Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thromboxane A2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0017 | 0.026 | 0.0327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.026 | 0.5 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0017 | 0.026 | 0.0327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0017 | 0.026 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.6697 | 0.8417 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0017 | 0.026 | 0.0327 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.7957 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0031 | 0.1782 | 0.1782 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0109 | 1 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0017 | 0.026 | 0.026 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0078 | 0.6697 | 0.6697 |
Brugia malayi | Protein kinase c protein 2 | 0.0093 | 0.8257 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0017 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.026 | 0.026 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0097 | 0.874 | 0.874 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0017 | 0.026 | 0.0327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0081 | 0.6997 | 0.8794 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.026 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0031 | 0.1782 | 0.1903 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0031 | 0.1782 | 0.1782 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.026 | 0.0327 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0017 | 0.026 | 0.026 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0017 | 0.026 | 0.026 |
Echinococcus granulosus | protein kinase c iota type | 0.0029 | 0.152 | 0.152 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0097 | 0.874 | 0.874 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0017 | 0.026 | 0.5 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0078 | 0.6697 | 0.6697 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0017 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0017 | 0.026 | 0.0327 |
Schistosoma mansoni | atypical protein kinase C | 0.0029 | 0.152 | 0.152 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0017 | 0.026 | 0.0327 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.0017 | 0.026 | 0.026 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0017 | 0.026 | 0.026 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0017 | 0.026 | 0.026 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0017 | 0.026 | 0.026 |
Toxoplasma gondii | AGC kinase | 0.0017 | 0.026 | 0.5 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0017 | 0.026 | 0.026 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0017 | 0.026 | 0.026 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0031 | 0.1782 | 0.2239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0031 | 0.1782 | 0.1782 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0017 | 0.026 | 0.026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0017 | 0.026 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0078 | 0.6697 | 0.6697 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 1 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0029 | 0.152 | 0.152 |
Trichomonas vaginalis | AGC family protein kinase | 0.0017 | 0.026 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 12 nM | Inhibitory activity against platelet aggregation, induced by arachidonic acid in human platelet rich plasma | ChEMBL. | 8496908 |
I50 (functional) | = 34 nM | Inhibitory activity against platelet aggregation, induced by U-46619 in human platelet rich plasma | ChEMBL. | 8496908 |
IC50 (functional) | = 12 nM | Inhibitory activity against platelet aggregation, induced by arachidonic acid in human platelet rich plasma | ChEMBL. | 8496908 |
IC50 (functional) | = 34 nM | Inhibitory activity against platelet aggregation, induced by U-46619 in human platelet rich plasma | ChEMBL. | 8496908 |
Kd (binding) | = 1.2 nM | Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand | ChEMBL. | 8496908 |
Kd (binding) | = 1.2 nM | Inhibitory binding activity against TXA2 receptor in human platelet membrane, using [3H]-SQ 29548 as the radioligand | ChEMBL. | 8496908 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8496908 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.