Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Encystation-specific protease | 0.0048 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0134 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0048 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin l1 | 0.0174 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0134 | 0.4054 | 0.4054 |
Brugia malayi | Papain family cysteine protease containing protein | 0.026 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0174 | 0.5946 | 0.5946 |
Plasmodium vivax | unspecified product | 0.0086 | 0.1791 | 0.1791 |
Toxoplasma gondii | cathepsin CPL | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5946 | 0.5946 |
Loa Loa (eye worm) | fibroinase | 0.026 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0174 | 0.5946 | 0.5946 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5946 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.026 | 1 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0174 | 0.5946 | 0.5946 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.026 | 1 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.026 | 1 | 1 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0174 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0086 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cysteine protease | 0.026 | 1 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1791 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0134 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.026 | 1 | 1 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.026 | 1 | 1 |
Plasmodium vivax | vivapain-3 | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5946 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0086 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Schistosoma mansoni | cathepsin s | 0.0086 | 0.1791 | 0.1791 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cysteine protease | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.026 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin L | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0174 | 0.5946 | 0.5946 |
Plasmodium vivax | vivapain-1 | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0086 | 0.1791 | 0.1791 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | Cathepsin L homolog | 0.026 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0134 | 0.4054 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.026 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.026 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0134 | 0.4054 | 0.4054 |
Plasmodium vivax | unspecified product | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Giardia lamblia | Cysteine protease | 0.0048 | 0 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0174 | 0.5946 | 0.5946 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0134 | 0.4054 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.026 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0134 | 0.4054 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.026 | 1 | 1 |
Onchocerca volvulus | 0.0174 | 0.5946 | 0.5946 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0174 | 0.5946 | 0.5946 |
Onchocerca volvulus | 0.026 | 1 | 1 | |
Leishmania major | cathepsin L-like protease | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0086 | 0.1791 | 0.1791 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0048 | 0 | 0.5 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.026 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0048 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0134 | 0.4054 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0048 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0048 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0048 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.026 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.026 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0134 | 0.4054 | 0.4054 |
Loa Loa (eye worm) | cysteine protease | 0.026 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.026 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.026 | 1 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0086 | 0.1791 | 0.1791 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0048 | 0 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0174 | 0.5946 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.026 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.026 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1791 | 0.1791 |
Giardia lamblia | Cysteine protease | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.026 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0174 | 0.5946 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0134 | 0.4054 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.026 | 1 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0048 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 10.6 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 10 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Inhibition (binding) | = 10.6 % | Inhibition of T-type calcium channel Cav3.1 with alpha1G subunit expressed in HEK293 cells at 10 uM by FDSS6000 assay | ChEMBL. | 17035033 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.