Detailed information for compound 420983

Basic information

Technical information
  • TDR Targets ID: 420983
  • Name: 2-[(2E)-2-pentan-2-ylidenehydrazinyl]-3-pheny lquinazolin-4-one
  • MW: 320.388 | Formula: C19H20N4O
  • H donors: 1 H acceptors: 1 LogP: 3.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC/C(=N/Nc1nc2ccccc2c(=O)n1c1ccccc1)/C
  • InChi: 1S/C19H20N4O/c1-3-9-14(2)21-22-19-20-17-13-8-7-12-16(17)18(24)23(19)15-10-5-4-6-11-15/h4-8,10-13H,3,9H2,1-2H3,(H,20,22)/b21-14+
  • InChiKey: MICUNAOFFZWKPU-KGENOOAVSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(N'E)-N'-(1-methylbutylidene)hydrazino]-3-phenyl-quinazolin-4-one
  • 2-[(N'E)-N'-(1-methylbutylidene)hydrazino]-3-phenyl-4-quinazolinone
  • 2-[(2E)-2-pentan-2-ylidenehydrazinyl]-3-phenyl-quinazolin-4-one
  • 2-((2E)-2-pentan-2-ylidenehydrazinyl)-3-phenylquinazolin-4-one
  • 2-((N'E)-N'-(1-methylbutylidene)hydrazino)-3-phenyl-quinazolin-4-one
  • 2-((N'E)-N'-(1-methylbutylidene)hydrazino)-3-phenyl-4-quinazolinone
  • 2-((2E)-2-pentan-2-ylidenehydrazinyl)-3-phenyl-quinazolin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Plasmodium falciparum glutathione reductase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast glutathione reductase 500 aa 561 aa 24.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0064 0.8139 0.5
Onchocerca volvulus 0.0064 0.8139 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.8139 0.8139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Brugia malayi RE15519p 0.0064 0.8139 0.8139
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0026 0.2424 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.2424 0.0746
Onchocerca volvulus 0.0064 0.8139 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.2424 0.0746
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.8139 0.8139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Echinococcus granulosus g protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus granulosus serotonin receptor 0.0064 0.8139 0.8139
Brugia malayi Cytochrome P450 family protein 0.0022 0.1814 0.1814
Onchocerca volvulus 0.0064 0.8139 0.5
Plasmodium falciparum glutathione reductase 0.0076 1 1
Brugia malayi G-protein coupled receptor 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0064 0.8139 0.8139
Schistosoma mansoni hypothetical protein 0.0022 0.1814 0.1814
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.2424 1
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine (5HT) receptor 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide f receptor 76f 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni amine GPCR 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Schistosoma mansoni hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi Serotonin receptor 0.0064 0.8139 0.8139
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.2424 0.0746
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.8139 0.8139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.2424 0.0746
Echinococcus granulosus dro:myosuppressin receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis serotonin receptor 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0064 0.8139 0.8139
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.3906 0.3906
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.3544 1
Echinococcus multilocularis allatostatin A receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.4412 0.4412
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0026 0.2424 0.0746
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Echinococcus multilocularis g protein coupled receptor 0.0064 0.8139 0.8139
Schistosoma mansoni amine GPCR 0.0064 0.8139 0.8139
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.2424 0.0746
Schistosoma mansoni biogenic amine receptor 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide F-like receptor 0.0064 0.8139 0.8139
Schistosoma mansoni hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis sex peptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0064 0.8139 0.8139
Brugia malayi Serotonin receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.1814 0.1814
Trypanosoma cruzi trypanothione reductase, putative 0.0076 1 1
Echinococcus multilocularis fmrfamide receptor 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus orexin receptor type 2 0.0064 0.8139 0.8139
Echinococcus granulosus 7tm_1 domain containing protein 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi putative neuropeptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Leishmania major trypanothione reductase 0.0076 1 1
Trypanosoma brucei trypanothione reductase 0.0076 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.2424 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0064 0.8139 0.8139
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.2424 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptide s receptor 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.8139 0.8139
Echinococcus granulosus hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0064 0.8139 0.8139
Echinococcus multilocularis g-protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Brugia malayi cytochrome P450 0.0022 0.1814 0.1814
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0026 0.2424 0.0746
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.2424 0.5
Schistosoma mansoni growth hormone secretagogue receptor 0.0064 0.8139 0.8139
Schistosoma mansoni amine GPCR 0.0064 0.8139 0.8139
Loa Loa (eye worm) cytochrome P450 0.0022 0.1814 0.1814
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.8139 0.8139
Brugia malayi putative neuropeptide receptor NPR1 0.0064 0.8139 0.8139
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis G-protein coupled receptor, putative 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.2424 0.0746
Loa Loa (eye worm) TYRA-2 protein 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis g protein coupled receptor 0.0064 0.8139 0.8139
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.1358 0.1358
Onchocerca volvulus 0.0064 0.8139 0.5
Onchocerca volvulus Neuropeptide F receptor homolog 0.0064 0.8139 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide receptor 0.0064 0.8139 0.8139
Schistosoma mansoni opsin-like receptor 0.0064 0.8139 0.8139
Echinococcus granulosus biogenic amine 5HT receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) neuropeptide F receptor 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Brugia malayi Dopamine receptor protein 2 0.0064 0.8139 0.8139
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 1 1
Schistosoma mansoni opsin-like receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.2424 1
Loa Loa (eye worm) CYP4Cod1 0.0022 0.1814 0.1814
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.2424 0.0746
Echinococcus multilocularis 0.0022 0.1814 0.1814
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0064 0.8139 0.8139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.8139 0.8139
Schistosoma mansoni opsin-like receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.3906 0.3906
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0064 0.8139 0.8139
Echinococcus granulosus G protein coupled receptor 139 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Echinococcus multilocularis somatostatin receptor 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Brugia malayi GnHR receptor homolog 0.0064 0.8139 0.8139
Schistosoma mansoni myosin xvIII 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi Thioredoxin reductase 0.0076 1 1
Schistosoma mansoni adenoreceptor 0.0064 0.8139 0.8139
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Plasmodium vivax thioredoxin reductase, putative 0.0076 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptide receptor A26 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.2424 0.0746
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi Dopamine receptor protein 1 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Echinococcus multilocularis orexin receptor type 2 0.0064 0.8139 0.8139
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.3906 0.3906
Echinococcus granulosus sex peptide receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0064 0.8139 0.8139
Schistosoma mansoni cytochrome P450 0.0022 0.1814 0.1814
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptide Y receptor 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Onchocerca volvulus 0.0064 0.8139 0.5
Echinococcus multilocularis fmrfamide receptor 0.0064 0.8139 0.8139
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.2424 0.2424
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.2424 0.0746
Loa Loa (eye worm) melatonin receptor type 1A 0.0064 0.8139 0.8139
Echinococcus multilocularis neuropeptide FF receptor 2 0.0064 0.8139 0.8139
Echinococcus multilocularis rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni amine GPCR 0.0064 0.8139 0.8139
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.2424 0.0746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Brugia malayi Cytochrome P450 family protein 0.0022 0.1814 0.1814
Schistosoma mansoni histamine h1 receptor 0.0064 0.8139 0.8139
Brugia malayi neuropeptide F receptor 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Echinococcus multilocularis g protein coupled receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus tm gpcr rhodopsin 0.0064 0.8139 0.8139
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0064 0.8139 0.8139
Brugia malayi G protein-coupled receptor 0.0064 0.8139 0.8139
Echinococcus granulosus allatostatin A receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) thioredoxin reductase 0.0076 1 1
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Plasmodium falciparum thioredoxin reductase 0.0076 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0064 0.8139 0.8139
Brugia malayi G-protein coupled receptor 0.0064 0.8139 0.8139
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.2424 0.5
Brugia malayi larval opioid receptor 0.0064 0.8139 0.8139
Schistosoma mansoni neuropeptide receptor 0.0064 0.8139 0.8139
Echinococcus granulosus somatostatin receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis G protein coupled receptor 139 0.0064 0.8139 0.8139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.2424 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.3544 1
Schistosoma mansoni amine GPCR 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0064 0.8139 0.8139
Echinococcus granulosus tachykinin peptides receptor 99D 0.0064 0.8139 0.8139
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.2424 0.0746
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus 7TM GPCR rhodopsin 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Brugia malayi Cytochrome P450 family protein 0.0022 0.1814 0.1814
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0064 0.8139 0.8139
Treponema pallidum NADH oxidase 0.0026 0.2424 0.5
Echinococcus multilocularis neuropeptide receptor 0.0064 0.8139 0.8139
Echinococcus granulosus rhodopsin orphan GPCR 0.0064 0.8139 0.8139
Brugia malayi neuropeptide F receptor 0.0064 0.8139 0.8139
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0064 0.8139 0.8139
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi AKH receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0064 0.8139 0.8139
Brugia malayi Tachykinin-like peptides receptor 99D 0.0064 0.8139 0.8139
Onchocerca volvulus 0.0064 0.8139 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.1814 0.1814
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis serotonin receptor 0.0064 0.8139 0.8139
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0064 0.8139 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0031 0.318 0.318
Echinococcus multilocularis neuropeptide receptor A26 0.0064 0.8139 0.8139
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.2424 0.0746
Echinococcus granulosus g protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus granulosus neuropeptide receptor 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0064 0.8139 0.8139
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus g protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus granulosus fmrfamide receptor 0.0064 0.8139 0.8139
Echinococcus granulosus g-protein coupled receptor 0.0064 0.8139 0.8139
Schistosoma mansoni biogenic amine receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.3906 0.3906
Plasmodium vivax glutathione reductase, putative 0.0076 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0064 0.8139 0.8139
Loa Loa (eye worm) glutathione reductase 0.0076 1 1
Echinococcus multilocularis neuropeptides capa receptor 0.0064 0.8139 0.8139
Echinococcus multilocularis dro:myosuppressin receptor 0.0064 0.8139 0.8139
Brugia malayi Cytochrome P450 family protein 0.0022 0.1814 0.1814
Brugia malayi ORL1-like opioid receptor 0.0064 0.8139 0.8139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.2424 0.2424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Echinococcus multilocularis neuropeptide s receptor 0.0064 0.8139 0.8139
Brugia malayi Melatonin receptor type 1A 0.0064 0.8139 0.8139
Mycobacterium tuberculosis Probable oxidoreductase 0.0026 0.2424 0.0746
Schistosoma mansoni hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis neuropeptide receptor 0.0064 0.8139 0.8139
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0064 0.8139 0.8139
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.4412 0.4412
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.1358 0.1358
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0064 0.8139 0.8139
Brugia malayi Dopamine receptor 0.0064 0.8139 0.8139
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.2424 0.2424
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0064 0.8139 0.8139
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0064 0.8139 0.8139
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Onchocerca volvulus 0.0064 0.8139 0.5
Brugia malayi hypothetical protein 0.0064 0.8139 0.8139
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0076 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.1814 0.1814
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.2424 0.0746
Brugia malayi sulfakinin receptor protein 0.0064 0.8139 0.8139
Toxoplasma gondii thioredoxin reductase 0.0076 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0064 0.8139 0.8139
Echinococcus multilocularis neuropeptide Y receptor 0.0064 0.8139 0.8139
Brugia malayi follicle stimulating hormone receptor 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus granulosus alpha 1A adrenergic receptor 0.0064 0.8139 0.8139
Schistosoma mansoni hypothetical protein 0.0064 0.8139 0.8139
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0064 0.8139 0.8139
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0064 0.8139 0.8139
Echinococcus granulosus peptide allatostatin:somatostatin 0.0064 0.8139 0.8139
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.2424 0.2424
Loa Loa (eye worm) hypothetical protein 0.0064 0.8139 0.8139

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 33 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 33 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 3 hrs ChEMBL. 17079148
Activity (functional) = 33 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 35 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 30 mins ChEMBL. 17079148
Activity (functional) = 41 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 1 hr ChEMBL. 17079148
Activity (functional) = 41 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 3 hrs ChEMBL. 17079148
Activity (functional) = 42 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 10 mg/kg after 2 hrs ChEMBL. 17079148
Activity (functional) = 43 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 43 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 45 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 45 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 3 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 46 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 30 min ChEMBL. 17079148
Activity (functional) = 48 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 48 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 50 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 50 % Analgesic activity in Wistar Albino mouse at 10 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 56 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 56 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 30 mins by tail-flick technique ChEMBL. 17079148
Activity (functional) = 58 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 1 hr ChEMBL. 17079148
Activity (functional) = 60 % Anti-inflammatory activity against carrageeenen-induced paw oedema rat model at 20 mg/kg after 2 hrs ChEMBL. 17079148
Activity (functional) = 62 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 62 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148
Activity (functional) = 62 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 1 hr by tail-flick technique ChEMBL. 17079148
Activity (functional) = 62 % Analgesic activity in Wistar Albino mouse at 20 mg/kg, po after 2 hrs by tail-flick technique ChEMBL. 17079148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.