Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.041 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.041 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.041 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0164 | 0.2785 | 0.2785 |
Onchocerca volvulus | Hexokinase homolog | 0.0119 | 0.1455 | 0.4126 |
Loa Loa (eye worm) | hypothetical protein | 0.041 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Loa Loa (eye worm) | hexokinase | 0.0119 | 0.1455 | 0.1455 |
Loa Loa (eye worm) | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Echinococcus granulosus | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Echinococcus multilocularis | carboxylesterase 5A | 0.041 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.041 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0164 | 0.2785 | 0.2785 |
Schistosoma mansoni | choline o-acyltransferase | 0.0164 | 0.2785 | 0.2785 |
Echinococcus granulosus | carboxylesterase 5A | 0.041 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Onchocerca volvulus | 0.0119 | 0.1455 | 0.4126 | |
Brugia malayi | Choline O-acetyltransferase | 0.0164 | 0.2785 | 0.2785 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0069 | 0 | 0.5 |
Leishmania major | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Onchocerca volvulus | 0.0189 | 0.3527 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.041 | 1 | 1 |
Onchocerca volvulus | 0.0189 | 0.3527 | 1 | |
Echinococcus multilocularis | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Treponema pallidum | hexokinase (hxk) | 0.0189 | 0.3527 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.041 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.0189 | 0.3527 | 0.3527 |
Onchocerca volvulus | 0.0189 | 0.3527 | 1 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.0164 | 0.2785 | 0.2785 |
Echinococcus granulosus | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Plasmodium vivax | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Trypanosoma brucei | hexokinase | 0.0189 | 0.3527 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0069 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0069 | 0 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Brugia malayi | Hexokinase family protein | 0.0119 | 0.1455 | 0.1455 |
Entamoeba histolytica | hexokinase 1 | 0.0189 | 0.3527 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0069 | 0 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.0189 | 0.3527 | 1 |
Echinococcus multilocularis | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Toxoplasma gondii | hexokinase | 0.0189 | 0.3527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.2785 | 0.2785 |
Entamoeba histolytica | hexokinase 2 | 0.0189 | 0.3527 | 0.5 |
Echinococcus multilocularis | hexokinase type 2 | 0.0189 | 0.3527 | 0.3527 |
Loa Loa (eye worm) | hexokinase type II | 0.0189 | 0.3527 | 0.3527 |
Echinococcus granulosus | choline O acetyltransferase | 0.0164 | 0.2785 | 0.2785 |
Trypanosoma brucei | hexokinase | 0.0189 | 0.3527 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1759 | 0.1759 |
Brugia malayi | Hexokinase family protein | 0.0189 | 0.3527 | 0.3527 |
Brugia malayi | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Echinococcus multilocularis | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Plasmodium falciparum | hexokinase | 0.0189 | 0.3527 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0189 | 0.3527 | 0.3527 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LC50 (ADMET) | = 0.031 uM | Cytotoxicity against rat K-ras transformed NRK K/1 cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 0.06 uM | Cytotoxicity against rat N-ras transformed NRK N/4.2 cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 0.1 uM | Cytotoxicity against rat NRK 52E cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 0.11 uM | Cytotoxicity against rat H-ras transformed NRK H/1.2 cells after 5 days | ChEMBL. | 17035024 |
LC50 (ADMET) | = 0.25 uM | Cytotoxicity against mouse 3LL cells after 5 days | ChEMBL. | 17035024 |
MTD (ADMET) | = 400 mg kg-1 | Toxicity in mouse | ChEMBL. | 17035024 |
Ratio (ADMET) | = 0.4 | Differential index, LC50 for rat NRK 52E cells to LC50 for mouse 3LL cells | ChEMBL. | 17035024 |
Ratio (ADMET) | = 0.9 | Differential index, LC50 for rat NRK 52E cells to LC50 for rat H-ras transformed NRK H/1.2 cells | ChEMBL. | 17035024 |
Ratio (ADMET) | = 1.6 | Differential index, LC50 for rat NRK 52E cells to LC50 for rat N-ras transformed NRK N/4.2 cells | ChEMBL. | 17035024 |
Ratio (ADMET) | = 3.2 | Differential index, LC50 for rat NRK 52E cells to LC50 for rat K-ras transformed NRK K/1 cells | ChEMBL. | 17035024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.