Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Rrm3p helicase | 0.0204 | 0.4632 | 0.5 |
Trypanosoma cruzi | UDP-glucoronosyl and UDP-glucosyl transferase, putative | 0.0422 | 1 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0204 | 0.4632 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Echinococcus multilocularis | neuroligin | 0.0028 | 0.0281 | 0.0606 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0028 | 0.0281 | 1 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0204 | 0.4632 | 0.4547 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF7, putative | 0.0204 | 0.4632 | 0.4547 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0281 | 0.0281 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3631 | 0.3631 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0028 | 0.0281 | 0.0606 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF6 | 0.0204 | 0.4632 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.3631 | 0.3631 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Trypanosoma cruzi | DNA repair and recombination helicase protein PIF6, putative | 0.0204 | 0.4632 | 0.4547 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Loa Loa (eye worm) | UDP-glucoronosyl and UDP-glucosyl transferase | 0.0023 | 0.0157 | 0.0157 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3631 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0204 | 0.4632 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.3631 | 0.3631 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.3631 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0028 | 0.0281 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Mycobacterium leprae | Possible glycosyl transferase | 0.0023 | 0.0157 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Echinococcus multilocularis | ATP dependent DNA helicase PIF1 | 0.0204 | 0.4632 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.3631 | 0.7838 |
Echinococcus granulosus | ATP dependent DNA helicase PIF1 | 0.0204 | 0.4632 | 1 |
Mycobacterium leprae | Probable glycosyltransferase | 0.0023 | 0.0157 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0028 | 0.0281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.3631 | 0.3631 |
Mycobacterium leprae | possible glycosyltransferase | 0.0023 | 0.0157 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0028 | 0.0281 | 0.0281 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Trypanosoma brucei | DNA repair and recombination helicase protein PIF7 | 0.0204 | 0.4632 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0281 | 1 |
Echinococcus granulosus | neuroligin | 0.0028 | 0.0281 | 0.0606 |
Brugia malayi | UDP-glucoronosyl and UDP-glucosyl transferase family protein | 0.0023 | 0.0157 | 0.0433 |
Schistosoma mansoni | acetylcholinesterase | 0.0028 | 0.0281 | 0.0606 |
Schistosoma mansoni | gliotactin | 0.0028 | 0.0281 | 0.0606 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0204 | 0.4632 | 0.5 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.3631 | 0.7838 |
Mycobacterium leprae | Possible glycosyl transferase | 0.0023 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0157 | 0.0157 |
Schistosoma mansoni | hypothetical protein | 0.0204 | 0.4632 | 1 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.3631 | 0.7838 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0028 | 0.0281 | 0.0606 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0204 | 0.4632 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.3631 | 0.7838 |
Brugia malayi | Carboxylesterase family protein | 0.0028 | 0.0281 | 0.0773 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0028 | 0.0281 | 1 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0281 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0028 | 0.0281 | 0.0606 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0016 | 0.00000016146 | 0.00000034854 |
Onchocerca volvulus | 0.0028 | 0.0281 | 0.5 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0028 | 0.0281 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0281 | 0.0281 |
Leishmania major | PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative | 0.0204 | 0.4632 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.32 uM | Inhibition of human serum BuChE | ChEMBL. | 17008100 |
IC50 (binding) | = 0.32 uM | Inhibition of human serum BuChE | ChEMBL. | 17008100 |
IC50 (binding) | = 3.15 uM | Inhibition of human erythrocyte AchE | ChEMBL. | 17008100 |
IC50 (binding) | = 3.15 uM | Inhibition of human erythrocyte AchE | ChEMBL. | 17008100 |
Ratio IC50 (binding) | = 0.1 | Ratio of IC50 for BuChE to IC50 for AchE | ChEMBL. | 17008100 |
Ratio IC50 (binding) | = 9.8 | Ratio of IC50 for AchE to IC50 for BuChE | ChEMBL. | 17008100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.