Detailed information for compound 421019

Basic information

Technical information
  • TDR Targets ID: 421019
  • Name: (1S,2S,5R,6R)-5-methyl-2-(phenylmethoxymethyl )-3,4,7-trioxabicyclo[4.1.0]heptane
  • MW: 236.264 | Formula: C13H16O4
  • H donors: 0 H acceptors: 0 LogP: 1.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@H]1OO[C@H]([C@@H]2[C@H]1O2)COCc1ccccc1
  • InChi: 1S/C13H16O4/c1-9-12-13(15-12)11(17-16-9)8-14-7-10-5-3-2-4-6-10/h2-6,9,11-13H,7-8H2,1H3/t9-,11+,12+,13-/m1/s1
  • InChiKey: SXWNQGFEAPKNCG-LPTSXCQYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,2S,5R,6R)-2-(benzyloxymethyl)-5-methyl-3,4,7-trioxabicyclo[4.1.0]heptane
  • (1S,2S,5R,6R)-2-(benzoxymethyl)-5-methyl-3,4,7-trioxabicyclo[4.1.0]heptane

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypoxia-induced factor 1 0.0608 0.396 0.3959
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0067 0.0342 0.0339
Plasmodium vivax amine transporter, putative 0.02 0.123 1
Schistosoma mansoni tyrosine kinase 0.0484 0.313 0.313
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Brugia malayi PHD-finger family protein 0.0027 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0269 0.0267
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0029 0.0027
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0051 0.0238 0.0235
Echinococcus granulosus tyrosine protein kinase Lyn 0.0056 0.0272 0.027
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0026 0.0026
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0051 0.0238 0.1188
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0129 0.0565
Brugia malayi Pre-SET motif family protein 0.0215 0.1336 0.1334
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.0325 0.6884
Onchocerca volvulus 0.02 0.123 0.1564
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0096 0.5
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0238 0.5043
Brugia malayi nuclear receptor NHR-88 0.002 0.0028 0.0025
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0861 0.4394
Echinococcus multilocularis transfer RNA-Lys 0.0145 0.0868 0.0866
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0241 0.0238
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0241 0.5107
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0096 0.0422
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0129 0.0126
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0318 0.0318
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0241 0.1204
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1167 0.1164
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Leishmania major DNA polymerase kappa, putative 0.0021 0.0039 0.0827
Brugia malayi steroid hormone receptor 0.0067 0.0342 0.0339
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0067 0.0342 0.0339
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0096 0.076
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0026 0.0024
Brugia malayi hypothetical protein 0.0448 0.2889 0.2887
Brugia malayi Cell death protein 3 precursor 0.0031 0.0105 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0247 0.0244
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.4559 0.4559
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0096 0.2033
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0307 0.0307
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.021 0.021
Brugia malayi Nuclear hormone receptor E75 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Entamoeba histolytica hypothetical protein 0.0019 0.0026 0.003
Plasmodium vivax SET domain protein, putative 0.0035 0.0132 0.1052
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0016 0.0013
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0219 0.0219
Toxoplasma gondii macro domain-containing protein 0.0042 0.0176 0.141
Echinococcus granulosus epidermal growth factor receptor 0.1512 1 1
Entamoeba histolytica aldose reductase, putative 0.0064 0.0325 0.1643
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0208
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0096 0.0311
Entamoeba histolytica protein kinase, putative 0.0038 0.0153 0.0713
Brugia malayi jmjC domain containing protein 0.0059 0.0294 0.0291
Mycobacterium leprae Possible regulatory protein 0.0051 0.0238 0.1628
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0107 0.2261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0342 0.0339
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0096 0.2033
Loa Loa (eye worm) hypothetical protein 0.0031 0.0105 0.0103
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.1176 0.7753 0.7752
Mycobacterium ulcerans carboxylesterase, LipT 0.0305 0.1933 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0056 0.0269 0.0267
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0067 0.0342 0.0339
Trypanosoma brucei unspecified product 0.0035 0.013 0.2746
Brugia malayi hypothetical protein 0.0019 0.0026 0.0024
Schistosoma mansoni hypothetical protein 0.0171 0.1041 0.1041
Onchocerca volvulus 0.0047 0.0209 0.0243
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0208
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Trypanosoma brucei aldo-keto reductase, putative 0.0064 0.0325 0.6884
Echinococcus multilocularis MACRO domain containing protein 2 0.0042 0.0176 0.0173
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0414 0.266 0.266
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0096 0.2033
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0325 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Echinococcus multilocularis lamin dm0 0.0027 0.0079 0.0076
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.0475 0.0473
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.016 0.0181
Echinococcus multilocularis tyrosine protein kinase HCK 0.0038 0.0153 0.015
Onchocerca volvulus 0.0023 0.0053 0.0042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0129 0.0129
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0129 0.0126
Plasmodium falciparum transporter, putative 0.02 0.123 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Schistosoma mansoni tyrosine kinase 0.0023 0.0053 0.0053
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0342 0.0339
Onchocerca volvulus 0.0048 0.0219 0.0256
Brugia malayi nuclear receptor RXR 0.0047 0.021 0.0208
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0026 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0181 0.0879
Schistosoma mansoni hypothetical protein 0.0171 0.1041 0.1041
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0307 0.0304
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0019 0.0021 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0238 0.1188
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Schistosoma mansoni tyrosine kinase 0.0813 0.5328 0.5328
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0209 0.0209
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0309
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0026 0.0026
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0241 0.0238
Brugia malayi mbt repeat family protein 0.0048 0.0219 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0238 0.1188
Echinococcus granulosus expressed protein 0.0377 0.2418 0.2416
Plasmodium falciparum Appr-1-p processing domain protein 0.0042 0.0176 0.141
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Onchocerca volvulus 0.0051 0.0238 0.0281
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0029 0.0027
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0241 0.5109
Brugia malayi Sodium:neurotransmitter symporter family protein 0.02 0.123 0.1228
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0241 0.1941
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Echinococcus multilocularis polycomb protein suz12 A 0.0971 0.6381 0.638
Schistosoma mansoni hypothetical protein 0.0031 0.0105 0.0105
Schistosoma mansoni nck2/grb4 0.0017 0.0013 0.0013
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0129 0.0126
Echinococcus granulosus tyrosine protein kinase ABL1 0.0023 0.0053 0.0051
Echinococcus granulosus ecdysone induced protein 78C 0.0067 0.0342 0.0339
Mycobacterium tuberculosis Possible lipoprotein LppD 0.0042 0.0176 0.0811
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0079 0.0076
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0241 0.0238
Brugia malayi Appr-1-p processing enzyme family protein 0.0042 0.0176 0.0173
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0307 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0241 0.1204
Schistosoma mansoni hypothetical protein 0.0971 0.6381 0.6381
Plasmodium vivax telomerase reverse transcriptase, putative 0.0086 0.0471 0.3817
Brugia malayi Pre-SET motif family protein 0.0035 0.0132 0.0129
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0051 0.0238 0.0235
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0096 0.0422
Echinococcus granulosus uncharacterized sodium dependent transporter 0.02 0.123 0.1228
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0042 0.0176 0.0853
Schistosoma mansoni tyrosine kinase 0.0023 0.0053 0.0053
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0067 0.0342 0.0339
Loa Loa (eye worm) DR-78 0.002 0.0028 0.0025
Echinococcus granulosus chromobox protein 1 0.007 0.0367 0.0365
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0096 0.2033
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0023 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase Blk 0.0052 0.0245 0.0243
Onchocerca volvulus 0.0064 0.0325 0.0393
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0219 0.0216
Echinococcus granulosus single minded 2 0.0145 0.0868 0.0866
Plasmodium falciparum glutathione reductase 0.003 0.0096 0.076
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0019 0.0021 0.0437
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0241 0.5107
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0067 0.0342 0.0339
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0039 0.0827
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0342 0.0342
Schistosoma mansoni gliotactin 0.0035 0.0129 0.0129
Schistosoma mansoni lamin 0.0027 0.0079 0.0079
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0017 0.0013 0.0013
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.021 0.0208
Brugia malayi polk-prov protein 0.0031 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.005 0.0231 0.0228
Brugia malayi Nuclear hormone receptor E75 0.002 0.0028 0.0025
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0241 0.5107
Loa Loa (eye worm) glutathione reductase 0.0086 0.0472 0.0469
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0003 0.0003
Plasmodium vivax aldehyde reductase, putative 0.0019 0.0021 0.0147
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0055
Echinococcus multilocularis aryl hydrocarbon receptor 0.0051 0.0238 0.0235
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Echinococcus multilocularis c src tyrosine kinase 0.0027 0.0078 0.0075
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1167 0.1164
Brugia malayi MH2 domain containing protein 0.0121 0.0703 0.0701
Trypanosoma brucei trypanothione reductase 0.0086 0.0472 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0021 0.0016
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.1871 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0861 0.6301
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.123 0.123
Brugia malayi PXA domain containing protein 0.0019 0.0026 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Echinococcus multilocularis apoptotic protease activating factor 1 0.0031 0.0105 0.0103
Brugia malayi MAP kinase sur-1 0.0052 0.0241 0.0238
Leishmania major protein kinase, putative 0.0052 0.0241 0.5109
Loa Loa (eye worm) oxidoreductase 0.0064 0.0325 0.0322
Brugia malayi SET domain containing protein 0.0283 0.1787 0.1785
Loa Loa (eye worm) oxidoreductase 0.0064 0.0325 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.0067 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.0659 0.4301 0.43
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.02 0.123 1
Brugia malayi ecdysteroid receptor 0.0544 0.353 0.3528
Onchocerca volvulus Protein ultraspiracle homolog 0.0067 0.0342 0.0415
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.4559 0.4557
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Schistosoma mansoni intermediate filament proteins 0.0027 0.0079 0.0079
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0019 0.0021 0.0016
Echinococcus multilocularis NCK adaptor protein 0.0017 0.0013 0.0011
Echinococcus multilocularis aldo keto reductase 0.0064 0.0325 0.0322
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0129 0.0129
Toxoplasma gondii hypothetical protein 0.02 0.123 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.02 0.123 0.123
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0343 0.034
Echinococcus granulosus tyrosine protein kinase Blk 0.0052 0.0245 0.0243
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0019 0.0021 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0156 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0067 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.0055 0.0264 0.0261
Schistosoma mansoni sodium/chloride dependent transporter 0.02 0.1233 0.1233
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0243 0.1519 0.1517
Mycobacterium tuberculosis Probable oxidoreductase 0.0064 0.0325 0.159
Schistosoma mansoni lamin 0.0027 0.0079 0.0079
Brugia malayi Protein kinase domain containing protein 0.0023 0.0053 0.0051
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0021 0.0016
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0026 0.0024
Brugia malayi photoreceptor-specific nuclear receptor 0.0067 0.0342 0.0339
Echinococcus multilocularis sodium and chloride dependent glycine 0.02 0.123 0.1228
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0096 0.0093
Plasmodium vivax glutathione reductase, putative 0.0086 0.0472 0.3821
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0139 0.0137
Trypanosoma cruzi Macro domain containing protein, putative 0.0042 0.0176 0.3726
Schistosoma mansoni tyrosine kinase 0.0803 0.5264 0.5264
Echinococcus granulosus c src tyrosine kinase 0.0027 0.0078 0.0075
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0056 0.0269 0.0267
Schistosoma mansoni nuclear hormone receptor 0.0067 0.0342 0.0342
Schistosoma mansoni potassium channel beta 0.0019 0.0021 0.0021
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0026 0.0024
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0096 0.2033
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0307 0.0304
Schistosoma mansoni sodium-dependent amino acid transporter 0.02 0.123 0.123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0345 0.0345
Brugia malayi Protein kinase domain containing protein 0.0023 0.0053 0.0051
Leishmania major trypanothione reductase 0.0086 0.0472 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0083 0.0355
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0026 0.0024
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0176 0.0838
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0028 0.0025
Onchocerca volvulus 0.0064 0.0325 0.0393
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0307 0.2478
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0055
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0026 0.0024
Schistosoma mansoni cpg binding protein 0.0033 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0026 0.0024
Schistosoma mansoni tyrosine kinase 0.0056 0.0269 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Echinococcus granulosus tumor protein p63 0.0342 0.2179 0.2177
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0026 0.0024
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.021 0.0208
Loa Loa (eye worm) TK protein kinase 0.0052 0.0245 0.0243
Loa Loa (eye worm) hypothetical protein 0.0048 0.0219 0.0216
Onchocerca volvulus 0.0023 0.0053 0.0042
Brugia malayi SH2 domain containing protein 0.0023 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Mycobacterium tuberculosis Probable oxidoreductase 0.0218 0.1355 0.6974
Echinococcus granulosus aldo keto reductase 0.0064 0.0325 0.0322
Plasmodium falciparum aldehyde reductase, putative 0.0019 0.0021 0.0147
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.006 0.0057
Giardia lamblia Aldose reductase 0.0064 0.0325 0.1559
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0174 0.0844
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0019 0.0021 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0056 0.0269 0.0267
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0067 0.0342 0.0339
Brugia malayi mbt repeat family protein 0.0048 0.0219 0.0216
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0241 0.5107
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.006 0.0057
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0208
Loa Loa (eye worm) serotonin transporter b 0.1176 0.7753 0.7752
Loa Loa (eye worm) oxidoreductase 0.0064 0.0325 0.0322
Loa Loa (eye worm) acetylcholinesterase 1 0.0035 0.0129 0.0126
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0243 0.1519 0.1517
Echinococcus multilocularis aldo keto reductase 0.0064 0.0325 0.0322
Plasmodium falciparum amino acid transporter, putative 0.02 0.123 1
Schistosoma mansoni single-minded 0.0197 0.121 0.121
Echinococcus multilocularis tyrosine kinase 0.0023 0.0053 0.0051
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.02 0.123 0.1228
Echinococcus multilocularis voltage gated potassium channel subunit 0.0019 0.0021 0.0018
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0056 0.0269 0.0267
Entamoeba histolytica aldose reductase, putative 0.0064 0.0325 0.1643
Trypanosoma brucei telomerase reverse transcriptase 0.0086 0.0471 0.9991
Echinococcus granulosus intermediate filament protein 0.0027 0.0079 0.0076
Echinococcus granulosus FTZ F1 alpha 0.0067 0.0342 0.0339
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0067 0.0342 0.0415
Echinococcus multilocularis polycomb protein EED 0.0283 0.1789 0.1787
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0013 0.0013
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0218 0.1355 0.6974
Echinococcus granulosus NCK adaptor protein 0.0017 0.0013 0.0011
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0325 0.1656
Loa Loa (eye worm) TK/INSR protein kinase 0.0484 0.313 0.3128
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0067 0.0342 0.0339
Schistosoma mansoni tyrosine kinase 0.0484 0.313 0.313
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0026 0.0024
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0129 0.06
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0029
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0012 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0067 0.0342 0.0342
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0028 0.0025
Brugia malayi SRC-1 0.0056 0.0269 0.0267
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.02 0.123 0.1228
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0055
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1176 0.7753 0.7752
Echinococcus granulosus growth factor receptor bound protein 2 0.0017 0.0013 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.016 0.0771
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0067 0.0342 0.0342
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0241 0.1204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0028 0.0028
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0174 0.0802
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0247 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.0544 0.353 0.4538
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0129 0.0565
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Echinococcus granulosus acetylcholinesterase 0.0035 0.0129 0.0126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0067 0.0342 0.0339
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0051 0.0238 0.1251
Echinococcus multilocularis epidermal growth factor receptor 0.0813 0.5328 0.5327
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0318 0.0315
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Onchocerca volvulus 0.0023 0.0053 0.0042
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0367 0.0365
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0028 0.0009
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Schistosoma mansoni aryl hydrocarbon receptor 0.0197 0.121 0.121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0067 0.0342 0.0339
Schistosoma mansoni coup transcription factor 0.0067 0.0342 0.0342
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0029 0.0027
Schistosoma mansoni zinc finger protein 0.0021 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0009 0.0183
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0027 0.0024
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0056 0.0269 0.0267
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0026 0.0024
Brugia malayi Bromodomain containing protein 0.0077 0.0414 0.0412
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.02 0.123 0.1228
Trichomonas vaginalis guanylate cyclase, putative 0.0051 0.0238 0.1188
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0086 0.0471 0.9991
Echinococcus granulosus cpg binding protein 0.0033 0.0115 0.0112
Onchocerca volvulus 0.0064 0.0325 0.0393
Schistosoma mansoni steroid hormone receptor ad4bp 0.0067 0.0342 0.0342
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0079 0.0076
Schistosoma mansoni tyrosine kinase 0.0027 0.0078 0.0078
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0029 0.0027
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Trypanosoma brucei protein kinase, putative 0.0052 0.0241 0.5107
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0176 0.0838
Echinococcus multilocularis tumor protein p63 0.0342 0.2179 0.2177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0067 0.0342 0.0342
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0056 0.0269 0.0269
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0026 0.0026
Echinococcus granulosus uncharacterized sodium dependent transporter 0.02 0.123 0.1228
Onchocerca volvulus 0.0067 0.0342 0.0415
Loa Loa (eye worm) hypothetical protein 0.0448 0.2889 0.2887
Loa Loa (eye worm) hypothetical protein 0.0042 0.0176 0.0173
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0028 0.0025
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0343 0.034
Onchocerca volvulus 0.0027 0.0079 0.0075
Brugia malayi Tyrosine-protein kinase abl-1 0.0027 0.0078 0.0075
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.02 0.123 1
Onchocerca volvulus 0.0023 0.0053 0.0042
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Plasmodium falciparum thioredoxin reductase 0.003 0.0096 0.076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0105 0.0105
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0096 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0196 0.1208 0.8903
Loa Loa (eye worm) hypothetical protein 0.0041 0.0172 0.0169
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0028 0.0025
Mycobacterium leprae Conserved hypothetical protein 0.0046 0.0201 0.135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0067 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0017 0.0013 0.0011
Brugia malayi Protein kinase domain containing protein 0.0023 0.0053 0.0051
Onchocerca volvulus 0.0064 0.0325 0.0393
Trypanosoma cruzi Macro domain containing protein, putative 0.0042 0.0176 0.3726
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0028 0.0025
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0342 0.0339
Loa Loa (eye worm) oxidoreductase 0.0064 0.0325 0.0322
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0264 0.0261
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.02 0.123 0.123
Loa Loa (eye worm) TK protein kinase 0.0038 0.0153 0.015
Brugia malayi hypothetical protein 0.002 0.0028 0.0025
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0343 0.0343
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0218 0.1355 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0096 0.2033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0067 0.0342 0.0339
Onchocerca volvulus 0.0064 0.0325 0.0393
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0009 0.0183
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0067 0.0342 0.0339
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0067 0.0342 0.0339
Brugia malayi chromobox protein homolog 3 0.0039 0.016 0.0158
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0181 0.0178
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0174 0.0844
Loa Loa (eye worm) hypothetical protein 0.0031 0.0107 0.0104
Schistosoma mansoni pol-related 0.0064 0.0325 0.0325
Onchocerca volvulus 0.0029 0.0091 0.0091
Echinococcus granulosus carboxylesterase 5A 0.0035 0.0129 0.0126
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0096 0.076
Onchocerca volvulus 0.0031 0.0103 0.0107
Echinococcus multilocularis expressed protein 0.0377 0.2418 0.2416
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0325 0.1656
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0176 0.141
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0343 0.7264
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0318 0.0318
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0028 0.0025
Brugia malayi Thioredoxin reductase 0.0086 0.0472 0.0469
Echinococcus granulosus insulin receptor 0.0484 0.313 0.3128
Mycobacterium tuberculosis Probable reductase 0.0196 0.1208 0.6209
Loa Loa (eye worm) carboxylesterase 0.0035 0.0129 0.0126
Echinococcus multilocularis serotonin transporter 0.1176 0.7753 0.7752
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0219 0.0216
Mycobacterium ulcerans lipoprotein LppD 0.0042 0.0176 0.0811
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0051 0.0238 0.1188
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Brugia malayi nuclear hormone receptor 0.002 0.0028 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0067 0.0342 0.0339
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0315 0.2 0.256
Entamoeba histolytica hypothetical protein 0.0019 0.0026 0.003
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0028 0.0025
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0241 0.0238
Echinococcus multilocularis geminin 0.0171 0.1041 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0342 0.0339
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0064 0.0325 0.2279
Onchocerca volvulus 0.002 0.0028 0.0009
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0155 0.0152
Brugia malayi hypothetical protein 0.0659 0.4301 0.43
Onchocerca volvulus 0.0023 0.0053 0.0042
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0086 0.0471 0.9991
Loa Loa (eye worm) carboxylesterase 0.0035 0.0129 0.0126
Leishmania major telomerase reverse transcriptase, putative 0.0086 0.0471 0.9991
Plasmodium falciparum aldo-keto reductase, putative 0.0019 0.0021 0.0147
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0043 0.004
Brugia malayi Protein kinase domain containing protein 0.0023 0.0053 0.0051
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.02 0.123 0.1228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0203
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0003 0.0055
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0028 0.0025
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0264 0.0261
Echinococcus granulosus epidermal growth factor receptor 0.0813 0.5328 0.5327
Toxoplasma gondii thioredoxin reductase 0.0086 0.0472 0.3821
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0325 0.0322
Echinococcus multilocularis cpg binding protein 0.0033 0.0115 0.0112
Echinococcus granulosus dnaJ subfamily B 0.0414 0.266 0.2658
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0343 0.174
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0206 0.0206
Echinococcus granulosus MACRO domain containing protein 2 0.0042 0.0176 0.0173
Onchocerca volvulus 0.02 0.123 0.1564
Echinococcus multilocularis acetylcholinesterase 0.0035 0.0129 0.0126
Schistosoma mansoni bromodomain containing protein 0.0066 0.0335 0.0335
Loa Loa (eye worm) hypothetical protein 0.0229 0.143 0.1427
Echinococcus granulosus aryl hydrocarbon receptor 0.0051 0.0238 0.0235
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0091 0.0088
Onchocerca volvulus 0.005 0.0231 0.0272
Brugia malayi PXA domain containing protein 0.0019 0.0026 0.0024
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0129 0.0129
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0028 0.0025
Toxoplasma gondii RNA-directed DNA polymerase 0.0086 0.0471 0.3817
Echinococcus multilocularis sodium and chloride dependent glycine 0.02 0.123 0.1228
Trichomonas vaginalis set domain proteins, putative 0.0245 0.153 0.8161
Onchocerca volvulus 0.0035 0.0129 0.014
Brugia malayi jmjC domain containing protein 0.0063 0.0318 0.0315
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0203
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0012 0.0009
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0028 0.0028
Loa Loa (eye worm) WD domain-containing protein 0.0283 0.1789 0.1787
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0028 0.0025
Trichomonas vaginalis adenylate cyclase, putative 0.0051 0.0238 0.1188
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0067 0.0342 0.0339
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0059 0.0291 0.6169
Schistosoma mansoni aldo-keto reductase 0.0064 0.0325 0.0325
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0013 0.0011
Mycobacterium ulcerans oxidoreductase 0.0064 0.0325 0.159
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Brugia malayi Bromodomain containing protein 0.0039 0.0155 0.0153
Echinococcus multilocularis acetylcholinesterase 0.0035 0.0129 0.0126
Loa Loa (eye worm) hypothetical protein 0.02 0.123 0.1228
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0219 0.0219
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0067 0.0342 0.0339
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0174 0.0172
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0241 0.5109
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0067 0.0342 0.0339
Brugia malayi hypothetical protein 0.0229 0.143 0.1427
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Brugia malayi Protein kinase domain containing protein 0.0484 0.313 0.3128
Echinococcus multilocularis aldo keto reductase 0.0064 0.0325 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0083 0.0355
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0283 0.1787 0.1785
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0342 0.0339
Schistosoma mansoni zinc finger protein 0.002 0.0028 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0105 0.0103
Echinococcus multilocularis tyrosine protein kinase Abl 0.0027 0.0078 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Trichomonas vaginalis chromobox protein, putative 0.007 0.0367 0.1887
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0243 0.1519 0.1517
Trypanosoma brucei prostaglandin f synthase 0.0064 0.0325 0.6884
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0139 0.0137
Schistosoma mansoni thyroid hormone receptor 0.0067 0.0342 0.0342
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Echinococcus multilocularis Protein lozenge 0.0056 0.0272 0.0269
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0026 0.0024
Brugia malayi PAS domain containing protein 0.0197 0.121 0.1207
Schistosoma mansoni nuclear receptor 0.002 0.0028 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0174 0.3691
Echinococcus granulosus polycomb protein EED 0.0283 0.1789 0.1787
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.013 0.2746
Brugia malayi nuclear receptor RXR 0.002 0.0028 0.0025
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0325 0.1656
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0206 0.0203
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0472 0.2358
Schistosoma mansoni hypothetical protein 0.0293 0.1856 0.1856
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0208
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0307 0.6506
Loa Loa (eye worm) TK/ABL protein kinase 0.0023 0.0053 0.0051
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0181 0.0207
Schistosoma mansoni chromobox protein 0.007 0.0367 0.0367
Schistosoma mansoni tyrosine kinase 0.0803 0.5264 0.5264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0101
Onchocerca volvulus 0.0035 0.0129 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Brugia malayi Protein kinase domain containing protein 0.0023 0.0053 0.0051
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0105 0.011
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0026 0.0024
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.02 0.123 0.123
Echinococcus multilocularis insulin receptor 0.0484 0.313 0.3128
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0241 0.5107
Trichomonas vaginalis chromobox protein, putative 0.007 0.0367 0.1887
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0019 0.0021 0.0147
Trypanosoma brucei Macro domain containing protein, putative 0.0042 0.0176 0.3726
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0343 0.7264
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0026 0.0024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0218 0.1355 0.6974
Brugia malayi protein-tyrosine kinase 0.0052 0.0245 0.0243
Schistosoma mansoni sodium/chloride dependent transporter 0.1176 0.7753 0.7753
Brugia malayi Sodium:neurotransmitter symporter family protein 0.02 0.123 0.1228
Echinococcus multilocularis carboxylesterase 5A 0.0035 0.0129 0.0126
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0129 0.0126
Leishmania major aldo-keto reductase-like protein 0.0064 0.0325 0.6884
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0238 0.5043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0067 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.0052 0.0247 0.0244
Loa Loa (eye worm) runx1 0.0056 0.0272 0.0269
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0026 0.0046
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0026 0.0024
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0243 0.1519 0.1517
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0027 0.0024
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0028 0.0025
Schistosoma mansoni chromobox protein 0.007 0.0367 0.0367
Onchocerca volvulus 0.1176 0.7753 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0264 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0067 0.0342 0.0339
Onchocerca volvulus 0.0035 0.0129 0.014
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0023 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Onchocerca volvulus 0.02 0.123 0.1564
Onchocerca volvulus 0.0448 0.2889 0.371
Brugia malayi Steroid receptor seven-up type 2 0.0067 0.0342 0.0339
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0196 0.1208 0.6209
Onchocerca volvulus 0.0035 0.0129 0.014
Echinococcus multilocularis chromobox protein 1 0.007 0.0367 0.0365
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.02 0.123 0.123
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0096 0.076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0067 0.0342 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0067 0.0342 0.0339
Giardia lamblia Telomerase catalytic subunit 0.0086 0.0471 0.2359
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0091 0.0088
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0096 0.076
Echinococcus multilocularis ecdysone induced protein 78C 0.0067 0.0342 0.0339
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0176 0.0838
Echinococcus granulosus hypothetical protein 0.0064 0.0325 0.0322
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0026 0.0024
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0027 0.0078 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.0067 0.0342 0.0342
Schistosoma mansoni sodium/chloride dependent transporter 0.02 0.123 0.123
Schistosoma mansoni tyrosine kinase 0.1512 1 1
Plasmodium falciparum glutathione reductase 0.0086 0.0472 0.3821
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0064 0.0325 0.6884
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0181 0.0178
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0067 0.0342 0.0339
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0294 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0067 0.0342 0.0339
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0027 0.0078 0.0075
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.02 0.123 0.123
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0129 0.06
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.123 0.123
Loa Loa (eye worm) MBCTL1 0.0055 0.0264 0.0261
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0241 0.1204
Echinococcus granulosus tyrosine protein kinase shark 0.0023 0.0053 0.0051
Echinococcus granulosus microtubule associated protein 2 0.0698 0.4559 0.4557
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0028 0.0025
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0325 0.1656
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0132 0.0132
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Brugia malayi tailless protein 0.002 0.0028 0.0025
Schistosoma mansoni RAR-like nuclear receptor 0.0067 0.0342 0.0342
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0026 0.0024
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0241 0.5107
Schistosoma mansoni adapter molecule crk 0.0017 0.0013 0.0013
Brugia malayi Variant SH3 domain containing protein 0.0017 0.0013 0.0011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.02 0.123 0.123
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0174 0.0802
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0325 0.1656
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0307 0.0307
Brugia malayi Sodium:neurotransmitter symporter family protein 0.02 0.123 0.1228
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0129 0.0129
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0703 0.0701
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0311 0.0309
Schistosoma mansoni tyrosine kinase 0.0803 0.5264 0.5264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0067 0.0342 0.0339
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0051 0.0238 0.5043
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0241 0.0238
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0067 0.0342 0.0342
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0026 0.0024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0861 0.4394
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0247 0.0244
Brugia malayi hypoxia-induced factor 1 0.0608 0.396 0.3959
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.02 0.123 0.1228
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0206 0.0203
Brugia malayi CXXC zinc finger family protein 0.0029 0.0091 0.0088
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0208
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0703 0.0701
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0343 0.7264
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0307 0.1496
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0012 0.0012
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0026 0.0024
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0051 0.0238 0.1188
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0026 0.0024
Onchocerca volvulus 0.0145 0.0868 0.1096
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0051 0.0238 0.1188
Echinococcus granulosus lamin dm0 0.0027 0.0079 0.0076
Loa Loa (eye worm) TK/EGFR protein kinase 0.1512 1 1
Mycobacterium ulcerans putative regulatory protein 0.0145 0.0868 0.4432
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0051 0.0238 0.0235
Toxoplasma gondii aldose reductase, putative 0.0064 0.0325 0.2623
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0294 0.0291
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0155 0.0152
Brugia malayi Telomerase reverse transcriptase 0.0229 0.1426 0.1423
Brugia malayi conserved hypotetical protein 0.002 0.0028 0.0025
Echinococcus multilocularis MACRO domain containing protein 2 0.0042 0.0176 0.0173
Echinococcus granulosus aldehyde reductase 0.0046 0.0201 0.0198
Echinococcus granulosus tyrosine protein kinase Src64B 0.0056 0.0269 0.0267
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0039 0.0096
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0028 0.0028
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.02 0.123 1
Brugia malayi hypothetical protein 0.0031 0.0105 0.0103
Onchocerca volvulus 0.002 0.0028 0.0009
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0019 0.0021 0.0018
Schistosoma mansoni embryonic ectoderm development protein 0.0283 0.1789 0.1789
Echinococcus granulosus voltage gated potassium channel subunit 0.0019 0.0021 0.0018
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.1871 0.2318
Schistosoma mansoni enhancer of zeste ezh 0.0283 0.1787 0.1787
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0067 0.0342 0.0339
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0264 0.0261
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0096 0.076
Onchocerca volvulus 0.0229 0.143 0.1822
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0027 0.0078 0.0078
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0026 0.0024
Onchocerca volvulus 0.0027 0.0079 0.0075
Echinococcus granulosus neuroligin 0.0035 0.0129 0.0126
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0096 0.0394
Leishmania major protein kinase, putative 0.0052 0.0241 0.5109
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0196 0.1208 0.6209
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0132 0.0129
Brugia malayi WD domain containing protein 0.0283 0.1789 0.1787
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0196 0.1208 0.6209
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0026 0.0026
Schistosoma mansoni cpg binding protein 0.0033 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0051
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0052 0.0245 0.0243
Treponema pallidum sodium- and chloride- dependent transporter 0.1176 0.7753 1
Schistosoma mansoni hypothetical protein 0.0021 0.0036 0.0036
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.1208 0.6209
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0813 0.5328 0.5327
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0051 0.0238 0.1188
Trichomonas vaginalis guanylate cyclase, putative 0.0051 0.0238 0.1188
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.006 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0472 0.3821
Brugia malayi intermediate filament protein 0.0027 0.0079 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Loa Loa (eye worm) hypothetical protein 0.1176 0.7753 0.7752
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0448 0.2889 0.2887
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0096 0.0394
Loa Loa (eye worm) solute carrier family 6 member 4 0.1176 0.7753 0.7752
Plasmodium falciparum telomerase reverse transcriptase 0.0086 0.0471 0.3817
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0026 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Plasmodium vivax hypothetical protein, conserved 0.02 0.123 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0219 0.0216
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0241 0.5107
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0283 0.1787 0.1785
Loa Loa (eye worm) steroid hormone receptor 0.0067 0.0342 0.0339
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0219 0.0216
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.266 0.2658
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0132 0.1052
Brugia malayi bHLH-PAS transcription factor 0.0145 0.0868 0.0866
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0009 0.0183
Echinococcus granulosus MACRO domain containing protein 2 0.0042 0.0176 0.0173
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0067 0.0342 0.0342
Brugia malayi hypothetical protein 0.002 0.0028 0.0025
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.016 0.0771
Toxoplasma gondii hypothetical protein 0.02 0.123 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1336 0.1334
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Brugia malayi Heterochromatin protein 1 0.007 0.0367 0.0365
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0056 0.0269 0.0267
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0343 0.7264
Loa Loa (eye worm) hypothetical protein 0.0035 0.0129 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0243 0.1519 0.1519
Echinococcus granulosus sodium and chloride dependent glycine 0.02 0.123 0.1228
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0107 0.2261
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0029 0.0027
Plasmodium falciparum thioredoxin reductase 0.0086 0.0472 0.3821
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0052 0.0241 0.5109
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0028 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0472 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0343 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0264 0.0264
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0096 0.0093
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0067 0.0342 0.0339
Echinococcus multilocularis lamin 0.0027 0.0079 0.0076
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0318 0.0315
Brugia malayi hypothetical protein 0.0023 0.0053 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0026 0.0026
Echinococcus multilocularis zinc finger protein 0.0021 0.004 0.0037
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0064 0.0325 0.6884
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Brugia malayi SET domain containing protein 0.0018 0.0014 0.0012
Echinococcus multilocularis aldehyde reductase 0.0046 0.0201 0.0198
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1176 0.7753 0.7753
Schistosoma mansoni lozenge 0.0056 0.0272 0.0272
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0079 0.0076
Echinococcus multilocularis tyrosine protein kinase shark 0.0023 0.0053 0.0051
Brugia malayi SH2 domain containing protein 0.0023 0.0053 0.0051
Brugia malayi glutathione reductase 0.0086 0.0472 0.0469
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.02 0.123 1
Echinococcus granulosus caspase 2 0.0031 0.0105 0.0103
Echinococcus granulosus acetylcholinesterase 0.0035 0.0129 0.0126
Schistosoma mansoni tyrosine kinase 0.0813 0.5328 0.5328
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.021 0.0208
Entamoeba histolytica hypothetical protein 0.0019 0.0026 0.003
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Loa Loa (eye worm) SRC-1 0.0056 0.0269 0.0267
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0026 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0096 0.2033
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0028 0.0025
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.021 0.0208
Brugia malayi Sex muscle abnormal protein 5 0.0017 0.0013 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0096 0.076
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0307 0.1496
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0174 0.3691
Brugia malayi nuclear receptor NHR-67 0.002 0.0028 0.0025
Schistosoma mansoni tyrosine kinase 0.0027 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0045 0.0196 0.0193
Schistosoma mansoni hypothetical protein 0.0042 0.0176 0.0176
Echinococcus granulosus zinc finger protein 0.0021 0.004 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0023 0.0053 0.0051
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Echinococcus multilocularis FTZ F1 alpha 0.0067 0.0342 0.0339
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0023 0.0053 0.0051
Echinococcus granulosus tyrosine protein kinase Srms 0.0023 0.0053 0.0051
Echinococcus granulosus tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0294 0.0291
Brugia malayi hypothetical protein 0.0035 0.0129 0.0126
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0096 0.2033
Brugia malayi hypothetical protein 0.0047 0.021 0.0208
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Entamoeba histolytica aldose reductase, putative 0.0064 0.0325 0.1643
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.1871 1
Echinococcus multilocularis 0.0468 0.3022 0.302
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0039 0.0827
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0043 0.004
Loa Loa (eye worm) SET domain-containing protein 0.0283 0.1787 0.1785
Loa Loa (eye worm) oxidoreductase 0.0064 0.0325 0.0322
Schistosoma mansoni acetylcholinesterase 0.0035 0.0129 0.0129
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0325 0.1656
Loa Loa (eye worm) hypothetical protein 0.1176 0.7753 0.7752
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0056 0.0269 0.0267
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0269 0.0267
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.021 0.0208
Leishmania major prostaglandin f synthase, putative 0.0064 0.0325 0.6884
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.0241 0.5109
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0307 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Brugia malayi hypothetical protein 0.0047 0.021 0.0208
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0019 0.0021 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0241 0.0241
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0243 0.1519 0.1517
Echinococcus multilocularis chromobox protein 1 0.007 0.0367 0.0365
Echinococcus multilocularis epidermal growth factor receptor 0.1512 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0325 0.1656
Trypanosoma cruzi aldo/keto reductase, putative 0.0019 0.0021 0.0437
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0317 0.2559
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0073
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0096 0.0394
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0181 0.0879
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0028 0.0025
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.02 0.123 0.1228
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0325 0.0322
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0051 0.0238 0.0235
Schistosoma mansoni aldo-keto reductase 0.0064 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0544 0.353 0.3528
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0325 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Echinococcus multilocularis thyroid hormone receptor alpha 0.0067 0.0342 0.0339
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0028 0.0025
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0484 0.313 0.3128
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.0475 0.0473
Schistosoma mansoni nuclear hormone receptor 0.002 0.0028 0.0028
Echinococcus multilocularis musashi 0.0027 0.0079 0.0076
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0052 0.0245 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0238 0.1188
Loa Loa (eye worm) hypothetical protein 0.0039 0.016 0.0158
Echinococcus granulosus tyrosine kinase 0.0023 0.0053 0.0051
Echinococcus granulosus aldo keto reductase 0.0064 0.0325 0.0322
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0472 0.0469
Schistosoma mansoni cpg binding protein 0.0029 0.0091 0.0091
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.02 0.123 0.1228
Echinococcus granulosus sodium and chloride dependent glycine 0.02 0.123 0.1228
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0219 0.0256
Schistosoma mansoni nuclear hormone receptor 0.002 0.0028 0.0028
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0129 0.0129
Brugia malayi NADH-dependent xylose reductase 0.0019 0.0021 0.0018
Echinococcus granulosus chromobox protein 1 0.007 0.0367 0.0365
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0042 0.0176 0.0853
Brugia malayi hypothetical protein 0.0019 0.0026 0.0024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0206 0.0203
Mycobacterium tuberculosis Carboxylesterase LipT 0.0305 0.1933 1
Giardia lamblia Aldose reductase 0.0064 0.0325 0.1559
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0067 0.0342 0.0339
Echinococcus granulosus lamin 0.0027 0.0079 0.0076
Echinococcus multilocularis tyrosine protein kinase Srms 0.0052 0.0245 0.0243
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0219 0.0219
Trypanosoma cruzi aldo-keto reductase 0.0064 0.0325 0.6884
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0243 0.1519 0.1517
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.1871 1
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0219 0.0216
Toxoplasma gondii aldo-keto reductase 0.0019 0.0021 0.0147
Echinococcus granulosus aldo keto reductase 0.0064 0.0325 0.0322
Schistosoma mansoni growth factor receptor-bound protein 0.0017 0.0013 0.0013
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0241 0.1102
Echinococcus granulosus apoptotic protease activating factor 1 0.0031 0.0105 0.0103
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0325 0.0322
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0024
Brugia malayi Carboxylesterase family protein 0.0035 0.0129 0.0126
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0096 0.0394
Echinococcus granulosus geminin 0.0171 0.1041 0.1039
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0005 0.0003
Loa Loa (eye worm) norepinephrine transporter 0.1176 0.7753 0.7752
Loa Loa (eye worm) hypothetical protein 0.0059 0.0291 0.0288
Trichomonas vaginalis ganglioside induced differentiation associated protein, putative 0.0042 0.0176 0.0853
Trichomonas vaginalis aldo-keto reductase, putative 0.0019 0.0021 0.0016
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0484 0.313 0.3128
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0067 0.0342 0.0339
Trypanosoma brucei aldo/keto reductase, putative 0.0019 0.0021 0.0437
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0026 0.0026
Echinococcus granulosus tyrosine protein kinase HCK 0.0038 0.0153 0.015
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0196 0.1208 0.6209
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.1871 1
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0129 0.0126
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0231 0.0231
Onchocerca volvulus 0.0023 0.0053 0.0042
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0017 0.0013 0.0011
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0056 0.0269 0.0267
Giardia lamblia Protein LRP16 0.0042 0.0176 0.0746
Brugia malayi hypothetical protein 0.02 0.123 0.1228
Schistosoma mansoni nuclear receptor 0.002 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0064 0.0325 0.0322
Echinococcus multilocularis growth factor receptor bound protein 2 0.0017 0.0013 0.0011
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0264 0.0261
Brugia malayi ecdysone receptor 0.002 0.0028 0.0025
Echinococcus granulosus serotonin transporter 0.1176 0.7753 0.7752
Echinococcus granulosus polycomb protein suz12 A 0.0971 0.6381 0.638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0206 0.0203
Loa Loa (eye worm) hypothetical protein 0.0072 0.0374 0.0372
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0026 0.0024
Echinococcus granulosus tyrosine kinase 0.0052 0.0245 0.0243
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.02 0.123 0.1228
Loa Loa (eye worm) carboxylesterase 0.0035 0.0129 0.0126
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0012 0.0009
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0096 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0026 0.0046
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0174 0.3691
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0021 0.0016
Brugia malayi nuclear hormone receptor 0.0067 0.0342 0.0339
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0067 0.0342 0.0339
Onchocerca volvulus 0.0031 0.0105 0.011
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322
Echinococcus granulosus dna polymerase kappa 0.0042 0.0174 0.0172
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.021 0.021
Onchocerca volvulus 0.0064 0.0325 0.0393
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0067 0.0342 0.0342
Echinococcus multilocularis neuroligin 0.0035 0.0129 0.0126
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0023 0.0053 0.0177
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0025
Onchocerca volvulus 0.0035 0.0129 0.014
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0028 0.0025
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0343 0.034
Onchocerca volvulus 0.0245 0.153 0.1952
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0294 0.0294
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0129 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0096 0.2033
Echinococcus multilocularis aldo keto reductase 0.0064 0.0325 0.0322
Echinococcus multilocularis caspase 2 0.0031 0.0105 0.0103
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0096 0.2033
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0325 0.0322

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 63 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152
IC50 (functional) = 63 uM Growth inhibition of Candida albicans JRW#5 ChEMBL. 17079152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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