Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | < 0.01 uM | Cytotoxicity against MOLT4 cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
IC50 (ADMET) | < 0.01 uM | Cytotoxicity against MOLT4 cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
IC50 (ADMET) | = 0.35 uM | Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
IC50 (ADMET) | = 0.35 uM | Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
IC50 (ADMET) | = 0.42 uM | Cytotoxicity against human HA22T cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
IC50 (ADMET) | = 0.68 uM | Cytotoxicity against SKBR3 cells after 72 hrs by MTT assay | ChEMBL. | 17107806 |
SC50 (binding) | = 2 uM | Binding affinity to Escherichia coli JM83 pUC19 DNA assessed as DNA intercalation assay | ChEMBL. | 17107806 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 17107806 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.