Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0085 | 0.271 | 1 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0085 | 0.271 | 1 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0085 | 0.271 | 0.2164 |
Mycobacterium tuberculosis | Beta lactamase like protein | 0.0085 | 0.271 | 0.4417 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.4542 | 1 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0085 | 0.271 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0127 | 0.4519 | 0.4519 |
Mycobacterium tuberculosis | Conserved protein | 0.0085 | 0.271 | 0.4417 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.271 | 0.2187 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0085 | 0.271 | 0.4417 |
Mycobacterium ulcerans | hydrolase | 0.0085 | 0.271 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1191 | 0.0492 |
Echinococcus granulosus | zinc phosphodiesterase | 0.0085 | 0.271 | 0.2164 |
Mycobacterium ulcerans | hydrolase | 0.0085 | 0.271 | 1 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0085 | 0.271 | 1 |
Plasmodium vivax | unspecified product | 0.0085 | 0.271 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0052 | 0.1323 | 0.0639 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6782 | 0.6729 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.005 | 0.1261 | 0.0564 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 0.271 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.005 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.271 | 0.271 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.3998 | 0.8342 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0133 | 0.4748 | 0.4461 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0085 | 0.271 | 0.2164 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0115 | 0.3998 | 0.7031 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.271 | 0.271 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.025 | 0.9714 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1191 | 0.1191 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1191 | 0.0492 |
Brugia malayi | hypothetical protein | 0.0252 | 0.981 | 0.981 |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 0.271 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.271 | 0.271 |
Mycobacterium ulcerans | putative regulatory protein | 0.0038 | 0.0751 | 0.2772 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0466 | 0.0466 |
Onchocerca volvulus | 0.0085 | 0.271 | 0.2118 | |
Treponema pallidum | ribonuclease Z | 0.0085 | 0.271 | 0.5 |
Entamoeba histolytica | metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.005 | 0.1261 | 0.4652 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0085 | 0.271 | 0.4417 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0085 | 0.271 | 0.271 |
Leishmania major | hypothetical protein, conserved | 0.0085 | 0.271 | 1 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0065 | 0.1894 | 0.1894 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.3998 | 0.8342 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1191 | 0.0487 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.9714 | 0.9714 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0085 | 0.271 | 0.2187 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.6499 | 0.6499 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.3998 | 0.8342 |
Loa Loa (eye worm) | thioredoxin reductase | 0.005 | 0.1261 | 0.1261 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1304 | 0.0618 |
Mycobacterium ulcerans | hydrolase | 0.0085 | 0.271 | 1 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0085 | 0.271 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0085 | 0.271 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0085 | 0.271 | 0.4417 |
Brugia malayi | hypoxia-induced factor 1 | 0.016 | 0.5928 | 0.5928 |
Echinococcus multilocularis | ETHE1 protein | 0.0085 | 0.271 | 0.2164 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0085 | 0.271 | 0.4417 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.4542 | 1 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.0085 | 0.271 | 1 |
Trypanosoma cruzi | glyoxalase II | 0.0085 | 0.271 | 1 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.025 | 0.9714 | 0.9894 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 0.5 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0067 | 0.1978 | 0.1978 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0127 | 0.4519 | 0.4519 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0085 | 0.271 | 0.2187 |
Mycobacterium ulcerans | hypothetical protein | 0.0085 | 0.271 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.4542 | 1 |
Brugia malayi | bHLH-PAS transcription factor | 0.0038 | 0.0751 | 0.0751 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0085 | 0.271 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.005 | 0.1261 | 0.4652 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0252 | 0.981 | 1 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0085 | 0.271 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.271 | 0.2187 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0089 | 0.2907 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0085 | 0.271 | 1 |
Schistosoma mansoni | single-minded | 0.0052 | 0.1323 | 0.0639 |
Trypanosoma brucei | cleavage and polyadenylation specificity factor subunit, putative | 0.0085 | 0.271 | 1 |
Leishmania major | trypanothione reductase | 0.005 | 0.1261 | 0.4652 |
Trypanosoma cruzi | glyoxalase II | 0.0085 | 0.271 | 1 |
Leishmania major | cleavage and polyadenylation specificity factor, putative | 0.0085 | 0.271 | 1 |
Chlamydia trachomatis | ribonuclease Z | 0.0085 | 0.271 | 0.5 |
Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.0085 | 0.271 | 1 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 0.5 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0085 | 0.271 | 0.2187 |
Echinococcus granulosus | geminin | 0.0181 | 0.6782 | 0.6657 |
Onchocerca volvulus | Putative hydrolase PNKD | 0.0085 | 0.271 | 0.2118 |
Entamoeba histolytica | metallo-beta-lactamase family protein | 0.0085 | 0.271 | 1 |
Brugia malayi | hypothetical protein | 0.0085 | 0.271 | 0.271 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0252 | 0.981 | 1 |
Trypanosoma cruzi | glyoxalase II | 0.0085 | 0.271 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1191 | 0.0487 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.3998 | 0.8342 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.3998 | 0.8342 |
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 0.2164 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1304 | 0.1304 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0085 | 0.271 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1191 | 0.0492 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0085 | 0.271 | 0.271 |
Mycobacterium ulcerans | hypothetical protein | 0.0085 | 0.271 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0085 | 0.271 | 1 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0085 | 0.271 | 1 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 0.271 |
Echinococcus multilocularis | zinc phosphodiesterase | 0.0085 | 0.271 | 0.2164 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0038 | 0.0751 | 0.0001 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.016 | 0.5928 | 0.5928 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1191 | 0.1191 |
Brugia malayi | PAS domain containing protein | 0.0052 | 0.1323 | 0.1323 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0085 | 0.271 | 1 |
Brugia malayi | hypothetical protein | 0.0174 | 0.6499 | 0.6499 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.025 | 0.9714 | 0.9894 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0085 | 0.271 | 0.4417 |
Entamoeba histolytica | alkyl sulfatase, putative | 0.0085 | 0.271 | 1 |
Echinococcus granulosus | ETHE1 protein | 0.0085 | 0.271 | 0.2164 |
Brugia malayi | hypothetical protein | 0.0038 | 0.075 | 0.075 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.3998 | 0.8342 |
Brugia malayi | ethe1-prov protein | 0.0085 | 0.271 | 0.271 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0085 | 0.271 | 0.2118 |
Leishmania major | metallo-beta-lactamase family-like protein | 0.0085 | 0.271 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0127 | 0.4519 | 0.4519 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.4542 | 1 |
Echinococcus multilocularis | geminin | 0.0181 | 0.6782 | 0.6657 |
Trypanosoma brucei | metallo-beta-lactamase-like protein, putative | 0.0085 | 0.271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.271 | 0.271 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1191 | 0.0487 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0085 | 0.271 | 0.2164 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1191 | 0.0487 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0466 | 0.0466 |
Leishmania major | metallo-beta-lactamase family protein-like protein | 0.0085 | 0.271 | 1 |
Brugia malayi | Thioredoxin reductase | 0.005 | 0.1261 | 0.1261 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0085 | 0.271 | 0.4417 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.4748 | 0.4748 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1304 | 0.0618 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0133 | 0.4748 | 0.4748 |
Brugia malayi | glutathione reductase | 0.005 | 0.1261 | 0.1261 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0085 | 0.271 | 1 |
Onchocerca volvulus | 0.0085 | 0.271 | 0.2118 | |
Onchocerca volvulus | 0.0256 | 1 | 1 | |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0085 | 0.271 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0085 | 0.271 | 0.4417 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0085 | 0.271 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.981 | 0.981 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.1304 | 0.0597 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.0085 | 0.271 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0256 | 1 | 1 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0085 | 0.271 | 1 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0085 | 0.271 | 0.271 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0133 | 0.4748 | 0.4461 |
Trypanosoma brucei | glyoxalase II | 0.0085 | 0.271 | 1 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.0085 | 0.271 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.005 | 0.1261 | 0.0564 |
Schistosoma mansoni | hypothetical protein | 0.0085 | 0.271 | 0.2187 |
Echinococcus granulosus | single minded 2 | 0.0038 | 0.0751 | 0.0001 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0085 | 0.271 | 0.2164 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0085 | 0.271 | 1 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0085 | 0.271 | 0.2164 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.6782 | 0.6729 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.025 | 0.9714 | 0.9714 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0085 | 0.271 | 1 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0089 | 0.2907 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.