 0.0356
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0071 0.008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0106 0.2872 1
Schistosoma mansoni hypothetical protein 0.0072 0.1829 0.2072
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.5952
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0017 0.0118 0.0118
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Leishmania major P-type ATPase, putative 0.0029 0.0482 0.1574
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.0338
Schistosoma mansoni jun-related protein 0.0072 0.1829 0.2072
Plasmodium vivax steroid dehydrogenase, putative 0.0106 0.2872 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Schistosoma mansoni hypothetical protein 0.011 0.2986 0.3382
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0038
Schistosoma mansoni memapsin-2 (A01 family) 0.0205 0.5933 0.672
Onchocerca volvulus Sepiapterin reductase homolog 0.0106 0.2872 0.4466
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0029 0.0487 0.0552
Brugia malayi protein kinase C3,putative 0.0164 0.4644 0.7141
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0337 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0989 0.0989
Echinococcus granulosus nervana 2 0.0148 0.4157 0.4708
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Onchocerca volvulus 0.0032 0.0591 0.0919
Echinococcus granulosus protein kinase c epsilon type 0.0027 0.0446 0.0505
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0048 0.1078 0.1657
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0206 0.594 1
Brugia malayi calcium ATPase 0.0014 0.0036 0.0055
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Brugia malayi hypothetical protein 0.0106 0.2872 0.4415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Mycobacterium ulcerans dehydrogenase/reductase 0.0106 0.2872 0.6077
Schistosoma mansoni hypothetical protein 0.0299 0.8829 1
Echinococcus multilocularis nervana 2 0.0148 0.4157 0.4708
Mycobacterium ulcerans hydrolase 0.002 0.0214 0.031
Brugia malayi p70 ribosomal S6 kinase beta 0.0016 0.0103 0.0158
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0775 0.0878
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Echinococcus granulosus carbonyl reductase 1 0.0106 0.2872 0.3252
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0016 0.0103 0.0117
Schistosoma mansoni tar DNA-binding protein 0.0057 0.1345 0.1523
Toxoplasma gondii ABC1 family protein 0.0032 0.0591 0.1957
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.2228 0.2523
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0039 0.0798 0.0904
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0029 0.0482 0.0546
Onchocerca volvulus 0.007 0.1754 0.2728
Brugia malayi Matrixin family protein 0.0016 0.0104 0.0159
Schistosoma mansoni nuclear receptor 0.0018 0.0153 0.0174
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0153 0.0174
Schistosoma mansoni ATPase 0.0026 0.04 0.0453
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Loa Loa (eye worm) sodium potassium adenosine triphosphatase 0.0014 0.0036 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0775 0.0878
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0106 0.2872 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0106 0.2872 1
Leishmania major short chain dehydrogenase-like protein 0.0106 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0214 0.0329
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Brugia malayi Na,K-ATPase alpha subunit 0.0075 0.1924 0.2958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0459 0.052
Entamoeba histolytica Ras family GTPase 0.0027 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Mycobacterium tuberculosis Probable hydrolase 0.0032 0.0591 0.0886
Echinococcus multilocularis retinol dehydrogenase 13 0.0106 0.2872 0.3252
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0029 0.0487 0.0552
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0775 0.0878
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0026 0.04 0.1285
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0106 0.2872 1
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0775 0.0878
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0032 0.0591 0.0886
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0106 0.2872 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0075 0.1924 0.2179
Loa Loa (eye worm) hypothetical protein 0.0085 0.2228 0.3425
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0071 0.0123
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0106 0.2872 0.3252
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0025 0.0379 0.0429
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0153 0.0236
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0028 0.0466 0.1517
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0071 0.0071
Leishmania major hypothetical protein, conserved 0.0032 0.0591 0.1957
Onchocerca volvulus 0.0018 0.0153 0.0238
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0459 0.052
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0106 0.2872 0.4772
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0775 0.1191
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Onchocerca volvulus 0.0106 0.2872 0.4466
Onchocerca volvulus 0.0028 0.0459 0.0714
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0973 0.1495
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.3056 0.5087
Entamoeba histolytica protein kinase, putative 0.0016 0.0103 0.0103
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0106 0.2872 1
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0029 0.0482 0.0546
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0159
Trichomonas vaginalis cation-transporting ATPase, putative 0.0026 0.04 0.04
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0048 0.1078 0.3674
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.1078 0.3674
Schistosoma mansoni carbonyl reductase 0.0106 0.2872 0.3252
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.4612 0.5223
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0459 0.1493
Onchocerca volvulus Matrix metalloproteinase homolog 0.0036 0.0719 0.1118
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0106 0.2872 0.3252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0106 0.2872 0.4772
Echinococcus multilocularis retinol dehydrogenase 11 0.0106 0.2872 0.3252
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0106 0.2872 0.3252
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0103 0.0117
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.006 0.1435 0.1626
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0106 0.2872 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0057 0.1345 0.1523
Onchocerca volvulus 0.0106 0.2872 0.4466
Loa Loa (eye worm) hypothetical protein 0.0047 0.104 0.1599
Trypanosoma cruzi short chain dehydrogenase, putative 0.0106 0.2872 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0071 0.0123
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0025 0.0379 0.0582
Loa Loa (eye worm) matrix metalloproteinase 0.0016 0.0104 0.0159
Trichomonas vaginalis ral, putative 0.0027 0.0418 0.0418
Trichomonas vaginalis set domain proteins, putative 0.0222 0.643 0.643
Leishmania major hypothetical protein, conserved 0.0106 0.2872 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0775 0.0878
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0029 0.0482 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.1115 0.1263
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.468 0.7853
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0153 0.0174
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0153 0.0236
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0048 0.1078 0.3674
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Loa Loa (eye worm) calcium ATPase 0.0014 0.0045 0.0068
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 1
Brugia malayi dehydrogenases, short chain protein 2 0.0106 0.2872 0.4415
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0016 0.0079 0.0014
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0106 0.2872 0.4772
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0029 0.0482 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0446 0.0505
Echinococcus granulosus jun protein 0.0089 0.2344 0.2654
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0775 0.0878
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0106 0.2872 0.4772
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0775 0.1191
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0071 0.0123
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus Na:K ATPase alpha subunit 0.0075 0.1924 0.2179
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0071 0.0109
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0026 0.04 0.1285
Brugia malayi Matrixin family protein 0.0016 0.0104 0.0159
Giardia lamblia Cathepsin B precursor 0.0028 0.0466 0.0398
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.2709 0.4495
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Leishmania major hypothetical protein, conserved 0.0106 0.2872 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0775 0.1191
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.1924 0.2958
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0015 0.0072 0.0072
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.022 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0106 0.2872 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.2709 0.4495
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0775 0.0878
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0029 0.0482 0.0546
Giardia lamblia Cathepsin B precursor 0.0028 0.0466 0.0398
Brugia malayi RNA binding protein 0.0057 0.1345 0.2067
Echinococcus granulosus tar DNA binding protein 0.0057 0.1345 0.1523
Brugia malayi cathepsin B-like cysteine proteinase 0.0085 0.2228 0.3425
Mycobacterium ulcerans short-chain dehydrogenase 0.0106 0.2872 0.6077
Leishmania major pteridine reductase 1 0.0106 0.2872 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0775 0.1191
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0018 0.0161 0.044
Leishmania major calcium motive p-type ATPase, putative 0.0029 0.0482 0.1574
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0591 0.0591
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.0338
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0016 0.0103 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0775 0.1191
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.1115 0.1115
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0029 0.0482 0.0482
Onchocerca volvulus 0.0106 0.2872 0.4466
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0106 0.2872 0.3252
Leishmania major short chain dehydrogenase/reductase, putative 0.0106 0.2872 1
Schistosoma mansoni transmemberane protein 0.0148 0.4157 0.4708
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0026 0.04 0.1285
Mycobacterium ulcerans short-chain dehydrogenase 0.0106 0.2872 0.6077
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Brugia malayi oxidoreductase 0.0106 0.2872 0.4415
Loa Loa (eye worm) hypothetical protein 0.003 0.0538 0.0827
Mycobacterium tuberculosis Probable esterase LipL 0.0032 0.0591 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0775 0.1191
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0075 0.1924 0.1866
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0775 0.0878
Onchocerca volvulus 0.0106 0.2872 0.4466
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0048 0.1078 0.3674
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1078 0.1078
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0106 0.2872 1
Mycobacterium ulcerans lipase LipD 0.0032 0.0591 0.1128
Echinococcus multilocularis thyroid hormone receptor alpha 0.0148 0.4162 0.4714
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0075 0.1924 0.2179
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0038
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.2228 0.2523
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0014 0.0045 0.0068
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0106 0.2872 0.4415
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0071 0.008
Treponema pallidum fructose-bisphosphate aldolase 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1404 0.2159
Trypanosoma brucei hypothetical protein, conserved 0.0032 0.0591 0.1957
Trichomonas vaginalis esterase, putative 0.0032 0.0591 0.0591
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0016 0.0103 0.0117
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0106 0.2872 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0775 0.0878
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0089 0.2344 0.2654
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.002 0.0214 0.0243
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0026 0.04 0.0332
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0153 0.0174
Leishmania major hypothetical protein, conserved 0.0106 0.2872 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Echinococcus multilocularis cathepsin b 0.0085 0.2228 0.2523
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.011 0.2986 0.3382
Onchocerca volvulus 0.0106 0.2872 0.4466
Echinococcus granulosus serine:threonine protein kinase N2 0.0016 0.0103 0.0117
Brugia malayi Ras protein let-60 0.0027 0.0418 0.0642
Giardia lamblia Fructose-bisphosphate aldolase 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.0338
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0106 0.2872 0.2872
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus ras gtpase 0.0027 0.0418 0.0473
Entamoeba histolytica hypothetical protein, conserved 0.0106 0.2872 0.2872
Onchocerca volvulus 0.0106 0.2872 0.4466
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0106 0.2872 1
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1078 0.1078
Loa Loa (eye worm) hypothetical protein 0.0026 0.04 0.0615
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0106 0.2872 0.2872
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.5952
Trichomonas vaginalis GTP-binding protein rit, putative 0.0027 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0159
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0026 0.04 0.1285
Loa Loa (eye worm) acetyltransferase 0.0167 0.4757 0.7313
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0106 0.2872 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0106 0.2872 0.2872
Onchocerca volvulus 0.0106 0.2872 0.4466
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Trichomonas vaginalis ras-dva small GTPase, putative 0.0027 0.0418 0.0418
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0148 0.4157 0.4708
Leishmania major calcium-transporting ATPase, putative 0.0029 0.0482 0.1574
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0073 0.1842 0.3843
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Brugia malayi steroid hormone receptor 0.0038 0.0775 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0591 0.1957
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.1115 0.3729
Loa Loa (eye worm) RNA binding protein 0.0057 0.1345 0.2067
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0106 0.2872 1
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.006 0.1435 0.1626
Entamoeba histolytica protein kinase, putative 0.0016 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.1078 0.122
Echinococcus granulosus steroid dehydrogenase 0.0106 0.2872 0.3252
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0989 0.0925
Leishmania major hypothetical protein, conserved 0.0106 0.2872 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0028 0.0466 0.1517
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0775 0.0878
Echinococcus multilocularis nervana 2 0.0122 0.3369 0.3815
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0148 0.4157 0.4708
Echinococcus granulosus nervana 2 0.0122 0.3369 0.3815
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.3056 0.5087
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0459 0.052
Plasmodium falciparum thioredoxin reductase 0.0044 0.0962 0.3182
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.4757 0.5387
Echinococcus multilocularis nervana 2 0.0148 0.4157 0.4708
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Brugia malayi Sodium/potassium-transporting ATPase alpha-3 chain, putative 0.0014 0.0036 0.0055
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0106 0.2872 1
Entamoeba histolytica Ras family GTPase 0.0027 0.0418 0.0418
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0148 0.4157 0.4708
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 1
Brugia malayi Hr1 repeat family protein 0.0016 0.0103 0.0158
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0032 0.0591 0.0908
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Mycobacterium tuberculosis Probable lipase LipE 0.0032 0.0591 0.0886
Echinococcus granulosus geminin 0.0299 0.8829 1
Brugia malayi Matrixin family protein 0.0016 0.0104 0.0159
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0026 0.04 0.0453
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0775 0.0878
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0029 0.0482 0.0546
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Echinococcus multilocularis retinol dehydrogenase 11 0.0106 0.2872 0.3252
Onchocerca volvulus 0.0148 0.4157 0.6465
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0775 0.1191
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0106 0.2872 0.5952
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0106 0.2872 0.3252
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0775 0.1205
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0016 0.0103 0.0117
Entamoeba histolytica hypothetical protein, conserved 0.0106 0.2872 0.2872
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.4757 0.7313
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0071 0.0071
Mycobacterium ulcerans hypothetical protein 0.0032 0.0591 0.1128
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0153 0.0174
Brugia malayi Membrane calcium atpase protein 3 0.0029 0.0482 0.0741
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0029 0.0487 0.0552
Echinococcus granulosus carbonyl reductase 1 0.0106 0.2872 0.3252
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0459 0.052
Echinococcus multilocularis carbonyl reductase 1 0.0106 0.2872 0.3252
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0153 0.0236
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0016 0.0103 0.0158
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Leishmania major dehydrogenase-like protein 0.0106 0.2872 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0962 0.109
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0775 0.0878
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0016 0.0103 0.0158
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0029 0.0482 0.1574
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0026 0.04 0.0332
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0029 0.0487 0.0419
Leishmania major short chain dehydrogenase, putative 0.0106 0.2872 1
Onchocerca volvulus 0.0032 0.0591 0.0919
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus protein kinase c iota type 0.0179 0.5118 0.5797
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0153 0.0174
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0106 0.2872 0.4466
Brugia malayi conserved hypotetical protein 0.0018 0.0153 0.0236
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.3056 0.6365
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0153 0.0174
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0106 0.2872 0.2872
Loa Loa (eye worm) TAR-binding protein 0.0057 0.1345 0.2067
Echinococcus multilocularis steroid dehydrogenase 0.0106 0.2872 0.3252
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0089 0.2344 0.2654
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0106 0.2872 0.4772
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.002 0.0214 0.0329
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0016 0.0104 0.0117
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0446 0.0505
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Schistosoma mansoni thyroid hormone receptor 0.0148 0.4162 0.4714
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0106 0.2872 0.3252
Brugia malayi hypothetical protein 0.0018 0.0153 0.0236
Echinococcus granulosus cathepsin b 0.0085 0.2228 0.2523
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Plasmodium vivax glutathione reductase, putative 0.0044 0.0962 0.3182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0775 0.1191
Echinococcus multilocularis oxidoreductase 0.0106 0.2872 0.3252
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Brugia malayi hypothetical protein 0.002 0.022 0.0338
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0106 0.2872 1
Brugia malayi TAR-binding protein 0.0057 0.1345 0.2067
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0071 0.0123
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0032 0.0591 0.0886
Echinococcus multilocularis conserved hypothetical protein 0.0106 0.2872 0.3252
Onchocerca volvulus Matrilysin homolog 0.0016 0.0104 0.0161
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0106 0.2872 0.3252
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0029 0.0482 0.0546
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0962 0.1479
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0026 0.04 0.1285
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0029 0.0482 0.1574
Entamoeba histolytica short chain dehydrogenase family protein 0.0106 0.2872 0.2872
Giardia lamblia Short-chain dehydrogenase, putative 0.0106 0.2872 0.2821
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0016 0.0103 0.0117
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.1115 0.3806
Loa Loa (eye worm) cathepsin B 0.0028 0.0466 0.0716
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0775 0.1205
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0106 0.2872 1
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0591 0.1957
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Brugia malayi Matrixin family protein 0.004 0.082 0.1261
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Plasmodium vivax P-type ATPase4, putative 0.0029 0.0482 0.1468
Brugia malayi Ras-related protein R-Ras2 0.0027 0.0418 0.0642
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0025 0.0379 0.0582
Mycobacterium ulcerans oxidoreductase 0.0106 0.2872 0.6077
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0106 0.2872 0.3252
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0033 0.0038
Trypanosoma brucei short-chain dehydrogenase, putative 0.0106 0.2872 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0148 0.4157 0.4708
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0106 0.2872 0.5952
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0153 0.0236
Schistosoma mansoni hypothetical protein 0.0045 0.099 0.1121
Loa Loa (eye worm) AGC/AKT protein kinase 0.0016 0.0103 0.0158
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0106 0.2872 1
Brugia malayi bZIP transcription factor family protein 0.0089 0.2344 0.3603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Mycobacterium ulcerans ketoacyl reductase 0.0106 0.2872 0.6077
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.022 0.0338
Mycobacterium ulcerans esterase/lipase LipP 0.0032 0.0591 0.1128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0775 0.0878
Leishmania major hypothetical protein, conserved 0.0106 0.2872 1
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Brugia malayi hypothetical protein 0.0018 0.0153 0.0236
Loa Loa (eye worm) hypothetical protein 0.0029 0.0487 0.0749
Trypanosoma brucei protein kinase, putative 0.0048 0.1078 0.3674
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0028 0.0466 0.0528
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 1
Brugia malayi nuclear receptor RXR 0.0018 0.0153 0.0236
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Trypanosoma brucei short-chain dehydrogenase, putative 0.0106 0.2872 1
Loa Loa (eye worm) dehydrogenase 0.0106 0.2872 0.4415
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0026 0.04 0.0453
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0106 0.2872 0.4772
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.2709 0.4495
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0153 0.0174
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0153 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0033 0.0038
Echinococcus multilocularis cathepsin b 0.0085 0.2228 0.2523
Brugia malayi Hemopexin family protein 0.0023 0.0315 0.0484
Onchocerca volvulus 0.0073 0.1842 0.2865
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0103 0.0117
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0026 0.04 0.1285
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0106 0.2872 0.3252
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.2709 0.4495
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0025 0.0379 0.0429
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0122 0.3369 0.3815
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.022 0.0249
Trypanosoma brucei rac serine-threonine kinase, putative 0.0016 0.0103 0.0236
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0591 0.1857
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0148 0.4157 0.4708
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0016 0.0103 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Mycobacterium ulcerans oxidoreductase 0.0106 0.2872 0.6077
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0106 0.2872 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0106 0.2872 0.4415
Leishmania major short chain dehydrogenase, putative 0.0106 0.2872 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Trypanosoma brucei oxidoreductase-like protein 0.0106 0.2872 1
Brugia malayi nuclear hormone receptor 0.0038 0.0775 0.1191
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0075 0.1924 0.2958
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.3056 0.5087
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0106 0.2872 1
Onchocerca volvulus 0.0018 0.0153 0.0238
Brugia malayi Dehydrogenases, short chain protein 30 0.0106 0.2872 0.4415
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0106 0.2872 0.6077
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0153 0.0236
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0029 0.0482 0.1468
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0106 0.2872 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0148 0.4157 0.4708
Leishmania major calcium-translocating P-type ATPase 0.0026 0.04 0.1285
Trypanosoma brucei short-chain dehydrogenase, putative 0.0106 0.2872 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Brugia malayi Protein kinase domain containing protein 0.0016 0.0103 0.0158
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0029 0.0482 0.1574
Brugia malayi Thioredoxin reductase 0.0044 0.0962 0.1479
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0029 0.0482 0.0546
Trichomonas vaginalis rap1 and, putative 0.0027 0.0418 0.0418
Trichomonas vaginalis cation-transporting ATPase, putative 0.0014 0.0036 0.0036
Brugia malayi nuclear receptor RXR 0.002 0.022 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0459 0.052
Schistosoma mansoni coup transcription factor 0.0038 0.0775 0.0878
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0153 0.0174
Onchocerca volvulus 0.0106 0.2872 0.4466
Loa Loa (eye worm) DR-78 0.0018 0.0153 0.0236
Mycobacterium ulcerans short-chain type oxidoreductase 0.0106 0.2872 0.6077
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0087 0.2268 0.3487
Trypanosoma brucei cysteine peptidase C (CPC) 0.0028 0.0466 0.1517
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.011 0.2986 0.3382
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0153 0.0174
Entamoeba histolytica short chain dehydrogenase family protein 0.0106 0.2872 0.2872
Echinococcus granulosus nuclear factor of activated T cells 5 0.0271 0.7946 0.9
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Trypanosoma brucei short-chain dehydrogenase, putative 0.0106 0.2872 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0106 0.2872 0.4772
Trichomonas vaginalis cation-transporting ATPase, putative 0.0026 0.04 0.04
Echinococcus granulosus retinol dehydrogenase 11 0.0106 0.2872 0.3252
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Schistosoma mansoni thyroid hormone receptor 0.0148 0.4162 0.4714
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0071 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Echinococcus granulosus protein kinase C gamma type 0.0016 0.0103 0.0117
Toxoplasma gondii cathepsin B 0.0028 0.0466 0.1517
Brugia malayi beta-lactamase family protein 0.0032 0.0591 0.0908
Brugia malayi beta-lactamase 0.0032 0.0591 0.0908
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0195 0.5601 0.8611
Mycobacterium ulcerans carveol-like dehydrogenase 0.0106 0.2872 0.6077
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0148 0.4157 0.4708
Onchocerca volvulus 0.0032 0.0591 0.0919
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0106 0.2872 0.4772
Echinococcus multilocularis geminin 0.0299 0.8829 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0029 0.0482 0.0741
Brugia malayi E1-E2 ATPase family protein 0.0017 0.0118 0.0181
Echinococcus granulosus hypothetical protein 0.0106 0.2872 0.3252
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0775 0.0878
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Echinococcus multilocularis tar DNA binding protein 0.0057 0.1345 0.1523
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Echinococcus granulosus nervana 2 0.0148 0.4157 0.4708
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0153 0.0238
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0032 0.0591 0.0591
Leishmania major trypanothione reductase 0.0044 0.0962 0.3266
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0062 0.1521 0.2926
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0122 0.3369 0.3815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0591 0.0669
Mycobacterium ulcerans short-chain dehydrogenase 0.0106 0.2872 0.6077
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0033 0.0051
Trypanosoma brucei trypanothione reductase 0.0044 0.0962 0.3266
Echinococcus granulosus mitogen activated protein kinase 0.0048 0.1078 0.122
Trichomonas vaginalis steroid dehydrogenase, putative 0.0106 0.2872 0.2872
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Loa Loa (eye worm) hypothetical protein 0.0051 0.1156 0.1777
Plasmodium falciparum steroid dehydrogenase, putative 0.0106 0.2872 1
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0014 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus hypothetical protein 0.0106 0.2872 0.3252
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0106 0.2872 0.2872
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0106 0.2872 0.4772
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0029 0.0487 0.0552
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0106 0.2872 0.4415
Giardia lamblia Hypothetical protein 0.0106 0.2872 0.2821
Schistosoma mansoni carbonyl reductase 0.0106 0.2872 0.3252
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Brugia malayi hypothetical protein 0.007 0.1754 0.2697
Echinococcus multilocularis calcium transporting atpase 0.0029 0.0482 0.0546
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0775 0.1191
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0071 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0033 0.0051
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0016 0.0079 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0103 0.0158
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0106 0.2872 0.4466
Schistosoma mansoni tar DNA-binding protein 0.0057 0.1345 0.1523
Echinococcus multilocularis serine:threonine protein kinase N2 0.0016 0.0103 0.0117
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0106 0.2872 0.2821
Echinococcus multilocularis carbonyl reductase 1 0.0106 0.2872 0.3252
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0026 0.04 0.1285
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0459 0.052
Trypanosoma brucei calcium-translocating P-type ATPase 0.0029 0.0482 0.1574
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Entamoeba histolytica ras-1, putative 0.0027 0.0418 0.0418
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0026 0.04 0.04
Toxoplasma gondii thioredoxin reductase 0.0044 0.0962 0.3266
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0775 0.1191
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0106 0.2872 0.6077
Brugia malayi Matrixin family protein 0.0016 0.0104 0.0159
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Plasmodium falciparum calcium-transporting ATPase 0.0029 0.0482 0.1468
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Mycobacterium tuberculosis Probable lipase LipD 0.0032 0.0591 0.0886
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Onchocerca volvulus 0.0122 0.3369 0.5239
Leishmania major short chain dehydrogenase/reductase, putative 0.0106 0.2872 1
Echinococcus multilocularis nervana 2 0.0122 0.3369 0.3815
Mycobacterium tuberculosis Probable reductase 0.0101 0.2709 0.4495
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0153 0.0174
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0122 0.3369 0.3815
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0048 0.1078 0.3674
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0085 0.2228 0.2523
Schistosoma mansoni atypical protein kinase C 0.019 0.5462 0.6186
Brugia malayi Protein kinase domain containing protein 0.0016 0.0103 0.0158
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0106 0.2872 0.2872
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0106 0.2872 0.2872
Schistosoma mansoni hypothetical protein 0.0299 0.8829 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.1078 0.3674
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0106 0.2872 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0016 0.0103 0.0117
Schistosoma mansoni nuclear receptor 0.0018 0.0153 0.0174
Echinococcus multilocularis protein kinase c epsilon type 0.0027 0.0446 0.0505
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Schistosoma mansoni retinal dehydrogenase 0.0106 0.2872 0.3252
Onchocerca volvulus 0.0023 0.0315 0.0489
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0775 0.0878
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0106 0.2872 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0775 0.0878
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0106 0.2872 0.4772
Onchocerca volvulus 0.0106 0.2872 0.4466
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0106 0.2872 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0962 0.109
Brugia malayi nuclear receptor NHR-88 0.0018 0.0153 0.0236
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0029 0.0482 0.0482
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0065 0.1602 0.2464
Brugia malayi Pre-SET motif family protein 0.0028 0.0459 0.0706
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0029 0.0482 0.1574
Giardia lamblia Cathepsin B precursor 0.0028 0.0466 0.0398
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0026 0.04 0.04
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0591 0.0591
Echinococcus multilocularis carbonyl reductase 1 0.0106 0.2872 0.3252
Loa Loa (eye worm) dehydrogenase 0.0106 0.2872 0.4415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Onchocerca volvulus 0.0222 0.643 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0459 0.0706
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0775 0.0878
Onchocerca volvulus 0.0106 0.2872 0.4466
Echinococcus multilocularis beta LACTamase domain containing family member 0.0032 0.0591 0.0669
Brugia malayi hypothetical protein 0.0106 0.2872 0.4415
Plasmodium falciparum glutathione reductase 0.0044 0.0962 0.3182
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0033 0.0038
Echinococcus granulosus GPCR family 2 0.0014 0.0033 0.0038
Mycobacterium ulcerans dehydrogenase 0.0106 0.2872 0.6077
Echinococcus multilocularis ras gtpase 0.0027 0.0418 0.0473
Plasmodium vivax calcium-transporting ATPase, putative 0.0029 0.0482 0.1468
Mycobacterium tuberculosis Conserved protein 0.0032 0.0591 0.0886
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0106 0.2872 1
Mycobacterium ulcerans ketoacyl reductase 0.0106 0.2872 0.6077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0029 0.0487 0.1591
Brugia malayi ecdysone receptor 0.0018 0.0153 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Echinococcus multilocularis serine:threonine protein kinase 38 0.0016 0.0103 0.0117
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0446 0.0505
Brugia malayi glutathione reductase 0.0044 0.0962 0.1479
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.468 1
Echinococcus multilocularis carbonyl reductase 1 0.0106 0.2872 0.3252
Toxoplasma gondii oxidoreductase, putative 0.0106 0.2872 1
Schistosoma mansoni ATPase 0.0026 0.04 0.0453
Mycobacterium leprae Probable lipase LipE 0.0032 0.0591 0.0845
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0029 0.0482 0.1574
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0973 0.1495
Toxoplasma gondii P-type ATPase4, putative 0.0029 0.0482 0.1574
Echinococcus multilocularis steroid dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0775 0.0878
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0538 0.0827
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0153 0.0238
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0962 0.3182
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0057 0.1345 0.2067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 0.4415
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0032 0.0591 0.1128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0033 0.0051
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0106 0.2872 0.5952
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0029 0.0487 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0057 0.1345 0.1523
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Brugia malayi nuclear hormone receptor 0.0018 0.0153 0.0236
Brugia malayi Retinol dehydrogenase 12 0.0106 0.2872 0.4415
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0026 0.04 0.1285
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0153 0.0174
Echinococcus granulosus mitogen activated protein kinase 3 0.0048 0.1078 0.122
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0032 0.0591 0.0908
Loa Loa (eye worm) hypothetical protein 0.0045 0.0973 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0775 0.1191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Brugia malayi follicle stimulating hormone receptor 0.0224 0.6504 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0071 0.0123
Toxoplasma gondii AGC kinase 0.0016 0.0103 0.0236
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Loa Loa (eye worm) hypothetical protein 0.0032 0.0591 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0775 0.1191
Brugia malayi tailless protein 0.0018 0.0153 0.0236
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0029 0.0482 0.0482
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0973 0.1495
Echinococcus multilocularis transient receptor potential cation channel 0.0106 0.2872 0.3252
Mycobacterium tuberculosis Conserved protein 0.0032 0.0591 0.0886
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0175 0.4987 0.7668
Toxoplasma gondii oxidoreductase, putative 0.0106 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1078 0.1078
Loa Loa (eye worm) AGC/PKN protein kinase 0.0016 0.0103 0.0158
Loa Loa (eye worm) hypothetical protein 0.0018 0.0161 0.0247
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0029 0.0482 0.0546
Brugia malayi calcium ATPase 0.0014 0.0045 0.0068
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0122 0.3369 0.3815
Trichomonas vaginalis D-aminoacylase, putative 0.0032 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0028 0.0466 0.0466
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0106 0.2872 0.4415
Toxoplasma gondii carbonyl reductase 1, putative 0.0106 0.2872 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0085 0.2228 0.7729
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0071 0.0123
Trypanosoma brucei calcium-transporting ATPase, putative 0.0018 0.0161 0.044
Onchocerca volvulus 0.0106 0.2872 0.4466
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0989 0.3277
Plasmodium vivax hypothetical protein, conserved 0.0106 0.2872 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0153 0.0174
Loa Loa (eye worm) matrixin family protein 0.004 0.082 0.1261
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0038
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0106 0.2872 0.3252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0775 0.1191
Leishmania major 3-keto-dihydrosphingosine reductase 0.0106 0.2872 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0775 0.1191
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0106 0.2872 0.2872
Loa Loa (eye worm) hypothetical protein 0.0148 0.4157 0.6391
Loa Loa (eye worm) hypothetical protein 0.0018 0.0153 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0051
Trichomonas vaginalis dexras1, putative 0.0027 0.0418 0.0418
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0029 0.0482 0.0546
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.2709 0.5588
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.4757 0.5387
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.1078 0.1078
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.2709 0.4495
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0106 0.2872 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0775 0.1191
Mycobacterium leprae Probable oxidoreductase 0.0106 0.2872 0.5952
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.1115 0.1115
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0153 0.0174
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0775 0.0878
Giardia lamblia Kinase, CMGC MAPK 0.0048 0.1078 0.1014
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0153 0.0236
Loa Loa (eye worm) glutathione reductase 0.0044 0.0962 0.1479
Echinococcus multilocularis jun protein 0.0089 0.2344 0.2654
Entamoeba histolytica hypothetical protein 0.0106 0.2872 0.2872
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0018 0.0161 0.0247
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0153 0.0174
Loa Loa (eye worm) AGC/NDR protein kinase 0.0016 0.0103 0.0158
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Brugia malayi Pre-SET motif family protein 0.0195 0.5601 0.8611
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0962 0.1518
Trypanosoma cruzi hypothetical protein, conserved 0.0106 0.2872 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0103 0.0117
Mycobacterium ulcerans beta-lactamase 0.0032 0.0591 0.1128
Schistosoma mansoni short chain dehydrogenase 0.0106 0.2872 0.3252
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Echinococcus granulosus calcium transporting atpase 0.0029 0.0482 0.0546
Loa Loa (eye worm) hypothetical protein 0.0027 0.0418 0.0642
Schistosoma mansoni serine/threonine kinase 0.0016 0.0103 0.0117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0775 0.1191
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0106 0.2872 1
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0029 0.0482 0.0546
Mycobacterium tuberculosis Probable oxidoreductase 0.0106 0.2872 0.4772
Echinococcus multilocularis GPCR, family 2 0.0014 0.0033 0.0038
Brugia malayi protein kinase C II. 0.0027 0.0446 0.0685
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0029 0.0482 0.0546
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0153 0.0236
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0071 0.5
Schistosoma mansoni zinc finger protein 0.0018 0.0153 0.0174
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.1115 0.3806
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0159
Echinococcus granulosus carbonyl reductase 1 0.0106 0.2872 0.3252
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0016 0.0103 0.0117
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0048 0.1078 0.3674
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0075 0.1924 0.2179
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0071 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0775 0.1191
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0029 0.0482 0.0546
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0048 0.1078 0.3674
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0085 0.2228 0.2523
Leishmania major quinonoid dihydropteridine reductase 0.0106 0.2872 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0775 0.1205
Mycobacterium leprae conserved hypothetical protein 0.0032 0.0591 0.0845
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0775 0.0878
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0775 0.0878
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0337 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0459 0.052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0032 0.0591 0.0669
Schistosoma mansoni hypothetical protein 0.003 0.0538 0.0609
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0106 0.2872 0.3252
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0775 0.1191
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0106 0.2872 0.3252
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0055
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.022 0.0338
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0962 0.3266
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0153 0.0174
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0775 0.0878
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.6504 1
Loa Loa (eye worm) oxidoreductase 0.0106 0.2872 0.4415
Brugia malayi beta-lactamase family protein 0.0032 0.0591 0.0908
Echinococcus granulosus cathepsin b 0.0085 0.2228 0.2523
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0032 0.0591 0.0886
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0106 0.2872 0.3252
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0106 0.2872 0.6077
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.022 0.0249
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Schistosoma mansoni carbonyl reductase 0.0106 0.2872 0.3252
Loa Loa (eye worm) beta-lactamase 0.0032 0.0591 0.0908
Loa Loa (eye worm) hypothetical protein 0.0106 0.2872 0.4415
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0106 0.2872 0.2872
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0775 0.1191
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0065 0.1602 0.2464
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0775 0.1191
Echinococcus multilocularis mitogen activated protein kinase 3 0.0048 0.1078 0.122
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0271 0.7946 0.9
Mycobacterium tuberculosis Conserved protein 0.0032 0.0591 0.0886
Echinococcus multilocularis protein kinase c iota type 0.0179 0.5118 0.5797
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0106 0.2872 0.4466
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.022 0.0338
Loa Loa (eye worm) E1-E2 ATPase 0.0014 0.0036 0.0055
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0029 0.0482 0.0892
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0018 0.0161 0.0247
Trichomonas vaginalis AGC family protein kinase 0.0016 0.0103 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0057 0.1345 0.1523
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0775 0.0878
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.022 0.0249
Loa Loa (eye worm) Ras protein let-60 0.0027 0.0418 0.0642
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0775 0.1191
Onchocerca volvulus 0.0106 0.2872 0.4466
Mycobacterium ulcerans short chain dehydrogenase 0.0106 0.2872 0.6077
Loa Loa (eye worm) matrixin family protein 0.0036 0.0719 0.1105
Echinococcus multilocularis mitogen activated protein kinase 0.0048 0.1078 0.122
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0103 0.0117
Schistosoma mansoni steroid dehydrogenase 0.0106 0.2872 0.3252
Echinococcus granulosus NDR protein kinase 0.0016 0.0103 0.0117
Echinococcus granulosus nervana 2 0.0122 0.3369 0.3815
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0016 0.0103 0.0158
Brugia malayi nuclear receptor NHR-88 0.0038 0.0775 0.1191
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0106 0.2872 0.6077
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0027 0.0446 0.0685

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 10 uM Antiviral activity against HIV1 by focal infectivity assay ChEMBL. 17074494
IC50 (ADMET) 0 Cytotoxicity against HeLa H1-JC.37 cells by MTS assay ChEMBL. 17074494
IC50 (binding) = 500 uM Inhibition of HIV1 integrase-mediated integration activity ChEMBL. 17074494
IC50 (binding) = 500 uM Inhibition of HIV1 integrase-mediated integration activity ChEMBL. 17074494
IC50 (binding) = 850 uM Inhibition of HIV1 integrase-mediated 3'-processing activity ChEMBL. 17074494
IC50 (binding) = 850 uM Inhibition of HIV1 integrase-mediated 3'-processing activity ChEMBL. 17074494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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