Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | androgen receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.149 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0503 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0503 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.149 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1156 | 0.6613 | 0.6522 |
Brugia malayi | ecdysteroid receptor | 0.0937 | 0.4394 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.4394 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0503 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0759 | 0.2591 | 0.2392 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1156 | 0.6613 | 0.6522 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0503 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0503 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0503 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0937 | 0.4394 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FI5 (functional) | > 10000 nM | Agonist activity at androgen receptor expressed in HeLa cells assessed as effect on dihydrotestosterone-induced transcriptional activity by reporter gene assay | ChEMBL. | 17064916 |
FI5 (functional) | > 10000 nM | Agonist activity at androgen receptor expressed in HeLa cells assessed as effect on dihydrotestosterone-induced transcriptional activity by reporter gene assay | ChEMBL. | 17064916 |
IC50 (binding) | > 10000 nM | Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cells | ChEMBL. | 17064916 |
IC50 (functional) | = 10000 nM | Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by reporter gene assay | ChEMBL. | 17064916 |
IC50 (binding) | > 10000 nM | Displacement of [3H]mibolerone from androgen receptor expressed in CHOK1 cells | ChEMBL. | 17064916 |
IC50 (functional) | = 10000 nM | Antagonist activity at androgen receptor expressed in HeLa cells assessed as inhibition of dihydrotestosterone-induced transcriptional activity by reporter gene assay | ChEMBL. | 17064916 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.